“Treating Knee Osteoarthritis with Wedged Insoles” Todd Royer In-shoe wedged orthoses have been shown to be an effective conservative approach in reducing pain in patients with medial compartment knee osteoarthritis (OA). The mechanism responsible for this pain reduction is not well-understood. It is not known whether placing a lateral wedge in the shoe results in alterations in lower extremity alignment, knee joint moments or some combination of the two. Therefore, the purpose of this study is to examine the effect of in-shoe wedged orthoses in patients with knee OA. Patients between the ages of 40-75 yrs with knee OA (KL grades II-IV) receive a laterally wedged orthosis and a pair of walking shoes. Following a two-week accommodation period, subjects performed walking and stair ascent/descent functional tests and rated their knee pain, completed a gait analysis, and received hip-to-ankle radiographs to identify differences between the wedged and no-wedged conditions. These data are a subset of our COBRE grant investigating the short and long-term effects of in-shoe wedged orthoses in subjects with either medial or lateral compartment knee OA.