Unit 3 - Infection Control: Aseptic and Nonaseptic Techniques Chapters 16-18 Infection Control Chapter 16 Infection Control in Healthcare Awareness has increased since rise of AIDS epidemic Infection control standards have become more stringent Health care workers have a responsibility to protect themselves and others from acquiring diseases Standard Precautions and isolation techniques help healthcare workers prevent transmission of disease Microorganisms o Pathogen o o Infection o o o Microorganism known to produce disease Establishment and growth of a microorganism on or in a host Many unidentified pathogens that produce newly recognized diseases Four major groups of microorganisms o o o o Bacteria Fungi Viruses Parasites Microorganisms o Some species produce disease, others not harmful, or are even useful o Determining pathogenicity o Natural flora in one area of body may produce infection in another area o o EX: E. coli – natural flora of the intestinal tract; causes urinary tract infection if it gains entrance to the urinary bladder Ability to find susceptible body tissue to invade o Staphylocci on skin surface; can cause infection if enters lungs Microorganisms o Small number of microbes may be harmless; increasing levels may become pathogenic o Resident (natural) flora – microbes that live in the body at all times in a quantity that is usually stable o Transient flora – acquired by contact with an object on which they are present Bacteria o o o Colorless, microscopic, one-celled organisms without a nucleus (Procaryotes) Reside in a host in a group called a colony. Morphology – Classification of bacteria by size or shape; determined by “gram staining” o o o Cocci (spheres) Bacilli (rods) Spirals Bacteria o May also be classified according to divisions o o o o Diplococci = groups of two Streptococci = chains Staphylocci = grapelike bunches Must be stained to be seen under a microscope o o o Gram-positive = take the stain Gram-negative = do not take the stain Acid-fast = resistant to colorization by acid alcohol Bacteria o Endospores o o o o Protective coat formed when conditions for survival become unfavorable “Survival mode”; dormant Encase the genetic material in the cell & protect it for many years When conditions improve, endospore germinates and bacterial cell grows and replicates Viruses Minute microorganisms that cannot be visualized under an ordinary microscope o Smallest microorganisms known to produce disease in humans o Have either DNA or RNA, never both Must invade a host cell in order to survive & reproduce o Viruses o o o Viral infection occurs when virion (virus particle) attaches to host cell and inserts its genetic material, then takes control. Uses genetic machinery of the host cell to reproduce Environment must be favorable for multiplication o o o Poor nutritional status of host Increased levels of stress in host Excessive use of drugs or alcohol Viruses o Viruses can lay dormant or latent for a period of time o Dormancy o o o “Sleeping”, but very much alive and destructive Invade nerve ganglia and leave genetic material in a latent phase after an acute infective period Remains there until the body is under some type of stress o o Examples: o Herpes simplex (cold sore) o Varicella (chickenpox virus—shingles) Other examples of viruses: o o Common cold Infectious mononucleosis Viruses Classified by Genetic composition Shape or size Symmetry The host it infects The type of disease it produces Its target cell and immune properties Fungi o Macroscopic o o Mushrooms, puff balls or Microscopic o Medically important pathogenic fungi: o o o Yeasts, molds Hygrocybe lanecovensis Larger than bacteria Eukaryotic cells (have nucleus) requiring an aerobic environment to live & reproduce Aspergillus, 400x Fungi o Yeasts o o o o One-celled forms of fungi Reproduce by budding Used commercially to produce beer, wine, bread Molds (mycelia) o o o Multicellular colonies Reproduce by spore formation Used in production of antibiotic drugs, enzymes for medical use, food production Diseases caused by Fungi o Superficial infection o o Cutaneous infection o o o Involves hair, nails, skin Ex. Tinea pedis (athlete’s foot), ringworm Subcutaneous infection o o Ex: Tinea nigra causes discoloration of skin Enters host resulting from some trauma to the skin Systemic infection – most serious o o Enters circulation Can be fatal Parasites Organisms that live on or in other organism at the expense of the host Protozoa – unicellular; neither plant nor animal; eucaryotic; motile Larger than bacteria Lack a cell wall Classified according to motility Amoeboid Flagella (protein tail) Cilia (hairlike projections) Sporozoans (nonmotile) Parasites o Examples of protozoan infections: o Trichomonas vaginalis o o STD which infects both male and female hosts Plasmodium vivax o Causes malaria The protozoan parasite Trypanosoma brucei causes a severe disease known as sleeping sickness How do we get infected? o Six steps must occur from contact with infectious agent until the disease is apparent: 1. 