Program Director/Principal Investigator (Last, First, Middle):
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Weimin Gao
eRA COMMONS USER NAME (credential, e.g., agency login)
Associate Professor and Associate Chair
gaoweimin
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
Nanjing Medical University
MB
07/94
MPH
07/97
University of Pittsburgh
MS
12/03
University of Pittsburgh
PhD
08/03
Postdoctoral
12/04
Chinese Academy of Preventive Medicine
The University of Michigan
Preventive Medicine
Toxicology and
Occupational Medicine
Biostatistics
Environmental and
Occupational Health
Proteomics
A. Personal Statement
I have more than 20 years of training and experience in public health and cancer research. Following my medical
training, my PhD in Environmental and Occupational Health from the University of Pittsburgh, Graduate School
of Public Health provided additional training in molecular epidemiology. My MS study in Biostatistics from the
University of Pittsburgh, Graduate School of Public Health contributes to my background and expertise in
Biostatistics. As a postdoctoral fellow in the Department of Pediatrics/Internal Medicine at the University of
Michigan, School of Medicine, I carried out proteomic studies. Since beginning my independent tenure-ship at
Texas Tech University, I have focused my research on molecular epidemiology, molecular toxicology,
chemoprevention, proteomics and metabolomics. My laboratory has established the needed facilities for
molecular analyses including gel-based proteomics and antibody arrays. I have published more than 50
peer-reviewed articles.
B. Positions and Honors
Positions and Employment
1994-1999
Research Assistant, Research Associate, Assistant Professor
Department of Toxicology, National Laboratory of Industrial Hygiene, Ministry of Health, Beijing,
P.R. China
2005-2006
Research Assistant Professor
Department of Critical Care Medicine, Safar Center for Resuscitation Research
University of Pittsburgh
2006-2012
Assistant Professor (tenure track)
Department of Environmental Toxicology and The Institute of Environmental and Human Health
Texas Tech University and Texas Tech University Health Sciences Center
2012-present Associate Professor (tenured)
Department of Environmental Toxicology and The Institute of Environmental and Human Health
Texas Tech University and Texas Tech University Health Sciences Center
2013-present Associate Chair
Department of Environmental Toxicology, Texas Tech University
2009-present Director of Thoracic Oncology Laboratory
Division of Hematology/Oncology, Department of Medicine
Member, Texas Tech Southwest Cancer Center, Texas Tech University Health Sciences Center
PHS 398/2590 (Rev. 06/10)
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Program Director/Principal Investigator (Last, First, Middle):
Honors
1991-1994
1994-1995
1996
Honoral student with scholarship, Nanjing Medical University
Outstanding graduate student award, Chinese Academy of Preventive Medicine
Third Prize for the oral presentation, "Effects of prenatal exposure to HTO on electrophysiology of
hippocampal neurons and neurobehavior of rats" Chinese Medical Association
1997
First Prize for the oral presentation, "Effects of prenatal low dose beta radiation from tritiated
water on learning and memory behavior of rats and their possible mechanisms", Beijing Branch of
Chinese Environmental Mutagen Society
2002
Travel Award, Genetic Toxicology Association, Environmental Mutagen Society (EMS)
33rd Annual Meeting, Anchorage, Alaska
2002-2003
Student Travel Grant, Graduate School of Public Health, University of Pittsburgh
2004
Outstanding Student Award, Graduate School of Public Health, University of Pittsburgh
2009 & 2011 Outstanding Faculty Award, The Institute of Environmental and Human Health, Texas Tech
University
Memberships
1997-1999
Chinese Society of Toxicology (Commissioner in Section of Radiotoxicology)
1997-1999
Chinese Society of Environmental Mutagen
2002-2004
Environmental Mutagen Society in the USA
2005-2006
National Neurotrauma Society (NNS)
2011-2012
Lone Star-Society of Toxicology (LSSOT) (Secretary, Vice-President)
2012-2013
Society of Toxicology Special Interest Groups-Collaboration Group (Board Member)
2012-2013
American Association of Chinese in Toxicology (AACT) (Councilor)
2012-2013
Lone Star-Society of Toxicology (LSSOT) (President-elect)
2002American Association for Cancer Research (AACR)
2004US Human Proteome Organization (HUPO)
2006Society of Toxicology (SOT)
2013American Association of Chinese in Toxicology (AACT) (Secretary)
2013Lone Star-Society of Toxicology (LSSOT) (President)
C. Selected Peer-reviewed Publications (in chronological order). (Publications selected from 59
