Using and manipulating REDCap – an
end user’s perspective
Vanessa Pirrone, Ph.D.
Department of Microbiology and Immunology
Center for Molecular Virology and Translational Neuroscience
Institute for Molecular Medicine and Infectious Disease
Vpirrone@drexelmed.edu
Bioinformatic analysis of demographic, clinical, and host and viral
genetic data of the DREXELMED HIV/AIDS Genetic Analysis Cohort
Patient interview &
Medical Chart Review
~400 individual fields
of data are collected
Neurocognitive Testing
Electronic
Medical
Record (EMR)
David Libon, Ph.D.
iPAD
Jeffrey Jacobson, M.D.
IMM&ID Center for
Genomic Sciences
Garth Ehrlich, Ph.D.
Bioinformatic analysis
Brian Moldover, Ph.D.
Biostatistic analysis
Rui Feng, Ph.D.
Tania Giovannetti, Ph.D.
Kate Devlin
Host and viral
genomics
database
Aydin Tozeren, Ph.D.
William Dampier, Ph.D.
Host and viral RNA and DNA
collected for each patient visit
INSTITUTE FOR MOLECULAR MEDICINE AND INFECTIOUS DISEASE
Summary of DREXELMED HIV/AIDS Genetic Analysis Cohort
ENROLLMENT UPDATE
Number
Definitive LTR
sequences2
R003
531
461
R01
295
232
R02
203
162
R03
134
99
R04
100
69
R05
70
44
R06
44
41
R07
34
9
R08
22
6
R09
8
1
R10
2
0
1443
1124
Visit1
TOTALS
1On
average,
patients are seen
every six months
2Definitive
LTR
sequences
3R00
has 1481
definitive LTR clones
from 110 patients
4Definitive
4.4 kB
clones containing
LTR, Tat, Vpr, and
Env from 45 patients
at 65 visits
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Things to consider PRIOR to
beginning: Tips for
REDCap success
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Longitudinal nature of REDCap
Utilize the longitudinal nature of REDCap
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REDCap functionality
You can set-up REDCap similar to your original form
INSTITUTE FOR MOLECULAR MEDICINE AND INFECTIOUS DISEASE
REDCap Functionality
Create standard nomenclature for any given data field
- Use function to write specific directions under a question
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REDCap allows data entry to be standarized
Use drop downs and radio buttons instead of entering text
Use the date calendar for dates
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Branching logic within REDCap forms
Utilize branching logic and auto-calculated fields to streamline
data entry
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Links between EMR and REDCap
Understand what the EMR (Allscripts) has and does not have
versus paper records in storage
- Discreet fields versus text
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Multiple forms within a single REDCap project
Use multiple forms to keep track of sample preparation and
storage so they are tied to the clinical data
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Multiple forms and projects within REDCap across several
sites
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Logging all data entry within REDCap
All changes made within REDCap are logged with dates, times and users
INSTITUTE FOR MOLECULAR MEDICINE AND INFECTIOUS DISEASE
Advice from the other side
• Capture all data-points at all visits
• Use free text to clarify information, not encode
information
• Be specific about units
• REDCap can be utilized across several
sites/investigators with planning
• All information is logged which allows for recall
of past entries
INSTITUTE FOR MOLECULAR MEDICINE AND INFECTIOUS DISEASE
Lastly…
Meet with bioinformaticians and biostatisticians
prior to start
Will Dampier, Ph.D.
wnd22@drexel.edu
Department of Microbiology and Immunology
Center for Molecular Virology and Translational Neuroscience
Institute for Molecular Medicine and Infectious Disease
INSTITUTE FOR MOLECULAR MEDICINE AND INFECTIOUS DISEASE
Brian Wigdahl, Ph.D., Professor & Chair
Department of Microbiology & Immunology
Drexel University College of Medicine
Director
Benjamas Aiamkitsumrit, Ph.D.
William Dampier, Ph.D.
Rui Feng, Ph.D.
Jeffrey Jacobson, M.D.
Pooja Jain, Ph.D.
Steve Jennings, Ph.D.
Zafar Khan, Ph.D.
Christina Kollias, Ph.D.
Sandhya Kortagere, Ph.D.
Fred Krebs, Ph.D.
Michele Kutzler, Ph.D.
David Libon, Ph.D.
NINDS
Julio Martin-Garcia, Ph.D.
Brian Moldover, Ph.D.
Olimpia Meucci, M.D., Ph.D.
Sonia Navas-Martin, Ph.D.
Michael Nonnemacher, Ph.D.
Nirzari Parikh, Ph.D.
Vanessa Pirrone, Ph.D.
Sonia Shah, Ph.D.
Laura Steel, Ph.D.
Marianne Strazza, Ph.D.
Katie Kercher, M.S.
Meghan Metz, M.S.
NIMH
NCI
Shendra Passic, M.S.
Greg Antell
Marianne Bonner
Brandon Blakey
Natalie Chen
Betty Condran
Jessica Cross
Satinder Dahiya
Archana Gupta
Shawn Keogan
Raphael Lukov
NIDA
Monique Maubert
Andrea Partridge
Renzo Perales
Germaine Rival
Fiorella Rossi
Luz Jeanette Sierra
Neil Sullivan
Gokul Swaminathan
Ken Thompson
Jean Williams
Wen Zhong
NIAID
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