Translating Research Into Policy & Practice Call for Papers New Approaches to Translating Research into Policy & Practice Chair: Linda Bilheimer, The Robert Wood Johnson Foundation Monday, June 27 • 9:00 am – 10:30 am ●A Review of Knowledge Transfer Models, Frameworks and Theories Ian Graham, Ph.D., Jo Logan, RN, Ph.D., Jacqueline Tetroe, MA, Nicole Robinson, The KT Theories Research Group Presented By: Ian Graham, Ph.D., Senior Social Scientist, Associate Director, Clinical Epidemiology Program, Ottawa Health Research Institute, 1053 Carling Avenue, ASB 2-008, Ottawa, NY K1Y 4E9; Tel: (613)798-5555 x18273; Fax: (613)7615402; Email: igraham@ohri.ca Research Objective: 1) To conduct a focused search for conceptual models, frameworks, or grand theories of knowledge translation, 2) To undertake a theory analysis of the identified models to determine their strengths and limitations and to determine similarities and differences among them, and 3) To determine the extent to which each model has been used and/or tested. Study Design: 1) A focused literature search of the social science, education, management, and health sciences literature, the internet, and hand searching of the journals Science Communication (formerly the journal Knowledge: Creation, Diffusion, Utilization), and Knowledge, Technology and Policy (formerly Knowledge and Policy: the International Journal of Knowledge Transfer and Utilization). 2) A theory analysis of the identified models/frameworks to determine their strengths, limitations, similarities and differences. 3) A bibliometric analysis using the science and social science citation journals to identify additional literature which might report on the use and/or testing of the models/theories. Population Studied: Conceptual models, frameworks, or grand theories of knowledge translation. Principal Findings: To date a total of 175 articles have been retrieved. They were classified as being either a theory, a framework or a model (the authors’ terminology was used for the classification – i.e. if the title used the term “framework”, it was classified that way). There were 41 theories, 63 models and 58 frameworks. In addition, there were 13 syntheses. The articles ranged in date of publication from 1903 to 2004. They were written by researchers representing a range of disciplines, including Nursing, Behavioural Sciences, Clinical Epidemiology, Geography & Geology, Education, Business, Law and Computer Sciences. Relatively few of the models/theories/frameworks have been evaluated. A set of common and unique components of the various conceptualizations of KT will be presented. Conclusions: The session will inform participants about conceptual models, frameworks and grand theories in the field of knowledge translation. Implications for Policy, Delivery, or Practice: The information provided will have the potential to increase understanding of research utilization and may be useful to guide best practice implementation endeavors. The findings may also provide foundational information upon which new theories or frameworks of knowledge translation may be derived. Primary Funding Source: Canadian Institutes of Health Research ●Towards Systematic Reviews that Inform Healthcare Management and Policymaking John N. Lavis, M.D., Ph.D. Presented By: John N. Lavis, M.D., Ph.D., Associate Professor and Canada Research Chair in Knowledge Transfer and Uptake, Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, L8N 3Z5; Tel: (905) 525-9140 x22907; Fax: (905) 529-5742; Email: lavisj@mcmaster.ca Research Objective: To inform discussions about how to improve the usefulness of systematic reviews for healthcare managers and policymakers, we asked five questions: 1) what is the nature of decision-making and approach to research evidence in healthcare management and policymaking? 2) what types of questions are asked in healthcare management and policymaking that could be informed by systematic reviews? 3) how is research evidence assessed before it is used to inform healthcare management and policymaking? 4) how much value is placed on researchers providing recommendations about a preferred course of action for healthcare managers and policymakers and on using language that is locally applicable? and 5) what is the optimal way to present research evidence for use in healthcare management and policymaking? Study Design: We reviewed studies of decision-making by healthcare managers and policymakers (phase 1), conducted our own interviews with healthcare managers and policymakers (phase 2), and reviewed websites that include healthcare managers and policymakers among their target audiences (phase 3). We built our systematic review on a completed review (thereby preserving its rigour in the identification and appraisal of studies) but we refined the selection criteria and the approach to data extraction and we analyzed the findings separately for healthcare managers and healthcare policymakers. We conducted semi-structured interviews with 10 healthcare managers and 19 healthcare policymakers in Canada and the United Kingdom to explore their experiences with acquiring information to inform their decisions and their perspectives on how researchers can better produce and adapt systematic reviews to inform healthcare management and policymaking. We reviewed the websites of 14 research funders, 14 producers/purveyors of research, and 17 journals to explore their approaches to reporting systematic reviews and whether and how their approaches matched with the suggestions arising from our systematic review and interviews. Population Studied: We conducted semi-structured interviews with a purposive sample of healthcare managers (or the senior staff of associations that seek to inform managers) in Ontario and England and healthcare policymakers in the Canadian federal and Ontario provincial governments and the United Kingdom government to explore their experiences with acquiring information to inform their decisions and their perspectives on how researchers can better produce and adapt systematic reviews to inform healthcare management and policymaking. Our sample frame was defined both by jurisdiction and role and we identified potential study participants through key informants and government websites. We interviewed 10 healthcare managers and 19 healthcare policymakers in Canada and the United Kingdom. The number of study participants counted in each role category is an underestimate, however, because many individuals had experience with and spoke about more than one role. Study participants were almost always drawn from the top ranks of their respective organizations (in the case of healthcare managers), department (in the case of civil servants) or office (in the case of political advisors). Principal Findings: Our systematic review demonstrated that the research evidence about decision-making by healthcare managers and policymakers is not that plentiful, rigorous (in the sense of using more than one data-collection method and adequately describing the sampling and measurement methods that were used) or consistent (in the sense of similar factors emerging across a number of contexts). The most rigorously demonstrated and consistent factors to emerge from the studies all pertained to healthcare policymakers: 1) individual-level interactions between researchers and healthcare policymakers increased the prospects for research use; 2) timing and timeliness increased (and poor timing or lack of timeliness decreased) the prospects for research use; 3) individuals’ negative attitudes towards research evidence decreased the prospects for research; and 4) individuals’ lack of skills and expertise decreased the prospects for research use. Our interviews with healthcare managers and policymakers suggest that: 1) most do not highly value systematic reviews as an information source; 2) nevertheless many have used systematic reviews to address many different types of questions; 3) some identified that they would benefit from having the attributes of the context in which the research was conducted highlighted in order to inform assessments of a review’s local applicability; 4) all would value information about the benefits, harms (or risks), and costs of interventions, the uncertainty associated with estimates, and variation in estimates by subgroup in order to inform programming decisions; 5) they disagree about whether researchers should provide recommendations; 6) almost all would value reports presented using something like a 1:3:25 format; and 7 ) some identified that they would value systematic reviews being made more readily available for retrieval when they are needed. Our analysis of websites found that: 1) attributes of the context in which the research was conducted were rarely provided; 2) recommendations were often provided; and 3) reports using a 1:3:25 format were rare. Conclusions: The exploratory nature of our research, and the general lack of research evidence against which we can compare our findings, mean that our interpretations and the guidance that we offer are provisional. Our provisional answers to question 1 lead us to argue for thinking broadly about healthcare managers and policymakers as target audiences, demonstrating to them the value of systematic reviews, engaging them in the production and adaptation of systematic reviews, and building their capacity to identify quality-appraised sources of systematic reviews and to appraise their local applicability. Our provisional answers to question 2 lead us to argue for the production of systematic reviews that address a broad array of questions. Our provisional answers to question 3 lead us to argue for making available an online source of all types of quality-appraised systematic reviews, identifying the benefits, harms (or risks) and costs of interventions (not just benefits), highlighting the uncertainty associated with estimates, describing any differential effects by sub-group (e.g., ethnocultural group), and identifying attributes of the context in which the research included in a systematic review was conducted to inform assessments of the applicability of the review in other contexts. Our provisional answers to question 4 lead us to argue for not providing recommendations in systematic reviews and avoiding the use of jargon in reports about systematic reviews. Our provisional answers to question 5 lead us to argue that more user-friendly “front ends” should be developed for potentially relevant systematic reviews (e.g., one page of take-home messages and a three-page executive summary) to facilitate rapid assessments of the relevance of a review and, when the review is deemed highly relevant, more graded entry into the full details of the review. Implications for Policy, Delivery, or Practice: Researchers could help to ensure that the future flow of systematic reviews will better inform healthcare management and policymaking by making three changes to how they produce and update systematic reviews: augment the stock of investigator-driven systematic reviews with reviews that involve healthcare managers and policymakers in posing questions, reviewing the proposed approach, and interpreting the results; for systematic reviews about “what works,” identify the benefits and harms (or risks) of interventions (not just benefits), highlight the uncertainty associated with estimates, and describe any differential effects by sub-group (e.g., ethnocultural group); and identify attributes of the context in which the research included in a systematic review was conducted to inform assessments of the applicability of the review in other contexts; Research funders could help to ensure that the global stock of systematic reviews will better inform healthcare management and policymaking by supporting three types of local adaptation processes led jointly by researchers and healthcare managers and policymakers: develop a more user-friendly “front end” for potentially relevant systematic reviews (e.g., one page of take-home messages and a three-page executive summary) to facilitate rapid assessments of the relevance of a review and, when the review is deemed highly relevant, more graded entry into the full details of the review; add additional local value to systematic reviews about “what works” by describing the benefits, harms (or risks) and costs that can be reasonably expected locally and to any type of systematic review by using language that is locally applicable; and make user-friendly “front ends” of systematic reviews available through an online database that can be linked to the full reviews through other sources, such as The Cochrane Library. Primary Funding Source: Canadian Health Services Research Foundation / National Health Service (NHS) Service and Delivery Organization R&D Programme ●Synthesizing Quality Improvement Research: Methodological and Empirical Challenges and Solutions Brian Mittman, Ph.D., Marjorie Pearson, Ph.D., Patricia Parkerton, Ph.D., Nancy Takahashi, MPH, Nina Smith, MPH Presented By: Brian Mittman, Ph.D., Senior Social Scientist, VA Center for the Study of Healthcare Provider Behavior, VA Greater Los Angeles Healthcare System, 16111 Plummer Street, mailcode 152, Sepulveda, CA 91343; Tel: (818)895-9544; Fax: (818)895-5838; Email: Brian.Mittman@med.va.gov Research Objective: Research synthesis methods such as meta-analysis and meta-regression have produced valuable evidence in the clinical sciences, leading to the development of evidence-based practice recommendations to facilitate improvements in clinical practices and outcomes. Metaanalysis represents an important tool for combining and reconciling seemingly inconsistent findings from individual clinical trials, as well as an effective mechanism to obtain value from small studies that offer little statistical power and thus limited value individually. The application of research synthesis methods to empirical studies of programs to improve healthcare quality is challenging, however, due to heterogeneity in intervention designs, research settings, and methods; and lack consistency and comparability in study measures and data. To address these challenges, variants and extensions of prevailing research synthesis tools have been developed, capturing qualitative data and accommodating the heterogeneity and other unique features of social and behavioral research. This presentation reviews the major challenges in effective application of research synthesis to QI evaluations, describes the newer synthesis methods applicable to QI studies and findings, and illustrates the application and benefits of these methods. Study Design: Literature review of research synthesis methods and application of innovative synthesis tools. Population Studied: The synthesis sample includes 54 studies of programs to improve healthcare quality conducted within the Veterans Health Administration (VHA) during 2001-2004. Each study addressed at least one of the eight chronic diseases targeted by VHA’s Quality Enhancement Research Initiative (QUERI) centers. Principal Findings: The application of prevailing synthesis methods to the VHA sample results in incomplete evidence tables containing only a subset of the factors hypothesized to influence QI program effectiveness, and few of the critical details of the improvement program interventions and settings. Expanding the synthesis effort to include a broader range of data sources and synthesis methods generates a more complete set of evidence tables and findings. For example, published data must be supplemented by reviews of key internal study documents (protocols, timelines, memos, progress reports) and in-depth interviews with study staff. The toolbox of synthesis methods is expanded from metaanalysis and meta-regression to include meta-synthesis of qualitative data and case study-based approaches. The latter involve generation and testing of