Associations Between Prior Authorization and Health Services Use Among Medicaid Patients with Bipolar Disorder Lu CY, Adams AS, Ross-Degnan D, Zhang a g F,, Zhang a g Y,, Soumerai Sou e a SB S 1 Acknowledgments Funding/Support: g/ pp Robert Wood Johnson Foundation’s Changes in Health Care Financing and Organization Program (PI: S. Soumerai) CL: Pharmaceutical Policy Research Fellowship (HMS), Sir Keith Murdoch Fellowship (AAA), Public Health Training Fellowship (NHMRC) This study was conducted at the Department of Population Medicine, Harvard Medical School & Harvard Pilgrim Health Care Institute. 2 Background & Research questions Maine Medicaid: July 2003 – Prior Authorization (PA) for non-preferred atypical antipsychotics (AA) and anticonvulsants (AC) Among patients with bipolar illness initiating a new treatment episode episode, what was the association between PA policy and: 1 1. Medication discontinuation? 2. Subsequent outpatient (ER, psychiatric) visits? 3 Methods Study population Diagnosed bipolar disorder Newly treated: (i) no bipolar drugs & (ii) <45 days institutionalized in the 90 days before initial drug dispensing (index date) Cohorts: stratify by receipt of care at Community Mental Health Centers (CMHC) CMHC attenders (2+ visits in baseline period) Policy (Jul 2003 – Feb 2004) Pre-policy Pre policy (historical; Jul 2002 – Feb 2003) Non-attenders Policyy Pre-policy 4 Methods Data: Maine Medicaid claims data (2001-2004) Outcome measures: Time to medication discontinuation Changes in outpatient visits (ER, psychiatric) pre & postinitiation in policy cohort vs. vs pre-policy cohort 3 time periods: pre-initiation, post-initiation on treatment, postinitiation after discontinuation Statistical analysis: Extended Cox regression analysis (≤30 days vs. >30 days) Linear mixed models 5 Baseline Characteristics Pre-policy cohort Policy cohort Attenders Non attenders Non-attenders Attenders Non attenders Non-attenders Female % 63 67 65 63 Aged 18-34 % 45 51* 49 56 Aged 35-54 % 50 41 45 39 Bipolar Rx used: AA 25 11* 26 12* AC 30 17* 27 16* Schizophrenia % 17 5* 16 6* No. medications 7.04.6 5.74.6* 7.45.1 5.64.5* 10 3* 11 4* 2 42 6 2.42.6 0 71 5* 0.71.5 2 22 1 2.22.1 0 71 3* 0.71.3 (n=275) Psych hospitalization % Psych visits * p<0.05 between groups (n=739) (n=275) (n=671) 6 Impact p on Drug g Discontinuation CMHC attenders: HR= 1.73 (95% CI 1.02.9) Nonattenders: tt d HR= 1.30 (95% CI 1.01 6) 1.6) 7 Psych y visits (p (per patient p per p month)) P1 vs P0 = 0.09 CMHC attenders: P2 vs P0 = -0.55 Estimate= E ti t -0.64 0 64 (95% CI -1.26 to -0.03) Non-attenders: Estimate 0.14 Estimate= (95% CI -0.18 to 0.46) ER visits (p (per patient p per p month)) CMHC attenders: P1 vs P0 = -0.05 Estimate= E ti t 0 0.06 06 (95% CI -0.13 to 0.24) P2 vs P0 = 0.10 Non-attenders: Estimate 0.16 Estimate= (95% CI 0.05 to 0.26) Summary P i Authorization Prior A th i ti policy li was associated i t d with: ith Increased medication discontinuation Seriously ill: Decline in psychiatric visits (less reason to visit physicians after discontinuation) Less seriously ill: Increased ER visits (attempts to manage medication access issues) Long-term consequences of PA? Further research! 10