USD 3001
Resolute® Linear Columns
Automated chromatography columns for pilot and
process scale
The Resolute Linear column range offers a unique combination of active multi-axis piston
control, precision linear actuation and fully automated unit operations that delivers the following
benefits to the end-user:
` Fully scalable technology
` Quiet, clean operation
` Reduced operator involvement and error
` Predictable time efficient packing
Overview
Software
Resolute Linear chromatography columns are designed for largescale pilot and production use. The range is available from 400 to
1200mm internal diameter, in all common sizes. The columns utilize
the proven Resolute wetted flowpath providing low pressure drop
and high-resolution chromatography over a wide range of normal
operating flow rates. The typical flow range is from 30 - 800 cm/hr.
In a departure from more traditional HMI and control cabinet
configurations, control of a Resolute Linear column is performed
using a handheld touch screen remote control, from which
the operator can initiate all the inbuilt Resolute functionality;
including fully automated packing, unpacking, CIP and hoist-free
maintenance.
The patented Resolute nozzle system is used, with identical
remote controlled three position nozzles at the top and bottom
of the column. This technology allows packing and unpacking
without opening the column.
The remote control is universal and can be used on all Resolute
Linear columns.
The software is purpose coded for the remote control and is
designed to be intuitive. For example, all operator actions and
commands are a maximum of four clicks away from the home
screen, making navigation and operation as easy as possible.
Integrated into the remote control is a safety enable system that
prevents operation while the operator is absent; this can be
disabled on request.
Resolute Linear columns support both fixed and variable
geometry pack in place methodology, however the platform
has been specifically designed to fully exploit the capabilities of
Resolute AutoPak; a one touch system for the fully automated
packing, unpacking and CIP of the Resolute range of actuated
columns. Where AutoPak is specified a packing skid is not
required.
A standard Resolute Linear column comes with the Resolute
AutoPak system, 20µm polyethylene sinters, an acrylic tube,
3 bar operating pressure and 100-400mm packed bed capability
(100-500mm packed bed capability for non-AutoPak columns).
A range of material options and accessories is available to
configure Resolute Linear to your requirements.
Multi-Axis Control
Precision control of the piston is delivered by three linear
actuators, which operate in unison through the control software
to deliver class-leading piston movement stability. This technology
is fully scalable across the entire range of columns.
The software actively monitors and controls the position of
the actuators to ensure that the piston is always kept level.
This provides a distinct advantage over central single actuator
designs, where the piston is held level solely by passive seal
action and design stiffness.
Figure 2: Resolute Linear Remote Control
Resolute Linear
Feature
Benefit
Active multi-axis levelling control of piston,
delivering class leading stability
Fully scalable column design,
reduced risk of column damage
over single axis designs
Small footprint, no cooling liquid
required, no risk of oil leakage
Safe operator environment, small
cleanroom footprint
Easier operator training, reduced
risk of operator error
Electric only control unit and
linear actuators
In built maintenance, enabling consumable
change out from ground level
Intuitive software
Figure 1: Cut through of a linear actuator
2
Resolute Linear with AutoPak
The AutoPak system was developed in direct response to an
industry need for fully automated operations. Often key column
preparation operations, particularly packing, are regarded as high
risk clean room events. These risks include human error, packing
failure, and absence of experienced operators; they can result in
plant downtime, loss of product or sorbent and inefficient use of
resources. By adopting a fully automated approach, the AutoPak
system greatly simplifies operation, effectively eliminates operator
error and reduces the burden on key operators. The automated
sequences assure that reproducible and consistent operation is
the norm.
Figure 3:
Typical Configuration Of A Resolute Linear Column With Integrated AutoPak
The scope of the installation above shows a Resolute Linear column with the AutoPak system, remote control and column mounted valve
control accessory. The illustration should not be interpreted as a process and instrumentation diagram.
AutoPak System
Feature
Benefit
Fully automated packing unpacking and CIP
Greatly simplified operator interaction
Ability to use all the sorbent in the tank
Simplified pipework over pump pack methods
Multiple fully configurable packing methods
Reproducible results, reduced time for column packing
Risk of operator error reduced, fewer operators required
Reduction in media costs
Quicker, error free set-up
Future-proofed ability to easily adjust to changing plant requirements,
ability to pack a wide range of sorbents
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3
Maintenance
Wetted Pathway Options
Hoist-Free Maintenance Mode
The following wetted pathway options are available.
All Resolute Linear columns have a patented maintenance
function inbuilt, allowing access to major consumable spare parts
from ground level, without the need for an external crane or hoist.
