CHAPTER 27 The Reproductive System © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-2 Learning Outcomes 27.1 List the organs of the male reproductive system and give the locations, structures, and functions of each. 27.2 Describe how sperm cells are formed. 27.3 Describe the substances found in semen. 27.4 Describe the process of erection and ejaculation. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-3 Learning Outcomes (cont.) 27.5 List the actions of testosterone. 27.6 Describe the causes, signs and symptoms, and treatment of various disorders of the male reproductive system. 27.7 List the organs of the female reproductive system and give the locations, structures, and functions of each. 27.8 Explain how ova develop. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-4 Learning Outcomes (cont.) 27.9 List the actions of estrogen and progesterone. 27.10 Explain how and when ovulation occurs. 27.11 Describe what happens to an ovum after ovulation occurs. 27.12 List the purpose and events of the menstrual cycle. 27.13 Define menopause and explain what causes it. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-5 Learning Outcomes (cont.) 27.14 Describe the causes, signs and symptoms, and treatments of various disorders of the female reproductive system. 27.15 Explain how and where fertilization occurs. 27.16 Describe the process of implantation. 27.17 Explain the difference between an embryo and a fetus. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-6 Learning Outcomes (cont.) 27.18 Describe the changes that occur in a woman during pregnancy. 27.19 List several birth control methods and explain why they are effective. 27.20 List the causes of and treatments for infertility. 27.21 Describe the causes, signs and symptoms, and treatments of the most common sexually transmitted diseases. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-7 Introduction • Male and female reproductive systems – Function together to produce offspring – Female reproductive system nurtures developing offspring – Produce important hormones © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-8 Male Reproductive System • Testes – Primary organs • Develop in the abdominal pelvic cavity of fetus • Scrotum – sac that holds the testes • Seminiferous tubules – On top of testes • Descend into scrotal sac shortly before or after birth – Filled with spermatogenic cells that produce sperm cells – Produce the male sex cells (sperm) – Produce the male hormone testosterone • Interstitial cells produce testosterone Male System © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-10 Spermatogenesis Spermatogenesis Spermatogonia (46 chromosomes) Mitosis – makes primary spermatocytes Undergo meiosis two secondary spermatocytes Divides – two spermatids = 4 spermatids Develop flagella to become mature sperm cells with 23 chromosomes © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-11 Sperm Cells • Head – Nucleus with 23 chromosomes – Acrosome – enzymefilled sac • Tail – Flagellum that propels sperm forward • Helps sperm penetrate ovum • Midpiece – Mitochrondria that generate cell’s energy © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-13 Male Internal Accessory Organs • Epididymis – Sits on top of each testis – Receives spermatids from seminiferous tubules – Spermatids become sperm cells • Vas deferens – Tube connected to epididymis – Carries sperm cells to urethra • Seminal vesicle – Secrete • Fluid rich in sugar used to make energy • Prostaglandins – stimulate muscular contractions in female to propel sperm forward – Seminal fluid • Released into vas deferens just before ejaculation • 60% of semen volume Male System © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-14 Male Internal Accessory Organs (cont.) • Prostate gland – Surrounds urethra – Produces and secretes a milky, alkaline fluid into urethra just before ejaculation – Fluid protects sperm in the acidic environment of the vagina – 40% of semen • Bulbourethral (Cowper’s) glands – Produce a mucus-like fluid • Secreted just before ejaculation • Lubricates end of penis • Semen – Alkaline mixture • Nutrients • Prostoglandins – 1.5 to 5.0 ml per ejaculate – Sperm count of 40 to 250 million/mL Male System © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-15 Male External Accessory Organs • Scrotum – Holds testes away from body • Penis – Shaft • Erectile tissues surround urethra – Temperature 1° below body temperature – Glans penis – Lined with serous membrane that secrets fluid – Prepuce • Testes move freely • Cone-shaped structure on end of penis • Skin covering glans penis in uncircumcised males – Functions • Deliver sperm • Urination Male System © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-16 Erection, Orgasm, and Ejaculation • Erection – Parasympathetic nervous system stimulates erectile tissue – Becomes engorged with blood • Orgasm – Sperm cells propelled out of testes into urethra – Secretions from accessory organs also released into urethra • Ejaculation – Semen is forced out of urethra – Sympathetic nerves then stimulate erectile tissue to release blood – Penis returns to flaccid state © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-17 Male Reproductive Hormones • Hypothalamus – Gonadotropin-releasing hormone (GnRH) • Stimulates anterior pituitary to release – Follicle-stimulating hormone (FSH) – initiates spermatogenesis – Luteinizing hormone (LH) – stimulates interstitial cells in the