Course Form (revised 8-2009)
I. Summary of Proposed Changes
Dept / Program
Biomedical & Pharmaceutical Sciences
Course Title
Pharmaceutical Biochemistry
Prefix and Course #
BMED 381
Short Title (max. 26 characters incl. spaces)
Pharmaceutical Biochem
Summarize the change(s) proposed
New Course
II. Endorsement/Approvals
Complete the form and obtain signatures before submitting to Faculty Senate Office
Please type / print name Signature
Requestor:
Elizabeth Putnam
Phone/ email :
x4794/elizabeth.putnam@umontana.edu
Program
Richard Bridges
Chair/Director:
Other affected programs None
Dean:
Date
CHPBS Dean Dave Forbes
III: To Add a New Course Syllabus and assessment information is required (paste syllabus into section V
or attach). Course should have internal coherence and clear focus.
YES
NO
Common Course Numbering Review: Does an equivalent course exist elsewhere in
the MUS? Do the proposed abbreviation, number, title and credits align with existing
course(s)? Please indicate equivalent course/campus 
No
Exact entry to appear in the next catalog (Specify course abbreviation, level, number, title, credits, repeatability
(if applicable), frequency of offering, prerequisites, and a brief description.) 
BMED 381, Pharmaceutical Biochemistry, 4 cr. Offered every Autumn. Prereq., admission to
Pharmacy School. Fundamental biochemistry from a pharmaceutical sciences perspective; management
of genetic information, molecular structure and function, and metabolic reactions, especially as relating
to drug actions and targets.
Justification: How does the course fit with the existing curriculum? Why is it needed?
In order to better align the progression of information taught throughout the pharmacy school
curriculum, the Pharmaceutical Biochemistry course was developed. This course allows the instructors
to emphasize topics essential to the pharmacy curriculum while ensuring coverage of basic biochemistry
concepts.
Are there curricular adjustments to accommodate teaching this course?
None are necessary
Complete for UG courses. (UG courses should be assigned a 400 number).
Describe graduate increment (Reference guidelines: http://www.umt.edu/facultysenate/Grad/UG.htm)
Fees may be requested only for courses meeting specific conditions determined by the Board of
Regents. Please indicate whether this course will be considered for a fee.
If YES, what is the proposed amount of the fee?
Justification:
IV. To Delete or Change an Existing Course – check X all that apply
Deletion
Title
Course Number
From:
Level U, UG, G
Change
To:
Description Change
Repeatability
From:
To:
YES
NO
Change in Credits
From:
To:
Prerequisites
1. Current course information at it appears in catalog
(http://www.umt.edu/catalog) 
Cross Listing
(primary program
initiates form)
Is there a fee associated with the course?
2. Full and exact entry (as proposed) 
3. If cross-listed course: secondary program & course number
4. Is this a course with MUS Common Course Numbering? If yes, then will this change eliminate the course’s
common course status? Please explain below.
5. Graduate increment if level of course is changed to UG.
Reference guidelines at:
http://www.umt.edu/facultysenate/Grad/UG.htm
(syllabus required in section V)
Have you reviewed the graduate increment
guidelines? Please check (X) space provided.
6. Other programs affected by the change
7. Justification for proposed change
V. Syllabus/Assessment Information
Required for new courses and course change from U to UG. Paste syllabus in field below or attach and send
digital copy with form.
Pharmaceutical Biochemistry (BMED 395)
FALL 2011
GENERAL INFORMATION
Class meets TR 10:10-11 in Chem 212 and WF 10:10-11 in SB117
Room
Coordinator:
Elizabeth Putnam
SB 282
Additional Instructors:
Richard Bridges
Kevan Roberts
SB 395B
SB 285B
Required Text:
Essential Biochemistry, 2nd Ed., Pratt & Cornely
Phone
243-4794
243-4972
243-4034
Objectives: At the conclusion of this one semester course, the student should be able to:
1. Understand DNA structure and replication
2. Understand RNA structure, transcription, and how the proteins involved in transcription can be
targeted therapeutically
3. Understand translation and how the proteins involved in translation can be targeted therapeutically
4. Carry out calculations related to how pH and pK values influences ionic species distributions and
absorption of drugs that are weak acids and bases
5. Understand how the structures of amino acids and peptides contribute to protein functionality and
relate to drug action
6. Understand carbohydrate structure and the functional properties of carbohydrate polymers
7. Understand lipid structure and the functional roles of lipids in membrane structure
8. Describe the metabolic reactions in the cell, specifically how these reactions consume and produce
energy by the synthesis and degradation of molecules
9. Understand how steps in the metabolic reactions in the cell can be targeted for drug action.
Evaluations: Students will evaluate the instructors online using Moodle. The evaluations will be
available to students during the last week of the semester. Students will receive one point of extra credit
for each evaluation they fill out during the appropriate time.
