Journal of Biological Chemistry
18 May 2012; Vol. 287, No. 21
Journal of Biological Chemistry Table of Contents Alert
A new issue of Journal of Biological Chemistry is available online:
18 May 2012; Vol. 287, No. 21
The below Table of Contents is available online at:
http://www.jbc.org/content/vol287/issue21/index.dtl?etoc
Papers of the Week
How Silkworms and Beetles Get Their Dark Colors
: Identification of the Bombyx Red
Egg Gene Reveals Involvement of a Novel Transporter Family Gene in Late Steps of the
Insect Ommochrome Biosynthesis Pathway
J. Biol. Chem. 2012 287: 17715. First Published ; doi:10.1074/jbc.P111.321331 [Full Text]
[PDF] [Author profile]
Reflections
How Enzymes Handle the Energy Derived from the Cleavage of High-energy Phosphate
Compounds
Leopoldo de Meis
J. Biol. Chem. 2012 287: 16987-17005. First Published on March 16, 2012;
doi:10.1074/jbc.X112.363200 [Full Text] [PDF] AUTHOR'S CHOICE
Bioenergetics
Electron Transfer in Subunit NuoI (TYKY) of Escherichia coli NADH:Quinone
Oxidoreductase (NDH-1)
Prem Kumar Sinha, Eiko Nakamaru-Ogiso, Jesus Torres-Bacete, Motoaki Sato, Norma
Castro-Guerrero, Tomoko Ohnishi, Akemi Matsuno-Yagi, and Takao Yagi
J. Biol. Chem. 2012 287: 17363-17373. First Published on April 2, 2012;
doi:10.1074/jbc.M111.329649 [Abstract] [Full Text] [PDF] [Supplemental Data]
Cell Biology
Multisite Phosphorylation Disrupts Arginine-Glutamate Salt Bridge Networks Required
for Binding of Cytoplasmic Linker-associated Protein 2 (CLASP2) to End-binding Protein
1 (EB1)
Praveen Kumar, Michael S. Chimenti, Hayley Pemble, André Schönichen, Oliver
Thompson, Matthew P. Jacobson, and Torsten Wittmann
J. Biol. Chem. 2012 287: 17050-17064. First Published on March 29, 2012;
doi:10.1074/jbc.M111.316661 [Abstract] [Full Text] [PDF] [Supplemental Data]
G Protein-coupled Receptor Kinase 5 Phosphorylates Nucleophosmin and Regulates Cell
Sensitivity to Polo-like Kinase 1 Inhibition
Christopher H. So, Allison M. Michal, Rouzbeh Mashayekhi, and Jeffrey L. Benovic
J. Biol. Chem. 2012 287: 17088-17099. First Published on March 30, 2012;
doi:10.1074/jbc.M112.353854 [Abstract] [Full Text] [PDF]
Involvement of S100A14 Protein in Cell Invasion by Affecting Expression and Function of
Matrix Metalloproteinase (MMP)-2 via p53-dependent Transcriptional Regulation
Hongyan Chen, Yi Yuan, Chunpeng Zhang, Aiping Luo, Fang Ding, Jianlin Ma,
Shouhui Yang, Yanyan Tian, Tong Tong, Qimin Zhan, and Zhihua Liu
J. Biol. Chem. 2012 287: 17109-17119. First Published on March 26, 2012;
doi:10.1074/jbc.M111.326975 [Abstract] [Full Text] [PDF] [Supplemental Data]
Intestinal Expression of Mouse Abcg2/Breast Cancer Resistance Protein (BCRP) Gene Is
under Control of Circadian Clock-activating Transcription Factor-4 Pathway
Ahmed M. Hamdan, Satoru Koyanagi, Erika Wada, Naoki Kusunose, Yuichi Murakami,
Naoya Matsunaga, and Shigehiro Ohdo
J. Biol. Chem. 2012 287: 17224-17231. First Published on March 6, 2012;
doi:10.1074/jbc.M111.333377 [Abstract] [Full Text] [PDF]
Redifferentiation of Expanded Human Pancreatic β-Cell-derived Cells by Inhibition of the
NOTCH Pathway
Yael Bar, Holger A. Russ, Elad Sintov, Leeat Anker-Kitai, Sarah Knoller, and Shimon
Efrat
J. Biol. Chem. 2012 287: 17269-17280. First Published on March 28, 2012;
doi:10.1074/jbc.M111.319152 [Abstract] [Full Text] [PDF] [Supplemental Data]
P2X7 Receptor-mediated Scavenger Activity of Mononuclear Phagocytes toward Nonopsonized Particles and Apoptotic Cells Is Inhibited by Serum Glycoproteins but Remains
Active in Cerebrospinal Fluid
Ben J. Gu, James A. Duce, Valentina A. Valova, Bruce Wong, Ashley I. Bush, Steven
Petrou, and James S. Wiley
J. Biol. Chem. 2012 287: 17318-17330. First Published on March 29, 2012;
doi:10.1074/jbc.M112.340885 [Abstract] [Full Text] [PDF] [Supplemental Data]
Small Efficient Cell-penetrating Peptides Derived from Scorpion Toxin Maurocalcine
Cathy Poillot, Hicham Bichraoui, Céline Tisseyre, Eloi Bahemberae, Nicolas Andreotti,
Jean-Marc Sabatier, Michel Ronjat, and Michel De Waard
J. Biol. Chem. 2012 287: 17331-17342. First Published on March 20, 2012;
doi:10.1074/jbc.M112.360628 [Abstract] [Full Text] [PDF] [Supplemental Data]
p14ARF-induced Apoptosis in p53 Protein-deficient Cells Is Mediated by BH3-only Proteinindependent Derepression of Bak Protein through Down-regulation of Mcl-1 and Bcl-xL
Proteins
Annika Müer, Tim Overkamp, Bernd Gillissen, Antje Richter, Thomas Pretzsch, Ana
Milojkovic, Bernd Dörken, Peter T. Daniel, and Philipp Hemmati
J. Biol. Chem. 2012 287: 17343-17352. First Published on February 21, 2012;
doi:10.1074/jbc.M111.314898 [Abstract] [Full Text] [PDF]
Endothelin Induces Rapid, Dynamin-mediated Budding of Endothelial Caveolae Rich in
ET-B
Phil Oh, Thierry Horner, Halina Witkiewicz, and Jan E. Schnitzer
J. Biol. Chem. 2012 287: 17353-17362. First Published on March 28, 2012;
doi:10.1074/jbc.M111.338897 [Abstract] [Full Text] [PDF] [Supplemental Data]
Adaptor Autoregulation Promotes Coordinated Binding within Clathrin Coats
Chao-Wei Hung, Quyen L. Aoh, Ajit P. Joglekar, Gregory S. Payne, and Mara C.