The maintenance function provides:
` assured operator safety
` foot print efficiency
Wetted Stainless Steel Component Options*
Can be applied to column tubes, bed supports, nozzle tubes and
pipework kits. As standard, columns are supplied with 1.4404
components.
Stainless Steel
(1.4404, 316L)
Entry into maintenance mode is made through easily followed
instructions on the handheld remote control. The column is
disassembled using the Linear drives without increasing the
column footprint. The list of key consumables and part numbers
for the standard Linear column range is provided in the list below.
Maintenance schedules are advised in the operating manuals.
Stainless Steel
(1.4435, 316L)
- not available
for meshes
Stainless Steel
(1.4539, 904L)
Stainless Steel
(C22, Hastelloy)
Increasing chloride resistance
* Stainless steel options are quoted on request.
Bed Support Pore Size Options
Bed supports are available in 10 micron and 20 micron pore
sizes. The mesh should be selected based on the sorbent
average particle size; generally a bed support size < 1/3 of the
average particle size is sufficient to prevent particle flow through.
For example, for a 90µm sorbent, 20µm bed supports would be
specified, for a 34µm media 10µm bed supports would be specified.
Note that the difference between a 10 and 20 micron bed support
pore size makes a negligible difference in overall column pressure
drop.
Key Accessories
Linear Remote Control
The remote control is the master controller for Resolute Linear
column and allows the full scope of operations to be initiated and
monitored.
At least one remote control must be purchased for each set
of columns. If packing, unpacking or CIP is to take place
simultaneously on more than one column, then additional remote
control(s) should be purchased as required.
Model Number
Description
Columns Applicable
LD-HMI
Resolute Linear
Remote Control
All
Figure 4: Resolute Linear 1000 in Maintenance Mode
Figure 5: Resolute Linear Remote Control
4
Column Mounted Valve Control
The touch screen device is fitted permanently to the column, and
allows the process valving and nozzles to be controlled when the
remote control unit is not connected. This permits the remote
control unit to be used with other columns.
This option should be obtained when multiple columns are
purchased and only one column is packed at a time.
Model Number
Description
Columns Applicable
LD-VC
Resolute Linear Column
Mounted Valve Control Kit
All
Figure 7: AutoPak Tank Valve Block
Resolute Drive Station
The Resolute Linear Drive Station supplies the power and drive
control for the three linear actuators.
One Drive Station can operate all columns sizes, therefore, at least
one drive station must be purchased for each set of columns.
If packing, unpacking or CIP is to take place simultaneously on
more than one column, then additional drive stations are required
as necessary. The drive station is not required when the column is
in process mode. However a separate 24V power supply will be
required to operate valves and nozzles using the Resolute Linear
Remote Control or Column Mounted Valve Control.
Figure 6: Column Mounted Valve Control
AutoPak Tank Valve Block
The AutoPak tank valve block provides the ability to switch
between buffer and slurry while controlling the agitation in the
tank. Included with the column is the valve block, mounting,
hoses to connect to the column tanks and associated clamps
and EPDM gaskets. As standard, pipework and GEMU block
valves are included in 316L (1.4404) stainless steel. If an
alternative stainless steel is selected then the material change
must be stated at the point of order.
The external material of the cabinet is stainless steel, suitable
for wipedown, and use in a clean environment. The cabinet is
rated to the requirements IP65. The drive station is a discrete unit
which occupies minimal floor space and requires only an electrical
supply to operate.
Model Number
Description
Columns Applicable
EPU
Resolute Linear Drive Station
All
At least one AutoPak tank valve block must be purchased for
each set of AutoPak columns.
If packing, unpacking or CIP is to take place simultaneously on
more than one column, then additional valve blocks should be
purchased as necessary.
Model Number
Description
Columns Applicable
TVB-1
TVB-2
AutoPak Tank Valve Block
AutoPak Tank Valve Block
<800
>800
Figure 8: Resolute Drive Station
www.pall.com/biopharm
5
Non-AutoPak Valve Kits
For Resolute Linear columns that are selected without the
AutoPak system, a valve kit is available to facilitate process and
packing connections. This kit enables manual selection of column
online and bypass modes and provides the required burst disk*
pressure relief. It is recommended for both chromatography skid
connection and packing operations.
As standard, pipework and GEMU block valves are included in
316L (1.4404) stainless steel with all necessary EPDM gaskets,
clamps and mounting brackets. If an alternative stainless steel is
selected then the material must be stated at the point of order.
This kit is factory fitted, and shipped with the column.
