CURRICULUM VITAE Jyoti Mishra, Ph.D Contact UCSF - Mission Bay Sandler Neurosciences Center Rm 502 MC 0444 675 Nelson Rising Lane San Francisco, CA 94158 Email: jyoti.mishra@ucsf.edu jyoti@gazzaleylab.ucsf.edu Phone: 415-476-2164 Positions and Employment 2013 - present Assistant Adjunct Professor, Neurology University of California, San Francisco 2009 - 2014 Senior Scientist, Brain Plasticity Institute PositScience Corporation, San Francisco 2009 - 2012 Postdoctoral Research Fellow, Neurology University of California, San Francisco 2008 - 2009 Postdoctoral Research Fellow, Neurosciences University of California, San Diego Education 1997-2000 2000 - 2003 2003 - 2008 B.Sc., Biochemistry with Honors Sri Venkateswara College, Delhi University, India Ranked 1st in the University year 1998; 2nd in year 2000 M.Sc., Life Sciences National Center for Biological Sciences, India Dissertation: Spatiotemporal modulation of Store-Released Calcium Dynamics in Neurons Ph.D., Biology with specialization in Computational Neurobiology University of California, San Diego Dissertation: Neural Processes underlying an Auditory-induced Visual Illusion Advisor: Dr. Steven A. Hillyard, Dept. of Neurosciences Co-advisor: Dr. Terrence J. Sejnowski, Salk Institute Professional Memberships 2004 - present Member, Society for Neuroscience 2007 - present Member, Society for Cognitive Neuroscience 2011 - present Member, Entertainment Software & Cognitive Neurotherapeutics Society 2006 - 2007 Vice President, Local Affairs, Neural Networks Inc. 2005 - 2007 President and Co-founder, Udai (student organization), UC San Diego Peer Reviewer Acta Psychologica, BMC Neuroscience, Brain Research, Brain Topography, Biological Psychology, Cerebral Cortex, European Journal of Neuroscience, Frontiers in Neurosience, Journal of Cognitive Neuroscience, Journal of Neuroscience, Journal of Neurolinguistics, Frontiers in Psychological and Behavioral Science, MIT Handbooks, Neurobiology of Aging, Neuroimage, Neuron, Neuropsychologia, PLOS One, Psychiatry Research: Neuroimaging Grant Reviewer Murdock College Research Program for Life Sciences, Flanders Research Foundation, Belgium, Wellcome Trust, UK Honors 2011 2011 2011 2010 2010 2010 2006 2004 2003 2003 2000 2000 2000 2000 2000 1997 Presentation award, Entertainment Software and Cognitive Neurotherapeutics Society Fellow, Fogarty International Clinical Research Finalist, Burroughs-Wellcome Career award at the Scientific Interface Postdoctoral Award, Program for Breakthrough Biomedical Research Postdoctoral Scholar Research Award, UCSF Graduate division Finalist, UC President’s Postdoctoral Fellowship Program Graduate Student award, International Multisensory Research Forum Graduate Internship award, RIKEN-Brain Research Institute, Japan NSF Integrative Graduate Education and Research Training (IGERT) award TIFR Alumni Association Scholarship for Career Development, India NCBS-TIFR Junior Scholarship, India 1st place. Bioinformatics & recent advances session, Biotechcellence, National Students’ Biotechnology Symposium, India 1st place. All India Masters in Biotechnology Combined Entrance 1st place. All India Institute of Medical Sciences M.S. Biotechnology Entrance 1st place. Ambedkar Center for Biomedical Research Post-Graduate Entrance 1st place. All India Entrance Scholarship, Delhi University, India Patents 1. Co-inventor. Methods of Suppressing of Irrelevant Stimuli. US Patent US20130216985 A1. 2013. http://www.google.com/patents/US20130216985 2. Co-inventor. Neuroplasticity Games by Posit Science Corporation (filed & pending). 2014. 