[[ research guest editorial report ]] Red Flags: To Screen or Display Light Headline for a NotMiller to Screen? Minimum of Two Lines author name, xx, xx1 • author name, xx, xx1 • author name, xx, xx1 • author name, xx, xx1 • author name, xx, xx1 • author name, xx, xx1 Michael D. Ross, PT, DHSc1 William G. Boissonnault, PT, DHSc2 J Orthop Sports Phys Ther 2010;40(11):682-684. doi:10.2519/jospt.2010.0109 T he physical therapy profession has long recognized the importance of physical therapists determining whether a need for a patient referral to another healthcare practitioner exists.5-8 More specifically, during each initial patient evaluation and subsequent reevaluation, physical therapists must decide whether to treat the patient, refer the patient, or initiate both treatment and referral.1,4 This clinical decision is based on physical therapists recognizing patient history and physical examination red flag findings consistent with pathology that requires physician consultation and examination.4 The challenge to physical therapists is the current lack of evidence describing what red flag findings are representative of specific pathological conditions. For example, night pain has long been taught to be red flag finding for serious medical conditions, such as cancer, but research shows that not all patients with musculoskeletal cancers experience night pain.23 In addition, night pain has also been associated with osteoarthritis and mechanical low back pain.9,29 So when should a physical therapist be concerned about a patient complaining of night pain? Is it a red flag finding or not? This uncertainty was a topic of recent publications that has appeared to call into question the usefulness of red flag questions for patients with low back pain. Henschke et al17 reported on the performance of 25 commonly recommended red flag questions in a prospective study of 1172 consecutive patients presenting with acute low back pain in a primary care setting of general practitioners, 1 physical therapists, and chiropractors. After 1-year follow-up, a serious cause for back pain was identified in only 11 patients. The prevalence of spinal fractures was 0.7%, and no cases of malignancy were reported. The low prevalence of serious pathology noted by the authors is not necessarily surprising, considering that their sample population’s mean age was 44 years (SD, 15.1 years). Previously reported values for the prevalence of osteoporotic fractures and malignancy are approximately 4% and 0.7%, respectively.13 Despite the low prevalence of serious pathology in the Henschke et al17 study, most patients (80.4%) had at least 1 red flag finding, suggesting that nearly all red flag questions, when considered individually, were uninformative. The findings by Henschke et al17 prompted Underwood28 to write in the editorial of that same issue of the journal Arthritis and Rheumatism that “Too great a focus on addressing red flag questions may distract the clinician from delivering key information to the patient: reassurance as to the benign nature of the disorder for the vast majority of patients and the benefits of avoiding bed rest and maintaining normal activity, including work.” He goes on to write that “The indiscriminate use of red flag symptoms as a trigger to order further investigations will lead to unnecessary investigations that are themselves harmful, through a combination of overmedicalizing a benign usually self-limiting disorder, the harmful effects of radiation from obtaining unnecessary radiographs and computed tomography scans, and the consequences of these investigations themselves producing false-positive results.” Underwood28 recommends that rather than recording an exhaustive list of red flags, clinicians should consider a small number of disorders in which early diagnosis and treatment might make a big difference (ie, cauda equina syndrome, major intra-abdominal pathology, focal infections, and fractures), and use time as a diagnostic tool for the remainder. If, in the clinician’s judgment, based upon skills and experience, the patient may have one of these serious conditions, appropriate investigation and treatment are indicated. We agree with Underwood28 that, with this extremely low prevalence of serious disease identified following a first consultation for a new episode of acute low Associate