USD2952a1
LevMixer® System
Ideal for buffer preparation and product contact mixing
Highlights and Benefits
True superconductive levitation technology:
no mechanical shear and no particle generation
to ensure product integrity
No shafts, seals or bearings inside the mixing system
Scalability; from 6 L to 2,000 L using one portable,
ergonomic and universal drive unit. This feature
helps lower capital costs and improve process
efficiency
Powerful mixing technology capable to suspend
powders and other solids without clogging
or shearing
Applications
Product homogenization
Suspension/re-suspension
Final formulation
Media, buffer preparation
Overview
The LevMixer system is specifically designed to fulfill the needs
of the bioprocess industry. This system is a mobile, flexible
mixing system that allows efficient and reproducible single-use
mixing of a wide range of volumes in a broad series of applications
ranging from buffer preparation to final formulation. The LevMixer
system is engineered for use with Pall Life Sciences single-use
mixing systems in cGMP certified cleanrooms.
The LevMixer system consists of an interchangeable superconducting drive unit and proprietary levitating-impeller-based
single-use mixing system fitted into into either plastic tanks
located on a trolley or stainless steel tanks. Once charged and
coupled with the single-use system, the superconducting drive
unit induces levitation and rotation of the impeller (Figure 1)
resulting in effective mixing action inside a closed mixing system.
Coupling of the impeller with the drive motor requires no dynamic
seals or shaft penetration inside the single-use system. The
drive motor is enclosed on a portable cart that can be easily
disconnected from the single-use system and reconnected to
another mixing system, allowing mixing in multiple single-use
mixing systems of various sizes with a single drive unit.
The LevMixer system includes a real-time reading of the impeller
speed and an process monitoring/ alert capability. In case of any
process disruption, the user is alerted. End users may access a
detailed activity report during on-going applications to monitor
the mixer either on site, or remotely from a different location.
Figure 1
The levitating impeller rotates inside a sterile single-use
mixing system
2
Additionally, the mixer may either be controlled on
site or remotely, based on user preference. When
operating onsite, users will benefit from an easy-to-use touchscreen PLC that features access to the mixing recipe in use.
The LevMixer system utilizes disposable mixing biocontainers
made from Allegro™ TK8 bioprocess film. The product-contacting
layer of Allegro TK8 film is blow-extruded in-house by Pall Life
Sciences under cleanroom conditions using medical-grade ultra
low-density polyethylene resin. It is then laminated to create a
gas barrier film of exceptional cleanliness, strength, and clarity
that is animal derived component free (ADCF) and complies fully
with USP Class VI requirements.
Figure 2
Mobile and flexible, the LevMixer system allows efficient mixing
in a wide range of volumes
Principle of Operation
The mixing technology of the LevMixer system is based on
non-contact magnetic coupling between conventional permanent
magnets in the impeller and superconducting material in the
drive (Figure 3). Superconducting material has the ability to trap
the magnetic field generated by the permanent magnets and
“lock the magnetic field in memory” in an equilibrium position.
The trapped magnetic field behaves like mechanical springs; if
the magnet is moved up, down or sideways by outside forces
(e.g., gravity or angular torque) it will tend to be pulled back to
an equilibrium position. The peculiar nature of magnet-superconductor interaction ties the two bodies together resulting in a very
stable magnetic coupling with finite equilibrium separation. This
system is housed in a universal drive unit (Figure 4).
Figure 3
The magnet-superconductor interaction results in a very stable
magnetic coupling
Technical Specifications
Parameter
LevMixer Drive Unit
Power
Input Wattage
Drive Unit Footprint
Drive Unit Height
Material of Construction
Interface Type
Control Box Rating
Single phase 100V–230V AC, 50/60 Hz
< 350 Watts
40 cm x 112 cm (16 in. x 44 in.)
92 cm to top of control box (36 in.)