3. Co-inventor. Neuroplasticity Games for Addicition by Posit Science Corporation (filed & pending). 2014 Peer-reviewed publications 1. Kothekar V, Sahi S, and Mishra J. Enzyme selectivity of new cyclooxygenase-2/5 lipoxygenase inhibitors using molecular modeling approach. Indian Journal of Biochemistry & Biophysics 37: 86-96. 2000. PMID: 10983419. 2. Kothekar V, Sahi S, and Mishra J. Molecular dynamics simulation of the interaction of 5-keto substituted 7tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives with cyclooxygenase-2. Current Science 80: 764770. 2001. 3. Kothekar V, Sahi S, Srinivasan M, Mohan A, and Mishra J. Recognition of cyclooxygenase-2 (COX-2) active site by NSAIDs: a computer modeling study. Indian Journal of Biochemistry & Biophysics 38: 56-63. 2001. PMID: 11563332. 4. Mishra J, and Bhalla US. Simulations of Inositol Phosphate Metabolism and its Interaction with InsP3 mediated Calcium Release. Biophysical Journal 83: 1298-1316. 2002. PMCID: PMC1302229. 5. Sivakumaran S, Hariharaputran S, Mishra J, and Bhalla US. The Database of Quantitative Cellular Signaling: management and analysis of chemical kinetic models of signaling networks. Bioinformatics 19: 408-415. 2003. PMID: 12584128. 6. Mishra J, Fellous JM, and Sejnowski TJ. Selective attention through phase relationship of excitatory and inhibitory input synchrony in a model cortical neuron. Neural Networks 19: 1329-46. 2006. PMCID: PMC1815390. 7. Mishra J, Martinez A, Sejnowski TJ, Hillyard SA. Early cross-modal interactions in auditory and visual cortex underlie a sound-induced visual illusion. Journal of Neuroscience 27: 4120-4131. 2007. PMCID: PMC2905511. 8. Bonath B, Noesselt T, Martinez A, Mishra J, Schwiecker K, Heinze H, Hillyard SA. Neural basis of the Ventriloquist illusion. Current Biology 17: 1-7. 2007. PMID: 17884498. 9. Mishra J, Martinez A, Hillyard SA. Cortical Processes Underlying Sound-Induced Flash Fusion. Brain Research 1242: 102-15. 2008. PMCID: PMC2584169. 10. Mishra J, Hillyard SA. Endogenous attention selection during binocular rivalry at early stages of visual processing. Vision Research 49: 1073-80. 2009. PMCID: PMC2758091. 2 11. Mishra J, Martinez A, Hillyard SA. Effect of Attention on Early Cortical Processes associated with the Sound-induced Extra Flash Illusion. Journal of Cognitive Neuroscience 22: 1714-1729. 2010. PMID: 19583464. 12. Mishra J, Zinni M, Bavelier D, and Hillyard SA. Neural basis of superior performance of video-game players in an attention-demanding task. Journal of Neuroscience 31: 992-998. 2011. PMID: 21248123. 13. Mishra J, Martinez A, Schroeder C, and Hillyard SA. Spatial attention boosts short-latency neural responses in human visual cortex. Neuroimage 59:1968-78. 2012. PMCID: PMC3230783. 14. Mishra J, Bavelier D, and Gazzaley A. How to assess Gaming-induced benefits on Attention and Working Memory. Games for Health Journal 1: 192-198. 2012. PMCID: PMC3833365. 15. Mishra J and Gazzaley A. Attention distributed across sensory modalities enhances perceptual performance. Journal of Neuroscience 32: 12294-12302. 2012. PMCID: PMC3449148. 16. Mishra J, Zanto T, Nilakantan A, and Gazzaley A. Comparable mechanisms of working memory interference by auditory and visual motion in youth and aging. Neuropsychologia 51: 1896-1906. 2013. PMCID: PMC3752408. 17. Mishra J, Martinez A and Hillyard SA. Audition influences color processing in the sound-induced visual flash illusion. Vision Research 93: 74-79. 2013. PMCID: PMC3872962. 18. Mishra J, Merzenich MM, Sagar R. Accessible online neuroplasticity-targeted training for children with ADHD. Child and Adolescent Mental Health 7:38-40. 