Attendance Policy: Attendance at all lectures is expected of students. Contact the course coordinator if
absences are anticipated or in case of illness or emergency. Instructors may deduct points for lecture
absences at their discretion. Seminar attendance may be assigned and available for extra credit at the
discretion of the instructors.
Grading: Quizzes may be given at the discretion of the instructors. Points for quizzes will be added to
the total points for the course.
Tests 1-4
Final Exam:
Test 5
Comprehensive Final
400 points
100 points
100 points
600 points
Test Schedule: Test 1: Sept. 26 (Putnam 100 points)
Test 2: Oct. 14 (Bridges 100 points)
Test 3: Oct. 31 (Bridges 100 points)
Test 4: Dec. 2 (Roberts 100 points)
Final Exam: Dec. 15 (Test 5: Roberts 100 points; Comprehensive Final: Putnam 25
points, Bridges 38 points, Roberts 37 points)
Test Policy: No tests will be given early. Only under extraordinary circumstances will an excused
absence from a test be permitted. When such an exception is granted, the appropriate form must be filed
with the Office of Student Services. A makeup test that can be either in written or oral format must be
taken within one week of the original test date. Students have one week from the time the test is returned
to resolve any grading questions. Such requests must be written, attached to the original test and
submitted to the course coordinator.
INSTRUCTOR
TOPIC
ASSIGNMENT
DATE
WEEK 1
8/30
Putnam
Introduction, Nucleotides and Nucleic Acids
8/31
DNA structure
9/1
DNA replication
9/2
DNA mutation
9/6
DNA repair
9/7
Recombination
9/8
Transcription in Prokaryotes
9/9
Transcription in Eukaryotes
9/13
Transcription in Eukaryotes
9/14
RNA modification and processing
9/15
The Genetic Code
9/16
Translation
Ch. 3
Ch. 20
WEEK 2
Ch. 21
WEEK 3
Ch. 22
WEEK 4
9/20
9/21
PCR, qPCR, microarrays and clinical testing
Bridges
Ch. 3
Biochemistry in Pharmacy
9/22
Water, Ionization, pH
9/23
pH, Buffers
9/26
TEST 1 on Putnam material, 1 - 2pm, SB 169
9/27
Buffers, Bicarbonate-Blood Buffering
Ch. 1, 2
WEEK 5
9/28
pH, Buffers, Drug Solubility
9/29
Amino Acids, Diet, Functional Groups
9/30
Protein Structure, primary amino acid sequence
Ch. 4
WEEK 6
10/4
Secondary, Tertiary Protein Structure
10/5
Protein Folding and Structure
10/6
Protein Structure, Enzymes, Receptors, Channels
10/7
Enzymes, Kinetics
10/11
Enzymes Kinetics, Inhibition
10/12
Enzymes Mechanisms
10/13
Enzymes Mechanisms and Regulation
10/14
Allosteric Regulation
Ch. 5
Ch. 6, 7
WEEK 7
TEST 2 on 9/20 to 10/11 material, 1 - 2pm, SB117
10/14
WEEK 8
10/18
Carbohydrates
10/19
Carbohydrates/Lipids
10/20
Lipids
10/21
Membrane Structure
10/25
Membrane Structure
10/26
Signal Transduction
10/27
Signal Transduction
Ch. 11
Ch. 8, 9
WEEK 9
10/28
Roberts
Digestion
WEEK
10
10/31
TEST 3 on remaining Bridges material, 1-2 pm, SB
169
Ch. 10
Ch. 12
11/1
Metabolism Overview, ATP and Vitamins
11/2
Metabolism Overview
11/3
Glycolysis I
11/4
Glycolysis II
11/8
Glycolysis III
11/9
Gluconeogenesis
11/10
Glycogen Metabolism I
11/11
HOLIDAY
11/15
Glycogen Metabolism II
11/16
Glycogen Metabolism III
11/17
Pentose Phosphate Pathway
Ch. 13
WEEK
11
WEEK
12
11/18
WEEK
13
11/22
Citric Acid Cycle I
11/23
NO CLASS – TRAVEL DAY
11/24
HOLIDAY
11/25
HOLIDAY
11/29
Citric Acid Cycle II
11/30
Electron transport chain I
12/1
Electron transport chain I
12/2
Electron transport chain II
12/2
TEST 4 on Roberts material, Ch 12-14
12/6
Oxidative Phosphorylation - Proton-motive force
12/7
Fatty Acid Degradation
12/8
Fatty Acid & Eicosanoid Synthesis
12/9
Lipid Synthesis
12/15
FINAL EXAM, 10:10 – 12:10 am, SB169
Ch. 14
WEEK
14
Ch. 15
WEEK
15
WEEK
16
TEST 5 on remaining Roberts material
AND COMPREHENSIVE EXAM
Ch. 17
VI Department Summary (Required if several forms are submitted) In a separate document list course
number, title, and proposed change for all proposals.
VII Copies and Electronic Submission. After approval, submit original, one copy, summary of proposals
and electronic file to the Faculty Senate Office, UH 221, camie.foos@mso.umt.edu.