study-specific hypotheses and development of new conclusions for each study individually, followed by quantitative and qualitative synthesis of these conclusions across the entire sample. Conclusions: The nature of quality improvement problems and solutions requires a diverse research approach combining “gold standard” clinical trial methods, program evaluation and qualitative research ranging from interpretive, inductive efforts to more conventional deductive strategies. The synthesis of findings and insights from these studies requires equivalent breadth and flexibility in synthesis methods and in their ability to handle diverse types of data and evidence. Implications for Policy, Delivery, or Practice: Limitations in the strength and utility of healthcare QI research findings represent an important barrier to the achievement of critical quality improvement goals. Enhanced methods for synthesizing QI research findings offer the possibility of accelerated development of a valid, useful QI evidence base and more effective applications of QI research results to achieve required improvements. Primary Funding Source: VA ●Realist Synthesis: An Approach to Synthesising Research Evidence on Complex Social Interventions for Policymakers and Managers Kieran Walshe, BSc(Hons), DipHSM, Ph.D., Dr Ray Pawson, Professor Trish Greenhalgh, Dr Gill Harvey Presented By: Kieran Walshe, BSc(Hons), DipHSM, Ph.D., Professor of Health Policy and Management, Centre for Public Policy and Management, Manchester Business School, University of Manchester, Booth Street West, Manchester, M15 6PB; Tel: 0(161)275 3852; Fax: 0(161) 273 5245; Email: kieran.walshe@man.ac.uk Research Objective: This paper describes a new model of research synthesis which is designed to work with complex social interventions or programmes, and which is based on the emerging “realist” approach to evaluation. Realist review is a relatively new strategy for synthesising research, which has an explanatory rather than judgemental focus. It seeks to ‘unpack the mechanism’ of how complex programmes work (or why they fail) in particular contexts and settings. Compared to clinical treatments, which are conceptually simple and have generally been evaluated in randomised controlled trials, the literature on healthcare management and policy-level interventions is epistemologically complex and methodologically diverse, which we argue makes it highly suited to realist review. Study Design: This paper does not report an empirical study, but the theoretical development of the realist review methodology. Principal Findings: The quest to understand ‘what works?’ in social interventions involves trying to establish causal relationships. The hallmark of realist inquiry is its distinctive generative (rather than successionist) understanding of causality. Under realism, the basic evaluative question – ‘what works?’ – changes to ‘what is it about this programme that works for whom in what circumstances?’. Because realist review is especially appropriate for highly complex interventions, we deliberate use complex examples in our paper such as a published review on the public disclosure of performance data (Marshall et al, 2000). Because of the predominant position of the conventional Cochrane style systematic review in health services research, we offer a comparison of the two approaches in terms of both theoretical assumptions and practical methods. Conclusions: Realist reviews do not provide simple answers to complex questions. They will not tell policymakers or managers whether something “works” or not, but they will provide the policy and practice community with the kind of rich, detailed and highly practical understanding of complex social interventions which is likely to be of much more use to them when planning and implementing programmes at a national, regional or organisational level. Implications for Policy, Delivery, or Practice: Commissioners of research reviews to inform policy and management decisionmaking should be increasingly involved in the production of the research synthesis, and reviewers should increasingly bring their technical expertise closer to the policy question by ensuring that their research takes account of the needs of a range of stakeholders. This healthy two-way dialogue is what Lomas has called ‘linkage’ (Lomas, 2000). Realist review raises the status of linkage from a recommendation to a methodological requirement. We argue that the tasks of identifying the review question and articulating key theories to be explored cannot meaningfully occur in the absence of input from practitioners and policymakers, because it is their questions and their assumptions about how the world works that form the focus of analysis. Furthermore, the ‘findings’ of a realist review must be expressed not as universal scientific truths but in the contextualised grammar of policy discourse. Key references: Pawson R, Greenhalgh T, Harvey G, Walshe K (2005). Using realist methods to produce syntheses of evidence for use by managers and policy makers. Journal of Health Services Research and Policy, submitted. Pawson R, Greenhalgh T, Harvey G, Walshe K. Realist synthesis: an introduction. Manchester: ESRC Research Methods Programme, 2004. Walshe K, Rundall T. Evidence based management: from theory to practice in healthcare. Milbank Quarterly, 2001; 79(3):429-457. Primary Funding Source: Canadian Health Services Research Foundation and NHS Service Delivery and Organisation research programme ●Applying Knowledge Transfer and Exchange Strategies to Promote Integrated Stroke Care Grace Warner, Ph.D., Stephen Phillips, M.D., Renee Lyons, Ph.D. Presented By: Grace Warner, Ph.D., Adjunct Faculty, Atlantic Health Promotion Research Centre, Dalhousie University, Suite 209, 1535 Dresden Row, Halifax, NS, B3J 3T1; Tel: (902)494-2604; Fax: (902)494-3594; Email: grace.warner@dal.ca Research Objective: The Atlantic Canada Integrated Stroke Strategy (ACISS) research project is a partnership between researchers, non-governmental agencies, and health care decision-makers funded through the Canadian Stroke Network. The ACISS project is evaluating how knowledge transfer and exchange (KT) strategies, such as using a knowledge broker, improve the exchange of best-practices research and policy implementation criteria between researchers and users of research in the Atlantic Provinces. This is one of the first research projects to evaluate the efficacy of the knowledge broker position. Study Design: This longitudinal study evaluates the efficacy of KT strategies over two years. The project assesses strategies using theoretical models from KT, diffusion of innovations, and quality improvement initiatives with both qualitative and quantitative methods. Key informant interviews assess: the needs and expectations of the partners, the process of creating acceptance for the knowledge broker position, the ability of the knowledge broker to meet partner expectations, and ways to improve the process of KT. In addition, key environmental drivers for health system change around stroke care are assessed using both qualitative and quantitative methods. Population Studied: Representatives from non-governmental agencies and health care decision-makers in the Atlantic Provinces Principal Findings: Initial partnering was challenging. Frequent personal communication, bi-annual forums, and salary support were used to facilitate the hiring of a knowledge broker, which took from 9-14 months in the different provinces. Key issues which affected this hiring process were political and in-kind support, confidentiality, prior biases, and outcome expectations. After the knowledge broker was hired different partner expectations were identified that the knowledge broker had to address when communicating between partners. For example, the drive to move forward from both the non-governmental and research partners contrasted with the cautionary speed of the government which made communications contentious. Although the knowledge broker was appreciated by all the partners an acceptable level of trust needed to be established before communications could be effective. Knowledge translation strategies, and especially knowledge brokers, have improved the communications and interactions between partners. Key KT deficiencies have been identified in the implementation of a complex integrated strategy, such as education of best practices research to administrative and health care practitioners who are affected by the strategy, the need to create a health care system that allows for best practices to evolve as research progresses, and improvements in communication channels between different sectors of government. Conclusions: Limited resources, the changing political climate, boundaries between health care decision makers and non-governmental advocates, and accountability to bureaucratic procedures pose strong barriers to acquiring and adapting new research evidence. Communication forums combined with a knowledge broker facilitates the implementation of evidence-based integrated care systems. Implications for Policy, Delivery, or Practice: The knowledge broker can be a good mediator for the push for system change and the reality of implementing those changes. It remains to be seen how a knowledge broker can be used and financed through out the health care system so we can have an evidence-based health care system. Primary Funding Source: Canadian Stroke Network Call for Papers Funders’ & Researchers’ Efforts to Translate Research into Policy & Practice Chair: John Lavis, McMaster University Tuesday, June 28 • 10:30 am – 12:00 pm ●Translating Research to Practice: Insights from Experience with AHRQ's IDSRN Initiative Marsha Gold, Sc.D., Erin Fries Taylor, Ph.D. Presented By: Marsha Gold, Sc.D., Senior Fellow, , Mathematica Policy Research Inc., 600 Maryland Avenue SW, Suite 550, Washington, DC 20024; Tel: (202)484-4227; Fax: (202)863-1763; Email: MGold@Mathematica-MPR.com Research Objective: To promote better understanding of what it means to "translate research to practice" by exploring lessons from the Agency for Healthcare Research and Quality's Integrated Delivery Systems Research Network (IDSRN) program. Begun in 1999, the IDSRN is one of AHRQ's earliest attempts to foster public-private collaboration between health services researchers and operational delivery systems. IDSRN's goals have increasingly focused on projects designed to support the translation of research to practice. Study Design: Independent program evaluation with analysis based on largely qualitative methods including: initial program review, descriptive analysis of characteristics of funded projects, structured interviews with AHRQ leadership and with staff associated with the IDSRN partners and their collaborators, and case studies of four successful projects. Population Studied: Experience in 58 projects funded for $14.2 million over 4 years (FY2000-FY2003) to 9 teams of researchers embedded in (5) or collaborating with (4) one or more collaborating managed care plans and delivery systems. Included interviews with 26 AHRQ staff and 65 individuals in IDSRN teams and their affiliated systems. Principal Findings: IDSRN supported a diverse variety of types of work that was subsumed under the rubric of "translating research to practice", some challenging traditional boundaries of health services research. Projects viewed as successful share a tendency to be responsive to user needs and operational interests, to benefit from ongoing support over multiple projects, and to involve work that is generalizable across multiple settings. Conclusions: Tying research to systems can help make that work more relevant and enhance AHRQ's links with those outside the research community. But effective translation also is challenging and even those actively engaged in translation view it differently and disagree on how it best can be carried out. Localized adoption does not translate to other settings automatically and research in practice is not the same as linking research to practices and taking full advantage of accumulated findings. Successful translation requires moving beyond funding individual projects to develop translation strategies and priorities for defined types of end users. Generating opportunities for translation also often requires an up front investment of resources. Implications for Policy, Delivery, or Practice: Though the value of health services research may be judged on its capacity for practical use in a way that has not occurred previously, there is little consensus even among researchers involved in IDSRN on the concept and variable buy-in. With resources scarce an open debate on what translation should mean, who it seeks to reach, and how it should be supported (including what share of research dollars should go to it) is crucial. For that, we need to learn as much as we can from existing experience with translation in all its forms. Primary Funding Source: AHRQ ●How and to Whom are Canadian Health Researchers Promoting the Uptake of their Findings? Part 1: The Quantitative Piece Ian Graham, Ph.D., Jacqueline Tetroe, MA, Jeremy Grimshaw, M.D., Ph.D., Nicole Robinson, Paul Hébert, M.D., MSc Presented By: Ian Graham, Ph.D., Senior Social Scientist, Associate Director, Clinical Epidemiology Program, Ottawa Health Research Institute, 1053 Carling Avenue, ASB 2-008, Ottawa, K1Y 4E9; Tel: (613)798-5555 x18273; Fax: (613)7615402; Email: igraham@ohri.ca Research Objective: 1) Determine what knowledge translation activities Canadian health researchers use to promote their findings and the extent to which researchers engage in these activities. 