2013. PMCID: PMC3828475. 19. Mishra J and Gazzaley A. Preserved Discrimination Performance and Neural Processing during Crossmodal Attention in Aging. PLOS One 8(11): e81894. 2013. PMCID: PMC3835740. 20. Mishra J, Anguera J, Ziegler D, Gazzaley A. A Cognitive Framework for Understanding and Improving Interference Resolution in the Brain. Progress in Brain Research 207: 351-377. 2013. PMCID: PMC4067257 21. Mishra J and Gazzaley A. Attentional Control of Multisensory Integration is preserved in Aging. In G.R. Mangun (Ed.), Cognitive Electrophysiology of Attention: Signals of the Mind (pp. 190-204). Elsevier. 2014 22. Mishra J, Gazzaley A. Harnessing the Neuroplastic Potential of the Human Brain & the Future of Cognitive Rehabilitation. Frontiers in Human Neuroscience 8:218. 2014. PMCID: PMC3990041. 23. Guerreiro MJS, Anguera JA, Mishra J, Van Gerven PWM, Gazzaley A. Age-equivalent top-down modulation during cross-modal selective attention. Journal of Cognitive Neuroscience 10: 1-13. 2014. PMID: 25010198. 24. Mishra J, Rolle C, Gazzaley A. Neural Plasticity underlying Perceptual training and its Relationship with Working Memory Gains. Brain Research (in press) 2014. 25. Mishra J, Bavelier D, and Gazzaley A. Probing the plasticity of Attention and Working Memory. Cambridge Handbook on Applied Perception Research (in press) 2014. Perspectives 1. Mishra J. Having it all. Science 345: 1090. 2014. PMID: 25170158. Pending Publications 1. Mishra J, deVillers Sidani E, Merzenich MM, and Gazzaley A. Adaptive training diminishes distractibility in aging across species. Neuron (in review) 2014. 2. Ziegler D, Mishra J, Gazzaley A. The acute and chronic impact of technology on our brain. in L.D. Rosen, L.M. Carrier, N.A. Cheever (Ed.), The Handbook of Psychology, Technology and Society. (in review) 2014. 3. Janowich J, Mishra J, Gazzaley A. A Cognitive Paradigm to Investigate Interference in Visual and Auditory Working Memory. Journal of Visualized Experiments (in review) 2014. 4. Mishra J, Gazzaley A. Closed Loop Rehabilitation of Age-related Cognitive Disorders. Seminars in Neurology (in review) 2014. 3 Media Publications 1. A Foot in Academia, The Other In Industry: Learnings from a Dual Career Training Experience. Perspective. Science Careers (in press). 2014. 2. When Women Have It All. Perspective. Science Careers. 2014. dx.doi.org/10.1126/science.caredit.a1400216. 3. Mindful Eating and Portion Control. Guest Health Post, Summer Tomato. 2011. http://summertomato.com/mindful-eating-and-portion-control/ Conference Presentations Posters. 1. Sahi S, Mishra J, and Kothekar V. Enzyme selectivity of new cyclooxygenase-2/5 lipoxygenase inhibitors using molecular modeling approach. Indian Biophysics Society Symposium. 1999 2. Mishra J, and Bhalla US. Simulations of Inositol Phosphate Metabolism and its Interaction with InsP3 mediated Calcium Release. International Symposium on Cell & Developmental Biology. 2001 3. Mishra J, and Bhalla US. Simulations of Inositol Phosphate Metabolism and its Interaction with InsP3 mediated Calcium Release. Networks and Behavior: International Neurobiology Symposium. 2003 4. Mishra J, Fellous JM, and Sejnowski TJ. A Biophysical Neuronal Model exploring Attention Mechanisms in Visual Cortex. Society for Neuroscience Meeting. 2004 5. Mishra J, Martinez A, Sejnowski TJ, and Hillyard SA. Effect of attention on cortical processes underlying the sound induced extra flash illusion. Cognitive Neuroscience Society Meeting. 2007 6. Mishra J, Zinni M, Bavelier D, and Hillyard SA. Neural basis of superior performance of video-game players in an attention-demanding task. Society for Neuroscience Meeting. 