Publications by HHMI-Sponsored Undergraduate Researchers
By Department and Lab at the University of Delaware 1999-2005
Department of Biological Sciences
Dr. Kamil Akanabi
Brian Jensen, Mary C. Farach-Carson, Erin Kenaley and Kamil A. Akanbi, (2004) High
Extracellular Calcium Attenuates Adipogenesis in 3T3-L1 Preadipocytes, Exp Cell Res.
301:280-92
Dr. Daniel Carson
Gomes, R.R., Joshi, S.S., Farach-Carson, M.C. and Carson, D.D. (2005) Perlecan
secretion by C3H10T1/2 fibroblasts is required for BMP-2 and Pln domain I supported
chondrogenic differentiation. Differentiation, in press.
Dr. Carlton Cooper
R.A.Sikes, C.R.Cooper, G.L.Beck, Freddie Pruitt, M.L.Brown, and G. Balian (2004)
Bone stromal cells as therapeutics targets in osseous metastasis. In: Cancer Growth and
Progression, Volume 15, "Integration/Interaction of Oncologic Growth." Ed. by Gary
Meadows, Series Ed, Kaiser H., Kluwer Academic Publishers, Boston, MA, in press
2004.
Dr. Patricia DeLeon
Martin-DeLeon P.A. Canaff L., Korstanje R., Bhide V., Selkirk M., Hendy G: (1999).
Rabbit Calcium-sensing Receptor (CASR) Gene: Chromosomal Localization and
Evidence for Related Genes. Cytogenet. Cell Gen. 86: 252-258.
Evans, EA.. Zhang, H., Martin-DeLeon, PA, (2003) SPAM1 (PH-20) protein and mRNA
expression in the epididymides of humans and macaques: utilizing laser
mircodissection/RT-PCR. Reprod. Biol. Endocrinol. 1:54.
Zhang H, Shertok, S, Miller, K., Taylor L., Martin-DeLeon, P. A. (2005) Sperm
Dysfunction in the Rb(6.16)- and Rb(6.15)-bearing mice revisited: Involvement of
Hyalp1 and Hyal5. Mol. Reprod. Dev. published Online: 3 Aug 2005 DOI:
10.1002/mrd.20360.
Dr. Melinda Duncan
Justin R. DiAngelo, Trusha K. Vasavada, William Cain and Melinda K. Duncan (2001)
Production of monoclonal antibodies against chicken Pop1 (BVES). Hybridoma and
Hybridomics 20, 377-382
Nicole L. Hill, Andres Laib and Melinda K. Duncan (2002) Mutation of The
Ectodysplasin-A gene results in bone defects in mice. J. Comp. Pathology 126, 220-225.
Dr. Deni Galileo
(Henninger) Stettler, E.M. and D.S. Galileo (2004). Radial glia produce and align the
ligand fibronectin during neuronal migration in the developing chick brain. J. Comp.
Neurol., 468, 441-451.
Cretu, A., Fotos, J.S., Little, B.W., and Galileo D.S. (2005). Human and rat glioma
growth, invasion, and vascularization in a novel chick embryo brain tumor model. Clin
Exper Metas, in press.
Dr. Norman Karin
Suzanne E. Biehn, Kirk J. Czymmek, Karla Leavens, and Norman Karin (2004)
Expression of the Sarco/Endoplasmic Ca2+-ATPase, SERCA1a, in Fibroblasts Induces
the Formation of Organelle Membrane Arrays. Experimental Cell Research, in press
Dr. Catherine Kirn-Safran
Stephanie A. Miller, Brown A.J., Farach-Carson M.C. and Kirn-Safran C. B. (2003)
HIP/RPL29 down-regulation accompanies terminal chondrocyte differentiation.
Differentiation, 71: 322-336. (source of cover photo for the issue.)
Dr. Eric Kmiec
Liu L, Hu Y, Usher M, Kmiec EB. The nuclease activity of Saccharomyces cerevisiae
Mre11 functions in targeted nucleotide alteration. Applied and Environmental
Microbiology 69, 10, 6216-6224 (2003).
Rice MC, Heckman B, Liu Y, Kmiec EB. Fluorescent detection and isolation of DNA
variants using stabilized RecA-coated oligonucleotides. Genome Research 14, 116-125
(2003).
Dr. Gary Laverty
Laverty, G., C. McWilliams, A. Sheldon and S.S. Arnason (2003). PTH stimulates a Cldependent and EIPA-sensitive current in chick proximal tubule cells in culture. Am. J.
Physiol. Renal Physiol. 284: F987-F995
Dr. Ulhas Naik
Parris, J. J., Cooke, V. G., Skarmes, W. C., Duncan, M. K., and Naik, U. P. (2005)
JAM-A Expression During Embryonic Development. Developmental Dynamics 233,
1517-24.