Duncan
J. Biol. Chem. 2012 287: 17398-17407. First Published on March 28, 2012;
doi:10.1074/jbc.M112.349035 [Abstract] [Full Text] [PDF]
Action of Multiple Endoplasmic Reticulum Chaperon-like Proteins Is Required for Proper
Folding and Polarized Localization of Kre6 Protein Essential in Yeast Cell Wall β-1,6Glucan Synthesis
Tomokazu Kurita, Yoichi Noda, and Koji Yoda
J. Biol. Chem. 2012 287: 17415-17424. First Published on March 23, 2012;
doi:10.1074/jbc.M111.321018 [Abstract] [Full Text] [PDF]
Siglec-15 Protein Regulates Formation of Functional Osteoclasts in Concert with DNAXactivating Protein of 12 kDa (DAP12)
Norihiro Ishida-Kitagawa, Kunitaro Tanaka, Xilinqiqige Bao, Takanori Kimura, Tadashi
Miura, Yoshiki Kitaoka, Kouhei Hayashi, Mizuho Sato, Masahiro Maruoka, Takuya
Ogawa, Jun Miyoshi, and Tatsuo Takeya
J. Biol. Chem. 2012 287: 17493-17502. First Published on March 26, 2012;
doi:10.1074/jbc.M111.324194 [Abstract] [Full Text] [PDF] [Supplemental Data]
Interaction of Notch Signaling Modulator Numb with α-Adaptin Regulates Endocytosis of
Notch Pathway Components and Cell Fate Determination of Neural Stem Cells
Yan Song and Bingwei Lu
J. Biol. Chem. 2012 287: 17716-17728. First Published on April 3, 2012;
doi:10.1074/jbc.M112.360719 [Abstract] [Full Text] [PDF] [Supplemental Data]
Enoxacin Directly Inhibits Osteoclastogenesis without Inducing Apoptosis
Edgardo J. Toro, Jian Zuo, David A. Ostrov, Dana Catalfamo, Vivian BradaschiaCorrea, Victor Arana-Chavez, Aliana R. Caridad, John K. Neubert, Thomas J. Wronski,
Shannon M. Wallet, and L. Shannon Holliday
J. Biol. Chem. 2012 287: 17894-17904. First Published on April 2, 2012;
doi:10.1074/jbc.M111.280511 [Abstract] [Full Text] [PDF] [Supplemental Data]
Developmental Biology
Leukotoxin (Leukothera®) Targets Active Leukocyte Function Antigen-1 (LFA-1) Protein
and Triggers a Lysosomal Mediated Cell Death Pathway
Kristina M. DiFranco, Anukriti Gupta, Lindsey E. Galusha, Jarelys Perez, To-Vy K.
Nguyen, Camille D. Fineza, and Scott C. Kachlany
J. Biol. Chem. 2012 287: 17618-17627. First Published on March 30, 2012;
doi:10.1074/jbc.M111.314674 [Abstract] [Full Text] [PDF]
Gli1 Protein Participates in Hedgehog-mediated Specification of Osteoblast Lineage
during Endochondral Ossification
Hironori Hojo, Shinsuke Ohba, Fumiko Yano, Taku Saito, Toshiyuki Ikeda, Keiji
Nakajima, Yuske Komiyama, Naomi Nakagata, Kentaro Suzuki, Tsuyoshi Takato,
Hiroshi Kawaguchi, and Ung-il Chung
J. Biol. Chem. 2012 287: 17860-17869. First Published on April 9, 2012;
doi:10.1074/jbc.M112.347716 [Abstract] [Full Text] [PDF]
DNA and Chromosomes
DNA Polymerase
and
Switch by Sharing Accessory Subunits of DNA Polymerase
Andrey G. Baranovskiy, Artem G. Lada, Hollie M. Siebler, Yinbo Zhang, Youri I.