2010 7. Mishra J, Nilakantan A, Merzenich M, Gazzaley A. Evaluation of a novel neuro-plasticity based auditory training program to remediate top-down cognitive control deficits in healthy aging. Entertainment Software and Cognitive Neurotherapeutics Society Meeting. 2011 8. Brang D, Zweig J, Mishra J, Suzuki S, Hillyard SA, Ramachandran VS, Grabowecky M. Anatomical and functional networks underlying audio-visual integration. Cognitive Neuroscience Society Meeting. 2013. 9. Brang D, Zweig J, Mishra J, Suzuki S, Hillyard SA, Ramachandran VS, Grabowecky M. Anatomical and functional networks underlying audio-visual integration. Society for Neuroscience Meeting. 2013. 10. Mishra J, Joseph E, Merzenich M, Sagar R. Accessible Online Cognitive Training for Children with ADHD in a Global Mental Health Setting. UCSF Global Health Research Symposium. 2014 11. Dorn B, Mishra J, Bollinger J, Gazzaley A. Neural correlates of the cost of Distractor Disengagement. Cognitive Neuroscience Society Meeting. 2014 12. Jain A, Mishra J, Gazzaley A. Non-invasive high resolution control techniques for Brain Machine Interfaces. National Academies and Keck Futures Initiative Grant Meeting. 2014 13. Mishra J, Joseph A, Merzenich M, Sagar A. Accessible Web-based Cognitive Therapeutics for Children with Attention Deficits in a Global Mental Health Setting. US Investigators' Symposium on Global NonCommunicable Diseases Research Meeting. Emory University. 2014 14. Mishra J, Joseph A, Merzenich M, Sagar A. Accessible Online Cognitive Training for Children with ADHD in a Global Mental Health Setting. Society for Neuroscience Meeting. 2014 (upcoming) Oral. 1. Mishra J. Computational model of visual face processing. National Computational Neuroscience Workshop. Bangalore, India. 2000 2. Mishra J, Martinez A, Salejarvi WT, Sejnowski TJ, and Hillyard SA. Cortical processes underlying the sound induced visual illusion. International Multisensory Research Forum. Dublin, Ireland. 2006 3. Mishra J, Gazzaley A. Attentional control of multisensory integration. Cognitive Neuroscience Society. San Francisco. 2011 4. Mishra J, de Villers-Sidani E, Merzenich M, Gazzaley A. Adaptive training diminishes distractibility in aging across species. Bay Area Memory Meeting. San Francisco. 2013 4 5. Mishra J. Building Behavioral and Neural Performance based Closed Loops for Cognitive Enhancement. UCSF Aging Retreat. San Francisco. 2014 6. Mishra J. Building Closed Loops for Cognitive Enhancement. UCSF Psychiatry Digital Mental Health Innovations Symposium. San Francisco. 2014 7. Mishra J. Developing Closed Loops to Enhance Attention, World Neuroscience Online Conference. San Francisco. 2014 8. Mishra J. Closing the Loop between the Brain & the Digital World. National Academies and Keck Futures Initiative Grant Meeting. Chicago. 2014 Invited Talks 1. Next Generation Neurotechnologies and UCSF Neuroscape Lab Tour. Occupational Therapy Dept., Samuel Merritt University. 2014 2. Developing Closed Loops to Enhance Attention. BrainLENS: Laboratory for Educational Neuroscience, UC San Francisco. 2014 3. Closed Loops for Enhanced Cognition. National Brain Research Centre, New Delhi, India. 2014 4. A Primer to Brain Computer Interfaces. Neurogaming Conference San Francisco. 2014 5. Scaling Cognitive Training Games for Worldwide Application. Rich Dynamic Environments and their Potential to Advance our Understanding of Cognition, National Science Foundation, Washington DC. 2014 6. Keynote: Developing Serious Games for Stronger Brains, Brighter Brains Conference, Berkeley. 