Editor; Director, US Air Force Physical Medicine Training Programs, Fort Sam Houston, TX. Associate Professor, Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI. 2 682 | november 2010 | volume 40 | number 11 | journal of orthopaedic & sports physical therapy 40-11 Guest Editorial.indd 682 10/20/10 12:53 PM [ back pain, the large number of patients with at least 1 red flag symptom (80%) is of considerable concern. As noted by Underwood,28 if nearly everyone with acute low back pain has a red flag, then the presence of a red flag will not help the clinician in deciding whether any further investigation or treatment is needed. We already are in the midst of a crisis when it comes to managing low back pain.12 Costs are soaring due to unnecessary diagnostic imaging, the prescribing of opioid analgesic medications, injections, and surgeries.12,19 These increased costs could perhaps be justified if they were associated with improved outcomes; but patient outcomes are not improving.12,19 Indiscriminate use of red flag findings would only delay the time for the indicated primary treatment of the patient’s low back pain and place more unnecessary strain on an already overburdened medical system. For some serious medical pathologies mentioned by Underwood28 that can potentially mimic mechanical low back pain, there are evidence-based screening strategies that may assist in ruling out pathology and avoid unnecessary physician referrals. For example, cancer causing low back pain can be ruled out with 100% sensitivity if the patient is less than 50 years old, does not exhibit unexplained weight loss, does not have a history of cancer, and is responding to conservative intervention. 11 If a red flag is present, a spine specialist referral is not immediately indicated; rather, evidence-based screening strategies suggest that completing lumbar spine radiographs and laboratory testing (erythrocyte sedimentation rate) is the next appropriate step, as this can rule out cancer causing low back pain with 100% sensitivity.11 One exception would be in a patient with low back pain with a recent history of cancer, as early referral and advanced diagnostic imaging may be warranted in this case. For patients older than 50 years who may even have general health changes, such as unexplained weight loss, response to conservative management will be key in guest editorial ] identifying those patients that may have potentially serious underlying disorders. However, given the large number of patients with nonspecific low back pain who will have false-positive red flag findings, is it time to recommend that physical therapists spend less time on screening for red flags? Although the prevalence of serious medical pathology, such as cancer, infection, or fracture, causing low back pain is extremely low, we still believe it is the physical therapist’s responsibility to utilize a management model for each patient that allows for the evaluation of red flag findings to make clinical judgments regarding the need for patient referral. There are 3 primary reasons for this. First, in primary care practice settings, there is a low rate of routine examination for red flag findings.2 Additionally, symptoms associated with serious conditions can develop between the physician consultation and the initial physical therapy evaluation. Second, some serious conditions, like a fracture, would contraindicate routine physical therapist interventions, like spinal manipulation. Third, there is therapeutic value in early diagnosis of serious conditions, like metastatic cancer, because specific treatment can be initiated. Furthermore, without some level of screening for red flag symptoms for each patient, how would a clinician begin to even consider whether or not serious pathology is present and if referral is warranted? Through the evaluation of risk factors and red flag screening questions from the history and physical examination, such as patient demographics, social and health habits, medical/surgical history, medications, family history, systems review, and review of systems, physical therapists have the examination data necessary to identify the need for medical referral.1 A lack of response to conservative management is also key in identifying those patients with potentially serious disorders which require medical referral.11 