Hindawi Publishing Corporation International Journal of Mathematics and Mathematical Sciences Volume 2010, Article ID 915958, 18 pages doi:10.1155/2010/915958 Research Article Geometric Sensitivity of a Pinhole Collimator Howard Jacobowitz1 and Scott D. Metzler2 1 2 Department of Mathematical Sciences, Rutgers University, Camden, NJ 08102, USA Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA Correspondence should be addressed to Howard Jacobowitz, jacobowi@camden.rutgers.edu Received 25 August 2009; Revised 7 December 2009; Accepted 19 February 2010 Academic Editor: Harvinder S. Sidhu Copyright q 2010 H. Jacobowitz and S. D. Metzler. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Geometric sensitivity for single photon emission computerized tomography SPECT is given by a double integral over the detection plane. It would be useful to be able to explicitly evaluate this quantity. This paper shows that the inner integral can be evaluated in the situation where there is no gamma ray penetration of the material surrounding the pinhole aperture. This is done by converting the integral to an integral in the complex plane and using Cauchy’s theorem to replace it by one which can be evaluated in terms of elliptic functions. 1. Introduction Nuclear-medicine imaging provides images that assess how the body is functioning 1, 2, as opposed to anatomical modalities e.g., X-ray computed tomography, commonly known as a CT or “CAT” scans that provide little or no information about function, but great detail of the body’s structure. Nuclear-medicine images the biodistribution of radiolabeled molecules that are typically intravenously injected into the patient in tracer i.e., nonpharmacological quantities. The compounds may have different biochemical properties that affect the biodistribution and, hence, the choice of pharmaceuticals used to assess the disease state of a patient. Two common nuclear-medicine techniques are single photon emission computed tomography SPECT and positron emission tomography PET. Molecules labeled with a SPECT tracer emit a single photon. PET tracers emit a positron, which annihilates with a nearby electron to produce two nearly back-to-back photons at 511 keV, the rest energy of an electron. The line of these two photons contains the emission point of the positron. Many photon pairs are detected in coincidence and reconstructed into a three-dimensional 3D image of the tracer’s distribution. Since SPECT tracers emit only one photon, the detection of the photon itself gives little information about the location of the emission since neither the direction nor origin 2 International Journal of Mathematics and Mathematical Sciences Photon source h 0, 0, 0 α θ Z0 θa ΔL α d ρ cos β, ρ sin β, 0 z Photon path y x Figure 1: Perspective View of the Knife-edge Pinhole Collimator. A point source at z h and angle θ emits a photon that intersects the z 0 plane at ρ cos β, ρ sin β, 0 with an incident angle θa . The acceptance angle of the collimator is α and the diameter of the aperture is d. ΔL is the path length of the photon in the c 2001 IEEE. attenuating medium. Reproduced from 3 with permission of the emission is known. Consequently, SPECT uses