peer-reviewed publications)
1. DeMarini DM, Landi S, Tian D, Hanley NM, Li X, Hu F, Roop BC, Mass MJ, Keohavong P, Gao W, Olivier M,
Hainaut P, Mumford JL. Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich
coal combustion emissions. Cancer Research 2001; 61(18): 6679-6681. PMID: 11559534
2. Gao WM, Mady HH, Yu GY, Siegfried JM, Luketich JD, Melhem MF, Keohavong P. Comparison of p53
mutations between adenocarcinoma and squamous cell carcinoma of the lung: unique spectra involving G to
A transitions and G to T transversions in both histologic types. Lung Cancer 2003; 40:141-150. PMID:
12711114
3. Gao WM, Romkes M, Day RD, Siegfried JM, Luketich JD, Mady HH, Melhem MF, Keohavong P. Association
of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related
non-small-cell lung cancer. Carcinogenesis 2003; 24:1671-1676. PMID: 12844488
4. Gao WM, Romkes M, Siegfried JM, Luketich JD, Keohavong P. No association between the XPD 312, 751,
or XRCC1 399 polymorphisms and K-ras gene mutation in smoking non-small-cell lung cancer. Cancer
Epidemiology, Biomarkers and Prevention 2004; 13:673-675. PMID: 15066937
5. Gao WM, Kuick R, Orchekowski RP, Misek DE, Qiu J, Greenberg AK, Rom WN, Brenner DE, Omenn GS,
Haab BB, Hanash SM. Distinctive serum protein profiles involving abundant proteins in lung cancer patients
based upon antibody microarray analysis. BMC Cancer 2005; 5(1):110. PMID: 16117833
6. Gao WM, Romkes M, Siegfried JM, Luketich JD, Keohavong P. Polymorphisms in DNA repair genes XPD
and XRCC1 and p53 mutations in lung carcinomas of never-smokers. Molecular Carcinogenesis 2006;
45(11):828-832. PMID: 16865671
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Program Director/Principal Investigator (Last, First, Middle):
7. Gao WM, Chadha MS, Berger RP, Omenn GS, Allen DL, Pisano M, Adelson PD, Clark RSB, Jenkins LW,
Kochanek PM. A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and
non-inflicted pediatric traumatic brain injury. Journal of Neurotrauma 2007; 24(1):43-53. PMID: 17263669
8. Gao W, Mady HH, Melhem MF, Keohavong P. Analysis of p53 mutations in histologically normal lung
tissues and lung tumors from non-small cell lung cancer patients. Molecular Carcinogenesis 2009;
48(7):633-641. PMID: 19072763
9. Shao C, Chen S, Chen L, Cobos E, Wang J-S, Haab BB, Gao W. Antibody microarray analysis of serum
glycans in esophageal squamous cell carcinoma cases and controls. Proteomics-Clinical Applications 2009;
3:923-931. PMID: 21136996
10. Chen L, Shao C, Cobos E, Wang J-S, Gao W. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces
CRM1-dependent p53 nuclear accumulation in human bronchial epithelial cells. Toxicological Sciences
2010; 116(1):206-215. PMID: 20421341
11. Shao C, Chen L, Lu C, Shen CL, Gao W. A gel-based proteomic analysis of the effects of green tea
polyphenols on ovariectomized rats. Nutrition 2011; 27(6):681-686. PMID: 20708377
12. Shao C, Lu C, Chen L, Koty PP, Cobos E, Gao W. p53-dependent anticancer effects of Leptomycin B on
lung adenocarcinoma. Cancer Chemotherapy and Pharmacology 2011; 67(6):1369-1380. PMID: 20803015
13. Singh KP, Treas J, Tyagi T, Gao W. DNA demethylation by 5-aza-2-deoxycytidine treatment abrogates 17
beta-estradiol-induced cell growth and restores expression of DNA repair genes in human breast cancer
cells. Cancer Letters 2012; 316(1): 62-69. PMID: 22082530
14. Lu C, Shao C, Cobos E, Singh KP, Gao W. Chemotherapeutic sensitization of leptomycin B resistant lung
cancer cells by pretreatment with doxorubicin. PLoS One 2012; 7(3):e32895. PMID: 22412944
15. Lu C, Zhu W, Shen CL, Gao W. Green tea polyphenols reduce body weight in rats by modulating
obesity-related genes. PLoS One, 2012; 7(6):e38332. PMID: 22715380
D. Research Support.
Ongoing Research Support
1R01HD055986-01A2
Berger (PI)
09/30/2009-08/31/2014
NIH/NICHD
Novel Approaches to Screening for Inflicted Childhood Neurotrauma
The major goal of this research proposal is to study novel markers for diagnosis of inflicted childhood
neurotrauma.
Role: Co-investigator
Completed Research Support
USDOD W911SR-07-C-0069 Smith (PI)
09/01/2008-08/31/2009
RDECOM
Mechanistic Studies of Combinative Toxicity of Biotoxin Mixtures
The major goal of this research contract is to study molecular mechanisms of combinative toxicity of biotoxin
mixtures using genomic and proteomics approaches.
Role: Co-investigator
1R01 CA 90997-05
Wang (PI )
06/16/2003-05/31/2008
NIH/NCI
Chemoprevention of Green Tea Polyphenols on Liver Cancer
The major goal of this research project is to evaluate chemopreventive effect of green tea polyphenols on
modulating carcinogen biomarkers and human liver cancer risks.
Role: Co-investigator
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