Welcome to the
Molecular Medicine
course!
Registration
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General information
Over-arching goals
Roll call
Course contents
Information about KS library
Coffee
Course evaluation HT 2012
Study design (research application)
Seminar assignments
Teacher exchange
Final examination
Molecular Medicine - from bed to bench
Course leader: Rachel Fisher
08-517 732 45 rachel.fisher@ki.se
Deputy course leader: Ewa Ehrenborg
08-517 761 91 ewa.ehrenborg@ki.se
Teaching assistant: Louisa Cheung
08-517 732 21 louisa.cheung@ki.se
Department of Medicine, Center for Molecular Medicine,
Karolinska University Hospital, L8:02
Course administrator: Sofia Asp (Laila Leidersten)
073 744 19 21 sofia.asp@ki.se
Course office:
Department of Medicine, Unit for Internal Medicine,
Karolinska University Hospital, A3:02
Office hours daily 8.00am - 3.00pm
Course office
(marked in yellow)
D1Lifts
Up to floor 2
Nanna
Svartz
A3:02
Lifts
KS main entrance
Over-arching goals
• To integrate previously gained knowledge
• To stimulate team work
• To analyse, evaluate and interpret raw data
• To design a study and write a research
application
• To provide “real life” experience
Roll call
Course set up
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Lectures, usually 9am – 3pm (check venue!)
Labs/demonstrations/work shops
Group work (+ preparation time)
Seminar assignments (+ preparation time)
Revision
Final written examination: 13th January
Presentation of group work (research application)
at end of course
Course contents (15 hp/ECTS)
Specific areas
• Circulation, ischemia, metabolic syndrome, diabetes
• Respiration, asthma, allergy
• Endocrinology
• Gastroenterology
• Pathology
• Clinical immunology / Clinical chemistry
Assignments etc.
• Molecular biology lab
• Research application
• Seminar assignments
• Workshops
• Revision
Course literature
• Text books from previous courses:
physiology, pharmacology, biochemistry,
molecular genetics, immunology
• Hand outs
• Lecture summary points (from lecturers)
• Selected articles
Does everyone want a paper copy of the hand outs?
Information about KS library
Marie Källberg
Seminar assignments
Lab “Methods in Molecular Biology”
Lectures, demos, labs, exam
Workshops
Research plan
Labs and Demonstrations
• Lab: “Methods in Molecular Biology –
Theory and Practice”
12/11 (introduction)
26-28/11, 3-5/12 (lab)
9-11/12 (analysis + statistics)
17/12 (discussion + review)
• Blood grouping lab (14-15/11)
• Lung/allergy demonstration (19/11)
not compulsory
• Angiography demonstration (22/11)
Labs
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You must bring your own lab coat
Compulsory to have a lab coat to perform the labs
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If you have lost the lab coat you were given when
you started the Biomedicine Programme, you can
buy a new one (380kr):
http://www.g-ess.se/
Tel: 08-449 85 70 (Stuvsta + Bromma)
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Some labs and demonstrations will be performed
in active research labs/clinics
- show consideration for those who work there
Course evaluation HT 2012
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Good
Research application
Lab “Methods in Molecular Biology”
Seminar assignment
Work shops
Examination relevant
Course leaders/administration
Mixed
• Clinical emphasis
• Lung/asthma/allergy demonstration
• Lecturers
Bad
• Lack of a course text book/absent summary points
• Work load too light
New for HT 2013
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Two seminar assignments
Teacher exchange
New workshop
Revision of lab “Methods in Molecular Biology”
Modification of research application
Lung/asthma/allergy demonstration voluntary
Workshops
• 3 workshops: Atherosclerosis
Endocrinology
Clinical immunology
(7/11)
(2/12)
(16/12)
• Questions/discussion topics handed out in
connection with relevant lectures
• Self-study/discussion + review with teacher
• Preparation for the exam
Evaluation of the course
• We rely on your feedback to improve the
course
• Please give constructive feedback
• Evaluation forms (online)
• Cinema ticket voucher if all evaluation forms
completed + submitted!
Course councils
• With class representatives
Thursday 21st November, 12 noon
• With whole class
Wednesday 15th January, 1 pm
Who are the class representatives?
Forms of feedback
reviewing
Research
progress with 
application
students
Peer-to-peer
to edit and
redraft
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Methods in
mol biol
Informing about
feedback
Course councils
and evaluations
Round-table feedback
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Methods in mol biol
feedback on seminar
assignment & exam
Pre-submission
guidance and feedback
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Research application
Workshops
feedforward
assignments
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Research
application
whole-class feedback
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Workshops
Course language
• All literature in English
• Lectures in English
• All assignments must be examined in English
(written + verbal)
Research application
• Group assignment
• Choose a specific issue to focus on
• Design a research project
• Write a research application
• Present the project orally
• Answer questions
• Team work
• Realistic exercise
Research application:
groups and topics
• Groups 1-6 each split in 2
• 12 “subgroups” of 3-4 people
• Each subgroup allocated a broad topic
• Detailed project chosen by the subgroup
• Discussions with and feed back from topic
“mentor” and from Ewa E
Research application – broad topics
• MicroRNA and vascular
disease
• Immunological aspects of
gastric disease
• Aneurysm
• Regenerative cardiology
• Thyroid diseases
• Allergy
• Coagulation
• Diabetes and co-morbidities
• Inflammatory lung diseases
• Vascular remodelling
• Cell death in metabolism
• Inflammation in
cardiovascular disease
2 topics/group, 3-4 people/research application
Research application
topic lottery
Research application:
new for HT2013
• Include writing a “popular science” project
summary
• Early discussions/feed back - start with
groups with topics relating to lectures at start
of course
→ timetable issues regarding groups
Groups will be announced today/tomorrow
Seminar assignments
• Two assignments
• Handed out at in advance
• Group or individual work / individual assessment
• Research based aspects, requires independent work
• Obtain appropriate information
- lectures, discussions, web, articles ..…
• Time scheduled to prepare answers
• Examination in seminar format, in groups:
No. 1
27th/29th November
No. 2
5th/6th December
• Grading = pass / fail
Teacher exchange
• Terhi Heino – University of Turku, Finland
• Seminar Assignment 2
Examination
• Final examination: Monday 13th January
Grades A-F
Questions testing knowledge + understanding
Grading of the examination
• F, Fx, E, D, C, B, A
• Goal-based assessment
• Evaluating the level of knowledge obtained not the
amount of knowledge
• F, Fx = fail
• E = basic pass: identify, describe, list
• C, D = pass with merit: compare, explain
connections, analyse, apply
• B, A = pass with distinction: theorise, hypothesise,
reflect
One relevant
aspect
Prestructural Unistructural
F
Fx
Several relevant
Integrated into
independent aspects a structure
Multistructural
E
Relational
C, D
Generalized to
new domain
Extended abstract
B, A
To pass the course …
• The student must obtain a grade of at least E for
the written examination (5 hp)
• The student must also pass
– the seminar assignments (3 hp)
– the research application (3 hp)
– all compulsory labs and demonstrations (4 hp)
Replacement assignments
• When compulsory parts of the course are
missed, there are replacement exercises
• If written, these must be handed in by the last
day of the course (17 January 2013)
• Next opportunity for submission = next course
(HT2014)
Use the web page!
We will communicate with
you via the web page
Molecular Medicine:
from bed to bench
• Important clinical contact
• Translational research
• Cross-disciplinary
• “From bench to bed and back again”