Department of Chemistry and Biochemistry
Dr. Brian Bahnson
Yeung DT, Josse D, Nicholson JD, Khanal A, McAndrew CW, Bahnson BJ, Lenz DE,
Cerasoli DM. (2004) Structure/function analyses of human serum paraoxonase
(HuPON1) mutants designed from a DFPase-like homology model. Biochim Biophys
Acta. 1702(1):67-77
Dr. Junghuei Chen
Zhaoqin Zhang, Amanda M. Simons, Vidhya P. Prabhu, Junghuei Chen, Strand
exchange protein 1 (Sep1) from Saccharomyces cerevisiae does not promote branch
migration in vitro.
Journal of Biolological Chemistry, 1998, 273(9):4950-4956.
J. Chen, E. Antipov, B. Lemieux, W. Cedeno, and D. H. Wood. (1999) DNA Computing
Implementing Genetic Algorithms” in L. Landweber, E. Winfree, R. Lipton, and S.
Freeland (eds.) Proceedings of DIMACS Workshop on Evolution as Computation, pp
39-49.
Junghuei Chen, Eugene Antipov, Bertrand Lemieux, Walter Cedeno, and David Harlan
Wood. In vitro selection for a max-1s DNA genetic algorithm. In David K. Gifford and
Erik Winfree, editors, Preliminary Proceedings of the Fifth Annual Workshop on DNA
Based Computers, held at MIT, June 14-16, 1999, page to appear. Massachusetts Institute
of Technology, 1999. Under review.
David Harlan Wood, Junghuei Chen, Eugene Antipov, Walter Cedeno, and Bertrand
Lemieux. A DNA implementation of the Max-1s problem. In Wolfgang Banzhaf, A. E.
Eiben, Max H. Garzon, Vasant Honavar, Mark Jakiela, and Robert E. Smith, editors,
GECCO-99: Proceedings of the Genetic and Evolutionary Computation Conference, July
13-17, 1999, Orlando, Florida USA, San Francisco, 1999. Morgan Kaufman.
E. Antipov, H. Bi, D. H. Wood, and J. Chen. Implementation of Genetic Algorithms
Using DNA Molecules” in preparation (2001).
D. H. Wood. J. Chen, E. Antipov, B. Lemieux, W. Cedeno A Design for DNA
Computation of OneMax Problem. Special issue on Biomolecular Approaches to
Soft Computing. Soft Computing 5, 19-24 (2001).
Zhaoquin Zhang, Dennis Yoon, Jacob R. LaPorte, and Junghuei Chen, Appropriate
Initiation of Strand Exchange Reaction Promoted by RecA Protein Requires ATP
Hydrolysis. J. Mol. Biol. 309, 29-43 (2001)
L. Cai, U. Marquardt, Z. Zhang, M. J. Taisey and J. Chen “Influences of DNA
Topology on Synaptic Complex Formation Promoted by RecA Protein of E. coli”
Nucleic Acids Research 29, 1389-1398 (2001).
Vidhya Prabhu VP, Amanda M. Simons AM, H. Iwasaki, D. Gai, Daniel T. Simmons,
Junghuei Chen. The Effect of p53 on the Rate of Spontaneous Branch Migration and
Resolution of the Holliday Junction by RuvC. J. Mol. Biol. 316, 1023-1032 (2002).
D. Yoon, Y. Wang, Kenneth Stapleford, L. Wiesmüller, and J. Chen. P53 Inhibits
Strand Exchange and Replication Fork Regression Promoted by Human Rad51”. J. Mol.
Biol. 336, 639–654 (2004).
Dr. Roberta F. Colman
Wang, J., Bauman, S. and Colman, R. F. Photoaffinity Labeling of Rat Liver Glutathione
S-Transferase, 4-4, by Glutathionyl S-[4-(Succinimidyl)-Benzophenone]. Biochemistry
37:15671-15679 (1998).
Wang, J., Bauman, S. and Colman, R. F. Probing Subunit Interactions in Alpha Class
Rat Liver Glutathione S-Transferase with the Photoaffinity Label Glutathionyl S-[4(Succinimidyl)-benzophenone]. J. Biol. Chem. 275: 5493-5503 (2000).
Palenchar, J.B., Crocco, J.M. and Colman, R.F. The Characterization of Mutant Bacillus
subtilis Adenylosuccinate Lyases Corresponding to Severe Human Adenylosuccinate
Lyase Deficiencies. Protein Science 12: 1694-1705 (2003).
Soundar, S., Fomulu, K. S., and Colman, R. F. Are Asp206, Asp230 and/or Asp234 of
the –Subunit of NAD-Specific Isocitrate Dehydrogenase Involved in Metal Ion Binding?
The FASEB Journal 19: A1400 (2005)
Dr. Mahendra K. Jain
Allison Liechty, J. Chen, and M. K. Jain. “Origin of Antibacterial Stasis by Polymyxin B
in Escherichia coli”. Biochimica et Biophysica Acta. 1463, 55-64. (2000).