2014 7. Serious Games for Stronger Brains. Mountain View High School STEM day. Mountain View. 2014 (upcoming) Teaching Experience Research Mentoring UC San Francisco: Graduate Students 2013 Benjamin Dorn Neuroscience Graduate Program All India Institute of Medical Sciences, New Delhi: Graduate Students 2011 Angela Joseph Clinical Neuropsychology UCSF: Post-doctoral Fellows 2013 Joaquin Anguera David Ziegler Neurology Post-doc, UCSF Neurology Post-doc, UCSF UC Berkeley: Undergraduate Honors Thesis 2011 Aneesha Neelakantan BS, UC Berkeley UC San Francisco: Research Associates 2013 Rajat Jain M Eng, Imperial College London Camarin Rolle BA BS, UC Davis 2012 - 14 Jacqueline Janowich BA, Colgate University 2010 - 12 Jacqueline Boccanfuso BS, UC San Diego UC San Francisco: Research Assistants 2012 - 14 Ana Ibarra Undergraduate, UC Berkeley Anirudh Wodeyar B Eng, BITS Pilani India Danna Lee BS, UC San Diego Hye-Min Oh BS, UC Los Angeles Katie Lee Undergraduate, UC Berkeley 5 Lillian Chiu Michael King Rabeea Abbas Radhika Gosavi 2010 - 11 Ariane Ling Eleanor Wang Joe Darin Melissa Nasiruddin Raquel Miller Pin-wei Chen Katie Zuppann Kristen Checksfield Miles Whedbee Omead Barari BS, Fordham University BS, SF State University Undergraduate, UC Berkeley BS, UC Berkeley BS, UC Berkeley BS, UC Berkeley BS, UC Berkeley BS, UC Berkeley BA, UC Berkeley BS, UC Berkeley BA, UC Santa Barbara BS, UC Berkeley BS, UC Berkeley BS, UC Berkeley UC San Diego: Visting Fellows 2007 Alessandra Stella 2006 Bjoërn Bonath Rhodes scholar, University of Motor Sciences, Italy MS, Max Plank Institute, Germany National Center for Biological Sciences, India: Visiting Fellow 2002 Susanna Neves Graduate student, Mt. Sinai School of Medicine Instruction Guest Lecturer 2014 2014 Perception, San Francisco State University 2013 Autism and Neurodevelopment Program, UC San Francisco 2013 Cognitive Neuroscience Course, San Francisco State University 2007, 2008 Summer Camp Grades 5-8, Reuben Fleet Science Center, San Diego Teaching Assistant 2007, 2005 Teaching Assistant: Information Processing in the Human Brain, UC San Diego 2006 Teaching Assistant: Basic Neurology; School of Medicine, UC San Diego 2005 Teaching Assistant: Mammalian Physiology, UCSD Instructor 2004 UCSD Oasis Outreach program STEM sciences (Chula Vista High, San Diego) 6 Leadership & Public Service 2014 UCSF School of Medicine Admissions Committee Member (ongoing) Conducted interviews and reviewed applications of UCSF Medical School applicants. 2014 NeuroGaming Hackathon Judge Judged participants and selected winners in the two-day neurogaming hackathon to develop apps for consumer brain computer interface devices. 2013-14 Toddler Classroom Parent, Bright Horizons Daycare Managed interaction between class teachers and parents; took care of monthly class needs such as materials for projects and book lending to class library; organized fieldtrips and teachers’ week activities; raised funds for teachers’ luncheons and holiday gift-giving. 2013 KQED Personal Biology Initiative Participated in and helped define the agenda for KQED radio’s new initiative to understand how technology and big data are influencing our lives, healthcare and scientific research and the future of precision medicine. 2011 Neuroscience and Art/Music Collaboration Collaborated with UCSF Memory & Aging Center visiting artist, Deborah Aschheim & musician, Lisa Mezzacappa exploring the neural basis of art, music and creativity. Exhibition: Art Diagnostics and Healing Devices (ADHD). Jaus Gallery, Los Angeles. 