Model using plasticine how a competitive & non competitive
inhibitor work, give examples of 2 inhibitors (1 poison, 1 medicine)
Competitive modelling space
Non-competitive modelling space
Allosteric site
Inhibitor example: 1
E.g. Malonate (respiration),
Protease inhibitor (HIV) or ethanol
Inhibitor example 2:
E.g. Copper Sulphate (Catalase)
Or Cynaide (resp.)
Must
Draw graphs to show how a competitive/non competitive inhibitor
alters the rate of reaction. Give an example linked to
poison/medicinal drug
Competitive inhibitor
Linked example: Malate blocks
succinate from entering
succinate dehydrogenase
directly (in respiration)
Non - Competitive inhibitor
Evaluate the positive/negative effects of inhibitors by completing
the table below:
+ve effects
-ve effects
Has medicinal values e.g. Could be
used to inhibit replication of virsus
(e.g. HIV – protease inhibitors)
Effects can sometimes be
irreversible e.g. Many poisons
Can be used to control a reaction
effectivly
Could cause a disease in itself
Effects only short term if reversible
(good & bad)
Can kill e.g. metabolic poison –
cyanide can stop cytochrome
oxidase from working in respiraiton
Could be used to stop an unwanted
substrate from being broken down
(e.g. Ethylene glycol in antifreeze)
Effects only short term if reversible
(good & bad)
Can be used as an advantage to
increase survival in the animal
kingdom (e.g. Snakes)
Could
Apply how a competitive inhibitor works by answering this exam
question.
Mark scheme
Linked example: Copper
Sulphate binds to catalase
indirectly stopping hydrogen
peroxide being broken down
Should
Application