Dr. Eugene Mueller
Vidhyashankar Ramamurthy, Steven L. Swann, Jennifer L. Paulson, Christopher J.
Spedaliere, and Eugene G. Mueller, Critical Aspartic Acid Residues in Pseudouridine
Synthases, Journal of Biological Chemistry 1999, 274, 22225-22230.
Eugene G. Mueller, Christopher J. Buck, Peter M. Palenchar, Lora J. Barnhart, and
Jennifer L. Paulson, (1998) Identification of a Gene Involved in 4-Thiouridine
Generation in tRNA, Nucleic Acids Research 26, 2606-2610.
Jaimie S. Robinson and Eugene G. Mueller (2001)Will Introduction of an E. Coli Gene
Lead to 4-Thiouridine in yeast tRNA? FASEB Journal 15, A188.
Dr. Clifford Robinson
Thevenin, D., Lazarova, T., Roberts, M. F., Robinson C. R, (2005) Oligomerization of
the fifth transmembrane domain from the adenosine A2A receptor. Protein Science 14,
2177-2186.
Dr. Joel Schneider
Kyung Lee, Valeria Dzubeck, Lauren Latshaw, and Joel P. Schneider, "De Novo
Designed Peptidic Redox Potential Probe: Linking Sensitized Emission to Disulfide Bond
Formation" J. Am. Chem. Soc. 2004 (ASAP).
Dr. Douglass Taber
Douglas F. Taber, Gina Bui, and Bei Chen, Synthesis of (-)-Delobanone. J. Org. Chem.
66, 3423-3426 (2001)
Dr. Colin Thorpe
Karen L. Hoober, Stacey L. Sheasley, Hiram F. Gilbert, Colin Thorpe, Sulfhydryl
oxidase from egg white. A facile catalyst for disulfide bondformation in proteins and
peptides. Journal of Biological Chemistry, 1999, 274(32):22147-22150.
Brohawn, S. G.; Miksa, I. R.; Thorpe, C. (2003) Avian Sulfhydryl Oxidase Is Not a
Metalloenzyme: Adventitious Binding of Divalent Metal Ions to the Enzyme,
Biochemistry, 42(37), 11074-11082
Daniel J. Cline, Sarah E. Redding, Stephen G. Brohawn, James A. Psathas, Joel P.
Schneider, Colin Thorpe (2004) Water-soluble Phosphines as Reductants of Peptide and
Protein Disulfide Bonds: Reactivity and Membrane Permeability, Biochemistry
43(48),15195-203.
Dr. John Koh
Hai Fen Ye, John T. Koh* and Kathryn E. O'Reilly, A subtype-selective thyromimetic
designed to bind a mutant thyroid hormone receptor implicated in resistance to thyroid
hormone (RTH), J. Am. Chem. Soc., 2001, 123, 1521-1522. (featured in C&E News)
Federico G. Cruz, Kristian H. Link, Hai-Fen Ye, Kathryn E. O'Reilly and John T. Koh
Photo-caged agonists of the nuclear receptors RARg and TRb provide unique timedependent gene expression profiles for light-activated gene expression.
* Submitted to Chemistry and Biology
Department of Chemical Engineering
Dr. Anne Skaja Robinson
K. J. Kauffman, E. M. Pridgen, F. J. Doyle, III, P. S. Dhurjati, and A. S. Robinson,
Decreased Protein Expression and Intermittent Recoveries in the BiP Levels Result from
Cellular Stress during Heterologous Protein Expression in Saccaromyces cerevisiae.
Biotech. Prog., 18, 942-950 (2002).
R.T.Niebauer, Allison Wedekind, and Anne Skaja Robinson (2004) Decreases in yeast
expression yields of the human adenosine receptor are a result of translational or posttranslational events, Protein Exp. Purif., 37 (1) 34-143.
Department of Medical Technology
Dr. Mary Ann McLane
Mary Ann McLane, Melissa A. Kuchar, C. Brando, D. Santoli, Carrie. A. PaquetteStraub, Mary Elizabeth Miele. New insights on disintegrin-receptor interactions:
Eristostatin and melanoma cells. Haemostasis 31: 177-182, 2001
Mary Ann McLane, Sanchez EE, Wong A, Paquette-Straub C, Perez JC. Disintegrins.
Current Drug Targets-Cardiovascular and Haematological Disorders 4: 327-355, 2004.
Mary Ann McLane, Xiaoming Zhang, Jing Tian, Claire Zelinskas, Apoorva Srivastava,
Brett Hensley, Carrie Paquette-Straub. Scratching below the surface: Wound healing and
alanine mutagenesis provide unique insights into interactions between eristostatin,
platelets and melanoma cells. Pathophysiology of Thrombosis and Haemostasis, in press
2006.