2008 Marathoner and top fundraiser for AID, San Diego Raised $2200 to fund construction of a primary school in rural south India & vocational training for tribal villagers in west India. 2007 Vice President, Local Affairs, Neural Networks Inc. Managed public awareness campaigns & fundraising to improve rural access to neurological healthcare in India. 2005-07 President & Co-founder, UDAI Led UDAI, a graduate student group at UCSD to promote awareness of health & education disparities in India; organized and moderated a UCSD colloquium on HIV/AIDS status in the developing world; organized fundraisers to curb child prostitution in Bangalore and to provide education & shelter to street children in Delhi. 2000 Joint Secretary, Science Association Sri Venkateswara College, Delhi University, India 1999 Child Counselor, Childline New Delhi, India Counseled street children & children under psychological duress in unhealthy family environments; made referrals to child-care facilities; petitioned against unlawful child labor practices. 7 Research Support Active PositScience Corporation Gift Support Mishra (PI) 09/01/14-08/31/15 Cognitive Training in Neglected Children $45,300 The goal of this project is to develop and evaluate the behavioral, cognitive and neurological benefits of cognitive training in children exposed to early life neglect. UCSF-Resource Allocation Program Global Health Award Mishra (PI) 02/01/14-01/31/15 Remediation of Cognition in Kids to Overcome Neglect (ROCK ON) $40,000 The goal of this project is to evaluate the behavioral, cognitive and neurological benefits of a new cognitive training program ‘ROCK ON’ in neglected children in Delhi, India. National Academies Keck Futures Initiative Gazzaley/Mishra (co-PI) 05/01/13-04/30/15 Closing the Loop between the Brain and the Digital World $100,000 The goal of this study is to develop a novel Brain-Computer-Interface (BCI) prototype technology that 'closes the loop between the brain and the digital world'. NIH/NIA R01 AG040333 Gazzaley (PI) 09/01/12-08/31/17 Neural mechanisms of learning to resolve interfence in younger and older adults $150,000 direct/year This project focuses on characterizing the neural changes associated with learning to reduce distractibility and improve multitasking abilities. Role: Co-Investigator Pending NIH/NIMH K01 Mishra (PI) 09/01/15-08/31/19 A novel Cognitive Brain Computer Interface (Cognitive BCI) to enhance Attention Abilities The goal of this mentored career development award is to train the applicant in the clinical and translational neurosciences and to evaluate the newly developed technology of Cognitive BCI to enhance attention and related cognitive functions in young adults with Attention-deficit/hyperactivity disorder (ADHD). Completed NIH/Fogarty 5R24 TW007988-05, subaward VUMC 38412 Mishra (PI) 07/01/11-06/31/14 Evaluation of a neuroplasticity-based training program to remediate attention deficits in ADHD $162,188 The goal of this Fogarty fellowship is to evaluate a novel neuroplasticity-based training program to remediate cognitive control deficits in Attention-deficit/hyperactivity disorder (ADHD) in adolescent children in Delhi, India. Program for Breakthrough Biomedical Research (PBBR) 41326 Mishra (PI) 01/01/11-12/31/11 Sandler Foundation $15,000 The goal of this study was to evaluate a novel training strategy to ameliorate attention and working memory deficits in the aging brain. Role: PI Postdoctoral Scholar Research Award Mishra (PI) 07/01/10-06/30/11 UCSF Graduate division $5,000 The goal of this study was to evaluate a novel auditory training program to ameliorate interference suppression deficits in the aging brain. Role: PI 8