2. 3. 4. 5. 6. Encounter Entry Spread Multiplication Damage Outcome Encounter o Microorganisms are typically encountered through the environment o o Congenital infections are passed through the placenta to unborn child Some microorganisms are normally found in the body; some cause disease Entry o Infectious microbes can be o o o Ingested (via contaminated water/food) inhaled (pneumonia) or via penetration o o o Ex. Using flagella to penetrate (syphilis) Mosquito bites (malaria, West Nile virus) Breaks in the skin Spread o o o o The propagation of the infectious organism Most important barrier is the host’s immune system Location of entry influences Methods of spread: o o o Contact Droplet Vector Multiplication o Infectious agents must multiply for the host to be impacted o Incubation period – time it takes for agents to overcome the host’s defenses. Damage o o Direct vs. Indirect Direct o o o Cell death caused by destruction of host cells Cell death caused by toxins or poisons secreted by the infectious agent Indirect o o Growth of the microbe can cause obstruction in a major organ system Can alter the metabolism of the host o Ex. botulism Outcome 1. The host gains control of the infectious agent and eliminates it 2. The infectious agent overcomes the hosts immunity to cause disease 3. The host and infectious agent compromise and live together Chain of Infection o Four factors present in the spread of disease. 1. 2. 3. 4. Host Infectious microorganism Mode of transportation Reservoir Human Host o Human body provides a favorable environment o o o o Contains nourishment for infectious agents Temperature pH Body fluid Infectious Microorganisms Include: Bacteria Viruses Fungi Protozoa Mode of Transmission o Exogenously – from outside the body o Transmission can be through o Direct host-to-host contact (touching) o o o o Indirect host-to-host contact o o o Ex. Hand holding, kissing, coughing, sexual contact STDs, staph infections Microbes often carried in body fluids (mucus, blood etc) Vector - EX: mosquito, flea, tick (Lyme disease) Fomite – an inanimate object that has been in contact with an infectious agent o EX: food, water, radiographic table, latex gloves Droplet contact – contact with infectious secretions that come from the conjunctiva of the eye, nose, or mouth of host as he/she coughs, sneezes, or talks o Droplets can travel 3 – 5 feet Mode of Transmission o Endogenously – from inside the body o o o Infected with organisms already present within the body (normal flora) Usually infects a different area of the body Staphylococci present on the skin can infect deeper tissues (laceration) Reservoir o The site where an infectious organism can stay alive and from which transmission can occur. o o People serving as a reservoir are called carriers. o o o o EX. People, animals inanimate objects Carrier doesn’t display disease symptoms but can infect others (Typhoid Mary) Animals (mad cow disease) Insects (malaria) Inanimate objects (contaminated linen) Nosocomial Infections o o Infections acquired in the course of medical care Hospital patients have a greater sensitivity to infection o o o o Compromised Immunosuppressed 5% of all hospital patients will acquire a nosocomial infection. It is the 8th leading cause of death in the U.S. Sources of Nosocomial Infections o Iatrogenic infection o Environment Nosocomial infection that results from a particular treatment or therapeutic procedure (physician-caused) Air contaminated with infectious agents Other patients with infectious diseases Contaminated instruments Medical personnel Therapeutic regimen Anitmicrobial therapy Immunosuppressive and cytotoxic drugs Sources of Nosocomial Infections Equipment Catheters IV tubing Respiratory therapy equipment Gastrointestinal tubes Contamination during medical procedures Dressing changes Catheter insertion Invasive procedures Surgical instruments Increasing Factors o Urinary tract o o o o Most common site of nosocomial infection Post-op wound infections Respiratory tract Early removal of urinary catheters, IV catheters, and other types of invasive treatment devices recommended to reduce incidence of nosocomial infections Factors of Susceptibility for Nosocomial Infection o Age o o Heredity o o o congenital & genetic factors Nutritional status o o very young, elderly malnourishment, obesity Stress Inadequate rest & exercise o Non-efficient eliminations & circulation Factors of Susceptibility for Nosocomial Infection o Personal habits o o Health History o o smoking, drugs/alcohol, unsafe sexual practices diabetes, heart disease, children who have not been immunized Inadequate