EDUCATION
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1991~1994: Ph.D. in Chromatography , Lanzhou Institute of Chemical Physics, Chinese
Academy of Sciences, Lanzhou, P. R. China.
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1985~1988: M.S. in Analytical Chemistry , Department of Chemistry, Shandong University,
Jinan, P. R. China.
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1981~1985: B.S. in Analytical Chemistry , Department of Chemistry, Shandong University,
Jinan, P. R. China
PROFESSIONAL EXPERIENCES
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2015~present: Assistant Professor , Department of Chemistry, Western Illinois University,
Macomb, IL
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2006~2015: Director of Mass Spectrometry Center, Department of Chemistry , the
University of Tennessee, Knoxville, TN
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2003~2005: Assistant Director of Biopolymer and Proteomics Resources
Cancer Institute, Buffalo, NY
, Roswell Park
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2001~2002: Visiting Scientist of Canada, Ottawa, Canada
, Institute for Biological Sciences, National Research Council
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1997~2000: Research Scientist , Department of Chemistry, Stony Brook University, Stony
Brook, NY
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1995~1997: Post-doctoral associate , Department of Chemistry, Wuhan University, Wuhan,
P. R. China
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1988~1991: Lecturer, Department of Applied Chemistry, Jinan University, Jinan, P. R.
China
TEACHING RESPONSIBILITIES
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Chem 440 Elementary Forensic Techniques (i.e. Criminalistics)
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Chem 451(G) Application of Forensic Chemistry
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Chem 551 Forensic Analytical Chemistry (i.e. Forensic Instrumental Analysis)
RESEARCH INTERESTS
My current research interest is forensic analysis of abused drugs, fire accelerants and toxicological specimens using ambient ionization mass spectrometry (AI/MS), gas chromatography mass spectrometry (GC/MS) and liquid chromatography mass spectrometry
(LC/MS). A common theme in my research is to explore novel ionization techniques such as
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direct analysis in real time (DART), atmospheric pressure photoionization (APPI) and electron capture ionization (ECI) in forensic analysis. There are three major research focuses:
1) Investigation of AI/MS for direct analysis of abused drugs and fire accelerants at the crime scène;
2) Development of novel GC/MS and LC/MS methods for the analysis of biodiesels and vegetable oils;
3) Exploration of GC/ECI/MS and LC/ECI/MS for trace level analysis of drugs in forensic toxicology and doping control.
FUNDED PROJECT
Project Title:
GOALI/RUI Collaborate Proposal: Characterization and Modeling for Improved performance of Batch Slurry Processes
Principle Investigators:
Dr. Paul Gemperline, Department of Chemistry, East Carolina University (CHE-
0750364, $280, 000)
Dr. Liguo Song, Department of Chemistry, University of Tennessee (CHE-0750287,
$210, 000)
Dr. Frank Chamber, Mechanical and Aerospace Engineering, Oklahoma State University
(CHE-0750333, $210, 000)
Source of Support:
NSF ($700,000, 05/15/2008 to10/31/2012)
DuPont Crop Protection (in-kind support to host interns, 05/15/2008 to 04/30/2014)
PROFESSIONAL AFFILIATIONS
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American Society for Mass Spectrometry, member
SELECTED PUBLICATIONS
Peer reviewed articles [1-41]
1. Zhu, Z. Q.; Bartmess, J. E.; McNally, M. E.; Hoffman, R. M.; Cook, K. D.; Song, L. G.
Quantitative Real-Time Monitoring of Chemical Reactions by Autosampling Flow Injection
Analysis Coupled with Atmospheric Pressure Chemical Ionization Mass Spectrometry. Analytical
Chemistry 2012, 84 , 7547-7554.
2. Zhu, Z. Q.; Song, L. G.; Bartmess, J. E. Differentiation of underivatized monosaccharides by atmospheric pressure chemical ionization quadrupole time-of-flight mass spectrometry. Rapid
Communications in Mass Spectrometry 2012, 26 , 1320-1328.
3. Song, L. G.; Cho, D. S.; Bhandari, D.; Gibson, S. C.; McNally, M. E.; Hoffman, R. M.;
Cook, K. D. Liquid chromatography/dopant-assisted atmospheric pressure chemical ionization mass spectrometry for the analysis of non-polar compounds. International Journal of Mass
Spectrometry 2011, 303 , 173-180.