Several published case reports have described how physical therapists have used history and physical examination findings, as well as response to intervention, in patients with signs and symptoms related to the lumbar spine to determine that physician referral was necessary.3,6-8,10,14,15,20,21,25,27 As seen in these case reports, the level of red flag screening for an individual patient may vary based on the medical complexity of the patient, emerging data from the patient history and physical examination, response to intervention, and the directions taken in the clinical decision-making process.1 In some of these cases, red flag findings were present early in the case, which led to the initiation of early referral.6,7,10,15,20,25 In other cases, overt red flag findings were not evident; rather, a cluster of findings that were atypical for nonspecific low back pain emerged through the course of care that prompted referral.3,6,8,14,15,21,27 Using a cluster of history and physical examination findings is also consistent with evidence-based screening strategies for serious conditions like cancer,11 fractures,17 and abdominal pain that is nonmusculoskeletal in nature.24 For example, in an individual with low back pain, advanced age, corticosteroid use, or pain caused by a traumatic incident may not be concerning when each finding is considered in isolation. However, when these factors are clustered in an individual with back pain, they are highly predictive of a fracture.17 There are also other conditions that are more prevalent than cancer, infections, or fractures that can influence the outcome of patients with low back pain that physical therapists should be aware of when evaluating history and physical examination data. For example, depression is a condition that can adversely influence the prognosis for patients with low back pain.18,22,26 Generally, depression is underrecognized by physical therapists, even in those cases when severe depression is evident.16 Additionally, the history and physical examination may also identify health restoration and prevention needs, as well as pre-existing medical comorbidities that may have implications for intervention and outcome.1 journal of orthopaedic & sports physical therapy | volume 40 | number 11 | november 2010 | 40-11 Guest Editorial.indd 683 683 10/20/10 12:53 PM [ editorial ] ] [ guest editorial Given the importance of red flag screening in determining the appropriateness of physical therapy4 and the goal of physical therapists to be the provider of choice for patients with musculoskeletal disorders, we believe that taking a less than adequate red flag screening approach for patients with low back pain will not facilitate optimal patient outcomes. Therefore, we suggest that physical therapists utilize a consistent management model for each patient that allows for the evaluation of red flag findings. Because a red flag finding will most likely be present for most patients with low back pain,17 physical therapists should carefully evaluate the findings to determine if a red flag finding is indeed present that warrants referral, while keeping in mind the low prevalence of serious pathology in patients with low back pain. t The opinions expressed herein are those of the authors and do not necessarily reflect the opinions of the Department of Defense, the United States Air Force, or other federal agencies. 6. 7. 8. 9. 10. 11. 12. 13. 14. REFERENCES 1. American Physical Therapy Association. Guide to Physical Therapist Practice. Second Edition. American Physical Therapy Association. Phys Ther. 2001;81:9-746. 2. Bishop PB, Wing PC. Knowledge transfer in family physicians managing patients with acute low back pain: a prospective randomized control trial. Spine J. 2006;6:282-288. http://dx.doi. org/10.1016/j.spinee.2005.10.008 3. Boeglin ER, Jr. Vertebral osteomyelitis presenting as lumbar dysfunction: a case study. J Orthop Sports Phys Ther. 1995;22:267-271. 4. Boissonnault WG. Primary Care for the Physical Therapist: Examination and Triage. Philadelphia, PA: W.B. Saunders; 2004. 5. Boissonnault WG, Bass C. Medical screening ex- 15. 16. 17. 18. 