2) Identify gaps in target audiences whom researchers report need to know about their findings but do not. Study Design: A cross-sectional self-administered mail survey of 368 Canadian health researchers Population Studied: Applied health researchers who were funded by the Canadian Institutes of Health Research, the former Medical Research Council of Canada, the former National Health Research and Development Program of Health Canada, and the Canadian Health Services Research Foundation between 1995 and 2001. Principal Findings: There was a 73% (229/312) response rate. 75% of the respondents reported that the study findings were quite or very useful to decision makers. The top four diffusion, dissemination, implementation activities included: conference presentation (86%), publication (80%), final report to funder (53%), non-peer reviewed publication (36%); summary to policy makers (25%), summary to practitioners (21%), tools creation (21%), press releases (18%); educational sessions with practitioners (43%), stakeholder involvement (40%), media involvement (23%), educational sessions with policy makers (19%). The largest gaps between needing to know about and actually being aware of study findings were for federal/provincial policy makers (gap=38%), patients/consumers (gap=35%), health care professional bodies (gap=35%), and health care managers (gap=29%). The smallest gap was for study stakeholders (7%). Researchers’ confidence in their ability to engage in KT activities varied: 43% (very or quite confident) with community/municipal organizations, media (45%), federal/provincial policy makers (48%), managers (53%), patients/consumers (54%), to health care practitioners (79%), study stakeholders (83%), researchers/academics (94%). Findings often differed depending on the specific agency funding the study. Conclusions: The researchers in this study engaged in KT activities to varying degrees and the majority tended not to focus their activities on policy makers. They acknowledged that their findings were relevant to policy makers, health care managers, and health care professional bodies, yet for over a third of the studies, these audiences were not aware of the findings. Furthermore, researchers were also least confident in their abilities to engage in KT activities with these audiences. Implications for Policy, Delivery, or Practice: Researchers need help to push findings to policy makers, or alternatively, to create a pull for these findings. They need the skills, experience and confidence to be able to interact productively with these audiences. The nature of the expectations/requirements that a given funding agency has of their funded researchers would appear to influence the type and successfulness of the KT activities engaged in by the researchers. Primary Funding Source: The Canadian Institutes of Health Research ●How and to whom are Canadian Health Researchers Promoting the Uptake of their Findings? Part 2: the Qualitative Piece Ian Graham, Ph.D., Jacqueline Tetroe, MA, Jeremy Grimshaw, M.D., Ph.D., Nicole Robinson, Paul Hébert, M.D., MSc Presented By: Ian Graham, Ph.D., Senior Social Scientist, Associate Director, Clinical Epidemiology Program, Ottawa Health Research Institute, 1053 Carling Avenue, ASB 2-008, Ottawa, K1Y 4E9; Tel: (613) 98-5555 x18273; Fax: (613)7615402; Email: igraham@ohri.ca Research Objective: To identify barriers and facilitators to researchers’ engagement in knowledge translation activities. Study Design: A cross-sectional self-administered mail survey of 368 Canadian health researchers. Semi structured telephone interviews were conducted with a purposive sample of 13 respondents. Population Studied: Applied health researchers who were funded by the Canadian Institutes of Health Research, the former Medical Research Council of Canada, the former National Health Research and Development Program of Health Canada, and the Canadian Health Services Research Foundation between 1995 and 2001. Principal Findings: Respondents identified a number of barriers to engaging in appropriate KT activities, including: lack of resources – such as time, funding, training, staff and expertise in KT; lack of ability and confidence – KT is a new requirement, it is time consuming and challenging; no reward or support system within universities, nor with policy makers – evidence is not perceived to be important to them; political and/or media backlash – policy makers may have to be strategic with their use of evidence and media quite often distort it; there is so much turn over in the decision making world and the process of research is so long that research results can lose their relevance before they can be implemented; and finally, some study findings are not “ready” for KT – for a variety of reasons. Many respondents also identified facilitators to engaging in KT activities: having the financial or administrative support of a funding agency that values KT and has a KT infrastructure; previous experience with KT and a having a team member who is committed to this activity; the current research climate puts KT in a positive light – hence it is valued more; having stakeholders involved in the research project from its inception results in a ready audience and relevant results; researching a “sexy” topic that the media/politicians want to exploit; and finally, having an established relationship with decision makers. Conclusions: Many of the respondents recognize the importance of actively trying to disseminate the results of their research and many are successfully doing so. However, many feel a lack of support for and recognition of these efforts from academic institutions – which largely reward publication in peer-reviewed journals and not the time spent in relationship building necessary for relevant applied research. More junior researchers could benefit from mentoring to build the skill set and contact list necessary for effective dissemination through partnerships. Implications for Policy, Delivery, or Practice: Funding agencies could consider providing capacity enhancing opportunities for researchers to hone their dissemination skills and to link them with relevant stakeholders. Academic institutions could consider acknowledging the contribution of research dissemination activities when making promotion and tenure decisions. Primary Funding Source: The Canadian Institutes of Health Research ●An International Study of Health Research Funding Agencies’ Support and Promotion of Knowledge Translation. Part 1: The Study Ian Graham, Ph.D., Jacqueline Tetroe, MA, Nicole Robinson, Jeremy Grimshaw, M.D., Ph.D. Presented By: Jacqueline Tetroe, MA, Research Program Manager, Clinical Epidemiology Program, Ottawa Health Research Institute, 1053 Carling Avenue, ASB 2-007, Ottawa, K1Y 4E9; Tel: (613) 798-5555 x19288; Fax: (613) 761-5402; Email: jtetroe@ohri.ca Research Objective: To increase our understanding of the knowledge transfer policies and activities of applied health research funding bodies within Canada and internationally by examining the perceived role of funding agencies in promoting the results of the research they fund. Study Design: This was a qualitative study in which semistructured interviews were conducted with a sample of key informants from applied health funding agencies identified by the collaborators. These were supplemented with information from the agency websites. Population Studied: Up to three representatives were interviewed in each of 30 applied health funding agencies in Canada, the United States, Scandinavia, the United Kingdom, France, the Netherlands and Australia. Principal Findings: Two thirds of the agencies had explicit or implicit reference to KT in their mission/mandate. All agencies engaged in some sort of KT activity. The majority of agencies consider KT as a shared responsibility between the agency and the researchers. Within the 30 agencies studied, 27 different terms used for KT were identified in the transcripts, many of which were not defined. The operational definitions of KT varied between agencies. The transcripts were analyzed in terms of two major categories: agency requirements of the researcher and agency initiatives that were broader than an individual funded study. We examined agency requirements of the researcher at the time of application, at the end of the study and in terms of allowable expenses for dissemination-related activities. Overall, there appeared to be a more systematic approach to the expectations of researchers than in the other broad category: initiatives taken by the agency. No single activity was practised by all of the agencies. We divided the agency initiated activities into the following broad categories: tools/techniques, services, linkage and funding. The most common activities/strategies were the creation of audience tailored web pages, consulting stakeholders in setting the research agenda, funding workshops, creating linkage and exchange opportunities with various parties (such as decision makers, the public, health managers, etc) and helping researchers with plain language writing and communicating with the media. Conclusions: This would appear to be a time of rapid evolution for agencies in terms of their approaches to and means of increasing the uptake and dissemination of the results of the research they fund. A wide range of knowledge transfer activities were reported across the 30 agencies, with large variation in terms of creating a pull for research findings; engaging in linkage and exchange between agencies, researchers and decision makers; and pushing results to various audiences. Evaluation of these activities is challenging and most agencies are either not ready to embark on a formal evaluation or are doing so on a very preliminary and/or exploratory basis. Implications for Policy, Delivery, or Practice: Little is known about the effectiveness of the range of KT strategies reported by the agencies in our study. This is an area that is seen as being very important to funding agencies because of the gap between research and practice and because of pressures they feel to be accountable to their funding sources. Agencies may benefit from an opportunity to examine what other agencies are doing in this important area. Primary Funding Source: The Canadian Institutes of Health Research ●An International Study of Health Research Funding Agencies’ Support and Promotion of Knowledge Translation. Part 2: The Workshop Ian Graham, Ph.D., Jacqueline Tetroe, MA, Nicole Robinson, Jeremy Grimshaw, M.D., Ph.D. Presented By: Jacqueline Tetroe, MA, Research Program Manager, Clinical Epidemiology Program, Ottawa Health Research Institute, 1053 Carling Avenue, ASB 2-007, Ottawa, K1Y 4E9; Tel: (613)798-5555 x19288; Fax: (613)761-5402; Email: jtetroe@ohri.ca Research Objective: We undertook a study of international health research funding agencies’ support and promotion of knowledge translation (KT) (abstract for this submitted separately). After compiling the results of the study we held a workshop with selected representatives of these agencies to elicit their interpretation of our findings and to discuss the various mechanisms that can be put into play to facilitate KT. Study Design: Agency representatives were invited to attend a one day workshop in which the investigator team presented the results of our qualitative study, based on semi-structured interviews and information from agency documents and websites, of 30 health research funding agencies in Canada, the United States, the United Kingdom, France, the Netherlands, Australia and Scandinavia. Population Studied: Representatives from the following agencies attended the workshop: CHSRF, CIHR, AHFMR, FRSQ, NCIC, AHRQ, NIH-NCI, RWJF, California HealthCare Foundation, Center for Evidence Based Policy, and CDC. Also in attendance were members of the investigator team and Réjean Landry, a Canadian expert in knowledge utilization. Principal Findings: Funding agencies discussed the need to set minimum expectations of researchers to encourage KT and to ensure that there is a scientific record of a project. Some of the suggestions included preparation of a structured final report; identification of target audiences for KT activities; and stakeholder involvement where appropriate. There was less agreement on the specific roles of funding agencies, but suggestions included linking with policy makers, in-house synthesis of funded research and creation of a research register. Agencies agreed that a systematic approach to KT is required. The specific activities may vary depending on the goal of the agency, the range of programs, the desired outcomes, and how the outcomes might be met. The workshop participants agreed that funders need to agree on a common set of terms and operational definitions; that it is important to fund the science of KT; that there is a need for a set of criteria for deciding what to disseminate, how and to whom and that these would be linked to the knowledge synthesis capability of the agency; that agencies can take on a training role through various mechanisms; that agencies can have a pivotal linking role between researchers and research users; and that evaluation of their KT programs is a new area that many agencies find difficult. Conclusions: Several key issues formed an overlay for the discussions: funding agencies need to decide what part of the KT agenda it can address internally and which through outside agencies; the understanding that work in this area depends on the “K” you are trying to “T” to whom; different agencies may see their role differently, depending on their mandate/mission or background in KT; and the amount of dedicated funding for KT in many agencies is minimal. Implications for Policy, Delivery, or Practice: Funders need to develop coordinated strategies and processes to effectively manage the issues raised in the workshop. One suggestion echoed by many of the participants is that there would be value in forming a funders’ association to provide a forum for sharing ideas and problems as well as to pool resources to leverage change. Primary Funding Source: The Canadian Institutes of Health Research Related Posters Poster Session B Monday, June 27 • 6:15 pm – 7:30 pm ●Logic Models as a Translational Research Tool: Lessons From the Los Angeles Medication Management Project Gretchen Alkema, MSW, Kathleen H. Wilber, Ph.D. Presented By: Gretchen Alkema, MSW, Doctoral Candidate, Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 900890191; Tel: (213)740-9685; Email: alkema@usc.edu Research Objective: To inform the translation of evidencebased research to practice by creating and applying a logic model to the implementation and evaluation process. Study Design: We used an iterative process of logic model development and application with an AoA-funded EvidenceBased Prevention Program site, the Los Angeles Medication Management Project, to create a logic model that informs the translational of evidence-based research into practice for all members of the project team. Logic model development included 1) literature review of logic models; 2) group facilitation with key team members to gain content for model; 3) draft of model; 4) consultation with representatives from original study and providers applying the model; 5) model revision; and 6) application of model in program implementation and translational research evaluation. Population Studied: Two Medicaid-waiver care management programs serving frail, community-dwelling, low-income older adults (65+) currently implementing evidence-based research. Principal Findings: Logic model development was valuable in 1) maintaining adherence to program fidelity and acknowledging where adaptations were needed due to agency context; 2) creating a shared vision of translating evidencebased research into the agency therefore building partnerships among stakeholders; and 3) creating a useable product to inform external parties of project’s core elements and intended outcomes. Conclusions: The logic model offers a useful tool for the Los Angeles Medication Management Project team to communicate to internal and external stakeholders the mechanics of implementing evidence based research into practice and its relationship to intended outcomes in new sites. Implications for Policy, Delivery, or Practice: As a roadmap for successful implementation in translational research projects, logic model development and application are useful for helping practitioners, program administrators, evaluators, funders, and other stakeholders understand their own roles and communicate more effectively with each other. Primary Funding Source: Administration on Aging ●State Mandated Benefits Review Laws: The Growth of Evidence-Based Health Insurance Policy Nicole Bellows, MHSA, Helen Halpin, Ph.D., Sara McMenamin, Ph.D. Presented By: Nicole Bellows, MHSA, Graduate Student Researcher, Center for Health and Public Policy Studies, UC Berkeley, 140 Warren Hall #7360, Berkeley, CA 94720-7360; Tel: (510) 643-1675; Fax: (510) 643-2340; Email: nstark@berkeley.edu Research Objective: The growth of state mandated health insurance benefits has given rise to concerns regarding the effects of these mandates on rising premium costs and access to health insurance. This paper examines the laws states have enacted to review mandated health insurance benefits and analyzes variations of the laws with regard to who has the responsibility and authority to conduct the reviews and the criteria they must use to evaluate the mandated benefits. Study Design: The state statutes for all fifty states and Washington D.C. were reviewed to determine which states have enacted mandated benefit review (MBR) laws as of September 2004. For those states where no statutory reference to a MBR process was found, the state legislative librarian or similar state official was contacted to confirm that such a law did not currently exist. Additionally, current state legislative agendas and activity were reviewed to confirm the list of states that had recently passed MBR legislation. Population Studied: This study analyzed the state laws for all 