4. Cho, D. S.; Gibson, S. C.; Bhandari, D.; McNally, M. E.; Hoffman, R. M.; Cook, K. D.;
Song, L. G. Evaluation of direct analysis in real time mass spectrometry for onsite monitoring of batch slurry reactions. Rapid Communications in Mass Spectrometry 2011, 25 , 3575-3580.
5. Song, L. G.; Gibson, S. C.; Bhandari, D.; Cook, K. D.; Bartmess, J. E. Ionization
Mechanism of Positive-Ion Direct Analysis in Real Time: A Transient Microenvironment
Concept. Analytical Chemistry 2009, 81 , 10080-10088.
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6. Song, L. G.; Dykstra, A. B.; Yao, H. F.; Bartmess, J. E. Ionization Mechanism of Negative
Ion-Direct Analysis in Real Time: A Comparative Study with Negative Ion-Atmospheric Pressure
Photoionization. Journal of the American Society for Mass Spectrometry 2009, 20 , 42-50.
7. Song, L. G.; Bartmess, J. E. Liquid chromatography/negative ion atmospheric pressure photoionization mass spectrometry: a highly sensitive method for the analysis of organic explosives. Rapid Communications in Mass Spectrometry 2009, 23 , 77-84.
8. Song, L. G.; Wellman, A. D.; Yao, H. F.; Bartmess, J. E. Negative ion-atmospheric pressure photoionization: Electron capture, dissociative electron capture, proton transfer, and anion attachment. Journal of the American Society for Mass Spectrometry 2007, 18 , 1789-1798 .
9. Song, L. G.; Wellman, A. D.; Yao, H. F.; Adcock, J. Electron capture atmospheric pressure photoionization mass spectrometry: analysis of fullerenes, perfluorinated compounds, and pentafluorobenzyl derivatives. Rapid Communications in Mass Spectrometry 2007, 21 , 1343-
1351.
10. Tang, L.; Li, G. L.; Song, L. G.; Zhang, Y. S. The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells. Anti-Cancer Drugs 2006, 17 , 297-305.
11. Choi, K. S.; Song, L. G.; Park, Y. M.; Marshall, J.; Lund, A. L.; Shion, H.; Park, E. M.;
Chae, H. Z.; Park, J. H. Analysis of human plasma proteome by 2DE-and 2D nanoLC-based mass spectrometry. Preparative Biochemistry & Biotechnology 2006, 36 , 3-17.
12. Abrams, S. M.; Mahoney, M. C.; Hyland, A.; Cummings, K. M.; Davis, W.; Song, L. G.
Early evidence on the effectiveness of clean indoor air legislation in New York State. American
Journal of Public Health 2006, 96 , 296-298.
13. Titus, M.; Hill, C.; Song, L. G.; Schell, M.; Tomer, K.; Mohler, J. Androgen tissue levels in recurrent prostate cancer using liquid chromatography tandem mass spectrometry. Journal of
Urology 2005, 173 , 413.
14. Song, L. G.; Prey, J. D.; Xue, J.; Kanter, P.; Manzotti, C.; Bombardelli, E.; Morazzoni, P.;
Pendyala, L. Pharmacokinetic measurements of IDN 5390 using electrospray ionization tandem mass spectrometry: structure characterization and quantification in dog plasma. Rapid
Communications in Mass Spectrometry 2005, 19 , 3617-3625.
15. Song, L. G.; James, S. R.; Kazim, L.; Karpf, A. R. Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry. Analytical Chemistry 2005, 77 , 504-510.
16. Song, L. G.; Davis, W.; Abram, S. M.; Hemiup, J.; Kazim, A. L.; Cummings, K. M.;
Mahoney, M. C. Sensitive and rapid method for the determination of urinary cotinine in nonsmokers: an application for studies assessing exposures to second hand smoke (SHS). Analytica
Chimica Acta 2005, 545 , 200-208.