Pavlov, and Tahir H. Tahirov
J. Biol. Chem. 2012 287: 17281-17287. First Published on March 30, 2012;
doi:10.1074/jbc.M112.351122 [Abstract] [Full Text] [PDF] [Supplemental Data]
Enzymology
GTP-binding Protein-like Domain of AGAP1 Is Protein Binding Site That Allosterically
Regulates ArfGAP Protein Catalytic Activity
Ruibai Luo, Itoro O. Akpan, Ryo Hayashi, Marek Sramko, Valarie Barr, Yoko Shiba,
and Paul A. Randazzo
J. Biol. Chem. 2012 287: 17176-17185. First Published on March 27, 2012;
doi:10.1074/jbc.M111.334458 [Abstract] [Full Text] [PDF]
Dual Role of the Molybdenum Cofactor Biosynthesis Protein MOCS3 in tRNA Thiolation
and Molybdenum Cofactor Biosynthesis in Humans
Mita Mullick Chowdhury, Carsten Dosche, Hans-Gerd Löhmannsröben, and Silke
Leimkühler
J. Biol. Chem. 2012 287: 17297-17307. First Published on March 27, 2012;
doi:10.1074/jbc.M112.351429 [Abstract] [Full Text] [PDF]
Functional Linkage of Adenine Nucleotide Binding Sites in Mammalian Muscle 6Phosphofructokinase
Antje Brüser, Jürgen Kirchberger, Marco Kloos, Norbert Sträter, and Torsten
Schöneberg
J. Biol. Chem. 2012 287: 17546-17553. First Published on April 3, 2012;
doi:10.1074/jbc.M112.347153 [Abstract] [Full Text] [PDF]
Trypanosoma brucei Thymidine Kinase Is Tandem Protein Consisting of Two Homologous
Parts, Which Together Enable Efficient Substrate Binding
Farahnaz Ranjbarian, Munender Vodnala, Sharvani Munender Vodnala, Reza
Rofougaran, Lars Thelander, and Anders Hofer
J. Biol. Chem. 2012 287: 17628-17636. First Published on March 21, 2012;
doi:10.1074/jbc.M112.340059 [Abstract] [Full Text] [PDF] [Supplemental Data]
Characterization of a novel Agrobacterium tumefaciens Galactarolactone Cycloisomerase
Enzyme for Direct Conversion of D-Galactarolactone to 3-Deoxy-2-keto-L-threo-hexarate
Martina Andberg, Hannu Maaheimo, Harry Boer, Merja Penttilä, Anu Koivula, and
Peter Richard
J. Biol. Chem. 2012 287: 17662-17671. First Published on April 5, 2012;
doi:10.1074/jbc.M111.335240 [Abstract] [Full Text] [PDF] [Supplemental Data]
Selective inhibition of Biotin Protein Ligase from Staphylococcus aureus
Tatiana P. Soares da Costa, William Tieu, Min Y. Yap, Nicole R. Pendini, Steven W.
Polyak, Daniel Sejer Pedersen, Renato Morona, John D. Turnidge, John C. Wallace,
Matthew C. J. Wilce, Grant W. Booker, and Andrew D. Abell
J. Biol. Chem. 2012 287: 17823-17832. First Published on March 21, 2012;
doi:10.1074/jbc.M112.356576 [Abstract] [Full Text] [PDF] [Supplemental Data]
Gene Regulation
Nkx3.1 Functions as Para-transcription Factor to Regulate Gene Expression and Cell
Proliferation in Non-cell Autonomous Manner
Jian Zhou, Li Qin, Jean Ching-Yi Tien, Li Gao, Xian Chen, Fen Wang, Jer-Tsong Hsieh,
and Jianming Xu
J. Biol. Chem. 2012 287: 17248-17256. First Published on March 31, 2012;
doi:10.1074/jbc.M111.336909 [Abstract] [Full Text] [PDF]
Lin-28 Homologue A (LIN28A) Promotes Cell Cycle Progression via Regulation of Cyclindependent Kinase 2 (CDK2), Cyclin D1 (CCND1), and Cell Division Cycle 25 Homolog A
(CDC25A) Expression in Cancer
Ning Li, Xiaomin Zhong, Xiaojuan Lin, Jinyi Guo, Lian Zou, Janos L. Tanyi, Zhongjun
Shao, Shun Liang, Li-Ping Wang, Wei-Ting Hwang, Dionyssios Katsaros, Kathleen
Montone, Xia Zhao, and Lin Zhang
J. Biol. Chem. 2012 287: 17386-17397. First Published on March 30, 2012;
doi:10.1074/jbc.M111.321158 [Abstract] [Full Text] [PDF] [Supplemental Data]
Immunology
Smurf1 Protein Negatively Regulates InterferonSignaling through Promoting
STAT1 Protein Ubiquitination and Degradation
Chao Yuan, Jianni Qi, Xueying Zhao, and Chengjiang Gao
J. Biol. Chem. 2012 287: 17006-17015. First Published on April 2, 2012;
doi:10.1074/jbc.M112.341198 [Abstract] [Full Text] [PDF]
A Comparative Study of Stress-mediated Immunological Functions with the Adjuvanticity
of Alum
Yufei Wang, Durdana Rahman, and Thomas Lehner
J. Biol. Chem. 2012 287: 17152-17160. First Published on April 3, 2012;
doi:10.1074/jbc.M112.347179 [Abstract] [Full Text] [PDF]
Sequence Variation in Promoter of Ica1 Gene, Which Encodes Protein Implicated in Type
1 Diabetes, Causes Transcription Factor Autoimmune Regulator (AIRE) to Increase Its
Binding and Down-regulate Expression
Samantha M. Bonner, Susan L. Pietropaolo, Yong Fan, Yigang Chang, Praveen
Sethupathy, Michael P. Morran, Megan Beems, Nick Giannoukakis, Giuliana Trucco,
Michael O. Palumbo, Michele Solimena, Alberto Pugliese, Constantin Polychronakos,
Massimo Trucco, and Massimo Pietropaolo
J. Biol. Chem. 2012 287: 17882-17893. First Published on March 24, 2012;
doi:10.1074/jbc.M111.319020 [Abstract] [Full Text] [PDF] [Supplemental Data]
Lipids
Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis
Benjamin T. Bikman, Yuguang Guan, Guanghou Shui, M. Mobin Siddique, William L.
