ALL of Genetics Unit Wednesday 2/11/2015 Genetics Genetics – the study of how organisms inherit different features from their parents • Parents send information about TRAITS (characteristics ) to their offspring. We refer to this information as a gene, which is a segment of DNA that codes for a specific trait. • GENES are found on chromosomes and are made up of DNA. Each individual has two copies of a gene, one from each Parent. (One copy from _____ & One from _______) •An ALLELE is a – form of a trait A DOMINANT trait – the Powerful trait (the stronger trait) always represented with a Capital letter Example: A RECESSIVE trait – the weaker trait, can be hidden by a dominant allele, always represented with a lowercase letter Example: • If the ALLELES you got from each parent are the same alleles the individual is said to be Homozygous for the trait. – Ex: • Homologous chromosomes are chromosomes with the ______ information, size, & shape. Homo means the _________. • If an individual has different alleles the individual is said to be Heterozygous for the trait. • Ex. _______ • Hetero means the opposite of homo, it means DIFFERENT PHENOTYPE its ______________ appearance. What an organism _________ like. I remember “PH” Phenotype/Physical Examples of Phenotypes: Height Or anything else you can SEE! GENOTYPE – the types of ALLELES that an organism has for a particular trait (i.e. tongue rolling) Examples of Genotypes: , , (The combination of the two alleles you have for a trait is your genotype) GENOTYPE – the types of ALLELES that an organism has for a particular trait (i.e. tongue rolling) Homozygous or Heterozygous refer to an organism’s ____________________ (Phenotype or Genotype) We defined the word “Hybrid” for our purposes it means two different parents or traits. If you have a ring that is a gold hybrid, it is made of some different things besides gold. What word that we discussed today would be a synonym (mean the same thing) as the word “Hybrid”? •Hybrid = ____________ If “Pure” means being the same throughout, as in pure gold has only gold. What word we discussed today would be a synonym (mean the same thing) as the word “Purebred”? Purebred = ________________________ QUESTIONS??? Genetics Genetics – the study of how organisms inherit different features from their parents New Tools Punnett Square – diagram used to predict the outcome of a genetic cross. Created by Reginald Punnett (1875 –1967), a British geneticist, in the early 1900s Test Cross! A test cross can be used to determine the Genotype of an individual for which the only the phenotype is known. An individual with a dominant phenotype could either have a _______________ or a __________________ genotype. Test Cross An individual with a dominant phenotype could either have a Homozygous (BB) or a Heterozygous (Bb) genotype. The ONLY way to efficiently test this is to cross the individual of unknown genotype with a ____________ _____________ individual, has the ____________ phenotype. Question of the Day 1/29 In a test cross I would always breed an individual with an unknown _________ but Dominant __________ with an individual who had a ________ _______ genotype and therefore also a __________ phenotype In peas Yellow is Dominant to green peas. Intermediate Inheritance Intermediate Inheritance/Incomplete Dominance - is when two alleles BLEND together. Co-Dominance = Dominant together Co-Dominance means: BOTH alleles are represented that is they both SHOW UP! (They are dominant together) Co-Dominance = Dominant together Imagine crossing a black dog with a white dog and getting puppies that were black and white spotted! *This is not how Dalmatians are really made. Intermediate inheritance & Co-Dominance * The difference between Intermediate Inheritance & Co-dominance is in the PHENOTYPE. In Intermediate Inheritance (aka Incomplete Dominance) the alleles _________ together. In Codominance both alleles _____ _______, are EXPERESSED (Both traits are seen in the phenotype) Multiple alleles Multiple alleles – Traits are controlled by more than 2 possible alleles. Each individual still only has 2 alleles – one from Mom & one from Dad Multiple alleles There are four possible types of human blood: – A, B, AB, and O •These are expressed by immunoglobulin proteins, so the three possible alleles are written in this way: IA & IB are both CO-DOMINANT (they both _______ ___) and i is recessive to them. Multiple alleles Blood types in Blood Type Alleles humans are a good (________type) (_______type) example of a multiple allele trait. AIA or IAi I - They are also an example of IBIB or IBi CO-Dominance – dominant together – I A IB Both alleles/traits ii _________ _____. Mendel’s Law of Segregation Each individual has a pair of factors (alleles) for each trait The alleles segregate (separate) during gamete (sperm & egg) formation Each gamete contains only one factor (allele) for each trait Fertilization gives the offspring two factors (alleles) for each trait Dihybrid Crosses Up until now we have been looking at Monohybrid crosses. Mono means _______. This is to say that we have been looking at one ________, or characteristic, at a time. Often times we want to look at two traits at once. If we are looking at the outcomes of two traits in one cross we will call it a __________ ___________. •Di = _______ Mono = _________ Dihybrid Crosses Often times we want to look at two traits at once. If we are looking at the outcomes of two traits in one cross we will call it a Dihybrid Cross Di = _______ Mono = ______ Dihybrid Crosses Dihybrid cross – two trait cross In monohybrid crosses each parent was represented with ___ alleles and there were ____ possible allele combinations. (Ex. A parent could be AA, Aa, or aa) Dihybrid Crosses Dihybrid cross – two trait cross In Dihybrid crosses there are ___ alleles/parent (that is 2 alleles for each trait) and ____ possible Allele Combinations. Genetics & Probability • Why might things not turn out the way we expected them to???? •PROBABILITY – IT’S JUST CHANCE!! Polygenic Inheritance –Many genes control a single trait (2 or more genes) • Traits tend to show CONTINUOUS Variation (Not 2 discrete possibilities) 33 Genetics & Probability What is “EPIgenetics”? What are the 4 major factors that affect our “EPIgenetics” (What genes are turned on/off)? • Stress • Toxins • Diet/Nutrition • Physical Activity Genetics & Probability Can we directly change our genetics (What we inherited from our __________)? Can we change our “Epigenetics” - what genes are turned on/off? (Diet, Physical Activity, Exposure to Toxins, Stress) Question of the Day 2/09 Give the sex chromosomes of a male & female. Female: Male: Question of the Day 2/10 Give the genotypes of the following individuals, looking at colorblindness, a recessive X-linked (sex-linked) trait. Color Blind Female: Color Blind Male: Carrier Female: Non-color blind Male: