Hak Choy, M.D.
Professor and Chair, Department of Radiation Oncology;
Nancy B. & Jake L. Hamon Distinguished Chair in
Therapeutic Oncology Research
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Marc Diamond, M.D.
Margaret Phillips, Ph.D.
Craig Malloy, M.D.
Professor and Director, Center for Alzheimer’s
and Neurodegenerative Diseases;
Distinguished Chair in Basic Brain Injury and Repair
Professor, Department of Pharmacology;
Carolyn R. Bacon Professorship in Medical Science and
Education; Beatrice and Miguel Elias Distinguished Chair in
Biomedical Science
Professor, Advanced Imaging Research Center,
Internal Medicine, Radiology;
Richard A. Lange, M.D. Chair in Cardiology
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H
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Heavy Ion Cancer Therapy:
Novel, Precise, and Potent
Cannibals, Kuru, and Common Dementias:
A Unification Theory
New Drugs for Malaria: From Bench to Bedside
Molecular Imaging and Beyond
January 19, 2016
March 29, 2016
September 13, 2016
November 1, 2016
world-renowned expert in chemoradiation therapy,
Dr. Hak Choy joined UT Southwestern Medical Center in
2003. As Chair of the Department of Radiation Oncology,
Dr. Choy has been the prime motivator in growing the medical
center’s radiation oncology practice to the region’s largest. He is
active in designing national clinical trials that combine chemotherapy with the latest radiation techniques and treats patients
with lung cancer.
“We have made tremendous progress in curing lung cancer
with chemotherapy and advanced radiation therapy,” Dr. Choy
said. “UT Southwestern has the latest technology – some of it is
the first of its kind in North America – to help facilitate extremely
accurate treatment.”
UT Southwestern is leading a Texas consortium of researchers
to establish the country’s first National Center for Heavy Ion
Radiation Therapy, and Dr. Choy is principal investigator for a
$1 million planning grant awarded by the National Cancer Institute to develop center proposals.
After graduating from the University of Texas Medical
Branch in Galveston, Dr. Choy completed a residency in internal
medicine/radiation oncology at Ohio State, as well as a residency
in radiation oncology at the University of Texas Health Science
Center in San Antonio.
He was Professor and Vice Chair of the Department of
Radiation Oncology at Vanderbilt University before coming to
Dallas, and he holds a patent for the radio-enhanced delivery of
camptothecin-derivative drugs for cancer treatment.
A
s Director of the Center for Alzheimer’s and Neurodegenerative Diseases, and Professor of Neurology and Neurotherapeutics, Dr. Marc Diamond has devoted his career to
identifying mechanisms and new therapies for neurodegenerative
diseases. Dr. Diamond’s lab works primarily with the protein tau,
which builds up in Alzheimer’s disease. His research focuses on
why toxic proteins accumulate and move from cell to cell, causing
destruction throughout the brain.
Understanding what triggers the progressive pathology
could lead to approaches for halting Alzheimer’s. Drugs such as
antibodies or small molecules can be used to attack toxic protein
“seeds” while they are between cells, and early detection of the
seeds could lead to diagnosis even before symptoms occur.
“The last few years have seen a huge number of studies that
suggest that proteins associated with neurodegeneration can
assume an abnormal conformation that allows them to move
between brain cells and spread pathology,” Dr. Diamond said. “We
are now at a very exciting moment in neurodegenerative disease
research, because this hypothesis has allowed us to conceive of
many new ways to diagnose and treat people. In fact, new therapies based on this idea are already in clinical trials.”
Dr. Diamond completed an internship, residency, and chief
residency in neurology at the University of California, San Francisco
(UCSF) in 1997. After a postdoctoral fellowship, he was a faculty
member in the Neurology Department at UCSF (2002-2009). From
2009 to 2014 he was the David Clayson Professor of Neurology at
Washington University in St. Louis, before being recruited to
UT Southwestern.
I
n 2003 a team directed by Dr. Margaret Phillips identified a
promising inhibitor of a specific enzyme that the malaria parasite requires for survival. The lead compound, uncovered during
high-throughput tests at UT Southwestern Medical Center’s core
screening laboratory, made possible the development of a new
medicine, DSM265, which kills drug-resistant malaria parasites in
the blood and liver by targeting their ability to replicate.