Model Number
Description
Columns Applicable
LD-PFK-XXXX**
Resolute Linear Pipe
and Manual Valving Kit
All
* Pressure relief valves can be quoted on request.
** XXXX = column diameter in mm
Additional Accessories
Other accessories such as column transport options, slurry tanks,
packing skids, bed support transporters and media handling
solutions are available upon request. Please contact your local
Pall representative or www.pall.com for more information.
The picture below shows a Resolute Linear column being moved
by an operator using a MasterMover. This makes moving the
columns a safe and operator friendly activity.
Figure 9: Resolute Linear with a MasterMover◆
6
Consumables
Name
ADJ PE bed support 20µm kit
ADJ 316L bed support 20µm kit
FIXED PE bed support 20µm kit
FIXED 316L bed support 20µm kit
Snap ring for PE sinters
Snap ring for SS meshes
Wiper ring for PE sinters
Wiper ring for SS meshes
Major seal kit (adjuster main seals
and fixed end main seals)
Intermediate fixing screw kit
Nozzle tip kit
Nozzle valve seal kit
Name
ADJ PE bed support 20µm kit
ADJ 316L bed support 20µm kit
FIXED PE bed support 20µm kit
FIXED 316L bed support 20µm kit
Snap ring for PE sinters
Snap ring for SS meshes
Wiper ring for PE sinters
Wiper ring for SS meshes
Major seal kit (adjuster main seals
and fixed end main seals)
Intermediate fixing screw kit
Nozzle tip kit
Nozzle valve seal kit
400
Part No
450
Part No
500
Part No
600
Part No
630
Part No
EEA14A136A13
EEA14A139A13
EEA14A142A13
EEA14A145A13
K400-3033
K400-3012
EEA12A181A129
EEA12A181A129
EEA14A136A27
EEA14A139A27
EEA14A142A27
EEA14A145A27
Contact Pall
K450-4058
EEA12A181A252
EEA12A181A252
EEA14A136A37
EEA14A139A37
EEA14A142A37
EEA14A145A37
Contact Pall
K500-3011-03
EEA12A181A253
EEA12A181A253
EEA14A136A14
EEA14A139A14
EEA14A142A14
EEA14A145A14
K600-3013
K600-3012
EEA12A181A130
EEA12A181A130
EEA14A136A189
EEA14A139A189
EEA14A142A189
EEA14A145A189
Contact Pall
K630-3025
EEA12A181A254
EEA12A181A254
EEA12A155A129
N/A
EEA13A159A20
EEA12A152A20
EEA12A155A252
N/A
EEA13A159A20
EEA12A152A20
EEA12A155A253
N/A
EEA13A159A21
EEA12A152A21
EEA12A155A130
N/A
EEA13A159A21
EEA12A152A21
EEA12A155A254
N/A
EEA13A159A21
EEA12A152A21
700
Part No
800
Part No
1000
Part No
1200
Part No
EEA14A136A227
EEA14A139A227
EEA14A142A227
EEA14A145A227
Contact Pall
K700-3073-01
EEA12A181A255
EEA12A181A255
EEA14A136A15
EEA14A139A15
EEA14A142A15
EEA14A145A15
K800-3075-01
K800-3249
EEA12A181A131
EEA12A181A131
EEA14A136A16
EEA14A139A16
EEA14A142A16
EEA14A145A16
K1000-3023-02
K1000-3023
EEA12A181A132
EEA12A181A132
EEA14A136A17
EEA14A139A17
EEA14A142A17
EEA14A145A17
K1200-3067
K1200-3039
EEA12A181A133
EEA12A181A133
EEA12A155A255
EEA13A220A15
EEA13A159A21
EEA12A152A21
EEA12A155A131
EEA13A220A15
EEA13A159A22
EEA12A152A22
EEA12A155A132
EEA13A220A16
EEA13A159A24
EEA12A152A24
EEA12A155A133
EEA13A220A17
EEA13A159A23
EEA12A152A23
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7
Specifications
Table 1: Weights and Dimensions
The table below provides indicative dimensions and weights for the standard range. For additional diameters and bed heights, please
contact your Pall representative for an engineered solution.