defenses o broken skin, burns, trauma, immunocompromised persons Transmission of Infection o Infectious agent o o o o o o Pathogenicity – ability to cause disease Virulence – ability to grow and multiply with speed Invasiveness – ability to enter tissues Specificity – attraction to a particular host Environment in which the pathogenic microbes can live an multiply (susceptible host) Portal of exit from reservoir Elements Needed To Transmit Infection o o o Vehicle transmission – by contaminated food, water, drugs, or blood Airborne transmission – evaporated droplets of disease microorganisms suspended in air for long periods of time; inhaled by susceptible host Vectors – insect or animal carriers of disease ; deposit diseased microbes by stinging or biting human host Blood-borne Pathogens o o Disease-causing microorganisms that may be present in human blood or body fluids. Two most serious: o HBV – Hepatitis B virus o o o o HIV – Human immunodeficiency virus o o o o o Primarily affects the liver Symptoms: flu-like symptoms, jaundice Test positive 2-6 weeks after symptoms develop Primarily affects the immune system Responsible for AIDS Symptoms: weight loss, fatigue, glandular pain and swelling, muscle and joint pain, night sweats. Long latent period (up to 10 years) Others: o Hepatitis C, Hepatitis D, Syphilis Viral Hepatitis o o o o Hepatitis A & hepatitis E – transmitted by fecal-oral route Others – transmitted by blood or body fluid contacts Health care workers most often contract hepatitis B from needle-stick injuries Susceptible to HVB and HVC o o o Persons who share contaminated needles Persons who have multiple sex partners Hemophiliacs Infection Control: Microbial Control Within the Host. o Inherent defenses of the body o o o o o Normal Microbial Flora (balance) Chemotherapy (Drugs) o o o Intact skin & mucous membranes Body secretions (mucus, acidic urine, tears, sweat) Phagocytes Static – inhibit microbial growth Cidal – kills susceptible microbes Immunization Infection Control: Environmental Control o Recommendations and Guidelines come from: o o o o U.S. Dept. of Heath & Human Services (HHS) Centers for Disease Control and Prevention (CDC) U.S. Dept. of Labor’s Occupational Safety and Health Administration (OSHA) World Health Organization (WHO) – International Environmental Control o o Controlling infection or breaking the cycle of infection – duty of all health care workers Asepsis – freedom from infection o o Medical asepsis – microorganisms have been eliminated through the use of soap, water, friction, and disinfectants Surgical asepsis – microorganisms and their spores have been completely destroyed by means of heat or by a chemical process Environmental Control: Chemical Methods o Disinfection - Removal by mechanical and chemical processes of pathogenic microorganisms from objects or body surfaces o o o o o but frequently not their spores, Antiseptic – used in reference to body surfaces Bacteriostatic – stops bacterial growth Bacteriocidal – kills bacteria Items are disinfected when they cannot withstand the sterilization process, or when it is not practical Environmental Control: Disinfection o Effectiveness of chemical disinfectants depends on: o o o o o Concentration Temperature Time of exposure, Types/numbers of microbes Nature of the object/person being treated Environmental Control: Physical Methods o Heat is the most frequently used method of sterilization. o o o o o o Moist heat is more effective than dry heat Moist heat = heat under pressure; requires use of an autoclave (250o F @ 15 lb/in2 for 15 minutes) Dry heat requires use of an oven (320oF for 120 minutes) Pasteurization – requires moderate heating followed by rapid cooling (kills heat-sensitive organisms) Freezing – can kill some organisms; NOT a reliable form of sterilization UV light – is used to control airborne contaminants Environmental Control: Physical Methods o o Barriers are one of the simplest methods of microbial control (PPE – Personal Protective Equipment) o Gloves o o o o Worn when contact with blood/body fluids is anticipated Gowns (fluid repellent) Masks Protective eyewear/Face shields Hand Washing aka. Medical Asepsis o o o o o o Single most important means of preventing the spread of infection. A chemical and physical process Wash / sanitize hands before and after each patient contact (even if gloves have been worn) Wash hands with soap and water if hands are visibly soiled Use of hand sanitizers is permissible if not Cover any exposed break in the skin with waterproof bandage Standard Precautions o o o Used at all times when caring for a patient Based on the assumption that every patient has the potential for having an infectious disease Used when coming in contact with: o o o o o Blood & body fluids Secretions Excretions Mucous membranes Non-intact skin Dress in the