Holland, Ji Yun Kim, Gemma Fabriàs, Markus R. Wenk, and Scott A. Summers
J. Biol. Chem. 2012 287: 17426-17437. First Published on April 2, 2012;
doi:10.1074/jbc.M112.359950 [Abstract] [Full Text] [PDF] [Supplemental Data]
Oxidatively Truncated Phospholipids Are Required Agents of Tumor Necrosis Factor α
(TNFα)-induced Apoptosis
Calivarathan Latchoumycandane, Gopal K. Marathe, Renliang Zhang, and Thomas M.
McIntyre
J. Biol. Chem. 2012 287: 17693-17705. First Published on March 20, 2012;
doi:10.1074/jbc.M111.300012 [Abstract] [Full Text] [PDF]
Membrane Biology
Conserved Asparagine Residue Located in Binding Pocket Controls Cation Selectivity and
Substrate Interactions in Neuronal Glutamate Transporter
Shlomit Teichman, Shaogang Qu, and Baruch I. Kanner
J. Biol. Chem. 2012 287: 17198-17205. First Published on April 4, 2012;
doi:10.1074/jbc.M112.355040 [Abstract] [Full Text] [PDF] [Supplemental Data]
Saccharomyces cerevisiae Porin Pore Forms Complexes with Mitochondrial Outer
Membrane Proteins Om14p and Om45p
Susann Lauffer, Katrin Mäbert, Cornelia Czupalla, Theresia Pursche, Bernard Hoflack,
Gerhard Rödel, and Udo Krause-Buchholz
J. Biol. Chem. 2012 287: 17447-17458. First Published on March 29, 2012;
doi:10.1074/jbc.M111.328328 [Abstract] [Full Text] [PDF] [Supplemental Data]
Cellular Pregnenolone Esterification by Acyl-CoA:Cholesterol Acyltransferase
Maximillian A. Rogers, Jay Liu, Mark M. Kushnir, Elena Bryleva, Alan L. Rockwood,
A. Wayne Meikle, David Shapiro, Boris L. Vaisman, Alan T. Remaley, Catherine C. Y.
Chang, and Ta-Yuan Chang
J. Biol. Chem. 2012 287: 17483-17492. First Published on April 2, 2012;
doi:10.1074/jbc.M111.331306 [Abstract] [Full Text] [PDF]
Cardiolipin and Mitochondrial Phosphatidylethanolamine Have Overlapping Functions in
Mitochondrial Fusion in Saccharomyces cerevisiae
Amit S. Joshi, Morgan N. Thompson, Naomi Fei, Maik Hüttemann, and Miriam L.
Greenberg
J. Biol. Chem. 2012 287: 17589-17597. First Published on March 20, 2012;
doi:10.1074/jbc.M111.330167 [Abstract] [Full Text] [PDF] [Supplemental Data]
Identification of the Bombyx Red Egg Gene Reveals Involvement of a Novel Transporter
Family Gene in Late Steps of the Insect Ommochrome Biosynthesis Pathway
Mizuko Osanai-Futahashi, Ken-ichiro Tatematsu, Kimiko Yamamoto, Junko
Narukawa, Keiro Uchino, Takumi Kayukawa, Tetsuro Shinoda, Yutaka Banno, Toshiki
Tamura, and Hideki Sezutsu
J. Biol. Chem. 2012 287: 17706-17714. First Published on April 2, 2012;
doi:10.1074/jbc.M111.321331 [Abstract] [Full Text] [PDF] [Supplemental Data][Author
profile] [Summary] AUTHOR'S CHOICE
Metabolism
The Iron Chelators Dp44mT and DFO Inhibit TGF-β-induced Epithelial-Mesenchymal
Transition via Up-Regulation of N-Myc Downstream-regulated Gene 1 (NDRG1)
Zhiqiang Chen, Daohai Zhang, Fei Yue, Minhua Zheng, Zaklina Kovacevic, and Des R.
Richardson
J. Biol. Chem. 2012 287: 17016-17028. First Published on March 27, 2012;
doi:10.1074/jbc.M112.350470 [Abstract] [Full Text] [PDF] [Supplemental Data]
ATP Synthesis-coupled and -uncoupled Acetate Production from Acetyl-CoA by
Mitochondrial Acetate:Succinate CoA-transferase and Acetyl-CoA Thioesterase in
Trypanosoma
Yoann Millerioux, Pauline Morand, Marc Biran, Muriel Mazet, Patrick Moreau, Marion
Wargnies, Charles Ebikeme, Kamel Deramchia, Lara Gales, Jean-Charles Portais,
Michael Boshart, Jean-Michel Franconi, and Frédéric Bringaud
J. Biol. Chem. 2012 287: 17186-17197. First Published on April 2, 2012;
doi:10.1074/jbc.M112.355404 [Abstract] [Full Text] [PDF] [Supplemental Data]
Potential Biological Functions of Cytochrome P450 Reductase-dependent Enzymes in
Small Intestine: NOVEL LINK TO EXPRESSION OF MAJOR
HISTOCOMPATIBILITY COMPLEX CLASS II GENES
Jaime D'Agostino, Xinxin Ding, Peng Zhang, Kunzhi Jia, Cheng Fang, Yi Zhu, David C.