collimation that allows only photons along certain lines to be detected. The origin is still unknown, but the 3D image may be reconstructed when photons from numerous angles are detected 4, 5. Pinhole collimation is often used when a small organ e.g., the thyroid is imaged by a large detector with a SPECT tracer. Figure 1 is a diagram of the apparatus. It is not hard to see that the pinhole collimation’s geometric efficiency, namely, the fraction of emitted photons that pass through the circular aperture of the collimator, is approximately given by g d2 sin3 θ , 16h2 1.1 where d is the diameter of the pinhole, h is the perpendicular distance, and θ is the incidence angle of the photon on the aperture plane at the center of aperture. This formula becomes exact in the limit that d goes to zero. Also, an exact formula is easily obtained when θ π/2 2 −1/2 d2 d 1 d 2 1 1 π 1 1 − 1 1− ≈ − . g θ 2 2 2 2h 2 2 2 2h 16h2 1.2 We derive stronger versions of these two results in the next section. But the main goal of this paper is to simplify the integral representation for the geometric sensitivity without taking International Journal of Mathematics and Mathematical Sciences 3 d or θ − π/2 to be small. We are concerned with the case where there is no penetration in the sense that not all gamma rays are stopped by the attenuating material surrounding the pinhole aperture. We take θ / π/2. The geometric sensitivity, as defined above, is given by the integral over the aperture of the flux times the sine of the incidence angle at that point on the aperture: g 1 4πh2 d/2 2π ρ dρ 0 1.3 dβ sin3 θa , 0 where ρ and β are polar coordinates on the aperture plane and θa is the incidence angle of the photon at a particular value of ρ and β, and is given by 3 ρ2 ρ cot2 θa cot2 θ − 2 cotθ cos β − φ 2 , h h 1.4 where φ is the third coordinate of the point source. For integrals over 2π the difference β − φ can be replaced with only β without loss of generality. This yields ρ2 ρ sin θa csc θ − 2 cotθ cos β 2 h h 2 2 −1 1.5 . Applying this to 1.3, 1 g 4πh2 d/2 2π ρ dρ 0 0 ρ2 ρ dβ csc θ − 2 cotθ cos β 2 h h −3/2 2 . 1.6 e−μΔL , 1.7 When there is penetration the above would be modified to 1 g 4πh2 2π ∞ ρ dρ 0 0 ρ2 ρ dβ csc θ − 2 cotθ cos β 2 h h −3/2 2 where the path length through attenuating material, ΔL, is zero for ρ < d/2 and is otherwise given by 11 in 3. Thus, 1.7 can be rewritten as 1 g gNP 4πh2 ∞ 2π ρ dρ d/2 0 ρ2 ρ dβ csc θ − 2 cotθ cos β 2 h h 2 −3/2 e−μΔL 1.8 gNP gPEN , where gPEN is the efficiency due to penetration and gNP , the efficiency under the assumption of no penetration, is given by 1.6. In this paper we use complex variable methods to calculate the β integral in 1.6. 4 International Journal of Mathematics and Mathematical Sciences 2. Two Approximations for gNP The special form of gNP makes it easy to derive approximations for d/h small and for θ − π/2 small which generalize 1.1 and 1.2. Before doing this, we observe that only even powers of d and of θ − π/2 can occur in the expansion of gNP . We see this by writing the integral as the sum of integrals from 0 to π and from π to 2π. 2.1. The Expansion for d Small Let us, in this section, denote gNP by g. Upon substituting r d/2h