L.O: 1) To describe how glucose levels are regulated 2) To explain the second-messenger model Starter: From BIOL1, what does ‘lysis’ mean? Think, what does ‘neo’ mean? And ‘genesis’? Secretion of hormones (endocrine function) Hormones are secreted from the cells in the islets of Langerhans α cells manufacture and secrete the hormone glucagon βcells manufacture and secrete the hormone insulin These are released directly into the blood Control of blood glucose Is a negative feedback process The normal blood glucose level is 90mg per 100ml of blood If the blood glucose levels get too high or too low, then the changes are detected by the α and βcells in the islets of Langerhans Activities Complete flowchart of glucoregulation Add new keywords to glossary Extension: Can you link why glucoregulation needs to happen with osmosis? Help: Use GCSE prompt sheet to recap fundamental basics Apply knowledge to past exam question Second Messenger Model In the activity I was… and what happened was… Key phrases to use: (extension words in blue) Specific receptor, glycogenolysis, adrenaline, cAMP, activates enzymes, cell membrane of liver, messenger 1, messenger 2, ATP, glucose, glycogen