50 states and Washington D.C. as of September 2004. Principal Findings: A total of 26 states were found to have a MBR in place. The oldest laws date back to the mid-1980s; however, almost half of the MBR laws have been enacted since 2000. These findings demonstrate that there is substantial variation in the way the MBR laws are constructed in terms of who conducts the review and the criteria that are used in conducting the review. Four types of reviewers are used in MBR laws: proponents of the legislation (5 laws), administrative or legislative personnel (12 laws), legislatively established commission or task force (8 laws), and a state university system (1 law). Five types of criteria used in conducting the reviews were identified: cost considerations, utilization and demand considerations, medical effectiveness, public health considerations, and other considerations. Conclusions: The strategies employed in conducting state mandated benefit reviews vary considerably from state to state. While each approach has strengths and weaknesses, we conclude that the unique aspects of the state university system used in the California MBR law can serve as a potential model for other states. Implications for Policy, Delivery, or Practice: The growth of MBR laws in recent years point to an increased reliance on systematic reviews of published research by health policy makers in determining whether health insurance mandates are beneficial to the state populations. The types of reviewers and criteria used in the review are important to understand because these differences have both strengths and weaknesses, particularly with respect to potential biases. Understanding these strengths and weaknesses can lead to improved state MBR laws. Primary Funding Source: No Funding Source ●Enrollment Barriers in the Medicare Lifestyle Modification Program Demonstration (LMPD) for Medicare Beneficiaries Sarita Bhalotra, M.D., Ph.D., Gail K. Strickler, MS, Donald S. Shepard, Ph.D., Grant Ritter, Ph.D., A. James Lee, Ph.D., William B. Stason, M.D., MSc Presented By: Sarita Bhalotra, M.D., Ph.D., Assistant Professor, Heller School, Brandeis University, 415 South Street, Waltham, MA 02454; Tel: (781)736-3960; Email: bhalotra@brandeis.edu Research Objective: In response to a White House directive, Medicare initiated a payment demonstration to test the feasibility and cost effectiveness of cardiovascular lifestyle modification in 1999. Brandeis University was awarded the contract to evaluate implementation, feasibility, and costeffectiveness. Evaluation design was predicated on enrolling 1,800 Medicare beneficiaries with heart disease into each of two programs, the Dr. Dean Ornish Program for Reversing Heart Disease (Ornish) and the Cardiac Wellness Extended Program of the Mind/Body Medical Institute (MBMI). Enrollment was capped anticipating that provision of lifestyle modification programs would attract many enrollees. At the end of 55 months (96% of the enrollment period), only 401 Medicare beneficiaries (11% of the target) had enrolled at the 39 sites nationwide. This study analyzes reasons for low enrollment into the LMPD. Study Design: Implementation was studied from both clinical and managerial perspectives, using a qualitative, case study design incorporating on-site and participant observation, semi-structured interviews, reviews of written materials, with quantitative evaluation of marketing, recruiting, enrollment, and retention. Data were triangulated and analyzed using principles of grounded theory. Population Studied: The units of analysis were demonstration sites. Implementation was studied in person or via telephone interviews and document review at many of the 28 Ornish and 11 MBMI sites nationwide over a four-year period. Principal Findings: Enrollment was low in both programs. Less restrictive eligibility criteria, adopted in 2001, increased enrollment only slightly. Ornish made several mid-course enhancements to its marketing and recruitment strategies, including engaging some nurse recruiters, yet its enrollment (114 participants, or 26 per year) was less than half that achieved by the MBMI (237 participants; 88 per year). MBMI provided less central support and oversight for both clinical and managerial activities than Ornish. The Ornish program was substantially more demanding to program sites (more specialized staff) and to participants (e.g. more hours per week of required activities). Barriers to enrollment were systematically identified at patient, provider and organizational levels for both programs: key were senior leadership support for the program, physician buy-in and referral, other insurance support, program personnel belief and practice of Program, collaborative relationship with related programs (e.g. cardiac rehabilitation), time demands on participants, ease of eligibility determination. Conclusions: Enrollment was restricted due to a complex interplay of barriers involving patients, providers, and organizations. These impediments occurred at multiple levels, and needed to be addressed through multi-pronged and interconnected strategies and tactics. In addition to clinical leadership, it was vital that managerial and political entities within organizations engage in implementation. Patient resistance to participation might benefit from social marketing. Implications for Policy, Delivery, or Practice: To improve health status and control costs of treating chronic illnesses, it is imperative that the health care system promote lifestyle modification. Unless health care policymakers and program planners learn more about the challenges, barriers and incentives for engaging in multi-component lifestyle modification programs and ways to overcome them, such efforts are likely to incur huge costs while providing little benefit to the overall population in need. Benefits that are complex in design and delivery will be difficult for organizations to implement, providers to employ, and patients to utilize. Primary Funding Source: CMS ●Is Acupuncture Complementary or Alternative Medicine? Machaon Bonafede, MPH Presented By: Machaon Bonafede, MPH, Doctoral Candidate, Community and Preventive Medicine, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 644, Rochester, NY 14642; Tel: (585) 766-8622; Email: machaon_bonafede@urmc.rochester.edu Research Objective: The objective of this study was to determine whether or not acupuncture is a complement to or substitute for conventional medicine. A secondary objective was to determine what factors influenced or were associated with acupuncture use, with a separate model predicting acupuncture expenditures. Study Design: Since causal estimates were desired, instrumental variables models were employed in this crosssectional study. The influence of acupuncture expenditures was estimated using OLS and instrumental variables regression (IVREG), while utilization models were estimated using PROBIT and Bivariate Probit models. In each case, acupuncture was included as an independent variable in a model and the conventional service of interest was the dependent variable. Distance to the nearest acupuncturist was the instrument used in these models. Population Studied: This study utilized claims data from a midsize metropolitan insurance company. After inclusion criteria were satisfied, the total sample included every eligible acupuncture user (n=1688) and every 18th eligible nonacupuncture user (n=17,790). Principal Findings: From the model predicting acupuncture use, several characteristics were associated with increased acupuncture use, namely, being female, being age 41 to 50, and suffering from musculoskeletal disorders or headaches. These same factors were also most strongly associated with increased acupuncture expenditures. Through instrumental variables models, causal estimates were generated to determine the nature of the relationship between acupuncture and the various conventional services of interest. Utilization models indicated that acupuncture was a statistically significant substitute for primary care (odds ratio = .51), all outpatient services (.78), pathology services (.63), all surgery (.63), and laxatives (.60). One expenditure model showed that an increase of one dollar spent on acupuncture resulted in a $6.32 reduction in primary care expenditures. Similar results were found in the seven different diagnostic subpopulations, those being: headaches, pain symptoms, digestive disorders, circulatory disorders, respiratory disorders, infectious diseases, and musculoskeletal disorders. In all, the study outlines results from over 200 models predicting acupuncture’s influence on utilization of or expenditures on various conventional services. Conclusions: In many situations, acupuncture was a substitute for conventional services in terms of both utilization and expenditures. In general, acupuncture substituted outpatient primary care services, all outpatient services, musculoskeletal surgery, total pharmacy, steroids, and pain medications. On the other hand, acupuncture tended to complement chiropractic, physical therapy, preventive services, and allergy-related services. Models predicting the effect of acupuncture on total expenditures yielded strongly negative, non-statistically significant results. These results suggest that acupuncture expenditures trend towards reducing total medical expenditures, or in the very least acupuncture expenditures balance themselves out by substituting for other conventional services. Implications for Policy, Delivery, or Practice: These findings are of particular importance to practitioners and policy-makers as they indicate what services are substituted by acupuncture. More importantly, these results show what services are not substituted by acupuncture combating the fear that people forego necessary medical treatment when using alternative medicines such as acupuncture. For managed and policymakers looking to contain costs, acupuncture coverage may be a valid cost-containment strategy as it replaces more expensive conventional therapeutic options. Primary Funding Source: AHRQ Training Grant ●The Cost-Effectiveness of Advanced Implant Options in Orthopaedic Surgery Kevin Bozic, M.D., MBA, Saam Morshed, M.D., Marc Silverstein, M.D., James Kahn, M.D., MPH, Harry E. Rubash, MD Presented By: Kevin Bozic, M.D., MBA, Assistant Professor in Residence, Institute for Health Policy Studies, University of California, San Francisco, 500 Parnassus, MU 320W, San Francisco, CA 94143-0728; Tel: (415) 476-3900; Fax: (415) 4761304; Email: bozick@orthosurg.ucsf.edu Research Objective: Total joint replacement (TJR) is one of the most common and clinically successful operations in surgery, with over 95% of patients experiencing significant improvements in quality of life for up to 20 years following surgery. However, costs associated with TJR implants continue to rise, and TJR now accounts for a higher proportion of the Medicare budget than any other inpatient diagnosis or procedure. The purpose of this study was to compare the impact of advanced implant technologies on the clinical and cost-effectiveness of total joint replacement. Study Design: A Markov decision analysis model was constructed to estimate the incremental lifetime costs, effectiveness, and net health benefits gained with four advanced implant options for use in total joint replacement. All new technologies were compared with the conventional or gold standard implants that have been in widespread use for over 20 years. Model inputs, including costs, clinical outcome probabilities, and health utility values, were derived from a hospital cost accounting system, the published literature, and expert opinion. Sensitivity analyses were performed to identify the key determinants of costs saved, quality adjusted life years (QALYs) gained, net health benefits, and the threshold values for the critical variables of interest. Population Studied: Adults over the age of 50 years old with advanced degenerative arthritis of the hip and knee. Currently, over 32 million Americans suffer from these conditions, with an estimated economic impact of over $80 billion per year in direct and indirect medical expenses. Principal Findings: Newer implant materials offer the possibility of improved implant longevity, therefore reducing the need for further surgery in the future. Based on the results of our model, this would result in both higher lifetime QALYs and lower lifetime costs per patient. However, the use of these newer technologies also leads to higher costs associated with the initial surgery, and as a result, many hospitals and payors have been reluctant to approve their use. Conclusions: Advanced implant technologies could be both more effective and cost saving over the lifetime of the patient. However, current reimbursement policies result in strong financial disincentives for hospitals and payors to approve the use of these technologies in TJR. Hospitals, payors, clinicians, and policy makers should work together to develop reimbursement policies that take into consideration the immediate and downstream costs, risks, and benefits of new medical technologies before accepting them into widespread use. Implications for Policy, Delivery, or Practice: Total joint replacement is one of the most common operations performed in the United States, with over 750,000 procedures per year. Currently, Medicare spends over $3.8 billion per year on total joint replacement procedures, more than any other inpatient procedure or diagnosis, and implants costs account for over 50% of the total expenditures. Documenting the clinical and cost-effectiveness of new implant technologies prior to widespread adoption and use is important in controlling costs and improving outcomes in surgery Primary Funding Source: Orthopaedic Research & Education Foundation Health Services Grant ●Patient Loyalty, Trust, and Satisfaction: Data and Observations from a Medical Group Practice Srinivas Emani, Ph.D., Craig Samitt, M.D., Robert Yood, M.D., Elizabeth Dugan, Ph.D. Presented By: Srinivas Emani, Ph.D., Senior Research Associate, Research Department, Fallon Clinic, 640 Lincoln Street, Worcester, MA 01605; Tel: (508)595-2206; Fax: (508) 595-2225; Email: srinivas.emani@fallon-clinic.com Research Objective: Along with patient satisfaction and trust, loyalty to healthcare providers is emerging as a key concept of interest to researchers and practitioners. The concept of loyalty has attained a prominent place in the business and marketing literature. Yet the literature on loyalty in healthcare is not as extensive and includes varied definitions and measures. The objective of this paper is two-fold: (1) To report the results of a systematic literature search and review on patient loyalty, and (2) To present the results of empirical studies relating trust, loyalty, and satisfaction. One such study is described in this abstract. Study Design: The study was conducted at Fallon Clinic, a multi-specialty medical group practice, located in Central Massachusetts. Between September and November 2004, patients seen by a physician or other healthcare professional at the Clinic were mailed a patient satisfaction survey a few days after their visit. The surveys are routinely conducted by the Clinic as part of its quality assessment and physician compensation process. One item on the survey asks patients whether they would recommend the physician/healthcare professional they saw to their family and friends (choices include Definitely No, Probably No, Maybe, Probably Yes, and Definitely Yes). We defined patients who responded Definitely Yes to this item as loyal patients. Population Studied: All patients who saw a Fallon Clinic provider or healthcare professional between the months of September and November 2004 received a survey. Patients were excluded if: (1) they had received the survey in the previous six months, and (2) the provider’s quota of 150 patients was reached. Principal Findings: Of 26,098 surveys that were mailed, 8,681 were returned (33% response rate). 