“DSM265, being developed with Medicines for Malaria Venture, is
one of several next-generation antimalarial drugs with the ability to
cure after a single dose,” said Dr. Phillips, Professor of Pharmacology.
“It’s expected to greatly increase patient compliance over current
medicines and will be developed in combination with another drug
to help prevent drug resistance.”
Malaria kills millions every year, and no vaccine prevents the
disease. Drug resistance to current frontline therapies has recently
emerged, which threatens to erase gains in reducing the disease.
Having done graduate work on African sleeping sickness,
Dr. Phillips continued studying that parasitic disease after coming
to UT Southwestern in 1992. She was soon drawn to expanding
her research efforts into the area of malaria drug development.
Dr. Phillips received her undergraduate degree in Biochemistry from the University of California, Davis and her Ph.D. in
Pharmaceutical Chemistry from the University of California,
San Francisco, where she was also a postdoctoral fellow in the
Department of Biochemistry.
C
ardiologist Dr. Craig Malloy, a pioneer in the use of
magnetic resonance methods to define complex
metabolic changes, is Medical Director of the Advanced
Imaging Research Center at UT Southwestern Medical Center.
In 1993, Dr. Malloy led the development of a new program at
the Medical Center to analyze cardiac metabolism using magnetic
resonance spectroscopy. This lab established new diagnostic
methods for patients with abnormal metabolism.
Today he is investigating real-time imaging of patient
metabolism and exploring new technologies to study biochemistry in cancer.
“We know a tremendous amount about the basic science
of metabolism in each vital organ, ” he said. “Metabolic changes
can cause disease, and diseases can profoundly disrupt normal
metabolism. But only a tiny fraction of this knowledge can actually
be used to help with individual patient care decisions. Our goal is
to translate this knowledge to improve personalized medical care.”
Dr. Malloy is a Professor in the Departments of Internal
Medicine and Radiology, and he serves on the Campus Advisory
Committee for all small animal imaging equipment (predominantly
MRI, PET/CT, and SPECT/CT) used by members of the Simmons
Comprehensive Cancer Center. He is also a mentor for the
UT Southwestern Graduate School of Biomedical Engineering.
After graduating from Stanford University with a degree in
chemistry, he earned his medical degree from the University of
California, San Francisco. Dr. Malloy completed his residency at
Parkland Memorial Hospital and a cardiology fellowship at
Harvard Medical School and Brigham and Women’s Hospital, as
well as a biochemistry fellowship at the University of Oxford.
President’s Research Council
2016
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Supporting the Advancement
of Medicine and Science
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Schedule of 2016 Programs
January 19
March 29
September 13
November 1
6:15 p.m. Reception
7 p.m. Program
Members of the President’s Research Council (PRC) directly
engage the advancement of medical research at UT Southwestern.
Joining the PRC brings opportunities to hear from internationally recognized scientists conducting translational, high-impact
research. Your membership supports promising young physicians
who are the innovators of tomorrow. As a member of the PRC,
you’ll be advancing the future of medicine, today.
President’s Research Council member functions and
activities include:
• Supporting the annual Distinguished Researcher Awards
for faculty members early in their research careers when federal grants can be difficult to obtain. Support may also
be given to a past recipient named as the Marnie and
Kern Wildenthal President’s Research Council Professorship
in Medical Science;
• Attending four stimulating programs each year by prominent faculty researchers;
• Meeting outstanding scientists who are revolutionizing
the scope and practice of medicine;
• Hosting an annual dinner with UT Southwestern
President Daniel K. Podolsky, M.D., to honor the recipients
of the Distinguished Researcher Awards;
• Learning about the latest advances in medical science
from one of the nation’s leading institutions.
Medical Education and Conference Center
T. Boone Pickens Biomedical Building
6001 Forest Park Road
Dallas, Texas 75390
President’s Research Council programming in 2016 will be
stimulating and informative. This year will offer members the
opportunity to hear directly from gifted researchers who are
rethinking and redefining what is possible in medical science
today. Biographies of the four exciting speakers scheduled can
be found on the back of this brochure.