Spink, and Qing-Yu Zhang
J. Biol. Chem. 2012 287: 17777-17788. First Published on March 27, 2012;
doi:10.1074/jbc.M112.354274 [Abstract] [Full Text] [PDF] [Supplemental Data]
Microbiology
Regulation of the Type IV Secretion ATPase TrwD by Magnesium: IMPLICATIONS
FOR CATALYTIC MECHANISM OF THE SECRETION ATPase SUPERFAMILY
Jorge Ripoll-Rozada, Alejandro Peña, Susana Rivas, Fernando Moro, Fernando de la
Cruz, Elena Cabezón, and Ignacio Arechaga
J. Biol. Chem. 2012 287: 17408-17414. First Published on March 30, 2012;
doi:10.1074/jbc.M112.357905 [Abstract] [Full Text] [PDF] [Supplemental Data]
Posttranslational Modification of Cellular Proteins by a Ubiquitin-like Protein in Bacteria
Naoki Shigi
J. Biol. Chem. 2012 287: 17568-17577. First Published on March 30, 2012;
doi:10.1074/jbc.M112.359844 [Abstract] [Full Text] [PDF] [Supplemental Data]
Elucidating Essential Role of Conserved Carboxysomal Protein CcmN Reveals Common
Feature of Bacterial Microcompartment Assembly
James N. Kinney, Annette Salmeen, Fei Cai, and Cheryl A. Kerfeld
J. Biol. Chem. 2012 287: 17729-17736. First Published on March 29, 2012;
doi:10.1074/jbc.M112.355305 [Abstract] [Full Text] [PDF] [Supplemental Data]
Response to Copper Stress in Streptomyces lividans Extends beyond Genes under Direct
Control of a Copper-sensitive Operon Repressor Protein (CsoR)
Srivatsa Dwarakanath, Amanda K. Chaplin, Michael A. Hough, Sébastien Rigali, Erik
Vijgenboom, and Jonathan A. R. Worrall
J. Biol. Chem. 2012 287: 17833-17847. First Published on March 26, 2012;
doi:10.1074/jbc.M112.352740 [Abstract] [Full Text] [PDF] [Supplemental Data]
Molecular Bases of Disease
Arsenic Promotes Ubiquitinylation and Lysosomal Degradation of Cystic Fibrosis
Transmembrane Conductance Regulator (CFTR) Chloride Channels in Human Airway
Epithelial Cells
Jennifer M. Bomberger, Bonita A. Coutermarsh, Roxanna L. Barnaby, and Bruce A.
Stanton
J. Biol. Chem. 2012 287: 17130-17139. First Published on March 30, 2012;
doi:10.1074/jbc.M111.338855 [Abstract] [Full Text] [PDF]
Impact of Manganese on and Transfer across Blood-Brain and Blood-Cerebrospinal Fluid
Barrier in Vitro
Julia Bornhorst, Christoph A. Wehe, Sabine Hüwel, Uwe Karst, Hans-Joachim Galla,
and Tanja Schwerdtle
J. Biol. Chem. 2012 287: 17140-17151. First Published on March 28, 2012;
doi:10.1074/jbc.M112.344093 [Abstract] [Full Text] [PDF]
Tumors with Nonfunctional Retinoblastoma Protein Are Killed by Reduced
Tubulin Levels
Åsa Ehlén, Catalina A. Rosselló, Kristoffer von Stedingk, Greta Höög, Elise Nilsson,
Helen M. Pettersson, Karin Jirström, and Maria Alvarado-Kristensson
J. Biol. Chem. 2012 287: 17241-17247. First Published on April 6, 2012;
doi:10.1074/jbc.M112.357038 [Abstract] [Full Text] [PDF] AUTHOR'S CHOICE
Familial Alzheimer Disease Presenilin-1 Mutations Alter the Active Site Conformation of
-secretase
De-Ming Chau, Christina J. Crump, Jennifer C. Villa, David A. Scheinberg, and YueMing Li
J. Biol. Chem. 2012 287: 17288-17296. First Published on March 29, 2012;
doi:10.1074/jbc.M111.300483 [Abstract] [Full Text] [PDF] [Supplemental Data]
Tyrosine-phosphorylated Caveolin-1 (Tyr-14) Increases Sensitivity to Paclitaxel by
Inhibiting BCL2 and BCLxL Proteins via c-Jun N-terminal Kinase (JNK)
Ayesha N. Shajahan, Zachary C. Dobbin, F. Edward Hickman, Sivanesan
Dakshanamurthy, and Robert Clarke
J. Biol. Chem. 2012 287: 17682-17692. First Published on March 20, 2012;
doi:10.1074/jbc.M111.304022 [Abstract] [Full Text] [PDF]
Mammary Epithelial Cell Polarity Is Regulated Differentially by p73 Isoforms via
Epithelial-to-mesenchymal Transition
Yanhong Zhang, Wensheng Yan, Yong Sam Jung, and Xinbin Chen
J. Biol. Chem. 2012 287: 17746-17753. First Published on March 28, 2012;
doi:10.1074/jbc.M112.358143 [Abstract] [Full Text] [PDF] [Supplemental Data]
Advanced Bone Formation in Mice with a Dominant-negative Mutation in the Thyroid
Hormone Receptor β Gene due to Activation of Wnt/β-Catenin Protein Signaling
Patrick J. O'Shea, Dong Wook Kim, John G. Logan, Sean Davis, Robert L. Walker, Paul
S. Meltzer, Sheue-yann Cheng, and Graham R. Williams
J. Biol. Chem. 2012 287: 17812-17822. First Published on March 22, 2012;
doi:10.1074/jbc.M111.311464 [Abstract] [Full Text] [PDF] [Supplemental Data]
Molecular Biophysics
Substrate Transport Activation Is Mediated through Second Periplasmic Loop of
Transmembrane Protein MalF in Maltose Transport Complex of Escherichia coli
Tomas Jacso, Erwin Schneider, Bernd Rupp, and Bernd Reif
J. Biol. Chem. 2012 287: 17040-17049. First Published on March 26, 2012;
doi:10.1074/jbc.M112.340679 [Abstract] [Full Text] [PDF]
Loop Diuretic and Ion-binding Residues Revealed by Scanning Mutagenesis of
Transmembrane Helix 3 (TM3) of Na-K-Cl Cotransporter (NKCC1)
Suma Somasekharan, Jessica Tanis, and Biff Forbush
J. Biol. Chem. 2012 287: 17308-17317. First Published on March 21, 2012;
doi:10.1074/jbc.M112.356014 [Abstract] [Full Text] [PDF] [Supplemental Data]
A Fluorescent Biosensor Reveals Conformational Changes in Human Immunoglobulin E
Fc: IMPLICATIONS FOR MECHANISMS OF RECEPTOR BINDING, INHIBITION,
AND ALLERGEN RECOGNITION
James Hunt, Anthony H. Keeble, Robert E. Dale, Melissa K. Corbett, Rebecca L.