60% of the patients were female and 40% male. The mean age of the patients was 63 years. With regard to loyalty, 77% responded Definitely Yes to recommending the physician/healthcare professional they saw to their family and friends. There were no differences in loyalty by gender: 77% of females and 78% of males reported that they were loyal to the provider they saw. Similarly, there was no association between loyalty and age (t=-1.56, p=0.117). With respect to the satisfaction measures, attributes of the providers (personal manner, technical skills, explanation of what was done, and time spent with the patient) rather than attributes of access to healthcare (such as getting through to the office by phone, length of time waiting in office, and length of time to get an appointment) were associated with loyalty. For example, 75% of the patients who responded that the technical skills of the provider they saw were Excellent also reported that they were loyal patients. Similarly, 77% of patients who responded that the personal manner of the provider they saw was Excellent reported themselves as loyal patients. In contrast, 36% who responded that the length of time waiting in the office was Excellent and 32% who responded that getting through to the office by phone was Excellent reported themselves as loyal patients. Controlling for overall satisfaction with visit, technical skills of the provider had the highest correlation with willingness to recommend the provider (r=0.33) followed by explanation of what was done (r=0.279) and personal skills of the provider (r=0.276). Satisfaction with attributes of access to healthcare was not related to willingness to recommend provider. Conclusions: More than three-fourths of the patients surveyed at a multi-specialty medical group practice reported that they were loyal to the provider they saw. Loyalty was associated with satisfaction with provider characteristics rather than satisfaction with access. The provider characteristics, including technical competence, personal manner, and explanation of what was done to the patient, have been examined as dimensions of trust in studies on trust in providers. Not surprisingly, there appears to be a close relationship between trust and loyalty. Additional studies are underway to explore these relationships. Implications for Policy, Delivery, or Practice: Patient loyalty and the factors driving loyalty are important characteristics of the practice delivery system. Data on such characteristics are also valuable to decision makers involved in efforts to improve the delivery of care and strengthen patient-provider relationships. However, further attention is required on transferring conceptual measures of loyalty to useful and practical guidelines for improving care. Primary Funding Source: No Funding Source ●The Role of Personal Experience in Health Management and Policy Mark Exworthy, Ph.D., BSc, Tim Scott, Ph.D., John E. McDonough, Ph.D. Presented By: Mark Exworthy, Ph.D., BSc, Senior Lecturer, School of Management, Royal Holloway - University of London, Egham, Surrey, TW20 0EX; Tel: 44-1784-414186; Fax: 44-1784-439854; Email: M.Exworthy@rhul.ac.uk Research Objective: To investigate the conceptual and practical implications of personal experience of ill-health and health-care upon decision-making by policy-makers and health service executives. Study Design: Two stage design. a. Conceptual stage: Knowledge from literatures of various disciplines was evaluated to understand and explain the interaction between evidence, experience and decision-making. b. Empirical stage: Qualitative analysis of written examples of how policy-makers and health-care executives have drawn on their personal experience of (ill-)health and health-care to shape and influence their decision-making. Population Studied: The written accounts about personal experience (of ill-health and health-care) by policy-makers and health service executives in the US and UK. Principal Findings: a. Conceptual findings: A conceptual `double movement’ was identified in decision-making which involved `experience-as-evidence’ and `evidence-asexperience.’ Conventional distinctions between evidence and experience became blurred but this allowed a more thorough examination of evidential norms and procedures and prompted analysis of the weight given to each of the terms: evidence-based and movement. b. Empirical findings: The influence of personal experience ranged from the subtle to the catastrophic and was used in various ways to justify decisions, to empathize with patients and staff, to inform co-workers etc. The mechanisms and degrees of change in personal and professional lives varied according to the nature of the experience and the purpose of the written account. These changes related to perception, ideas, attitudes, values, assumptions and/or actions. This generated different interpretations of the transition to the newly ‘awakened’ state. Policy-makers and executives relied more on first or secondhand accounts of experience than on a scientifically derived evidence base. Conclusions: Policy-makers and executives were heterogeneous groups, their organizations equally varied. A coherent body of specialist knowledge was lacking. Decisionmaking was often fragmented between and within organizations. Dynamic executives shaped the tone and character of an organization’s culture and decision-making. Policy-makers and executives have been urged to incorporate research evidence into their decisions but incomplete or contradictory research evidence hardly altered the character of such decision-making. Evidence-based management and policy has largely ignored the role that personal experience plays in shaping the decisions of health system executives and policy-makers. This is unfortunate. Personal experience is the common denominator of knowledge: the body, its thoughts, actions and the ability to generate, define, search, sift and synthesise evidence, consciously and unconsciously. By combining and applying empirical, intuitive and cognitive knowledge to practical problems, experience is capable of providing an intensity of insight incorporating, but unmatched by, all other methods. This paper concludes by questioning whether the concept of evidence-based policy and management is appropriate given qualitative differences between policy, management and clinical sciences. Implications for Policy, Delivery, or Practice: Changes in professional conduct were initiated by movement in other compartments of their personal lives. Policy-makers and health service executives should expect such changes in their professional lives, embrace them and account for them. Furthermore, given a lack of evidence, the paper calls for an acknowledgement of and investigation into the uncertain influence of personal experience on health policy and executive decision-making processes. Primary Funding Source: No Funding Source ●Establishing an Interdisciplinary Research Center: A Component of the NIH Roadmap Kristine Gebbie, Ph.D., Beth Fatato, BA, Frank Lowy, M.D. Presented By: Kristine Gebbie, Ph.D., Associate Dean for Research, Columbia University School of Nursing, 630 West 168th Street, New York, NY 10032; Tel: (212) 305-0723; Fax: (212) 305-0722; Email: ell23@columbia.edu Research Objective: As identified by the Institute of Medicine's Clinical Research Roundtable, two major gaps that hinder the translation of research to improved health outcomes are the translation from basic science to human studies, and from clinical research to practice and policy. These translational blocks “impede efforts to apply science to better human health in a expeditious fashion.” Translational research collaboratives have a high failure rate. The purposes of this presentation are to (1) describe the establishment of an NIH-funded Interdisciplinary Research Center which is based on a translational model of research to policy and practice, (2)discuss the major challenges and barriers associated with the translation of research across disciplines and into policy and practice,and (3)summarize the views of core Center members on what constitutes success for such a translational center. Study Design: Systematic review of research on outcomes of collaborative research and interviews with the 14 core members of the Center. Population Studied: 14 core members of the translational research Center from diverse disciplines including medicine, public health, epidemiology, nursing, microbiology, dentistry, and education. Principal Findings: Few data are published regarding the success of collaborative approaches and assessment of comprehensive, step-by-step pathways for collaboration. Predictors of success identified in the literature include strong leadership, contributions and early 'buy-in' by all members, efficiency, identifiable work products, and formal training in interdisciplinary research. In one-on-one interviews, Center team members identified 27 measures of success of a translational research center. 74.1% described publications, fundable grants, and new networks, connections and ideas as the primary measures of success. 11% (3 individuals) listed the establishment of interdisciplinary training programs, but only one person (4%) indicated that policy change would be an indicator of success. Conclusions: Most members of this interdisciplinary research Center focused on specific work products related to their own research rather than policy implications of the Center. Implications for Policy, Delivery, or Practice: For individual researchers and clinicians to have an impact on the health care policy and practice, their awareness and interest in the broader policy implications of their work will need to be enhanced. Primary Funding Source: National Center for Research Resources, NIH ●Assessing the Financial Impact of State Health Benefit Mandates in California: Findings from the California Health Benefits Project Kominski Gerald, Ph.D., Miriam Laugesen, Ph.D., Nadereh Pourat, Ph.D., Jay Ripps, FSA, MAAA, Robert Cosway, FSA, MAAA Presented By: Kominski Gerald, Ph.D., Associate Director, Center for Health Policy Research, UCLA, 10911 Weyburn Avenue, Suite 300, Los Angeles, CA 90024; Tel: (310) 7942681; Fax: (310) 794-2686; Email: kominski@ucla.edu Research Objective: To develop a model for estimating financial impacts of proposed health insurance benefit mandates introduced in the California legislature. Study Design: Using three primary data sets (The California Health Interview Survey, the Health Research and Education Trust’s California Employer Health Benefits Survey, health care cost guidelines and claims data compiled by Milliman), we developed a cost and coverage model to produce baseline estimates of California’s insured population, grouped by insurer and type of coverage (HMO, PPO, POS, FFS), and the average expenditures for each group, including insurance premiums and out-of-pocket expenditures. We then estimate changes in the covered population affected by a mandate and changes in utilization resulting from the mandate to produce estimates of the overall change in total expenditures, including both insurance premiums and out-of-pocket expenditures. Population Studied: California's privately insured population (n equals 16,261,000). The specific population studied varies by mandate based on the treatment mandated and the covered populations affected by the mandate. Principal Findings: (1) To date, the estimated impact of the seven mandates examined as part of this project on permember per-month (PMPM) expenditures among insured Californians has been very small, usually less than 0.1 percent. (2) The impact is low in most cases because coverage of mandated benefits is already high. (3) The impact varies by market segment, with low impact for most large employer groups and a greater impact on small employer groups. (4) Mandates have a greater impact on the individual market, and particularly affects some subgroups within the individual market who may face substantial premium increases resulting from proposed mandates, however. For example, a proposed mandate requiring maternity benefits would have produced an estimated average increase in premiums within the individual market of 13 percent for those currently holding policies that exclude maternity benefits. Conclusions: Our model is the first comprehensive effort to develop an “open source” model by actuaries and health services researchers to estimate the effects of health insurance benefit mandates for different types of insurers and for different employer firm sizes and individuals. Benefit mandates are not necessarily costly, but their impact is much greater in the individual market. Implications for Policy, Delivery, or Practice: When making policy on mandates, policymakers should consider the differential impact among individuals and groups, rather than ‘averaging’ costs. Analysis of financial impacts of proposed state health benefit mandates, combined with analyses of evidence of medical effectiveness and public health impacts produced as part of this project, provides state legislators with evidence-based information for public decision making. Our ability to develop a California-specific model to estimate the financial impacts of proposed mandates in a timely fashion provided California legislators during the 2004 legislative session with more-detailed, specific coverage and cost information than is generally available to legislative bodies. Our work represents an important contribution in translating research findings directly into the legislative process. Primary Funding Source: CHBRP ●Improving Otitis Media Care through the Implementation of National Guidelines in an Integrated Delivery System Margaret J. Gunter, Ph.D., Sarah J. Beaton, PhD, Kathryn A. Paez, MBA, MSN, Lance Chilton, M.D., Denise Dougherty, Ph.D. Presented By: Margaret J. Gunter, Ph.D., President and Executive Director, Lovelace Clinic Foundation, 2309 Renard Place SE, Suite 103, Albuquerque, NM 87106; Tel: (505) 2623152; Fax: (505) 262-7598; Email: maggie@LCFresearch.org Research Objective: The purpose of this study was to contribute to the scientific and practical understanding of the most effective methods of changing physician behavior in accordance with evidence-based guidelines. The specific aims of the study were to: (1) implement an evidence-based practice guideline for otitis media, and (2) evaluate the effectiveness of the implementation methods used to change physician behavior in accordance with the otitis media guideline. Study Design: The study used a quasi-experimental design, with the guideline intervention (formal education program, sequential reminder mailings to providers, and repair of otoscopes) implemented in half the primary care, pediatric, and urgent care clinics in a large southwestern integrated delivery system, and the remaining clinics serving as controls (mailed guidelines only). Population Studied: The study population was limited to health plan members, aged six months through five years, who were seen by a staff-model physician. The clinical outcome measures obtained from claims data were: (1) percentage of otitis media episodes with a primary diagnosis of either acute otitis media (AOM) or otitis media with effusion or otalgia (combined into OME/Otalgia); (2) rate of antibiotic fills for each of the two diagnosis categories; and (3) rate of analgesic drop fills for pain relief. A post-intervention provider survey provided self-reported outcome measures. In addition, all measures were examined with respect to provider specialty type (urgent care, family practice, and pediatrics). Principal Findings: Claims data analysis showed significant improvement for intervention clinic providers over control group providers in decreased diagnosis of AOM (94.0% prevs. 