Cholinesterase Inhibitors and Music Therapy: A good
combination for Alzheimer’s disease?
Author: Akiko Rockers|Health Sciences, Pre-PA
Advisor: Masaru Teramoto, PhD, MPH |College of Nursing and Health Professions
RESULTS
Study
Aims of Study
Conclusion
1. The clinical use of cerebrospinal fluid biomarker testing for
Alzheimer’s disease diagnosis:
a consensus paper from the
Alzheimer’s Biomarkers
Standardization Initiative.
Standardize CSF use for AD diagnosis.
The authors of this study promote the use of
CSF biomarkers to make a more accurate
AD diagnosis.
2. Understanding the beneficial and
detrimental effects of donepezil
and rivastigmine to improve their
therapeutic value.
To shed light on how effective current AD
medications are.
Prescribing the correct AD medication can
greatly improve symptoms of AD and
reduce common side effects.
3. Alzheimer’s disease: The pros and
cons of pharmaceutical, nutritional,
botanical, and stimulatory therapies
with a discussion of treatment strategies
from the perspective of patients and
practitioners.
Although there is little research, music therapy
can promote elevated moods and some
improved cognition.
Music therapy can be beneficial in
reducing stress and depression not only in
the person with AD, but the caregiver as well.
4. Efficacy of music therapy in treatment
for the patients with Alzheimer’s disease.
A randomized control trial explored
the efficacy of music therapy.
Music therapy was shown to improve
behavioral functioning, benefitting the
patient and the caregiver.
CONCLUSIONS
OBJECTIVES
•
•
•
State background information
on Alzheimer’s disease
Determine efficacy of current
pharmacotherapies
Determine efficacy of music
therapy
Testing of AD by biomarkers in CSF can lead to an early and more accurate diagnosis.
The proper prescription and use of cholinesterase inhibitors are beneficial in treating symptoms of mild-tomoderate Alzheimer’s disease
REFERENCES
Music therapy has been shown to improve behavior issues in people suffering from Alzheimer’s disease.
Fukui, H., Arai, A., & Toyoshima, K. (2012). Efficacy of music therapy in
treatment for the patients with Alzheimer’s disease. International Journal of
Alzheimer’s Disease: 2012(2012).
Music therapy has also been shown to provide relief to the caregiver.
Despite the perceived efficacy of current treatments, they are not a cure for Alzheimer’s
disease.
Future goal of this study:
Perform a longitudinal study examining the interaction of cholinesterase inhibitors and music therapy.
Lane, R. L., & Darreh-Shori, T. (2014). Understanding the beneficial and
detrimental effects of donepezil and rivastigmine to improve their
therapeutic value. Journal of Alzheimer’s Disease: DOI 10.3233/JAD142268.
Molinuevo, J. L., Blennow, K., Dubois, B., Engelborghs, S., Lewczuk, P.,
Perret-Liaudet, A., et al. (2014). The clinical use of cerebrospinal fluid
biomarker testing for Alzheimer’s disease diagnosis: a consensus paper
from the Alzheimer’s Biomarkers Standardation Initiative. Alzheimer’s &
Dementia: 10(6), 808-817