testes to produce testosterone – Testosterone • Secondary sex characteristics • Maturation of male reproductive organs • Regulated by negative feedback © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-18 Apply Your Knowledge Matching: ANSWER: D Vasectomy ___ A. Spermatogenesis ___ F Mixture of sperm and fluids B. Testes A Sperm cell formation ___ C. Penis ___ G Secrete alkaline fluid/prostaglandins D. Vas deferens B Produce testosterone ___ E. Hypothalamus E GnRH ___ F. Semen ___ C Erectile tissue G. Seminal vesicle © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-19 Diseases and Disorders of the Male Reproductive System Disease/Disorder Description Benign prostatic hypertrophy (BPH) Nonmalignant enlargement of the prostate gland; common in older men Epididymitis Inflammation of an epididymis; usually starts as an urinary tract infection Impotence or erectile Disorder in which erection cannot be achieved or dysfunction (ED) maintained; about 50% of males between 40 and 70 have some degree of ED © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-20 Diseases and Disorders of the Male Reproductive System Disease/Disorder Description Prostate cancer Most common form of cancer in men over 40; risks of developing it increase with age Prostatitis Inflammation of the prostate gland; may be acute or chronic Testicular cancer Malignant growth in one or both testicles; more common in males 15–30 years; more aggressive malignancy © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-21 Apply Your Knowledge Your patient has an elevated PSA. What is a PSA and what does it indicate? ANSWER: The PSA is a prostate-specific antigen in the blood. Elevations of the PSA may indicate prostate cancer. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-22 Female Reproductive System • Ovaries (2) – Primary sex organs produce • Sex cells called ova • Hormones estrogen and progesterone – Located in the pelvic cavity – Medulla • Inner area; contains nerves, lymphatic vessels, and blood vessels – Cortex • Outer area; contains ovarian follicles – Covered by epithelial and dense connective tissues Female System © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-24 Ovum Formation (cont.) • Primordial follicles develop before birth and contain – A primary oocyte or immature ovum (born with maximum number) – Follicular cells • Oogenesis is the process of ovum formation – At puberty, primary oocytes are stimulated to continue meiosis • Becomes 1 polar body (a nonfunctional cell) and • A secondary oocyte – Secondary oocyte released during ovulation – If fertilized, the oocyte divides to form a mature, fertilized ovum © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-25 Female Internal Accessory Organs • Fallopian tube – oviduct – Infundibulum and fimbriae • Fringed, expanded end of fallopian tube near ovary • Function to “catch” an ovum – Muscular tube • Lined with mucous membrane and cilia • Propels ovum toward uterus Internal Accessory Organs © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-26 Female Internal Accessory Organs (cont.) • Uterus – Hollow, muscular organ – Receives embryo and sustains its development – Divisions • Fundus – domed upper portion • Body – main portion • Cervix – narrow, lower section extending into vagina (cervical orifice) Internal Accessory Organs – Wall of uterus • Endometrium – Innermost lining – Vascular – Tubular glands – mucus • Myometrium – Middle, thick, muscular layer • Perimetrium – Thin layer covering the myometrium – Secretes serous fluid to coat and protect uterus © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-27 Female Internal Accessory Organs (cont.) • Vagina – Tubular, muscular organ – Extends from uterus to outside body (vaginal introitus) – Muscular folds – rugae – enable expansion • Receive erect penis • Passage for delivery of offspring and uterine secretions – Wall • Innermost mucosal layer • Middle muscular layer • Outer fibrous layer Internal Accessory Organs © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-28 Internal Female Organs Back © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-29 External Accessory Organs • Mammary glands – Secretion of milk – Structures • Nipple – Oxytocin induces lactiferous ducts to deliver milk through openings • Areola – pigmented area around nipple • Alveolar glands – within mammary glands – Make milk when stimulated by prolactin © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-30 External Genitalia • Collectively known as the vulva • Labia majora – Rounded folds of adipose tissue and skin – Protect other external reproductive organs • Labia minora – – – – Folds of skin between labia majora Very vascular Merge to form hood over clitoris Vestibule – space enclosed by labia minora • Bartholin’s glands secrete mucus during sexual arousal External Genitalia © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-31 External Genitalia (cont.) • Clitoris – Anterior to urethral meatus – Contains female erectile tissue – Rich in sensory nerves • Perineum – Between vagina and anus – Area for episiotomy, if needed, during birth process External Genitalia © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-32 Erection, Lubrication, and Orgasm • Nervous stimulation – Clitoris becomes erect – Bartholin’s glands activate – lubrication – Vagina elongates • Orgasm – Sufficient stimulation of clitoris – Walls of uterus and fallopian tubes contract to propel sperm up tubes © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-33 Female Reproductive Hormones Hypothalamus secretes GnRH GnRH Anterior pituitary releases FSH & LH Estrogen and progesterone Ovaries to produce estrogen and progesterone Responsible for development of secondary sex characteristics © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-34 Reproductive Cycle • Menstrual cycle – Regular changes in uterine lining, resulting in monthly bleeding • Menarche – first menstrual period • Menopause – termination of cycle due to normal aging of ovaries © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-35 Reproductive Cycle (cont.) Anterior pituitary releases FSH Then releases LH Ovarian follicle matures and secretes estrogen Triggers ovulation Follicular cells become corpus luteum, which secretes progesterone Uterine lining thickens Lining more vascular and glandular Without fertilization Corpus luteum degenerates Estrogen and progesterone levels fall Uterine lining breaks down – menses starts Cycle begins again with release of FSH © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-36 YIPPEE! Apply Your Knowledge True or False: ANSWER: F The ovaries only produce estrogen. ___ produce estrogen and progesterone F Ovulation is the process of ovum formation. ___ Oogenesis T The fallopian tube is also called the oviduct. ___ F The endometrium is the outer layer of the uterine wall. ___ inner layer T Alveolar glands produce milk. ___ F ___Oxytocin induces the alveolar glands to deliver milk through the nipples. lactiferous ducts ___ F Menarche is the termination of the menstrual cycle. first T Menopause occurs due to normal aging of the ovaries. ___ © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-37 Diseases and Disorders of the Female Reproductive System Disease/Disorder Description Breast cancer Second leading cause of cancer deaths in women; classified as stage 0 to 4 Cervical cancer Slow to develop; Pap smear detects abnormal cervical cells Cervicitis Inflammation of the cervix usually due to an infection Dysmenorrhea Condition with severe menstrual cramps that limit normal activities © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-38 Diseases and Disorders of the Female Reproductive System (cont.) Disease/Disorder Description Endometriosis Tissues of uterine lining growing outside of the uterus Fibrocystic breast disease Abnormal cystic tissue in the breast; size varies related to menstrual cycle; common in 60% of women between 30 and 50 Fibroids Benign tumors in the uterine wall; affect 25% of women in their 30s and 40s Ovarian cancer Considered more deadly than other types; detection difficult and often spreads before detection © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-39 Diseases and Disorders of the Female Reproductive System (cont.) Disease/Disorder Description Premenstrual syndrome (PMS) Collection of symptoms occurring just before a menstrual period Vaginitis/ vulvovaginitis Inflammation of the vagina/inflammation of vagina and vulva; both associated with abnormal vaginal discharge Uterine (endometrial) cancer Most common in post-menopausal women; causes about 6% of cancer deaths in women © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-40 Apply Your Knowledge Matching: ANSWER: ___ E Inflammation of the cervix A. Dysmenorrhea ___ G Cancer common in post-menopausal women B. Cervical cancer ___ B Develops slowly; detected by Pap smear C. Fibroids ___ F Uterine tissue grows outside uterus D. Breast cancer ___ D Second leading cause of cancer death in women E. Cervicitis ___ A Severe menstrual cramps F. Endometriosis ___ C Benign tumors in the uterine wall G. Uterine cancer © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-41 Pregnancy • Pregnancy – condition of having a developing offspring in the uterus • Fertilization – process in which a sperm cell unites with an ovum; results in pregnancy – Only one sperm cell penetrates the follicular cells and the zona pellucida that surround the ovum’s cell membrane – After fertilization, ovum releases enzymes that cause the zona pellucida to become impenetrable to other sperm – Zygote forms from union of ovum and sperm • Contains 46 chromosomes © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-42 The Prenatal Period • Time before birth • Zygote – undergoes rapid mitosis – First week after fertilization – Cleavage – rapid cell division – Morula – ball of cells resulting from cleavage • Travels down fallopian tube to uterus • Becomes blastocyst, which implants in endometrial wall – Blastocyst • Some cells (inner cell mass) become embryo • Others, along with cells from uterus, form placenta © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-43 The Prenatal Period (cont.) • Embryonic period – Week 2 through 8 – Inner cell mass organizes into three primary germ layers • Ectoderm • Mesoderm • Endoderm – Formation of • Placenta • Amnion • Umbilical cord • Yolk sack • Most internal organs and external structures of embryo © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-44 The Prenatal Period (cont.) – Last 3 months – fetal brain cells rapidly divide – GI and respiratory systems last to develop • Fetal period – Week 8 through birth – Rapid growth – 5th month – skeletal muscles active – 6th month – gains weight © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-45 Fetal Circulation • Placenta and umbilical blood vessels carry out the exchange of nutrients, oxygen, and waste products • Unique