and η ρ/h into 1.6 we obtain gr, θ 1 4π 1 4π 2π r 0 csc2 θ − 2ηcotθ cos β η2 η dη dβ, 0 2π r 0 −3/2 ηφ β, η, θ dη dβ. 2.1 0 Clearly, g0, θ 0. Since gr r, θ 1 4π 2π rφ β, r, θ dβ, 2.2 0 we have gr 0, θ 0. Differentiating 2.12 three more times with respect to r we obtain 1 2π rφr β, 0, θ φ β, r, θ dβ, 4π 0 1 2π rφrr β, 0, θ 2φr β, r, θ dβ, grrr r, θ 4π 0 1 2π rφrrr β, 0, θ 3φrr β, r, θ dβ, grrrr r, θ 4π 0 grr r, θ 2.3 and then setting r 0 in each of the resulting equations we obtain grr 0, θ grrr 0, θ 1 4π 1 2π 3 grrrr 0, θ 4π 2π φ β, 0, θ dβ, 0 2π φr β, 0, θ dβ, 0 2π 0 φrr β, 0, θ dβ. 2.4 International Journal of Mathematics and Mathematical Sciences 5 For convenience let us write 2.5 v cotθ, u csc2 θ, so φ becomes −3/2 φ β, r, θ u − 2vr cos β r 2 . 2.6 φ β, 0, θ u−3/2 , φr β, 0, θ 3u−5/2 v cos β, φrr β, 0, θ 15u−7/2 v2 cos2 β − 3u−5/2 . 2.7 Then We substitute into the Taylor expansion gr, θ g0, θ gr 0, θr 1 1 1 grr 0, θr 2 grrr 0, θr 3 grrrr 0, θr 4 · · · 2! 3! 4! 2.8 and obtain 1 gr, θ 2 1 4π u −3/2 0 1 4π 1 4! 2π 1 dβ r 3! 2 3 2π 2π −5/2 6u v cos β dβ r 3 0 2π −7/2 2 2 −5/2 dβ r 4 · · · . 3 15u v cos β − 3u 2.9 0 Since 2π 0 cos β dβ 0, 2π cos2 β dβ π 2.10 0 and u−1 sin2 θ we obtain gr, θ 3 r2 3 sin θ 5sin5 θcos2 θ − 2sin5 θ r 4 · · · . 4 32 2.11 Finally we replace cos2 θ by 1 − sin2 θ and r by d/2h and obtain gNP 2 d 4 1 d 3 3 5 2 sin θ sin θ 3 − 5sin θ O d6 . 16 h 512 h 2.12 6 International Journal of Mathematics and Mathematical Sciences 2.2. The Expansion for θ − π/2 Small To start we let −3/2 f θ, η, β csc2 θ − 2ηcotθ cos β η2 2.13 and compute its Taylor expansion at θ π/2, −3/2 −5/2 π f θ, η, β 1 η2 − 3 1 η2 η cos β θ − 2 −7/2 −5/2 π 2 1 2 2 2 2 15 1 η η cos β − 3 1 η θ− 2! 2 3 π O θ− . 2 2.14 Since gNP 1 4π 2π d/2h 0 f θ, η, β η dη dβ 2.15 0 and since we know that only even powers of θ − π/2 occur, we obtain ⎛ gNP 1⎜ ⎝1 − 2 ⎞ π 2 π 4 d/2h2 ⎟ 3 θ − O θ − . ⎠− 5/2 8 2 2 1 d/2h2 1 d/2h2 1 2.16 3. The Contour Integral We have I 2π 0 ρ2 ρ dβ csc θ − 2 cotθ cos β 2 h h 2 gNP 1 4πh2 −3/2 , d/2 Iρ dρ. 3.1 3.2 0 I may be recast as a contour integral by setting z eiβ : −3/2 dz −b 2 a z −2 z 1 b Γ iz 2z 3/2 1 2 z − x0 x1 − z −3/2 dz , b i Γ z z I 3.3 International Journal of Mathematics and Mathematical Sciences 7 where Γ is the unit circle, a csc2 θ ρ2 , h2 ρ b 2 cotθ, h ⎤ ⎡ a⎣ b2 ⎦ x0 1− 1− 2 , b a 3.4 ⎤ ⎡ a⎣ b2 ⎦ x1 1 1− 2 . b a We note that a > b and so 0 < x0 < 1 < x1 . In this section we take ρ, θ, and h to be constant. We write 1/2 z z 1 Fz z z − x0 x1 − z z − x0 x1 − z 1/2 z 1 , z − x0 x1 − z z − x0 x1 − z 3/2 2 1 I Fzdz. b i Γ 3.5 We need to be careful because of the square roots. We use the usual convention that lim± −1 iy ±i. y→0 3.6 We wish to show that Fz is holomorphic and single valued in {z : |z| < 1} − {x : 0 < x < x0 }. 3.7 To isolate the square root factor in F we set gz z . z − x0 x1 − z 3.8 We take |z| ≤ 1. If in addition Re z < 0 and | Im z| |z − x0 | then Re z − x0 x1 − z < 0. This implies that gz never takes on negative real values and so has a single valued square root in Re z < 0. Similarly, if |z| ≤ 1, and Re z > x0 no condition on Im z now then Re z−x0 x1 −z > 0 and gz has a single valued square root in Re z > x0 . 