Workplace o o o o Short fingernails – no acrylic nails Closed toe shoes Limited amount of jewelry Freshly laundered clothing o o o Was uniforms separate from family laundry Short sleeves recommended Wear a protective gown when it is possible that blood or body fluids will contaminate clothing Hair o o o Major source of staphylococcal contamination Should be shampooed frequently Wear hair short or in a way that keeps it up and away from your clothing and the patient Personal Protective Equipment (PPE’s) Eye Protection o o When splattering of blood or body fluids is possible, wear goggles to protect eyes from becoming contaminated Keep hands away from eyes so that infection is not introduced into them Gloves o o Wear disposable, single-use gloves any time you feel that you might touch a patient’s blood or body substances Wash hands BEFORE and AFTER donning gloves! Needle Recapping o NEVER use two hands to recap a needle! o o o o 800,000 needle stick injuries to healthcare workers annually! Use “scoop” technique or NERD (needle recapping device) All “sharps” should be disposed of in a sharps (puncture resistant) container Cleaning & Proper Waste Disposal o o Pillow cases and linens should be changed after each use by a patient Radiographic table and imaging equipment should be cleaned with disinfectant after each patient use o o Clean least soiled areas first, then move to more soiled areas (10% bleach solution) Discard items if they have fallen on the floor Transmission-based Precautions o o o Used in addition to standard precautions Used to prevent the spread of highly infectious diseases between infected persons and the healthcare providers 3 specific routes of transmission o o o Airborne Droplet Contact Airborne Precautions o o Microbes are spread on evaporated droplets that remain suspended in air or carried on dust particles in the air Particles may be inhaled by persons in that room o o Examples include: Tuberculosis, Varicella (chicken pox), rubeola (measles) Requires o o o Negative air-pressure isolation room Mask upon entry into room (special mask for TB) Mask for patient during transport within the hospital Droplet Precautions o o Contaminated droplets are placed in the air when patient sneezes, coughs, or talks Contaminated droplets are inhaled or internalized by uninfected person (no more than 3 feet) o Examples include: Influenza, pneumonia Droplet Precautions o Requires o o o o Private room or A room with another person infected with same disease or A room where beds are at least 3 feet away Mask for any procedure that requires less than 3 feet in proximity to the infected patient Contact Precautions o o Direct contact – susceptible person actually touches an infected person’s body surface in an area where infectious microbes are present Indirect contact – susceptible person touches or comes into contact with an object that has been contaminated with infectious microbes o o Fomites – contaminated objects Examples include: o MRSA (methicillin-resistant Staphyloccus aureus, hepatitis A, impetigo, varicella and varicella zoster Contact Precautions o Requires o o o Private room or room with another person with same disease Gloves upon entrance into room Wearing a gown if there is a possibility of touching patient or items in room Protective or Reverse Isolation Negative-pressure air flow – prevents pathogenic microorganisms from flowing out of the isolation room Patient who is highly susceptible to becoming infected require isolation precautions to protect them from becoming infected Disinfection o Responsibility to prevent the spread of infection o o o o o If patient is coughing and sneezing, provide tissues and a place to dispose of them Instruct patient to cough or sneeze into tissues Wear gown, mask, gloves if necessary Disinfect table and anything in radiographic room the patient touched Wash hands Aseptic Techniques Chapter 16 Surgical Asepsis o Medical asepsis o o o Removal or destruction of infected matreial Ex: Hand washing Surgical asepsis (Aseptic technique) o o Complete removal of microorganisms & their spores from the surface by means of heat or chemical action Invasive procedures require use of surgical aseptic techniques o Ex: angiography, arthrorography, hysterosalpingography, radiography in surgery Draping for a Sterile Procedure o Sterile drapes placed around area of skin that has been prepared o o o o o o Establishes a sterile field Limits area exposed to environment Fenestrated drape – opening over surgical site Sterile packages must be clean and dry Check for expiration date Once drapes are in place, they must not be moved; underside contaminated by patient’s skin Opening Sterile Packs o Cloth-Wrapped Packs o o o o Wash hands before handling Lines on tape change color if pack has been correctly sterilized Place pack on clean tabletop