Decreased Functional Ability and Altered Joint Loading with the Progression of Medial Compartment Knee Osteoarthritis Osteoarthritis (OA) is a major contributor to physical disability in middle age and elderly individuals. While the economical, physical and emotional impact of this disease is explicit, many of the biomechanical alterations associated with the disease progression are not well understood. Many of the previous investigations into biomechanical changes associated with OA have not evaluated how these changes progress as the severity of OA increases. In order to assess how OA severity affects the muscluloskeletal system, we are proposing to investigate the progressive biomechanical and functional changes in subjects with knee OA. In particular, we will utilize a cross-sectional design to understand how multiple measures of joint loading and clinical functional assessments change with a progressive increase in OA severity. We plan to utilize computational optimization techniques to predict muscle forces and subsequent intersegmental joint compression forces. In addition, we will incorporate a longitudinal strategy to evaluate the causative relationship between medial compartment joint loading and decreased functional ability in the same subjects with OA of the knee.