91.2% post-intervention, p=.0231) and increased analgesic drop fills (7.6% pre- vs. 10.4% post-intervention for AOM; 2.4% to 11.5% for OME/otalgia, p=.0250), but no statistical significance for reduction in antibiotic fills. The provider survey showed statistically significant self-reported differences between the intervention and control clinic providers in the hypothesized direction for all three outcome measures. Significant differences in outcomes were seen by provider type (family practice, urgent care, or pediatrician). Of the ten intervention methods used, those ranked by the providers as highest in value were: repair of the otoscopes, the formal training, and the guidelines themselves. Conclusions: The analyses indicated that the interventions were effective in changing diagnosis and treatment patterns in compliance with guidelines, especially in the reduced diagnosis of AOM and in the increased prescribing of analgesic drops for pain. Improvement was more marked in the provider self-reports than in the claims data. Outcome differences were mediated by provider specialty. Implications for Policy, Delivery, or Practice: This study was designed to be practical yet rigorous in its design in order to create and validate guideline implementation tools and approaches that would be both feasible and effective in a variety of health care settings. Effective implementation of guidelines requires multiple, reinforcing interventions over time, tailored to the specific needs and barriers of the practice setting. Primary Funding Source: AHRQ ●Assessing the Public Health Impact of State Health Benefit Mandates Helen Halpin, Ph.D., MSc, Sara McMenamin, Ph.D., MPH, MSc, Ted Ganaits, M.D. Presented By: Helen Halpin, Ph.D., MSc, Professor of Health Policy, School of Public Health, University of California, Berkeley, 140 Warren Hall MC#7360, Berkeley, CA 947207360; Tel: (510) 642-2862; Fax: (510) 643-2340; Email: helenhs@berkeley.edu Research Objective: To develop a methodology for assessing the public health impacts of proposed state health insurance benefit mandate legislation in California. Study Design: Four primary date sets are used (The California Health Interview Survey, the California Behavioral Risk Factor Survey, Centers for Disease Control and Prevention WONDER database, and Milliman USA claims data) to estimate the covered population affected by a mandate, changes in utilization resulting from the mandate, and to estimate changes in health outcomes using estimates of effectiveness of utilization from the literature and projecting to the affected population. Population Studied: California's insured population. The specific population studied varies by mandate based on the treatment mandated and the covered populations affected by the mandate. Principal Findings: Baseline data on important health outcomes and information on differences in health services utilization by race/ethnicity are often not available at the state. Using estimates of medical efficacy from the scientific literature to estimate health outcomes in a population is likely to overstate the effects of a mandate. However, limitations in available data are likely to underestimate the scope of reported public health impacts. Conclusions: The approach California has developed for assessing the public health impacts of benefit mandate legislation, while challenging, represents a leap forward towards a more comprehensive assessment of proposed state health benefit mandates. The approach represents the first attempt to translate health insurance benefits policy into population health outcomes. Implications for Policy, Delivery, or Practice: Analysis of public health impacts of proposed health benefit mandates, combined with analysis of evidence of medical efficacy and costs, enables state legislators to consider the "value" of health care services in policy making. Value represents the improvement in health status realized for an investment of health care dollars. Such analysis has the potential to lead to the design of more cost-effective health insurance policy. Primary Funding Source: State of California ●Pharmaceuticals, Prescription Plans, and Promoting Progress James Henderson, Ph.D., Earl Grinols, Ph.D. Presented By: James Henderson, Ph.D., Ben Williams Professor in Economics, Economics, Baylor University, One Bear Place #98003, Waco, TX 76798; Tel: (254)710-4139; Fax: (254)710-6142; Email: Jim_Henderson@baylor.edu Research Objective: In this paper we discuss a socially preferable alternative to the patent system as a mechanism protecting intellectual property rights. Study Design: Three important issues are addressed. 1) How can we deal effectively with the above-mentioned monopoly pricing response to a prescription drug co-pay? 2) What is the best way to reward innovators to insure that the benefits of innovation are spread quickly and widely (at marginal cost prices)? 3) How do we go about calculating the reward for innovation? Population Studied: NA Principal Findings: The only way out of the unacceptable quandary is to sever the link between monopoly power created by the patent system and drug distribution. In fact, patent protection for new inventions is an anachronistic holdover compromise solution from an earlier era. Modern theory and tools imply an entirely different approach. This paper reviews historical policies toward research and development in light of the intervention principles of public finance. Conclusions: The paper concludes that an intertemporal bounty satisfying certain conditions is more efficient than current law and also dominates other structures including patent buyouts, except for a full-economy Ramsey pricing solution. Since Ramsey pricing is unlikely ever to be seen in practice, the investigation of efficient replacements for pharmaceutical patenting is timely and significant. The investigation identifies a mechanism for marginal cost drug pricing consistent with inducement to innovation as strong as provided by patents, consistent with increased social efficiency and practical implementation. The latter is argued from positive consideration of the fact that a similar system is successfully in place and has been used for many years in another sector of high innovation, the music industry. Implications for Policy, Delivery, or Practice: Pharmaceutical patent protection places Americans on the horns of an untenable dilemma. On one hand, monopoly protection limits the treatment options for individuals without prescription drug coverage and causes American consumers – many of whom are sick and not working – to pay too much for their medications. On the other hand, providing insurance for prescription drugs brings into play the monopolist's response which is to raise the drug's price in proportion to the inverse of the plan co-pay. A 20% co-pay, for example, creates an overwhelming incentive that leads the supplier to raise price to 5 times the initial level and reap the profit windfall. The firm adjusts its price-output pair from the (5p0, q0) point only if profits are thereby raised further. The present research raises the possibility of change in the pharmaceutical drug industry as part of the larger movement in the United States to find a more desirable social ethic that can drive and sustain our health care system. Primary Funding Source: No Funding Source ●Prevalence, Treatment, and Control of Chest Pain Syndromes, Blood Pressure, and LDL Cholesterol in Hypertensive Patients Katharine Hendrix, Ph.D., MS, Brent M Egan, M.D., Susan Mayhan, MS, Daniel T Lackland, DrPH Presented By: Katharine Hendrix, Ph.D., MS, Assistant Professor, General Internal Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, 826 CSB, Charleston, SC 29425; Tel: (843)792-6340; Fax: (843)792-0816; Email: hendrikh@musc.edu Research Objective: The purpose of this study was to define the prevalence and medical management of chest pain, angina pectoris, chronic angina, and pre-infarction angina/intermediate coronary syndrome (ICS) among hypertensive patients in primary care. Study Design: The Hypertension Initiative database (N=72,508 hypertensive patients’ primary care records) was analyzed to characterize prevalence and management of chest pain syndromes (CPS) and control of blood pressure (<140/90 mm/Hg) and LDL-cholesterol (<100 mg/dL). Patients with more than one CPS were categorized by the most severe diagnosis. Principal Findings: Eleven percent of patients (n=7996) had a CPS diagnosis. Of these, 66% (5284) were diagnosed with chest pain only, 15% (1204) with angina, and 19% (1508) with ICS. More men than women were diagnosed with angina (18% vs. 4%) and ICS (21% vs. 10%). More women than men were diagnosed with chest pain only (86% vs. 61%). (Figure 1) African Americans received more chest pain diagnoses (71% vs. 62%), similar angina diagnoses (14% vs. 16%), and fewer ICS diagnoses (15% vs. 22%) than Caucasians. Most striking, women and African-Americans received fewer medications than men and Caucasians within each diagnostic category. In addition, prescription rates differed more by gender (male/female) than by racial group (Caucasian/AfricanAmerican) for angiotensin converting enzyme inhibitors, diuretics, aspirin, statins, and nitrates. Conclusions: We conclude that Hypertensives with CPS received more medications and achieved better cardiovascular risk factor control (blood pressure <140/90 mm/Hg and LDLcholesterol <100 mg/dL) than hypertensives without a CPS diagnosis but the majority in both groups remained above recommended levels. Primary care physicians treat cardiovascular risk factors relatively aggressively in these highrisk hypertensive patients. However, concerning numbers of these patients do not reach BP or LDL-c goals and substantial differences in treatment and outcomes, especially between gender groups, represent opportunities to reduce disparities. Implications for Policy, Delivery, or Practice: Accurate, confidential, and regular feedback to primary care physicians such as is provided by the Hypertension Initiative database could assist health care providers track their adherence to treatment guidelines and their patients progress to reduce or eliminate some of the observed disparities. Primary Funding Source: Duke Endowment ●Impact of Nonresponse on Medicare Current Beneficiary Survey Estimates Galina Khatutsky, MS, Gregory C. Pope, MS, James R. Chromy, Ph.D., Gerald S. Adler, MPhil Presented By: Galina Khatutsky, MS, , Aging, Disability, and Long Term Care Program, RTI International, 411 Waverley Oaks Road, Suite 330, Waltham, MA 02452; Tel: (781) 7888100 x 125; Fax: (781) 788-8101; Email: gkhatutsky@rti.org Research Objective: The Medicare Current Beneficiary Survey (MCBS) is used by policymakers and research analysts to provide information on a wide array of topics about the Medicare program. This study had several objectives in evaluating the impact of nonresponse on MCBS estimates: 1) to examine unit nonresponse for beneficiaries in their initial interview round; 2) to evaluate panel attrition; 4) and to measure item nonresponse. The study also sought to recommend possible improvements to the current procedures for handling missing data in the MCBS. Study Design: Initial round unit nonresponse was decomposed into the response rate and the difference in respondent and nonrespondent means, and estimated for variables available for both respondents and nonrespondents (demographic, enrollment, health status, and service utilization measures). In addition to analyzing the components of nonresponse bias, we analyzed nonresponse bias directly by comparing means (proportions) for respondents and eligibles. We estimated bias before and after applying MCBS nonresponse adjustment weights. The analysis of second, third, and fourth year panel attrition was performed using a similar methodology but employing the conditional response rates. Item nonresponse rates were calculated using the ratio of item nonrespondents to item eligibles. Population Studied: The sample for analyzing initial round unit nonresponse was confined to MCBS eligibles in their initial round of the survey with beneficiaries pooled across three years of MCBS data (1997-1999) to maximize sample size. For panel attrition, two pairs of MCBS file years, i.e., 1997–98 and 1998–99, were pooled to construct three separate panel attrition analysis samples. The analysis sample for item nonresponse was confined to 1999 MCBS Access to Care sample respondents. Principal Findings: For initial round nonresponse, although statistically significant differences occurred between respondents and nonrespondents on such demographic characteristics as gender, race and geographic distribution, the magnitude of the differences between eligibles and respondents was relatively small and unlikely to cause a major potential for bias. However, current nonresponse adjustments were not as effective for health status, expenditure, and service utilization characteristics. Although initial nonresponse bias was small and further reduced by MCBS nonresponse weights, it was not entirely eliminated. Beneficiary characteristics affecting the response propensity varied for each attrition sample, but because of the high MCBS conditional response rates for each attrition sample, the magnitude of the differences between eligibles and respondents was relatively small, and thus unlikely to create bias. Cumulative response rates were found to be comparable to other large national surveys. While conditional response rates increased over the MCBS interview cycle, cumulative response rates decreased. Item nonresponse was generally low in the MCBS, with the exception of several items pertaining to recall of past events and knowledge of certain health insurance information. Conclusions: Our findings indicated that for most of the analysis variables studied, the bias caused by differences between nonrespondents and respondents was substantially reduced or eliminated by the nonresponse procedures currently employed in the MCBS. Implications for Policy, Delivery, or Practice: Implications for future MCBS administration are grouped into several domains and include recommendations on new or improved weighting adjustment procedures. Primary Funding Source: CMS ●Assessing the Financial Impact of State Health Benefit Mandates in California: Findings from the California Health Benefits Project Gerald Kominski, Ph.D., Jay Ripps, FSA, MAAA, Miriam Laugesen, Ph.D., Robert Cosway, FSA, MAAA, Nadereh Pourat, Ph.D. Presented By: Gerald Kominski, Ph.D., Professor, Health Services, UCLA School of Public Health, 650 Charles E. Young Drive South, Los Angeles, CA 90095-1772; Tel: (310) 794-1238; Email: kominski@ucla.edu Research Objective: To develop a model for estimating financial impacts of proposed health insurance benefit mandates introduced in the California legislature. Study Design: Using three primary data sets (The California Health Interview Survey, the Health Research and Education Trust’s California Employer Health Benefits Survey, health care cost guidelines and claims data compiled by Milliman), we developed a cost and coverage model to produce baseline estimates of California’s insured population, grouped by insurer and type of coverage (HMO, PPO, POS, FFS), and the average expenditures for each group, including insurance premiums and out-of-pocket expenditures. We then estimate changes in the covered population affected by a mandate and changes in utilization resulting from the mandate to produce estimates of the overall change in total expenditures, including both insurance premiums and out-of-pocket expenditures. Population Studied: California's privately insured population (n=16,261,000). The specific population studied varies by mandate based on the treatment mandated and the covered populations