17. Song, L.; Choi, K. S.; Park, Y. M.; Kazim, A. L.; Marlar, K.; Kong, E. S.; Park, E. M.;
Kim, Y. H.; Koo, K. H.; Chae, H. Z. Capillary-LC-mu ESI-MS/MS and nano-LC-nano ESI-
MS/MS analysis using a single binary pump capillary LC system: Applications in proteomics.
Journal of Liquid Chromatography & Related Technologies 2005, 28 , 1271-1289.
18. Xue, J.; Song, L. G.; Khaja, S. D.; Locke, R. D.; West, C. M.; Laine, R. A.; Matta, K. L.
Determination of linkage position and anomeric configuration in Hex-Fuc disaccharides using electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry
2004, 18 , 1947-1955.
19. Park, E. M.; Choi, K. S.; Song, L. G.; Kong, E. S.; Lund, A. L.; Shion, H.; Park, Y. M.
Comparative evaluation of 2D PAGE and 2D nanoLC based sample preparation procedures on pre/post-depleted serum/plasma proteome identification. Molecular & Cellular Proteomics 2004,
3 , S85-S85.
20. Song, L. G.; Liu, T. B.; Liang, D. H.; Wu, C. H.; Zaitsev, V. S.; Dresco, P. A.; Chu, B.
Coupling of optical characterization with particle and network synthesis for biomedical applications. Journal of Biomedical Optics 2002, 7 , 498-506.
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21. Song, L. G.; Liu, T. B.; Liang, D. H.; Fang, D. F.; Chu, B. Separation of double-stranded
DNA fragments by capillary electrophoresis in interpenetrating networks of polyacrylamide and polyvinylpyrrolidone. Electrophoresis 2001, 22 , 3688-3698.
22. Song, L. G.; Liang, D. H.; Kielescawa, J.; Liang, J.; Tjoe, E.; Fang, D. F.; Chu, B. DNA sequencing by capillary electrophoresis using copolymers of acrylamide and N,N-dimethylacrylamide. Electrophoresis 2001, 22 , 729-736.
23. Song, L. G.; Liang, D. H.; Fang, D. F.; Chu, B. Fast DNA sequencing up to 1000 bases by capillary electrophoresis using poly(N,N-dimethylacrylamide) as a separation medium.
Electrophoresis 2001, 22 , 1987-1996.
24. Song, L. G.; Liang, D.; Chen, Z.; Fang, D.; Chu, B. DNA sequencing by capillary electrophoresis using mixtures of polyacrylamide and poly(N,N-dimethylacrylamide). Journal of
Chromatography A 2001, 915 , 231-239.
25. Liu, T. B.; Liang, D. H.; Song, L. G.; Nace, V. M.; Chu, B. Spatial open-network formed by mixed triblock copolymers as a new medium for double-stranded DNA separation by capillary electrophoresis. Electrophoresis 2001, 22 , 449-458.
26. Liang, D. H.; Song, L. G.; Chen, Z. J.; Chu, B. Clay-enhanced DNA separation in lowmolecular-weight poly(N,N-dimethylacrylamide) solution by capillary electrophoresis.
Electrophoresis 2001, 22 , 1997-2003.
27. Liang, D. H.; Song, L. G.; Chen, Z. J.; Chu, B. Effect of glycerol-induced DNA conformational change on the separation of DNA fragments by capillary electrophoresis. Journal
of Chromatography A 2001, 931 , 163-173.
28. Liang, D. H.; Liu, T. B.; Song, L. G.; Chu, B. J. Mixed triblock copolymers used as DNA separation medium in capillary electrophoresis. Journal of Chromatography A 2001, 909 , 271-
278.
29. Liang, D. H.; Song, L. G.; Quesada, M. A.; Tian, Z. W.; Studier, F. W.; Chu, B. Formation of concentration gradient and its application to DNA capillary electrophoresis. Electrophoresis
2000, 21 , 3600-3608.
30. Song, L. G.; Fang, D. F.; Kobos, R. K.; Pace, S. J.; Chu, B. Separation of double-stranded
DNA fragments in plastic capillary electrophoresis chips by using E99P69E99 as separation medium. Electrophoresis 1999, 20 , 2847-2855.