8 International Journal of Mathematics and Mathematical Sciences ε 2δ 0 z0 Figure 2: The curve γ. It follows from Cauchy’s theorem that the integral of Fz over the unit circle Γ is equal to the integral over the “ barbell” γ around 0 and x0 . More explicitly, γ is the boundary of B B 0 ∪ B x0 ∪ R, 3.9 where B x is the ball of radius and centered at x and R is the rectangle R z x iy : 0 ≤ x ≤ x0 , −δ ≤ y ≤ δ 3.10 with δ , see Figure 2. The curve γ decomposes into smooth pieces which we describe using the angle α arcsinδ/ γr z : |z − x0 | , −π α ≤ arg z − x0 ≤ π − α , γl z : |z| , α ≤ argz ≤ 2π − α , 3.11 γ± {z : z x ± iδ, cos α ≤ x ≤ x0 − cos α}. To bound the integral over γl we set z eiθ 2π−α iθ iθ F e e dθ Fzdz α γl O 3/2 . To evaluate γr 3.12 Fzdz we set z x0 eiθ . Then F x0 eiθ C−3/2 e−3/2iθ O −1/2 3.13 with C x01/2 x1 − x0 3/2 , 3.14 International Journal of Mathematics and Mathematical Sciences 9 and so Fzdz γr π−α −π α −3/2 Ce−3/2iθ O −1/2 ieiθ 1 Odθ π−α −π α Ci −1/2 −1/2iθ e O 1/2 3.15 dθ. Since α O, we may set α 0 and absorb the error in the O1/2 term. We then do the integration and obtain 4iC Fzdz √ O 1/2 . γr 3.16 We want to compute the integral of F over γ . We need to be careful about the square root. Recall that we are assuming cos α < x < x0 − cos α, δ . 3.17 Lemma 3.1. On γ Fz ix0 − xx1 − x−3/2 x1/2 Oδ 3.18 Fz −ix0 − xx1 − x−3/2 x1/2 Oδ. 3.19 and on γ− Proof. This is a consequence of the branching of the square root function. Let Hz z zz − x0 x1 − z , z − x0 x1 − z |z − x0 |2 |x1 − z|2 3.20 hz zz − x0 x1 − z. We see that hx iδ xx − x0 x1 − x iδ x2 − 1 O δ2 . 3.21 Recall that δ is replaced by −δ on γ− and that 0 < x < x0 < x1 . So Re Hz < 0 on both γ and γ− while Im Hz < 0 on γ and Im Hz > 0 on γ− . Thus on γ 1/2 x Oδ x − x0 x1 − x 1/2 x −i Oδ, x0 − xx1 − x Hz1/2 −i 3.22 10 International Journal of Mathematics and Mathematical Sciences while on γ− Hz1/2 i x x0 − xx1 − x 1/2 Oδ. 3.23 Since 1 Hz1/2 Oδ x − x0 x1 − x Fz Fx Oδ 1 Hz1/2 Oδ x0 − xx1 − x 1/2 x 1 Oδ, −i − x0 − xx1 − x x0 − xx1 − x − 3.24 the lemma follows. We also need to be careful about the orientation. The curve γ is oriented counterclockwise. This means that the integration over γ goes in the direction of x0 to 0. We need to reverse its sign in order to write it in the conventional way Fzdz − x0 − cos α Fx iδdx cos α γ − x0 − cos α cos α 3.25 ix1/2 dx x0 − x3/2 x1 − x3/2 O. We let x x0 t and Δ x0−1 cos α and use δ to obtain Fzdz − 1−Δ γ ix0 3/2 t1/2 dx x0 − x0 t3/2 x1 − x0 t3/2 Δ O. 3.26 Now let τ x1 > 1. x0 3.27 We have Fzdz − γ i x0 3/2 1−Δ Δ t1/2 dt τ − t3/2 1 − t3/2 O. 3.28 International Journal of Mathematics and Mathematical Sciences 11 We may let Δ → 0 in the lower limit, but not in the upper limit. So we now have Fzdz − γ i 1−Δ x0 3/2 0 t1/2 dt τ − t3/2 1 − t3/2 O. 3.29 Here Δ x0 −1 cos α. We may let δ → 0 and redefine Δ to be x0 −1 . We get the same value for the integral over γ− . This is because the integrand is the negative of that in 3.29 but the orientation is reversed and so the two negatives cancel. For any function gt, continuously differentiable on the interval 0, 1, we have 1−Δ 0 gt 1 − t dt 2 3/2 1 g1 − 2g0 − 2 1 − t−1/2 g tdt O Δ1/2 1/2 Δ 0 3.30 as can easily be seen by an integration by parts. We apply this to gt t1/2 /τ − t3/2 as in 3.29. This yields Fzdz γ −2i τ − 13/2 x03/2 Δ1/2 1 i x03/2 t−1/2 τ − t −3/2 −5/2 3t1/2 τ − t dt 3.31 O 1/2 . 