Beavil, James Levitt, Marcus J. Swann, Klaus Suhling, Simon Ameer-Beg, Brian J.
Sutton, and Andrew J. Beavil
J. Biol. Chem. 2012 287: 17459-17470. First Published on March 22, 2012;
doi:10.1074/jbc.M111.331967 [Abstract]
[Full Text] [PDF] [Supplemental Data]
Ultrafast Excited-state Deactivation of Flavins Bound to Dodecin
Heike Staudt, Dieter Oesterhelt, Martin Grininger, and Josef Wachtveitl
J. Biol. Chem. 2012 287: 17637-17644. First Published on March 26, 2012;
doi:10.1074/jbc.M111.331652 [Abstract] [Full Text] [PDF] [Supplemental Data]
Neurobiology
Generation and Nuclear Translocation of Sumoylated Transmembrane Fragment of Cell
Adhesion Molecule L1
David Lutz, Gerrit Wolters-Eisfeld, Gunjan Joshi, Nevena Djogo, Igor Jakovcevski,
Melitta Schachner, and Ralf Kleene
J. Biol. Chem. 2012 287: 17161-17175. First Published on March 19, 2012;
doi:10.1074/jbc.M112.346759 [Abstract] [Full Text] [PDF]
Casein Kinase 2-mediated Synaptic GluN2A Up-regulation Increases N-Methyl-Daspartate Receptor Activity and Excitability of Hypothalamic Neurons in Hypertension
Zeng-You Ye, Li Li, De-Pei Li, and Hui-Lin Pan
J. Biol. Chem. 2012 287: 17438-17446. First Published on April 3, 2012;
doi:10.1074/jbc.M111.331165 [Abstract] [Full Text] [PDF]
Slit2 Regulates the Dispersal of Oligodendrocyte Precursor Cells via Fyn/RhoA Signaling
Xiujie Liu, Yan Lu, Yong Zhang, Yuanyuan Li, Jiazhen Zhou, Yimin Yuan, Xiaofei
Gao, Zhida Su, and Cheng He
J. Biol. Chem. 2012 287: 17503-17516. First Published on March 20, 2012;
doi:10.1074/jbc.M111.317610 [Abstract] [Full Text] [PDF]
Targeted Deletion of LPA5 Identifies Novel Roles for Lysophosphatidic Acid Signaling in
Development of Neuropathic Pain
Mu-En Lin, Richard R. Rivera, and Jerold Chun
J. Biol. Chem. 2012 287: 17608-17617. First Published on March 29, 2012;
doi:10.1074/jbc.M111.330183 [Abstract] [Full Text] [PDF]
Differential Dorso-ventral Distributions of Kv4.2 and HCN Proteins Confer Distinct
Integrative Properties to Hippocampal CA1 Pyramidal Cell Distal Dendrites
Béatrice Marcelin, Joaquin N. Lugo, Amy L. Brewster, Zhiqiang Liu, Alan S. Lewis,
Shawn McClelland, Dane M. Chetkovich, Tallie Z. Baram, Anne E. Anderson, Albert
Becker, Monique Esclapez, and Christophe Bernard
J. Biol. Chem. 2012 287: 17656-17661. First Published on April 16, 2012;
doi:10.1074/jbc.C112.367110 [Abstract] [Full Text] [PDF] [Supplemental Data]
L-MPZ, a Novel Isoform of Myelin P0, Is Produced by Stop Codon Readthrough
Yoshihide Yamaguchi, Akiko Hayashi, Celia W. Campagnoni, Akio Kimura, Takashi
Inuzuka, and Hiroko Baba
J. Biol. Chem. 2012 287: 17765-17776. First Published on March 28, 2012;
doi:10.1074/jbc.M111.314468 [Abstract] [Full Text] [PDF]
Plant Biology
Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia
chartacea and Effects of Methionine Oxidation on Bioactivities
Giang Kien Truc Nguyen, Wei Han Lim, Phuong Quoc Thuc Nguyen, and James P.