304 L Stainless Steel, at least 35 µin. Ra
Touchscreen PLC
IP 65
Parameter
Single-Use Impeller
Type
Number of Blades
Material
Maximum Speed
Impeller Bag Location
6.25 in. diameter radial flow
Four (4)
USP Class VI, ADCF, gamma stable HDPE
210 RPM
Center, off-center
Ordering Information
Drive Unit for Use with LevMixer System
Part Number
Description
LT- DBTL300
LevMixer 3 Universal Drive Unit
Tanks for Use with LevMixer System
Part Number
Description
Figure 4
LevMixer universal drive unit.
LEV30PR
LEV30NJ420SLC
LEV50PR
LEV50NR
LEV50NR420SLC
LEV50JR
LEV50JR420SLC
LEV50NC
LEV50NC420SLC
LEV50JC
LEV50JC420SLC
LEV100PR
LEV100NR
LEV100NR420SLC
LEV100JR
LEV100JR420SLC
LEV100NC
LEV100NC420SLC
LEV100JC
LEV100JC420SLC
LEV200PR
LEV200NR
LEV200NR420SLC
LEV200JR
LEV200JR420SLC
LEV200NC
LEV200NC420SLC
LEV200JC
LEV200JC420SLC
30 L, Round, MDPE
30 L, Round, Stainless Steel, Load Cells
50 L, Round, MDPE
50 L, Round, Stainless Steel
50 L, Round, Stainless Steel, Load Cells
50 L, Round, Stainless Steel, Jacketed
50 L, Round, Stainless Steel, Jacketed, Load Cells
50 L, Cubical, Stainless Steel
50 L, Cubical, Stainless Steel, Load Cells
50 L, Cubical, Stainless Steel, Jacketed
50 L, Cubical, Stainless Steel, Jacketed, Load Cells
100 L, Round, MDPE
100 L, Round, Stainless Steel
100 L, Round, Stainless Steel, Load Cells
100 L, Round, Stainless Steel, Jacketed
100 L, Round, Stainless Steel, Jacketed, Load Cells
100 L, Cubic , Stainless Steel
100 L, Cubic , Stainless Steel, Load Cells
100 L, Cubical, Stainless Steel, Jacketed
100 L, Cubical, Stainless Steel, Jacketed, Load Cells
200 L, Round, Dual Port, MDPE
200 L, Round, Stainless Steel
200 L, Round, Stainless Steel, Load Cells
200 L, Round, Stainless Steel, Jacketed
200 L, Round,Stainless Steel, Jacketed, Load Cells
200 L, Cubical, Stainless Steel
200 L, Cubical, Stainless Steel, Load Cells
200 L, Cubical, Stainless Steel, Jacketed
200 L, Cubical, Stainless Steel, Jacketed, Load Cells
www.pall.com
3
Tanks for Use with LevMixer System
Part Number
Description
LEV350PR
LEV350NR
LEV350NR420SLC
LEV350JR
LEV350JR420SLC
LEV400NC
LEV400NC420SLC
LEV400JC
LEV400JC420SLC
LEV500PR
LEV500NR
LEV500NR420SLC
LEV500JR
LEV500JR420SLC
LEV650NC
LEV650NC420SLC
LEV650JC
LEV650JC420SLC
LEV1000NR
LEV1000NR420SLC
LEV1000JR
LEV1000JR420SLC
LEV1000NC
LEV1000NC420SLC
LEV1000JC
LEV1000JC420SLC
LEV2000NR
LEV2000NR420SLC
LEV2000JR
LEV2000JR420SLC
LEV2000NC420SLC
LEV2000JC420SLC
350 L, Round, Dual Port, MDPE
350 L, Round, Stainless Steel
350 L, Round, Stainless Steel Load Cells
350 L, Round, Stainless Steel, Jacketed
350 L, Round, Stainless Steel, Jacketed, Load Cells
400 L, Cubical, Stainless Steel
400 L, Cubical, Stainless Steel, Load Cells
400 L, Cubical, Stainless Steel, Jacketed
400 L, Cubical, Stainless Steel, Jacketed, Load Cells
500 L, Round, Dual Port, MDPE
500 L, Round, Stainless Steel
500 L, Round, Stainless Steel, Load Cells
500 L, Round, Stainless Steel, Jacketed
500 L, Round, Stainless Steel, Jacketed, Load Cells
650 L, Cubical, Stainless Steel
650 L, Cubical, Stainless Steel, Load Cells
650 L, Cubical, Stainless Steel, Jacketed
650 L, Cubical, Stainless Steel, Jacketed, Load Cells
1000 L, Round, Stainless Steel
1000 L, Round, Stainless Steel, Load Cells
1000 L, Round, Stainless Steel, Jacketed
1000 L, Round, Stainless Steel, Jacketed, Load Cells
1000 L, Cubical, Stainless Steel
1000 L, Cubical, Stainless Steel, Load Cells
1000 L, Cubical, Stainless Steel, Jacketed
1000 L, Cubical, Stainless Steel, Jacketed, Load Cells