0 We now take twice this quantity and add to it the results of 3.14 and 3.16, |z|1 Fzdz Fzdz γ √ −2i x0 4iC √ 2 √ x1 − x0 −3/2 1 i x0 3/2 3.32 1 − t−1/2 τ − t−3/2 t−1/2 3t1/2 τ − t−5/2 dt 0 O 1/2 . We substitute the value for C from 3.14 and let → 0 |z|1 Fzdz 2i x0 3/2 1 0 1 − t−1/2 τ − t−3/2 t−1/2 3t1/2 τ − t−5/2 dt. 3.33 12 International Journal of Mathematics and Mathematical Sciences Finally, we evaluate this integral using Mathematica and obtain |z|1 Fzdz 2i x0 3/2 22τE1/τ − −1 τK1/τ , √ τ − 12 τ 3.34 where K and E are the complete elliptic functions of the first and second kinds Km 1 1 − mt2 −1/2 1 − t2 −1/2 dt, 0 Em 1 1 − mt2 1/2 1 − t2 −1/2 3.35 dt. 0 We now have I 3/2 1 2 Fzdz b i Γ 3/2 2 2 22τE1/τ − τ − 1K1/τ √ b x0 3/2 τ − 12 τ 3.36 3/2 4τ 1/4 2 2τE1/τ − τ − 1K1/τ, b τ − 12 gNP 1 4πh2 d/2 3.37 ρI dρ 0 with ρ b 2 cotθ, h τ a csc2 θ ρ2 , h2 3.38 1 x1 , x0 x0 2 ⎤ ⎡ a⎣ b2 ⎦ x0 1− 1− 2 , b a ⎤ ⎡ a⎣ b2 ⎦ 1 1− 2 . x1 b a 4. Limiting Cases We validate 3.36 by considering two limiting cases. 3.39 International Journal of Mathematics and Mathematical Sciences 13 4.1. Expansion for Small d We look for an expansion of gNP under the assumption that d/h is small and rederive 2.12. The dependence of x0 on ρ is given in 3.39. The two-term Taylor expansion of x0 as a function of ρ is x0 Aρ Bρ3 O ρ5 4.1 with A cos θ sin θ , h B A3 − A . h2 csc2 θ 4.2 Since τ 1 , x0 2 4.3 we have 1 A2 ρ2 O ρ4 , τ 1 τ − 1 2 1 2 3 O ρ8 . 2 τ τ 4.4 4.5 It is convenient to work with the quantity ρ2 τ, so we note, using 4.1, ρ2 τ 1 2B 2 − ρ O ρ4 . A2 A3 4.6 We start with I 3/2 4τ 1/4 2 1 1 2τE − − 1K . τ 2 b τ τ τ − 1 4.7 Substituting the expression for b from 3.38 and for τ − 12 from 4.5 we obtain, after some manipulation I h cotθ 3/2 4 1 4 2 3/4 τ O ρ ρ τ 1 1 − τ − 1K . 2τE τ τ 4.8 14 International Journal of Mathematics and Mathematical Sciences We now use the expansions as given by Mathematica π πt − O t2 , 2 8 π πt O t2 . Kt 2 8 Et 4.9 So I h cotθ 3/2 4 2 3/4 ρ τ π π π 2 8τ τ O ρ4 . 4.10 From the expression for ρ2 τ in 4.6, we derive 1 3B 2 3/2 ρ O ρ4 , 1 2 3/4 A 2A ρ τ 4.11 3/2 π h π π 3Bρ2 π 3/2 I4 O ρ4 . A cotθ 2 8τ τ 4A 4.12 and this leads to We now substitute for A and B using 4.2 and also for τ −1 using 4.4 ρ2 3π I sin θ 2π 3sin2 θ − 5sin4 θ 2 2 h 3 O ρ4 . 4.13 Substituting this into 3.37 and integrating, we again derive 2.12. 4.2. An Expansion for θ Near π/2 We show how 4.7 also gives the expansion of Section 2.2. From 3.38 we see that ρ2 π 2 π 4 θ − O θ − , 2 2 h2 2ρ π π 3 θ− O θ− . b− h 2 2 a1 4.14 4.15 International Journal of Mathematics and Mathematical Sciences 15 So from 3.39 we have b x0 2a b2 π 3 . 1 2 O θ− 2 4a 4.16 Thus 4a2 π 2 − 2 O θ − , 2 b2 π 4 1 1 2 O θ − 1 , τ 2 τ − 12 τ 2 1 1 π 9π π 4 1 O θ− 2τE − τ − 1K . τ τ τ 2 8τ 2 τ 4.17 4.18 These expansions let us write 4.7 as I 3/2 2 π 9π π 4 4 2 O θ − 1 b τ 2 8τ 2 τ 3/4 π 9π π 4 2 2 O θ − 1 . 3/4 τ 2 8τ 2 b2 τ 4.19 7/2 Using 4.15 and 4.17 we obtain a substitute for 4.1 1 b2 τ −3/4 −3/2 3/4 4 a 3b2 1 2 8a π 4 O θ− . 