Tam
J. Biol. Chem. 2012 287: 17598-17607. First Published on March 30, 2012;
doi:10.1074/jbc.M111.338970 [Abstract] [Full Text] [PDF] [Supplemental Data]
Two Chimeric Regulators of G-protein Signaling (RGS) Proteins Differentially Modulate
Soybean Heterotrimeric G-protein Cycle
Swarup Roy Choudhury, Corey S. Westfall, John P. Laborde, Naveen C. Bisht, Joseph
M. Jez, and Sona Pandey
J. Biol. Chem. 2012 287: 17870-17881. First Published on April 2, 2012;
doi:10.1074/jbc.M112.353219 [Abstract] [Full Text] [PDF] [Supplemental
Data][Supplemental Data]
Protein Structure and Folding
Structural Snapshots of Yeast Alkyl Hydroperoxide Reductase Ahp1 Peroxiredoxin
Reveal a Novel Two-cysteine Mechanism of Electron Transfer to Eliminate Reactive
Oxygen Species
Fu-Ming Lian, Jiang Yu, Xiao-Xiao Ma, Xiao-Jie Yu, Yuxing Chen, and Cong-Zhao
Zhou
J. Biol. Chem. 2012 287: 17077-17087. First Published on April 2, 2012;
doi:10.1074/jbc.M112.357368 [Abstract] [Full Text] [PDF] [Supplemental Data]
Autoantigen Conformation Influences Both B- and T-cell Responses and
Encephalitogenicity
Katrien L. de Graaf, Monika Albert, and Robert Weissert
J. Biol. Chem. 2012 287: 17206-17213. First Published on April 5, 2012;
doi:10.1074/jbc.M111.304246 [Abstract] [Full Text] [PDF]
Calcium-induced Conformational Changes in C-terminal Tail of Polycystin-2 Are
Necessary for Channel Gating
Andjelka S. Celic, Edward T. Petri, Jennifer Benbow, Michael E. Hodsdon, Barbara E.
Ehrlich, and Titus J. Boggon
J. Biol. Chem. 2012 287: 17232-17240. First Published on April 3, 2012;
doi:10.1074/jbc.M112.354613 [Abstract] [Full Text] [PDF] [Supplemental Data]
Selective Recruitment of an E2
Ubiquitin Complex by an E3 Ubiquitin Ligase
Donald E. Spratt, Kenneth Wu, Jordan Kovacev, Zhen-Qiang Pan, and Gary S. Shaw
J. Biol. Chem. 2012 287: 17374-17385. First Published on March 20, 2012;
doi:10.1074/jbc.M112.353748 [Abstract] [Full Text] [PDF] [Supplemental Data]
AUTHOR'S CHOICE
Extra-domain B in Oncofetal Fibronectin Structurally Promotes Fibrillar Head-to-tail
Dimerization of Extracellular Matrix Protein
André Schiefner, Michaela Gebauer, and Arne Skerra
J. Biol. Chem. 2012 287: 17578-17588. First Published on March 22, 2012;
doi:10.1074/jbc.M111.303131 [Abstract]
[Full Text] [PDF]
3'-Phosphoadenosine 5'-Phosphosulfate (PAPS) Synthases, Naturally Fragile Enzymes
Specifically Stabilized by Nucleotide Binding
Johannes van den Boom, Dominik Heider, Stephen R. Martin, Annalisa Pastore, and
Jonathan W. Mueller
J. Biol. Chem. 2012 287: 17645-17655. First Published on March 26, 2012;
doi:10.1074/jbc.M111.325498 [Abstract] [Full Text] [PDF] [Supplemental Data]
AUTHOR'S CHOICE
Atypical Membrane-embedded Phosphatidylinositol 3,4-Bisphosphate (PI(3,4)P2)-binding
Site on p47phox Phox Homology (PX) Domain Revealed by NMR
Pavlos Stampoulis, Takumi Ueda, Masahiko Matsumoto, Hiroaki Terasawa, Kei
Miyano, Hideki Sumimoto, and Ichio Shimada
J. Biol. Chem. 2012 287: 17848-17859. First Published on April 4, 2012;
doi:10.1074/jbc.M111.332874 [Abstract] [Full Text] [PDF] [Supplemental Data]
Protein Synthesis and Degradation
Cathepsins L and Z Are Critical in Degrading Polyglutamine-containing Proteins within
Lysosomes
Nidhi Bhutani, Rosanna Piccirillo, Raphael Hourez, Prasanna Venkatraman, and Alfred
L. Goldberg
J. Biol. Chem. 2012 287: 17471-17482. First Published on March 27, 2012;
doi:10.1074/jbc.M112.352781 [Abstract] [Full Text] [PDF] [Supplemental Data]
RNA
Extra Double-stranded RNA Binding Domain (dsRBD) in a Squid RNA Editing Enzyme
Confers Resistance to High Salt Environment
Juan Pablo Palavicini, Rodrigo A. Correa-Rojas, and Joshua J. C. Rosenthal
J. Biol. Chem. 2012 287: 17754-17764. First Published on March 28, 2012;
doi:10.1074/jbc.M112.366005 [Abstract] [Full Text] [PDF] [Supplemental Data]
The FF4 and FF5 Domains of Transcription Elongation Regulator 1 (TCERG1) Target
Proteins to the Periphery of Speckles
Noemí Sánchez-Hernández, Lidia Ruiz, Miguel Sánchez-Álvarez, Marta Montes, Maria
J. Macias, Cristina Hernández-Munain, and Carlos Suñé
J. Biol. Chem. 2012 287: 17789-17800. First Published on March 27, 2012;
doi:10.1074/jbc.M111.304782 [Abstract] [Full Text] [PDF] [Supplemental Data]
Signal Transduction
Selective Gαi Subunits as Novel Direct Activators of Transient Receptor Potential
Canonical (TRPC)4 and TRPC5 Channels
Jae-Pyo Jeon, Chansik Hong, Eun Jung Park, Ju-Hong Jeon, Nam-Hyuk Cho, In-Gyu
Kim, Han Choe, Shmuel Muallem, Hyun Jin Kim, and Insuk So
J. Biol. Chem. 2012 287: 17029-17039. First Published on March 28, 2012;