2000 L, Round, Stainless Steel
2000 L, Round, Stainless Steel, Load Cells
2000 L, Round, Stainless Steel, Jacketed
2000 L, Round, Stainless Steel, Jacketed, Load Cells
2000 L, Cubical, Stainless Steel, Load Cells
2000 L, Cubical, Stainless Steel, Jacketed, Load Cells
Dollies for Use with LevMixer System
Part Number
Description
LM-DBMC034
LM-DBMC036
LevMixer System, Round
Tubing Type A
Part Number*
Description
Tubing Type B
Part Number**
705114
730440
730307
705116
705117
705118
705119
730218
–
705121
730221
30 L, 2 in. Powder Port, Allegro
TK8 Film, Side EZ Drain, Sterile
50 L, 2 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
100 L, 4 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
200 L, 4 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
350 L, 4 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
425 L, 4 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
500 L, 4 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
1000 L, 4 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
1900 L, 4 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
2000 L, 4 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
730493
730442
730443
730444
730445
730446
730359
730448
730449
LevMixer System, Cubical
Tubing Type A
Part Number*
Description
Tubing Type B
Part Number**
730182
730467
730183
730184
730185
730186
730187
50 L, 2 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
100 L, 4 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
200 L, 4 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
400 L, 4 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
650 L, 4 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
1000 L, 4 in. Powder Port, Allegro
TK8 Film, EZ Drain, Sterile
730468
730469
730470
730471
730472
*Tubing Type A: Standard Systems with Altimex tubing
**Tubing Type B: Standard Systems with Saint Gobain tubing
LevMixer dolly, 316 stainless steel, dual impeller port,
full handle
LevMixer dolly, 316 stainless steel, dual impeller port,
partial handle
Visit us on the Web at www.pall.com/biopharm
E-mail us at allegro@pall.com
Corporate Headquarters
Port Washington, NY, USA
+1.800.717.7255 toll free (USA)
+1.516.484.5400 phone
biopharm@pall.com e-mail
European Headquarters
Fribourg, Switzerland
+41 (0)26 350 53 00 phone
LifeSciences.EU@pall.com e-mail
Asia-Pacific Headquarters
Singapore
+65 6389 6500 phone
sgcustomerservice@pall.com e-mail
International Offices
Pall Corporation has offices and plants throughout the world in: Argentina, Australia, Austria, Belgium, Brazil,
Canada, China, France, Germany, India, Indonesia, Ireland, Italy, Japan, Korea, Malaysia, New Zealand, Norway,
Philippines, Poland, Russia, Singapore, South Africa, Spain, Sweden, Switzerland, Taiwan, Thailand, United
Kingdom, and Vietnam. Distributors in all major industrial areas of the world. To locate the Pall office or distributor
nearest you, visit www.pall.com/contact.
The information provided in this literature was reviewed for accuracy at the time of publication. Product data
may be subject to change without notice. For current information consult your local Pall distributor or contact
Pall directly.
© 2015, Pall Corporation. Pall
, and Allegro are trademarks of Pall Corporation. ® indicates a trademark
registered in the USA and TM indicates a common law trademark. Filtration. Separation. Solution. is a
service mark of Pall Corporation.
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