19. amination: not optional for physical therapists. J Orthop Sports Phys Ther. 1991;14:241-242. Boissonnault WG, Bass C. Pathological origins of trunk and neck pain: part I - pelvic and abdominal visceral disorders. J Orthop Sports Phys Ther. 1990;12:1-207. Boissonnault WG, Bass C. Pathological Origins of Trunk and Neck Pain: Part II - Disorders of the Cardiovascular and Pulmonary Systems. J Orthop Sports Phys Ther. 1990;12:208-215. Boissonnault WG, Bass C. Pathological Origins of Trunk and Neck Pain: Part III - Diseases of the Musculoskeletal System. J Orthop Sports Phys Ther. 1990;12:216-221. Boissonnault WG, Fabio RP. Pain profile of patients with low back pain referred to physical therapy. J Orthop Sports Phys Ther. 1996;24:180-191. Crowell MS, Gill NW. Medical screening and evacuation: cauda equina syndrome in a combat zone. J Orthop Sports Phys Ther. 2009;39:541-549. http://dx.doi.org/10.2519/ jospt.2009.2999 Deyo RA, Diehl AK. Cancer as a cause of back pain: frequency, clinical presentation, and diagnostic strategies. J Gen Intern Med. 1988;3:230-238. Deyo RA, Mirza SK, Turner JA, Martin BI. Overtreating chronic back pain: time to back off? J Am Board Fam Med. 2009;22:62-68. http:// dx.doi.org/10.3122/jabfm.2009.01.080102 Deyo RA, Weinstein JN. Low back pain. N Engl J Med. 2001;344:363-370. http://dx.doi. org/10.1056/NEJM200102013440508 Gray JC. Diagnosis of intermittent vascular claudication in a patient with a diagnosis of sciatica. Phys Ther. 1999;79:582-590. Greenwood MJ, Erhard RE, Jones DL. Differential diagnosis of the hip vs. lumbar spine: five case reports. J Orthop Sports Phys Ther. 1998;27:308-315. Haggman S, Maher CG, Refshauge KM. Screening for symptoms of depression by physical therapists managing low back pain. Phys Ther. 2004;84:1157-1166. Henschke N, Maher CG, Refshauge KM, et al. Prevalence of and screening for serious spinal pathology in patients presenting to primary care settings with acute low back pain. Arthritis Rheum. 2009;60:3072-3080. http://dx.doi. org/10.1002/art.24853 Linton SJ. A review of psychological risk factors in back and neck pain. Spine (Phila Pa 1976). 2000;25:1148-1156. Martin BI, Deyo RA, Mirza SK, et al. Expendi- 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. tures and health status among adults with back and neck problems. JAMA. 2008;299:656-664. http://dx.doi.org/10.1001/jama.299.6.656 Mechelli F, Preboski Z, Boissonnault WG. Differential diagnosis of a patient referred to physical therapy with low back pain: abdominal aortic aneurysm. J Orthop Sports Phys Ther. 2008;38:551-557. http://dx.doi.org/10.2519/ jospt.2008.2719 Ross MD, Bayer E. Cancer as a cause of low back pain in a patient seen in a direct access physical therapy setting. J Orthop Sports Phys Ther. 2005;35:651-658. http://dx.doi. org/10.2519/jospt.2005.2105 Shaw WS, Means-Christensen AJ, Slater MA, et al. Psychiatric Disorders and Risk of Transition to Chronicity in Men with First Onset Low Back Pain. Pain Med. http://dx.doi. org/10.1111/j.1526-4637.2010.00934.x Slipman CW, Patel RK, Botwin K, et al. Epidemiology of spine tumors presenting to musculoskeletal physiatrists. Arch Phys Med Rehabil. 2003;84:492-495. http://dx.doi.org/10.1053/ apmr.2003.50125 Sparkes V, Prevost AT, Hunter JO. Derivation and identification of questions that act as predictors of abdominal pain of musculoskeletal origin. Eur J Gastroenterol Hepatol. 2003;15:1021-1027. http://dx.doi.org/10.1097/01. meg.0000059173.46867.0c Stowell T, Cioffredi W, Greiner A, Cleland J. Abdominal differential diagnosis in a patient referred to a physical therapy clinic for low back pain. J Orthop Sports Phys Ther. 2005;35:755764. http://dx.doi.org/10.2519/jospt.2005.2052 Sullivan MJ, Reesor K, Mikail S, Fisher R. The treatment of depression in chronic low back pain: review and recommendations. Pain. 1992;50:5-13. Thein-Nissenbaum J, Boissonnault WG. Differential diagnosis of spondylolysis in a patient with chronic low back pain. J Orthop Sports Phys Ther. 2005;35:319-326. http://dx.doi. org/10.2519/jospt.2005.1564 Underwood M. Diagnosing acute nonspecific low back pain: time to lower the red flags? Arthritis Rheum. 2009;60:2855-2857. http://dx.doi. org/10.1002/art.24858 Woolhead G, Gooberman-Hill R, Dieppe P, Hawker G. Night pain in hip and knee osteoarthritis: a focus group study. Arthritis Care Res (Hoboken). 62:944-949. http://dx.doi.org/10.1002/ acr.20164 684 | november 2010 | volume 40 | number 11 | journal of orthopaedic & sports physical therapy 40-11 Guest Editorial.indd 684 10/20/10 12:53 PM