doi:10.1074/jbc.M111.326553 [Abstract] [Full Text] [PDF] [Supplemental Data]
α2β1 Integrin Promotes Chemoresistance against Doxorubicin in Cancer Cells through
Extracellular Signal-regulated Kinase (ERK)
Dalila Naci, Mohammed-Amine El Azreq, Nizar Chetoui, Laura Lauden, François
Sigaux, Dominique Charron, Reem Al-Daccak, and Fawzi Aoudjit
J. Biol. Chem. 2012 287: 17065-17076. First Published on March 28, 2012;
doi:10.1074/jbc.M112.349365 [Abstract] [Full Text] [PDF] [Supplemental Data]
Loss of T Regulatory Cell Suppression following Signaling through Glucocorticoidinduced Tumor Necrosis Receptor (GITR) Is Dependent on c-Jun N-terminal Kinase
Activation
Anthony Joetham, Hiroshi Ohnishi, Masakazu Okamoto, Katsuyuki Takeda, Michaela
Schedel, Joanne Domenico, Azzeddine Dakhama, and Erwin W. Gelfand
J. Biol. Chem. 2012 287: 17100-17108. First Published on March 29, 2012;
doi:10.1074/jbc.M111.316943 [Abstract] [Full Text] [PDF]
Physical and Functional Interaction between Ribosomal Protein L11 and the Tumor
Suppressor ARF
Mu-Shui Dai, Kishore B. Challagundla, Xiao-Xin Sun, Lakshmi Reddy Palam, Shelya
X. Zeng, Ronald C. Wek, and Hua Lu
J. Biol. Chem. 2012 287: 17120-17129. First Published on March 30, 2012;
doi:10.1074/jbc.M111.311902 [Abstract] [Full Text] [PDF]
Prostaglandin EP1 Receptor Down-regulates Expression of Cyclooxygenase-2 by
Facilitating Its Proteasomal Degradation
Ariz Haddad, Galit Flint-Ashtamker, Waleed Minzel, Rapita Sood, Gilad Rimon, and
Liza Barki-Harrington
J. Biol. Chem. 2012 287: 17214-17223. First Published on April 3, 2012;
doi:10.1074/jbc.M111.304220 [Abstract] [Full Text] [PDF] [Supplemental Data]
Megakaryocytes Regulate Expression of Pyk2 Isoforms and Caspase-mediated Cleavage
of Actin in Osteoblasts
Melissa A. Kacena, Pierre P. Eleniste, Ying-Hua Cheng, Su Huang, Mahesh Shivanna,
Tomas E. Meijome, Lindsey D. Mayo, and Angela Bruzzaniti
J. Biol. Chem. 2012 287: 17257-17268. First Published on March 23, 2012;
doi:10.1074/jbc.M111.309880 [Abstract] [Full Text] [PDF]
Small Ubiquitin-like Modifier (SUMO) Modification of Zinc Finger Protein 131
Potentiates Its Negative Effect on Estrogen Signaling
Yohan Oh and Kwang Chul Chung
J. Biol. Chem. 2012 287: 17517-17529. First Published on March 30, 2012;
doi:10.1074/jbc.M111.336354 [Abstract] [Full Text] [PDF] [Supplemental Data]
Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in
Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling
Bruno D. Fonseca, Graham H. Diering, Michael A. Bidinosti, Kush Dalal, Tommy
Alain, Aruna D. Balgi, Roberto Forestieri, Matt Nodwell, Charles V. Rajadurai, Cynthia
Gunaratnam, Andrew R. Tee, Franck Duong, Raymond J. Andersen, John Orlowski,
Masayuki Numata, Nahum Sonenberg, and Michel Roberge
J. Biol. Chem. 2012 287: 17530-17545. First Published on April 2, 2012;
doi:10.1074/jbc.M112.359638 [Abstract] [Full Text] [PDF] [Supplemental Data]
p53 Binding Prevents Phosphatase-mediated Inactivation of Diphosphorylated c-Jun Nterminal Kinase
Pramod S. Gowda, Fuchun Zhou, Linda V. Chadwell, and Donald G. McEwen
J. Biol. Chem. 2012 287: 17554-17567. First Published on March 30, 2012;
doi:10.1074/jbc.M111.319277 [Abstract] [Full Text] [PDF] [Supplemental Data]
Involvement of Phosphoinositide 3-Kinase and PTEN Protein in Mechanism of Activation
of TRPC6 Protein in Vascular Smooth Muscle Cells
Michaël Monet, Nancy Francoeur, and Guylain Boulay
J. Biol. Chem. 2012 287: 17672-17681. First Published on April 5, 2012;
doi:10.1074/jbc.M112.341354 [Abstract] [Full Text] [PDF] [Supplemental Data]
Forkhead Transcription Factor FOXO3a Protein Activates Nuclear Factor
B through
B-cell lymphoma/leukemia 10 (BCL10) Protein and Promotes Tumor Cell Survival in
Serum Deprivation
Zhaodong Li, Haisheng Zhang, Ying Chen, Li Fan, and Jing Fang
J. Biol. Chem. 2012 287: 17737-17745. First Published on April 2, 2012;
doi:10.1074/jbc.M111.291708 [Abstract] [Full Text] [PDF]
The Role of ERp44 in Maturation of Serotonin Transporter Protein
Samuel Freyaldenhoven, Yicong Li, Arif M. Kocabas, Enrit Ziu, Serra Ucer, Raman
Ramanagoudr-Bhojappa, Grover P. Miller, and Fusun Kilic
J. Biol. Chem. 2012 287: 17801-17811. First Published on March 26, 2012;
doi:10.1074/jbc.M112.345058 [Abstract] [Full Text] [PDF]
Additions and Corrections
Dihydroceramide-based response to hypoxia.
Cecilia M. Devlin, Tim Lahm, Walter C. Hubbard, Mary Van Demark, Kevin C. Wang,
Xue Wu, Alicja Bielawska, Lina M. Obeid, Mircea Ivan, and Irina Petrache
J. Biol. Chem. 2012 287: 17425. First Published ; doi:10.1074/jbc.A111.297994 [Full Text]
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