with sealed end toward you Commercial (disposable) Packs o o o Wrapped in paper or plastic wrappers Read directions on packaging for opening Never cut packs open or piece with a sharp object Surgical Scrub o Purpose o o To remove as many microorganism as possible from the skin of the hands & lower arms by mechanical & chemical means and running water Must put on lead apron before beginning scrub! Surgical Scrubbing o o o Preparatory cleaning of skin of hands and forearms to reduce the # of microorganisms prior to donning sterile gloves. Requires scrubbing with soap and water using a nail brush. Two methods: o o Numbered stroke method Timed scrub Surgical Scrubbing o o o o o o o Use scrub brushes, antiseptic soap, & nail cleaners Remove all jewelry Wash fingers, hands & arms above elbow Clean under nails Scrub sides of each finger, between fingers, back & front hand for 2 minutes; 3” above elbows for 1 minute Keep hands higher than elbows Dry Sterile Gowning & Gloving o o o Self-gowning vs. gowning another person Gown AFTER scrubbing Self-Gowning o o o o o Grasp gown & remove it from table Step away from table; gown will be folded inside out Hold gown away from body, and allow it to unfold without touching the floor Open gown & hold it by the shoulder seams; place both arms into armholes & wait for assistance Assistant will place gown over shoulders & tie back of gown o After the gown is on ONLY THE SLEEVES AND FRONT OF THE GOWN ABOVE THE WAIST ARE CONSIDERED STERILE!!! o Once in sterile gown and gloves, persons must pass each other BACK TO BACK! Sterile Gowning & Gloving o o Self-gloving vs. Gloving another person Self-Gloving – open technique o o o Glove dominant hand first Pick up right glove with left hand at the folded cuff & slide right hand into glove, leaving the cuff folded down When glove is over hand, leave it & pick up left glove with gloved right hand under fold. Pull glove over hand & cuff of gown Sterile Gowning & Gloving o Closed Gloving o o Restricted for use when sterile gown has already been put on & hands remain enclosed within cuffs of the gown With nondominant hand covered by the gown sleeve cuff, pick up the right glove & place it palm-side down on the palm of your right hand (covered with cuff); fingers of glove pointed toward elbow Sterile Gowning & Gloving o o Grasp cuff of glove through the gown with your right hand. Your covered left hand pulls the glove over your right hand, gently inserting fingers into finger spaces of the glove. Be certain cuff of glove covers the cuff of the gown Proceed with other hand in similar way Gloving another person Sterile Procedures Tracheostomies Urinary Catheters Chest Tubes Intravenous & Intraarterial Lines Changing Dressings o o o o o Must not remove or reapply dressings without physician’s order Must be to able to remove dressings without contaminating wound or yourself All dressings must be treated as contaminated Standard precautions/gowns & gloves should be worn. Sterile technique should be used Tracheostomies o o o o o An incision in the trachea; can be permanent or temporary Purpose: provides an airway needed due to upper-airway obstruction Always covered with a dressing Should not be touched except under sterile conditions Patient cannot talk; communication can be a challenge Chest Tubes Purpose: to remove fluid blood or air from the pleural cavity. Assists in re-inflating collapsed lungs Attached to a collection chamber (providing drainage) Chest radiographs often used to check for placement of chest tubes Chest Tubes o o Care must be taken so tube is not dislodged. Drainage system must remain BELOW the incision AT ALL TIMES! Urinary Catheters Catheter is inserted into the urinary bladder using aseptic technique. Purpose: to drain urine from the bladder Relieve retention of urine or bypass obstruction Irrigate the bladder Permit accurate measuring of urine output Relieve incontinence Two types: Foley (has a retention balloon) Straight type Urinary Catheters o Care must be taken not to pull out when moving or transporting the patient o Drainage bag must be kept below the bladder Intravenous and Intra-arterial Lines o o o AKA. Central venous and arterial lines Sterile technique is required for both when lines are placed. Central venous lines o o o o ex. for introduction of fluids/medications measurement of central venous pressure; Swan-Ganz (measure heart pumping ability) Arterial lines o o For drawing blood Measuring pressure Pacemakers o o o Using sterile technique, it is inserted under the patient’s skin to regulate the heart rate Subclavian vein is accessed to insert guidewire. Fluoroscopy and chest radiography are used to confirm correct placement of the wire Skin Preparation for Sterile Procedures o o o o Required before any invasive procedure Remove oils, dirt, and as many microorganisms as