Annual tax-deductible memberships in the President’s
Research Council start at $750 for individuals or couples and
$1,000 for businesses, but larger gifts to support the work of
UT Southwestern medical scientists are always appreciated.
A corporate membership allows a business to send up to two
different people to each meeting or event.
u t s o u t h w e s t e r n . edu
For additional information about the President’s
Research Council, please call the Office of Development
at 214-648-2344.
About UT Southwestern Medical Center
One of the top academic medical centers in the world,
UT Southwestern is a premiere educational, clinical, and research
institution with an innovative approach to medicine. Our physicians and researchers seamlessly integrate breakthroughs in
science, advances in comprehensive patient care, and prestigious
educational programs to improve health care in North Texas and
around the world.
Consistently ranking among the top institutions for biomedical
research, UT Southwestern is home to six Nobel laureates, 19 members of the National Academy of Medicine (formerly the Institute of
Medicine), and more members of the National Academy of Sciences
than all other academic medical centers in Texas combined. More
than 3,300 research projects totaling almost $415 million annually
are underway at UT Southwestern on a host of medical disorders,
including cancer, heart disease and stroke, neurological diseases,
arthritis, diabetes, and Alzheimer’s disease.
Faculty and residents provide care to nearly 92,000 hospitalized
patients and oversee more than 2.1 million outpatient visits each
year. UT Southwestern also impacts the regional economy as an
employer of nearly 13,800 people in North Texas.
President’s Research Council Co-chairs
Susan and Gene Palma
Membership Co-chairs
Martha and Max Wells
Members
(as of September 1, 2015)
Peggy and Richard Allison*
Luis Antiles
Emy Lou and Jerald Baldridge
Miriam and Mitchell Barnett
Mary Susan Barnhill
Carla Bass
Julie and Craig Beale
Jeanie Beasley
Barbara and Bob Bigham
Beverly Blumenthal
Bill Booziotis
Colleen and Peter Bowler
Beverly and Bruce W. Bowman Jr.
Susan Bowman
Toni Brinker and T. Boone Pickens
Pamela and Don Buckroyd
Linda and Bob Buford
Mary and Rick Bush
Estrella and Luis Campos
Cissy and Plack Carr Jr.
Bitsy and Harold Dee Carter
Dorothy and John Castle
Mary and Bill Ceverha
Bev and Martin Coben
Mona Hersh Cochran
B. J. Coffman
Jean and George Coleman*
Suzanne and Jan Collmer
Mary McDermott Cook
Terry and Steve Crane
Nancy and Barry Crossman
Margaret Anne Cullum
Lynn and Peter Dauterman
Clarice M. Davis
Peggy S. Dear
Anne and Brian Dethrow
Barbara and Kenneth Dickerson
Mary and Neil Dorflinger
Adrienne and Dennis Drapkin
Pat and Ed Ducayet*
LaVerne M. Dutton
Laurie Dutton
Gano and Mel Ehlers
Ann and Charles W. Eisemann
Julie and Robert W. England
Alina and Ruben Esquivel
Sandra and Henry Estess
Elizabeth and Mike Fannin
Kathy and Jerrell Farr
Beth and Forest Felvey
Reba and Ralph T. Ferrell
Amy and Lee Fikes
Gloria and Henry Fleischer*
Marion Flores
Peter Fonberg
Eloise and Joe Foster
Margie and Ray Francis
Elizabeth and Dirk Frater
Beverly and Don Freeman
Katherine L. Freiberger
Peggy Galvin
Diane and Donnie Gaskins
Emily and Bill Gaylord
Judy and Jim Gibbs
Kathleen and Robert E. Gibson
Kathryn and Alfred G. Gilman
Laurie and Major Ginsberg
Sue and Joe Graham
Irma and Irwin Grossman
Lorraine and John J. Gurun
Olivia and James W. Guthrie
Rosann S. and Richard E. Gutman
Sandi and Ron W. Haddock
Karen and Charles M. Hansen Jr.