affected by the mandate. Principal Findings: (1) To date, the estimated impact of the seven mandates examined as part of this project on permember per-month (PMPM) expenditures among insured Californians has been very small, usually less than 0.1%. (2) The impact is low in most cases because coverage of mandated benefits is already high. (3) The impact varies by market segment, with low impact for most large employer groups and a greater impact on small employer groups. (4) Mandates have a greater impact on the individual market, and particularly affects some subgroups within the individual market who may face substantial premium increases resulting from proposed mandates, however. For example, a proposed mandate requiring maternity benefits would have produced an estimated average increase in premiums within the individual market of 13% for those currently holding policies that exclude maternity benefits. Conclusions: Our model is the first comprehensive effort to develop an “open source” model by actuaries and health services researchers to estimate the effects of health insurance benefit mandates for different types of insurers and for different employer firm sizes and individuals. Benefit mandates are not necessarily costly, but their impact is much greater in the individual market. Implications for Policy, Delivery, or Practice: When making policy on mandates, policymakers should consider the differential impact among individuals and groups, rather than ‘averaging’ costs. Analysis of financial impacts of proposed state health benefit mandates, combined with analyses of evidence of medical effectiveness and public health impacts produced as part of this project, provides state legislators with evidence-based information for public decision making. Our ability to develop a California-specific model to estimate the financial impacts of proposed mandates in a timely fashion provided California legislators during the 2004 legislative session with more-detailed, specific coverage and cost information than is generally available to legislative bodies. Our work represents an important contribution in translating research findings directly into the legislative process. Primary Funding Source: California State Legislature ●An Investigation of the First-Mover Advantage of Pharmaceutical Advertising and its Implications for Regulations W. Jacqueline Kwong, PharM.D., Ph.D., Edward C. Norton, Ph.D., Marisa Domino, Ph.D. Presented By: W. Jacqueline Kwong, PharM.D., Ph.D., Health Outcomes Manager, Global Health Outcomes, GlaxoSmithKline, MAI C4674.4B, P.O. Box 13398, Reserach Triangle Park, NC 27709-3398; Tel: (919)483-3945; Fax: (919)483-3096; Email: jackie.w.kwong@gsk.com Research Objective: The objective of this study was to determine if there was an asymmetry in the effectiveness of advertising between earlier and later entrants that would support the entry deterrence theory of advertising in the pharmaceutical market. The effect of advertising is often assumed to be durable, because consumers are likely to retain memory of the information they heard and that memory depreciates over time. As such, products that come to the market earlier may have a competitive advantage over later entrants. As a result, advertising can create potential barriers of entry and regulation may be needed. Study Design: The effectiveness of advertising was evaluated using estimates of advertising elasticity of demand (i.e., the percent change in a product’s sales per each percent change in its advertising expenditures). Advertising elasticity of demand of existing products and new entrants in the periods following new entry was estimated using time and disease fixed effects estimation. Because the effect of advertising on product sales is not immediate, one-period and two-period lag models were estimated. For instance, if a new product entered the market during period t, the advertising expenditures for existing products and the new product in period t+1 or t+2 were analyzed. The logarithm of a product’s sales was regressed on its own advertising expenditure, the total advertising expenditure of competing products in the same market, the number of competing products, number of years the product has been on market, a dummy variable indicating whether the product is a new entrant, and an interaction term between the dummy variable and the product’s own advertising expenditure. Population Studied: Advertising expenditure and product sales data were obtained from Scott-Levin Market Research Audit data. New product entry data were from USPDI, Orange Book and the Scott-Levin Market Research Audit data. Data from January 1995 to December 2001 were used. The analysis was conducted on a quarterly basis. Products from eight therapy markets were examined: asthma, migraine, obesity, Parkinson’s disease, seizure, depression, lipid disorder, and gastric and duodenal ulcer. Principal Findings: In both lag models, product sales significantly increased with a product’s own advertising expenditure, and significantly decreased with the total advertising expenditure of competing products, and the number of competing products. For existing products, advertising elasticity of demand was estimated to be 0.068% in the one-period lag model and 0.062% in the two-period lag model. The elasticity estimates for new entrants was lower at 0.046% and 0.044%, respectively. The elasticity estimates between new and existing products were not significantly different. Comparing results of the two lag models, advertising elasticity of demand depreciated at 8.7% per quarter. Conclusions: The analysis did not find any significant firstmover advantage in the effectiveness of advertising between earlier and later entrants that would support the potential entry deterrence effect of advertising in the pharmaceutical market. Implications for Policy, Delivery, or Practice: These results did not support regulation of pharmaceutical advertising based on anti-competitive grounds. Primary Funding Source: American Foundation for Pharmaceutical Education ●All Improvement is Local: Evaluating the Use of an Innovative, Multi-faceted Intervention by a National Professional Organization to Translate its Guidelines into Practice Suzanne Lazorick, M.D., MPH, Virginia L.H. Crowe, RN, MS, Judith C. Dolins, MPH, Carole M. Lannon, M.D., MPH Presented By: Suzanne Lazorick, M.D., MPH, Primary Care Research Fellow, Center for Children's Healthcare Improvement, UNC Chapel Hill, 200 Timberhill Place, Suite 201, Chapel Hill, NC 27599-7226; Tel: (919)966-0045; Fax: (919)966-9203; Email: lazorick@email.unc.edu Research Objective: Professional organizations have not engaged in partnership at local levels to translate guidelines into practice. The objective of this study was to understand facilitators, barriers, and outcomes of using American Academy of Pediatrics (AAP) chapters to implement the evidence-based guidelines for diagnosis and treatment of Attention Deficit Hyperactivity Disorder (ADHD). With support from a quality improvement (QI) organization, this intervention targeted: 1) leadership of AAP state chapters and 2) primary care practices (including participation in online education modules, attendance at a workshop, completion of chart reviews, and ongoing coaching in QI). Study Design: Qualitative analysis of responses from semistructured interviews and chapter monthly progress reports. Two researchers coded responses for factors related to program implementation. Outcomes assessed were development of infrastructure to support participating practices, or future plans for expansion. Practices audited charts to identify gaps and track improvements in care based on the guidelines Population Studied: Five state chapters were selected from 22 applications. We interviewed project leaders from the four chapters that completed the intervention phase: the physician champion, executive director, and project director, where applicable. One state deferred participation due to competing state priorities. Principal Findings: All nine project leaders, representing 60 practice teams, were interviewed and all 22 reports were reviewed. Facilitators to involving practices, sustaining interest, and stimulating changes included: personal contact from local opinion leaders, a face-to-face gathering of teams, involvement of office staff in addition to a physician, regular conference calls with teams and chapter staff, involving experts on calls, frequent contact from project administrators, and use of measurement to identify gaps in care. Baseline chart audits demonstrated that no practice was providing care consistent with the seven components of the guidelines, but few teams continued ongoing measurement. Barriers included time commitment, lack of reimbursement for children’s mental health services, competing clinical priorities (e.g., winter “flu” season), time required for clinicians to complete online modules, and lack of availability of data about progress for tracking changes in care. Three chapters plan ongoing activities with current practices in improving ADHD care. Two have secured funding to expand the program and engage additional practices. Three have specific plans to use the QI infrastructure developed to address additional clinical topics. Conclusions: Chapter leaders believe this intervention helped them develop the nascent infrastructure needed to support local practice teams in quality improvement activities. Direct contact from state opinion leaders and a face-to-face meeting engaged participants and facilitated collaboration. Use of baseline measurement identified gaps in care and motivated participation; however, lack of ongoing measurement inhibited the use of data to drive further improvements. Support from the national AAP and a QI organization was important. Implications for Policy, Delivery, or Practice: These findings will be applied in the next project year involving six additional chapters. Professional societies at the national and state level are interested in and can develop local infrastructure for improvement and translation of guidelines into practice. Coaching, tools, and support from the national organization and quality improvement experts are helpful in facilitating these efforts. Primary Funding Source: AHRQ ●Knowledge Dissemination in a System of Care: Moving from policy to the front line Louise Lemieux-Charles, Ph.D., Larry Chambers, Ph.D., Ken LeClair, M.D., Carole Cohen, M.D., Barbara Schulman, Rhonda Cockerill, Ph.D. Presented By: Louise Lemieux-Charles, Ph.D., Chair, Health Policy, Management and Evaluation, University of Toronto, 12 Queen's Park Crescent West, Toronto, M4E 3R1; Tel: (416) 978-4210; Fax: (416)978-8350; Email: l.lemieux.charles@utoronto.ca Research Objective: To analyze, at local and system levels, the use of knowledge transfer processes by studying the effectiveness of four community-based dementia service delivery networks in Ontario, Canada. The study was funded under a collaborative researcher-partner program to maximize information exchange among researchers, policy makers and clinical decision makers. Partners included the Ontario Ministry of Health and Long Term Care and the Ontario Alzheimer’s Association. Funding coincided with the province’s adoption of a strategy to implement networks throughout the province. Researchers participated at the policy level in assisting decision makers to develop guidelines for network development; while simultaneously studying the four networks which were in existence. Study Design: A case study design was used. Using Nonaka’s model of knowledge creation processes, knowledge translation elements employed throughout the three year study are described. The model assumes a continuous learning process as understanding deepens and changes. It represents the processes that take place through the sustained interaction of receptor functions involving researchers and decision makers. We describe how multiple organizations, professionals, managers and policy makers developed a shared understanding of what was entailed in creating a dementia network. The researcher’s role and the complex interactions involved in translating knowledge are analyzed. Population Studied: Key informant interviews and document analyses were carried out. Key informants were drawn from three groups associated directly or indirectly with the study: 1) the Research Steering Committee, involving researchers and clinical decision-makers from the four networks ; 2) the Provincial Working Group, comprised of researchers and policy decision-makers associated with the provincial government’s Alzheimer Strategy; and 3) clinical decision- makers from developing dementia care networks who participated in either local workshops delivered by researchers involved in the study or in a centralized train-the-trainer workshop for individuals associated with dementia care networks. A knowledge transfer timeline was developed. Principal Findings: The knowledge transfer timeline reveals that researchers were involved in the development of collaborations prior to the funding of the study, and have remained involved with the ongoing provincial Alzheimer’s strategy. The receptor functions facilitated the linkage among people, ideas and resources and the translation of policy between the provincial and local levels. A fine balance existed between carrying out of research and sharing expert knowledge about network development. There were pressures to share research findings prior to their finalization. However, the input of an experienced research team legitimized the guidelines developed for other networks. Conclusions: Sustained interactivity is considered to be essential to the dissemination of knowledge. However, there has been little consideration of the complexity of these interactions when system change is implemented. What are the implications for academics of this interactivity over time? Does the commitment assume a life long work? Implications for Policy, Delivery, or Practice: It became evident that processes and interactions alone are not sufficient to sustain change, though we found that these interactions led to individuals developing new relationships and exploring other areas for improvement. The use of learning forums to codify knowledge and its institutionalization are critical, as are models such as “trainthe-trainers” to build system capacity. Primary Funding Source: Other Foundation ●Coding Algorithms for Defining Comorbidities in ICD-9CM and ICD-10 Administrative Data Hude Quan, M.D., Ph.D., Vijaya Sundararajan,Patricia Halfon, M.D., MPH, FACP, Andrew Fong,Bernard Burnand, BComm; M.D., MPH, Jean-Christophe Luthi, Duncan Saunders, M.D., Ph.D., MBBCh, Cynthia Beck, Thomas E Feasby, M.D., MASc; M.D., William A Ghali, M.D., MPH Presented By: Hude Quan, M.D., Ph.D., Assistant Professor, Community Health Science, University of Calgary, 911 - South Tower, FMC 1402-29th Street NW, Calgary, T2N 2T9; Tel: (403) 944-8912; Fax: (403)944-8950; Email: hquan@ucalgary.ca Research Objective: Implementation of the International Statistical Classification of Disease and Related Health Problems, 10th Revision (ICD-10) coding system has presented challenges for using administrative data. To develop ICD-10 coding algorithms to define Charlson and Elixhauser comorbidities in administrative data and to compare the consistency between ICD-9-CM and ICD-10 coding algorithms in defining these comorbidities. Study Design: ICD-10 coding algorithms were developed by "translation" of the ICD-9-CM codes constituting Deyo's (for Charlson comorbidities) and Elixhauser's coding algorithms and by physicians' assessment of the face-validity of selected ICD-10 codes. The process of carefully developing ICD-10 algorithms also produced modified and enhanced ICD-9-CM coding algorithms for the Charlson and Elixhauser comorbidities. We then used in-patients