Molecular Genetics BSCI410
Review for 3rd exam, Lectures 13-17
The third exam will be Tues., Nov. 29, 2007
------------------------------------------------------------------------------------------------------------Study material.
This study guide covers material for the third exam:
Transcription, post-transcriptional gene expression, gene mapping, positional cloning, LOD scores,
complex traits and types of allele.
This material was given in lectures Oct. 23 through Nov. 8. See the syllabus for readings.
Be able to define, discuss, and explain the following concepts:
promoter
transcription factor
epigenetics
DNase hypersensitivity
mediator
heterochromatin
dosage compensation
Xist RNA
macronucleus
polyadenylation signal
U1 snRNP
pan editing
exportins
eIF4
NMD
RNAi
miRNA
FISH
informative meioses
haplotype
complex traits
QTL mapping
null
allelic series
antimorph
enhancer
maternal effect genes
nucleosomes
locus control region
DNA hemimethylase
euchromatin
X-inactivation
roX RNA
micronucleus
polyadenylation site
U2 snRNP
Ran GTPase
IRES
aminoacyl tRNA
exosome
dicer
siRNA
STS
LOD scores
allelic association
phenocopy
transmission disequilibrium test
amorph
hypomorph
neomorph
core promoter
gap genes
DNase sensitivity
core histones
de novo methylation
position effect variegation
Barr bodies
imprinting
RNA polymerase IV
spliceosome
RNA editing
importins
eIF2
peptidyl tRNA
EJC
RISC
ubiquitin
radiation hybrid mapping
autozygosity
linkage disequilibrium
penetrance
sib pair analysis
haploinsufficient
hypermorph
Know features associated with active and inactive chromatin.
Be familiar with sex determination in Drosophila melanogaster.
Be able to explain the A, P and E sites of the ribosome.
Be able to summarize the key differences between prokaryotic and eukaryotic translation.
Be able to distinguish linkage maps, physical maps and cytological maps and know methods that
allow each type of map to be correlated with the others.
Be able to look at a pedigree and identify recombinants and nonrecombinants, alleles identical by
descent and informative vs. uninformative meioses. Be able to describe or recognize pedigrees
showing maternal imprinting, paternal imprinting and anticipation.
Be familiar with the definition of a LOD score and how it might change with different models.
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