possible before the procedure Prevents contamination of the operative site to reduce risk of infection Hair is a contaminant Skin Preparation for Sterile Procedures o Mechanical methods o Hair removal o o o By physician’s order Depilatory agent, electric clipper, safety edge razor Friction scrub with antiseptic soap & water o o • Ask patient if he or she is allergic to iodine or any other antiseptic solutions Prepackaged prep trays – include basins, sponges, sterile towel, & antiseptic solutions o Solutions – iodophor, chlorhexidine gluconate Skin prep – sterile procedure; must don sterile gloves Skin Preparation for Sterile Procedures o Chemical method o o o After mechanical methods, paint with antiseptic solution Destroys remaining microbes & deters further microbial growth Circular motion beginning at the center & working outward The Surgical Environment o Unrestricted zone o o Semi-restricted zone o o Persons may enter in street clothing Must wear surgical scrubs, surgical cap, & shoe covers Restricted zone o Must wear surgical scrubs, cap, shoe covers, & mask The Surgical Environment o Strict rules o o o Jewelry, long fingernails, artificial fingernails, & polish prohibited – harbor microorganisms Hair must be secured back in surgical cap Health care worker with acute infection or open skin lesion must not enter the surgical suite The Surgical Environment o o o o o o Change into surgery scrubs Place shoe covers over shoes Put on surgical cap to cover all hair (hood for beard) Cover pierced ear studs with cap Remove all jewelry Fingernails must be short The Surgical Environment o Masks must be worn in restricted areas o o o o o Protects patient from droplet contamination Protects health care worker from airborne pathogens during surgical procedure Must cover nose & mouth Wear only for one procedure & then discard Be constantly aware of which areas are sterile o o Any break in sterile technique increases patient’s susceptibility to infection Never reach over a sterile area The Surgical Environment o o o Doors must always be kept closed; traffic in & out of rooms should be controlled Conversation must be kept to a minimum Radiographic equipment must be cleaned before bringing into surgery or leave dedicated equipment there The Surgical Environment o Lead aprons o o o To be worn during fluoroscopy or if team is unable to protect themselves while radiographic exposures are being taken should be put on before scrub has begun Place mask on face so that it covers nose & mouth o Do not touch mask after being placed, easily contaminated What is wrong with this picture?????? The Surgical Environment o Responsibility for protecting yourself & all persons in the OR from radiation o Must be knowledgeable of areas that are sterile & protecting them & the patient during your work o Responsible for making certain radiographic equipment is clean & dust-free Nonaseptic Techniques Chapter 18 Nasogastric NG Tubes o Inserted through the nasopharynx into the stomach. o Used for decompression or removal of gas and fluids from stomach. o Can be used for feeding Nasogastric Tubes Salem sump tube (Lt) Levin tube (Rt) Placement is often verified using fluoroscopy Sometimes connected to suction or clamped off Take care when moving or transporting pt. Urinals & Bedpans Male urinals Bedpans Metal or plastic Disposable or resterilizable Metal or plastic Disposable or resterilizable Fracture pan Enemas Cleansing enemas are typically performed prior to diagnostic studies of the colon. Typically used in conjunction with purgatives (laxatives) Often requires dietary restrictions too Low residue NPO after midnight Barium Enema Performed to study the lower GI tract radiographically Plain tip vs. inflatable cuff (retention cuff) Maximum inflation – 30-90 ml air Be sure to deflate BEFORE removing! Barium Sulphate is instilled into the bowel Barium Enema Single Contrast Double (Air) Contrast Sponsored by: This workforce solution was funded by a grant awarded under the President’s Community-Based Job Training Grants as implemented by the U.S. Department of Labor’s Employment and Training Administration. The solution was created by the grantee and does not necessarily reflect the official position of the U.S. Department of Labor. The Department of Labor makes no guarantees, warranties, or assurances of any kind, express or implied, with respect to such information, including any information on linked sites and including, but not limited to, accuracy of the information or it’s completeness, timeliness, usefulness, adequacy, continued availability, or ownership. This solution is copyrighted by the institution that created it. Internal use by an organization and/or personal use by an individual for non-commercial purposes is permissible. All other uses require the prior authorization of the copyright owner.