aged 18 years and over in ICD-9-CM and ICD-10 administrative hospital discharge data from a Canadian health region to assess the comorbidity frequencies and mortality prediction achieved by the original ICD-9-CM algorithms, the enhanced ICD-9-CM algorithms, and the new ICD-10 coding algorithms (these coding algorithms will be presented in detail) Population Studied: Inpatients of the Calgary Health Region, 2001/2002 to 2002/03 fiscal year. Calgary, Alberta. Canada. Principal Findings: Among 56585 patients in the ICD-9-CM data and 58805 patients in the ICD-10 data, frequencies of the 17 Charlson comorbidities and the 30 Elixhauser comorbidities remained generally similar across algorithms. The new ICD-10 and enhanced ICD-9-CM coding algorithms either matched or outperformed the original Deyo and Elixhauser ICD-9-CM coding algorithms in predicting in-hospital mortality. The Cstatistic was 0.842 for Deyo's ICD-9-CM coding algorithm, 0.859 for the ICD-10 coding algorithm, and 0.859 for the enhanced ICD-9-CM coding algorithm. The Elixhauser ICD-9CM coding algorithm yielded a C-statistic of 0.867, versus 0.871 for the ICD-10 coding algorithm and 0.880 for the enhanced ICD-9-CM coding algorithm. Conclusions: These newly developed ICD-10 and ICD-9-CM comorbidity coding algorithms detect similar estimates of comorbidity prevalence in administrative data, and may outperform existing ICD-9-CM coding algorithms. Implications for Policy, Delivery, or Practice: Primary Funding Source: Canadian Institute of Health Research ●Combination of Hospital Discharge and Physician Claims Data Improves Detection of Procedures Hude Quan, M.D., Ph.D., Corrine Truman, Ph.D., Yan Jin, MA, William A Ghali, M.D., MPH Presented By: Hude Quan, M.D., Ph.D., Assistant Professor, Community HealthScience, University of Calgary, 911 - South Tower, Foothills Medical Centre 1403 29th Street NW, Calgary, T2N 2T8; Tel: (403)944-8912; Fax: (403)944-8950; Email: hquan@ucalgary.ca Research Objective: We have previously reported that administrative hospital discharge data had low validity in coding some minor procedures (Medical Care 2004; 42:8019). Physician claims data could be a potential source of information to improve validity of detecting procedures. However, little is known about validity of physician claims in coding procedure. Therefore, we assessed agreement between physician claims data and chart review data for surgical/diagnostic procedures and whether a combination of hospital discharge and physician claims data increased detection of procedures compared with either hospital discharge or physician claims data alone Study Design: Procedure information was extracted from hospital discharge data for a sample of 1200 (600 general surgery and 600 general internal medicine) randomly selected 1996/97 separation records from three hospitals in a Canadian health region. Unique personal identifier of personal health numbers was used in conjunction with admission and discharge dates to retrieve corresponding physician's claims information. A nursing trained professional coder examined the corresponding medical charts for evidence of 5 major procedures (i. e. appendectomy, cholecystectomy, colectomy, mastectomy and repair of hernia) and 12 minor surgical or diagnostic procedures (i.e. arterial catheterization, arteriogram, bone and marrow aspirate, cardiac catheterization/coronary angiography, chest tube, esophagogastroduodenoscopy, hemo/peritoneal dialysis, lumbar puncture, percutaneous abdominal drainage, pulmangiography, sigmoidoscopy and thoracentesis). To interpret the extent of agreement with chart review data above chance, we calculated kappa for hospital discharge, physician claims data and both of the databases and categorized values into five groups: <0.2 (poor agreement), 0.21-0.40 (fair agreement), 0.41-0.60 (moderate agreement), 0.61-0.80 (substantial agreement), and 0.81-1.00 (near perfect agreemen Population Studied: Inpatients from three hospitals in Calgary Health Region, Alberta, Canada. Principal Findings: Physician claims data had near perfect agreement for 4 major procedures and substantial agreement for 1 major procedure relative to chart data. Hospital discharge data also had near perfect agreement with chart data for 4 major procedures and substantial agreement for 1 major procedure relative to chart data. For the 12 minor surgical or diagnostic procedures assessed, physician claims data had near perfect agreement with chart data for 4, substantial agreement for 1, moderate agreement for 4 and fair agreement for 1 and hospital discharge data had near perfect agreement for 5, substantial agreement for 6 and fair agreement for 1 relative to chart data. The agreement was improved for 13 procedrues when both of the hospital discharge and physician claims data were used as opposed to the hospital discharge or physician claims data alone, reaching near perfect agreement for 5 major procedures and 8 minor procedures, substantial agreement for 2 minor procedures and moderate agreement for 1 minor procedure relative to chart data Conclusions: Physician claims data appear to have a high level of agreement with medical charts for major procedures but varing, sometimes low, levels of agreement for minor procedures. Primary Funding Source: Calgary Health Region ●Genetic Influences on Health Services Use and Healh Status James Romeis, Ph.D, Hong Xian, Ph.D, Nancy Pedersen, Ph.D, Andrew Heath, DPHil Presented By: James Romeis, Ph.D, Professor of Health Services Research, Health Management & Policy, School of Public Health, 3545 Lafayette Avenue, St. Louis, MO 63104; Tel: (314)977-8148; Fax: (314)977-8150; Email: romeisjc@slu.edu Research Objective: The overall goal of the study is to assess genetic and environmental influences on condtion, health services use and health status as outcome. Study Design: Classical twin design using telephone survey and tri-variate analytical model fitting methods. Population Studied: The Vietnam Era Twin Registry - a nonclinical, community sample of white, middle age, middle class, male-male twins [n=2936 pairs]. Principal Findings: The analysis indicates that there are moderate unique and common genetic effects for conditon [alcohol dependence], all cause health services use and health status as reflected in self-reports. Variance component analysis indicates that specific additive genetic influences are found for condition [55%], health services use [41%] and health status [29%]. Small, but significant effects were found across all variables. The majority of variance is explained by nonshared environmental factors and error. Conclusions: The data reinforce previous research designed to assess the the relative importance of genes and environmental influence on help-seeking and use of services. Genetic effects are not trivial and should be incorportated in our models if our theories are to advance. Implications for Policy, Delivery, or Practice: Health services research has mostly ignored behavioral genetics in explaining individual differences in health behavior. As the magnitude of genetic influences increase, serious consideration needs to be given to altering policies and interventions to account for this important source of variation. Primary Funding Source: NIA, NIAAA, VAHSRD ●Building Community Capacity for Evidence-Based Practice Shiloh Turner, MPA, Eric Rademacher, Ph.D., Mark Carrozza, MA Presented By: Shiloh Turner, MPA, Director, Health Data Improvement, Program, The Health Foundation of Greater Cincinnati, 3805 Edwards Road, Suite 500, Cincinnati, OH 45209; Tel: (513) 458-6608; Fax: (513) 458-6610; Email: sturner@healthfoundation.org Research Objective: The objective of this session is to describe a variety of community and state level research approaches for gathering, analyzing and disseminating health information for the purposes of planning, evaluation, and policy work. Study Design: The Health Foundation of Greater Cincinnati, in partnership with the University of Cincinnati’s Institute for Policy Research, has developed a strategic research agenda aimed at providing community health data for use by state and local healthcare agencies. Organizations use this information for needs assessments, program design and evaluation, and policy analysis. Research approaches employed by the Foundation include community-based participatory research of the emerging Hispanic and Latino population, a broad-based computeraided telephone survey of over 2,000 adults in Greater Cincinnati assessing community health status, and a statewide telephone survey of 800 respondents assessing public opinions regarding a variety of health policy issues. Each approach provides data that are not otherwise available at the state or local level. The surveys are conducted semiregularly, utilize national indicators whenever possible, and build on past work to allow for trending capability. The strategic research agenda does not end with the production of the various health data resources. It also provides technical assistance in communication and dissemination efforts. For example, some organizations are quite intimidated by data. They are not staffed with experts in program evaluation or health policy. However, this does not mean that their program work is unsophisticated. It simply means that their ability to evaluate and communicate their success sometimes falls short. Good technical assistance can get them over this barrier, and can lead to some of the best success stories in policy change. Other organizations are quite sophisticated in working with health data. The capacity exists, but they need access to the information in a timely manner. For this group, it is ideal to offer some sort of online data dissemination system. Population Studied: Greater Cincinnati residents living in Southwest Ohio, Northern Kentucky, and Southeast Indiana. Principal Findings: Based on the application of this model, we have found that certain strategies for data gathering and dissemination are a more natural fit to some organizations, while other strategies work better for others. A couple of case studies that illustrate this point include: 1) a rural mental health board was able to achieve policy change for their jail diversion program through collecting a few key data elements and benchmarking them with the region; 2) a local health collaborative was able to analyze community obesity data using an innovative web application called the Online Analysis and Statistical Information System (OASIS). Once the need for programming was identified, the collaborative convened a large group of stakeholders to address the problem. Based on this effort, national funding was obtained to create the Ohio affiliate to the America on the Move program. In both cases, the organization achieved success, but the approach used was quite different. Conclusions: Having a pro-active strategic research agenda is an efficient way of filling data gaps in a community. However, it is important to surround those data collection efforts with technical assistance and training. It is also important to offer a variety of methods for accessing and disseminating data, as the same approach does not work for all. A complete strategy of data collection, analysis, and dissemination encourages widespread community participation in the health policy arena. Implications for Policy, Delivery, or Practice: Communities given access to quality state and local health data, surrounded by technical assistance on how to use the data for their own areas of interest, are empowered to design programs that better address service gaps in the region. They are better able to evaluate the services offered and make adjustments to improve service delivery. And finally, communities are able to take evaluation data and contextualize it within the larger community. This builds a much stronger case for influencing policymaker decisions about funding and other means of support for programs. Primary Funding Source: The Health Foundation of Greater Cincinnati ●Transitional Research on Nursing Home Practice: an Optimization System for Health Care Management Ning Zhang, M.D., Ph.D., Thomas T.H. Wan, Ph.D., MS, Lynn Unruh, Ph.D., RN, Shriram Marathe, MBA, M.D. Presented By: Ning Zhang, M.D., Ph.D., Assistant Professor, Department of Health Administration/College of Health and Public Affairs, University of Central Florida, 3280 Progress Drive, Orlando, FL 32826; Tel: (407)823-3344; Fax: (407)8234895; Email: nizhang@mail.ucf.edu Research Objective: To develop a decision support system for optimizing nursing home performance based on a theoretically informed framework and to evaluate the effectiveness of the system through multilevel structural modeling of the quality improvement on resident outcomes. Study Design: This is a longitudinal study using the 19992002 Minimum Data Sets (MDS) and Online Survey Certification and Reporting System (OSCAR) which include all the resident care and facility management information for Medicare and Medicaid certified nursing homes. We linked these clinical and administrative data to Area Resource File (ARF) and state reimbursement data. A data warehouse was established to structure the multilevel data. A managerial decision support system was formulated in three steps. First, our analysis established multi-factor measurement of organizational efficiency and quality using confirmatory factor analysis. Second, a benchmarking tool was developed to determine the best practice of performance in the market. Finally, organizational, market and financial factors, and resident characteristics that affect organizational performance, such as geographic area, nurse staffing, market competition, operating margins, acuity levels were identified by using multilevel modeling of panel data. With a user-friendly, graphics-user interface (GUI), nursing home administrators and practitioners are able to compare their practice with their competitors in the similar metropolitan area and find best practice models to optimize the performance or output of facilities under the internal and external environmental constraints. To assess the applicability of the decision support system for performance improvement, this study used simulation techniques to examine its stability in varying homogeneous subgroups of nursing homes. Population Studied: This study included approximately 15,000 nursing homes and 13 million residents each year for four consecutive years. Principal Findings: Multilevel modeling of the quality improvement on resident outcomes identified higher performance facilities that differed in many aspects of organizational structure and operating processes from lower performance facilities. A strong evidence shows that this modeling approach yields stable results to profile the best practice in nursing home quality (r=0.93). A small root-meansquare-error estimate (<0.05) was generated by the model. The decision support system, based on the theoretically specific model coupled with the constraint-oriented methodology, has been formulated to provide decision makers to optimize their operational management. Conclusions: This graphic-user interface based expert system can simulate the optimal performance of management practices in nursing homes. The study demonstrates that this decision making system is reliable and cost-effective. Implications for Policy, Delivery, or Practice: This system allows health care executives and decision makers rely on theoretically based and empirically validated evidence in management. Such evidence-based knowledge can be integrated with practical and experiential knowledge to shed light on the cause-and-effect relationships between the problems and solution sets. The study demonstrates the feasibility and strength of translating health services research for improving nursing home practice and performance. Primary Funding Source: NIA, NINR