2 4.20 This gives, in light of 4.14, I 2πa−3/2 15 2 −7/2 π 4 πb a O θ− 8 2 ρ2 2π 1 2 h 15 ρ2 π 2 2 h −3/2 ρ2 1 2 h ρ2 − 3π 1 2 h −7/2 θ− −5/2 θ− π 2 2 π 2 π 4 O θ− . 2 2 4.21 16 International Journal of Mathematics and Mathematical Sciences Finally, we integrate term by term. g 1 4πh2 d/2 ρI ρ dρ 0 ⎛ ⎛ ⎞ 2 −1/2 d 1 ⎝ 2⎝ ⎠ 2πh 1 − 1 2h 4πh2 ⎞ ⎛ 2 −3/2 2 d 1 ⎠ θ− π − 3πh2 ⎝1 − 1 3 2h 2 ⎛ ⎞ ⎞ 2 −5/2 2 π 2 5d/2h2 d 15 2 ⎝ 2 ⎠ θ− ⎠ πh − 1 2 15 15 2h 2 4.22 π 4 O θ− 2 ⎞ ⎛ 2 −1/2 2 −5/2 2 3 π 2 d d 1⎝ d ⎠− θ− 1− 1 1 2 2h 8 2h 2h 2 π 4 O θ− . 2 5. Numerical Confirmation The result in 3.36 is further validated in this section with numerical integration of 3.1. In this original formulation, the integral depends on the ratio of ρ/h and on the value of θ. We analytically considered one limiting case for each of these quantities in the previous section. We consider these and other values for these quantities in this section using numerical methods. For fixed values of ρ/h, the numerical integration solid lines is shown with the results of the residue calculation open circles in Figure 3 as a function of θ. Figure 4 shows the numerical integration and residue results for fixed values of θ as a function of ρ/h. All corresponding values of the residue calculation and the numerical integration agree. 6. Conclusions The accuracy of collimator efficiency is important for design and for quantitative reconstruction programs. Analytic forms obviate the need for numerical models, which do not readily offer insight into the interplay of collimator parameters. This paper approaches the problem by recasting one of the integrals in terms of contour integration. This integration was completed, but the authors were unable to execute the second integral to yield a complete analytic solution. The result was studied for special cases with known outcomes for validation. Future efforts may be able to build on this validated result to find a complete analytic solution. International Journal of Mathematics and Mathematical Sciences 17 Integrals versus θ 7 Integrals 6 5 4 3 2 π/4 π/2 θ ρ/h 0 ρ/h 0.2 ρ/h 0.4 ρ/h 0.6 ρ/h 0.8 ρ/h 1 Figure 3: Numerical integration of 3.1 solid lines and residue calculation of 3.36 open circles as a function of θ for fixed values of ρ/h: 0.0, 0.2, 0.4, 0.6, 0.8, and 1.0. Integrals versus ρ/h 7 Integrals 6 5 4 3 2 0 0.2 0.4 0.6 0.8 1 ρ/h θ 50 deg θ 60 deg θ 70 deg θ 80 deg θ 90 deg Figure 4: Numerical integration of 3.1 solid lines and residue calculation of 3.36 open circles as a function of ρ/h for fixed values of θ: 50, 60, 70, 80, and 90 degrees. Acknowledgment Scott D. Metzler was supported by the National Institute for Biomedical Imaging and Bioengineering of the National Institutes of Health under Grant R01-EB-6558. 18 International Journal of Mathematics and Mathematical Sciences References 1 M. E. Phelps, “PET: the merging of biology and imaging into molecular imaging,” Journal of Nuclear Medicine, vol. 41, no. 4, pp. 661–681, 2000. 2 S. H. Britz-Cunningham and S. J. Adelstein, “Molecular targeting with radionuclides: state of the science,” Journal of Nuclear Medicine, vol. 44, no. 12, pp. 1945–1961, 2003. 3 S. D. Metzler, J. E. Bowsher, M. F. Smith, and R. J. 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