31. Liang, D. H.; Zhou, S. Q.; Song, L. G.; Zaitsev, V. S.; Chu, B. Copolymers of poly(Nisopropylacrylamide) densely grafted with poly(ethylene oxide) as high-performance separation matrix of DNA. Macromolecules 1999, 32 , 6326-6332.
32. Liang, D. H.; Song, L. G.; Zhou, S. Q.; Zaitsev, V. S.; Chu, B. Poly(Nisopropylacrylamide)-g-poly(ethyleneoxide) for high resolution and high speed separation of
DNA by capillary electrophoresis. Electrophoresis 1999, 20 , 2856-2863.
33. Song, L. G.; Xu, Z. H.; Kang, J. W.; Cheng, J. K. Analysis of environmental pollutants by capillary electrophoresis with emphasis on micellar electrokinetic chromatography. Journal of
Chromatography A 1997, 780 , 297-328.
34. Chen, H.; Song, L. G.; Xiong, S. X.; Cheng, J. K. Separation of DNA fragments by capillary electrophoresis with non-gel sieving matrix of hydroxyethyl cellulose and sucrose.
Chemical Journal of Chinese Universities-Chinese 1997, 18 , 1769-1773.
35. Song, L. G.; Zhang, S. M.; Ou, Q. Y.; Yu, W. L. Electrokinetic Chromatography of
Diterpenoid Alkaloids from Aconitum-Sinomontanum Nakai. Journal of Microcolumn
Separations 1995, 7 , 123-126.
36. Song, L. G.; Ou, Q. Y.; Yu, W. L.; Xu, G. F. Effect of High-Concentrations of Salts in
Samples on Capillary Electrophoresis of Anions. Journal of Chromatography A 1995, 696 , 307-
319.
37. Song, L. G.; Ou, Q. Y.; Yu, W. L.; Li, G. Z. Separation of 6 Phenylureas and
Chlorsulfuron Standards by Micellar, Mixed Micellar and Microemulsion Electrokinetic
Chromatography. Journal of Chromatography A 1995, 699 , 371-382.
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38. Song, L. G.; Ou, Q. Y.; Yu, W. L.; Fang, L. C.; Jin, Y. B. Determination of the Petroleum
Tracers Nitrate and Thiocyanate in Subterranean Waters by Capillary Ion Electrophoresis.
Journal of Chromatography A 1995, 715 , 376-384.
39. Song, L. G.; Zhang, S. M.; Ou, Q. Y.; Yu, W. L. Studies of Crude Chloroform Extract of
Roots of Podophyllum-Emoddii Var Chinesis Sprague by Micellar Electrokinetic
Chromatography. Chromatographia 1994, 39 , 682-686.
40. Song, L. G.; Ou, Q. Y.; Yu, W. L. Study Om Phosphate of Ethylenediamine, 1,3-
Diaminopropane and 1,4-Diaminobutane as Carrying Electrolyte in Open-Tubular Capillary
Electrophoresis. Journal of Liquid Chromatography 1994, 17 , 1953-1969.
41. Song, L. G.; Ou, Q. Y.; Yu, W. L. Improved Capillary Zone Electrophoretic Separation of
Basic-Proteins in Uncoated Fused-Silica Capillary by Using Ethylene Diamine as a Buffer
Additive. Journal of Chromatography A 1993, 657 , 175-183.
Book chapters
1.
Song, L.; Bartmess, J. E., Ionization mechanism of direct ionization in real time (DART).
In Ambient ionization mass spectrometry , Cody, C., Ed. Royal Society of Chemistry: 2014.
2.
Weile Yu, Qingyu Ou, Liguo Song, and et al. "Capillary gas chromatography and several recently developed separation techniques" First Edition, China Science Publication, February,
1999.
Patent
1.
Benjamin Chu, Liguo Song, Dufei Fang, Dehai Liang, Tianbo Liu. Polymer solution for separation of charged macromolecules by electrophoresis. US Patent, US 6,770,698 , 2004.
2.
Benjamin Chu, Liguo Song, Dufei Fang, Dehai Liang, Tianbo Liu, Yanmei Wang,
Qicong Ying. Quasi-Interpenetrating Network Used for Separation Media. US Patent, US
7,037,978, 2006.
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