Jan and Bruce H. Harbour*
Richard Hardison
Linda W. Hart and Milledge A. Hart III
Sarah and Jody Hawn
Kent Hayden
Jan and Frederick B. Hegi Jr.
Carol and Jeff Heller
Aurelia and Brad Heppner
Sydney S. and Forrest C. Hicks*
Lyda Hill
Bobbie and Al Hopkins
Jo Hopper and Jack Hooper
Kathy Hornbach
Anne and George Howard
Vicki and G. Dulany Howland
Frieda and Bob Hudspeth*
Vester T. Hughes Jr.
Mary and Robert Hyde
Gwen and Richard Irwin*
Sue and Mike Kearins
Joan and Jack Kickham
Patti and Tom Kiernan
Mary and Thomas Kimball
Carole and Jack Kinnebrew
Samara Kline and Andy McCarthy
Rita Koger
Joyce and Howard Korn
Suzanne and Robert Kriscunas
Cece and Ford Lacy*
Sally and Olin Lane
Sophie and Harry Lee
Mary Lois and J. Sloan Leonard*
Donna and Anthony J. LeVecchio
Ann and Waymon Levell
Richard C. Levin
Barbara and Franklin R. Lloyd*
Sharon Lyle and Mark Mutschink*
Joy and Ron Mankoff
Linda Marcus
Judy and Benton W. Markey
Charlene and Tom F. Marsh
Sara and David F. Martineau
Becky and James P. McCulley
Effie and Tom McCullough
Mrs. Eugene McDermott
Brenda B. and M. Joseph McHugh
Marcia Messinger and
Joseph C. Picken*
Anne McNamara and
Errol P. Mitlyng
Sophie and Mike C. McWilliams
Barbara and Clifford Miercort*
Ruth Ann Montgomery
Chelen and Bill Moore
Mary Ann and Patrick M. Murray*
Judy and Jack Myers
Charles E. Nearburg
Douglas Newby
Mr. and Mrs. Peter O’Donnell Jr.
Nancy O’Neil and John Q. Stilwell
Jane and Tom O’Toole
Cookie and Dan Owen
Susan and Gene Palma*
Lauren and Scott Palmer
Dianne and James Patterson
Katherine and Bob Penn
Carol and Daniel K. Podolsky
Karen and Richard Pollock
Joan and Robert G. Pollock
Patsy and James W. (Bud) Porter
Lorraine and Grier Raggio
Heidi and Don Reynolds
Nancy Riddle
Billie Leigh Rippey
Laura and John L. Roach
Wendy and Randy Robinson*
Ruth Robinson
Catherine and Will Rose
Sally and Bob Rosen
Eileen and Harvey Rosenblum
Annadele (Ann) Ross
Bobbie and Ronald Rowland
Lee and Bill Schilling
Stefanie Schneidler and
Jeff Robinson
Enika and Richard Schulze
Ann and Irwin Sentilles
Diane and Donald Shimmer
Genie and Gary Short*
Nancy Shutt
Lynn and Ira Silver
Dee Simmons
Cindy and Bill Skeeters
Meredith and E.L. (Terry) Smith III
Nancy and John Solana*
Eliza Solender and Gary L. Scott
Gay and William T. Solomon
Karla and Larry Steinberg
Norma and Don Stone
Karen Stuart
Judy Stubbs and Jay Grekin
Nancy and Jerry Szor
Deanne and Raymond Termini
Jere W. Thompson
Joanna and Peter T. Townsend
Janet and Joe H. Tydlaska
Lee D. (Tom) Vendig
Carol and Howard Wahl
Jean and Tom Walter
Martha and Max Wells*
Nancy and Ben West*
Linda and Bob Westerburg*
Martha and Dan Weston
Jane A. Wetzel
Ann and Steve Whitcraft
Katsy and James A. Whittenburg III
Karen and Jim Wiley
Ellen and J. McDonald Williams
Sherry and Robert Wilson
Abby and George M. Yates
Carole and Jim Young
Barbara and Donald Zale
* Steering Committee Members
© 2015 UT Southwestern Medical Center. MKT 674
Supporting the Advancement
of Medicine and Science