Weight
Empty
Footprint
Smallest Dimension
Not Inc. Valves
Heights
Length
Depth
At Minimum
Height
Type
kg
mm
mm
mm
Drive station
90
510
600
850
400
400 with AutoPak
450
450 with AutoPak
500
500 with AutoPak
600
600 with AutoPak
630
630 with AutoPak
700
700 with AutoPak
800
800 with AutoPak
900
900 with AutoPak
1000
1000 with AutoPak
1200
1200 with AutoPak
580
700
650
780
720
860
860
1030
1060
1270
1270
1520
1680
2010
1970
2370
2270
2730
3550
4250
840
840
880
880
920
920
1010
1010
1100
1100
1180
1180
1360
1360
1440
1440
1510
1510
1800
1800
1050
1050
1050
1050
1050
1050
1060
1060
1150
1150
1250
1250
1450
1450
1480
1480
1510
1510
1780
1780
1700
2000
1700
2000
1700
2000
1700
2000
1760
2040
1820
2070
1930
2140
1940
2150
1950
2160
2180
2410
At Maximum
Packed bed
Height
Maximum
Height During
Maintenance
mm
mm
2200
2750
2200
2750
2200
2750
2200
2750
2260
2790
2320
2820
2430
2890
2440
2900
2450
2910
2680
3160
2200
2550
2200
2540
2200
2530
2200
2510
2270
2560
2340
2600
2470
2700
2540
2700
2620
2700
2870
2960
Table 2: Materials of Construction
Table 3: Standard Surface Finishes
Process Wetted Fixed Components Material
Stainless Steel*
Column tube
Distribution cell
Nozzle body
Non-wetted
Wetted
Mobile phase termination
Slurry nozzle tip
Slurry inlet port
Main seals
Nozzle tip seals
Wiper ring
Acrylic (PMMA) / Stainless Steel*
Polypropylene
480 – 1000 mm Ø Column: PVDF
1200 mm Ø Column: Polypropylene
480 – 1000 mm Ø Column: PEEK
1200 mm Ø Column: Stainless
Steel 316L
PEEK
400 – 1200 mm Ø Column: Stainless
Steel 316L*
EPDM (Peroxide Cured) / FEP
FEP Encapsulated Silicone
PTFE
All non-wetted materials are suitable for wipe down and clean room use.
* Different grades of stainless steel are available. See Wetted Pathway Options.
1.5 micron Ra
0.5 micron Ra
Plastics
Acrylic (PMMA)
All others
Polished smooth
Not applicable
*Improved surface finishes quoted on request.
Certification & Technical Construction File
Resolute Linear columns can be designed to meet either of the
following pressure vessel codes.
ASME Boiler & Pressure Vessel Code 2013 addition.
PD 5500: 2012 + A2: 2013
All columns and accessories come with a full technical
documentation file. Examples are available on request.
8
Table 4: Operating Temperature
Ambient Temperature Ranges
Operating Temperature Static*
Operating Temperature Dynamic**
2 - 30ºC
15 - 25ºC
* The static temperature range refers to when the column is in process mode and no piston movement
will take place.
** The dynamic temperature range refers indicates the acceptable temperature range when the column
piston is moving.
Temperature ranges outside of these values above are quoted
upon request. Columns can be designed for operational ranges
up to 60 degrees C.
Visit us on the Web at www.pall.com/biopharm
E-mail us at biopharm@pall.com
Corporate Headquarters
Port Washington, NY, USA
+1.800.717.7255 toll free (USA)
+1.516.484.5400 phone
biopharm@pall.com e-mail
European Headquarters
Fribourg, Switzerland
+41 (0)26 350 53 00 phone
LifeSciences.EU@pall.com e-mail
Asia-Pacific Headquarters
Singapore
+65 6389 6500 phone
sgcustomerservice@pall.com e-mail
International Offices
Pall Corporation has offices and plants throughout the world in locations such as: Argentina, Australia, Austria,
Belgium, Brazil, Canada, China, France, Germany, India, Indonesia, Ireland, Italy, Japan, Korea, Malaysia, Mexico,
the Netherlands, New Zealand, Norway, Poland, Puerto Rico, Russia, Singapore, South Africa, Spain, Sweden,
Switzerland, Taiwan, Thailand, the United Kingdom, the United States, and Venezuela. Distributors in all major
industrial areas of the world. To locate the Pall office or distributor nearest you, visit www.pall.com/contact.
The information provided in this literature was reviewed for accuracy at the time of publication. Product
data may be subject to change without notice. For current information consult your local Pall distributor
or contact Pall directly.
, Pall and Resolute are trademarks of Pall Corporation, Filtration.Separation.Solution. is a service
mark of Pall Corporation, ® indicates a trademark registered in the USA, © 2014 Pall Corporation,
MasterMover is a Registered Trade Name of MasterMover.
09/14, PDF, GN14.9516
USD 3001