differences from normal circulation – Foramen ovale – hole between right and left atria enables most of fetal blood to bypass lungs – Ductus arteriosus – connection between pulmonary trunk and aorta – Ductus venosus – vessel that bypasses liver © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-46 Hormonal Changes During Pregnancy • Embryonic cells secrete human chorionic gonadotropin (HCG) – Maintains the corpus luteum • Estrogen and progesterone – Secreted by corpus luteum and placenta – Functions • Stimulate uterine lining to thicken, development of mammary glands, enlargement of female reproductive organs • Inhibit release of FSH and LH from anterior pituitary gland (preventing ovulation) and uterine contractions © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-47 Hormonal Changes (cont.) • Relaxin – From corpus luteum – Inhibits uterine contractions and relaxes ligaments of pelvis • Lactogen – From placenta – Stimulates enlargements of mammary glands • Aldosterone – From adrenal gland – Increases sodium and water retention • Parathyroid hormone (PTH) – Helps maintain high calcium levels in the blood © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-48 Apply Your Knowledge What are the primary germ layers and what tissue develops from them? ANSWER: The primary germ layers are the: Ectoderm – nervous tissue and some epithelial tissue Mesoderm – connective tissue and some epithelial tissue Endoderm – epithelial tissue only © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-49 The Birth Process • Begins when progesterone levels fall • Prostaglandins secreted by uterus stimulate uterine contractions • Uterine contractions stimulate posterior pituitary gland to release oxytocin • Oxytocin stimulates strong uterine contractions © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-50 The Birth Process (cont.) • Three stages – Dilation • Cervix thins and softens (effacement) • Lasts 8 – 24 hours – Expulsion or parturition • Actual birth • May take 30 minutes or less – Placental stage – 10 to 15 minutes after the birth, the placenta separates from uterine wall and is expelled © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-51 The Birth Process (cont.) • The postnatal period – Six-week period following birth • Neonatal period – first four weeks • Neonate is adjusting to life outside uterus • Milk production and secretion – Prolactin – production of milk – Oxytocin – ejection of milk from mammary gland ducts – Production continues as long as breastfeeding continues © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-52 Apply Your Knowledge What are the three stages of the birth process and what occurs during each? ANSWER: The three stages are: Dilation – the cervix thins, softens (effacement), and dilates to approximately 10 cm Expulsion – also called parturition; the actual birth stage Placental stage – placenta separates from uterine wall and is expelled Impressive! © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-53 Contraception Method Description Coitus interruptus Penis is withdrawn from vagina before ejaculation; not a reliable method Rhythm method Requires abstinence around time of ovulation; not a reliable method Mechanical barriers Prevent sperm from entering female reproductive tract Chemical barriers Destroy sperm in the female reproductive tract; primarily spermicides; often used with mechanical barriers © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-54 Contraception (cont.) Method Description Oral contraceptives Birth control pills; prevent ovulation by preventing LH surge Injectable contraceptives Prevent ovulation and alter lining of uterus to prevent implantation of blastocyst Insertable contraceptives Ring inserted vaginally and removed at the beginning of the 4th week to allow menstruation Contraceptive implants Small rods of progesterone implanted beneath skin; prevent ovulation © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-55 Contraception (cont.) Method Description Transdermal contraceptives Contraceptives in the form of a patch; applied weekly for 3 weeks; not used the 4th week to allow menstruation Intrauterine device Small, solid devices placed into uterus by MD; (IUD) prevents implantation of blastocyst Surgical methods Tubal ligation – fallopian tube fulgurated to prevent sperm from reaching oocyte Vasectomy – vas deferens is fulgurated to prevent ejaculation of sperm © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-56 Apply Your Knowledge Your patient has just been told that she is pregnant, but she does not understand why she could get pregnant. She states, “ I have been using the rhythm method of birth control very carefully.” What patient teaching would you do to assist her to understand? ANSWER: The rhythm method is not as effective as other birth control, because it is sometimes difficult to tell when ovulation occurs. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-57 Infertility • Inability to conceive a child – Primary – no prior pregnancy, unable to achieve pregnancy in 12 months – Secondary – at least one prior pregnancy, unable to achieve pregnancy after one year – Causes • 15% unknown • 35% male-related problems • 50% female-related problems © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-58 Infertility (cont.) • Male-related – Impotence – Retrograde ejaculation – Low or absent sperm count – Medications/drugs – Decreased testosterone – Scarring from STDs – Prior mumps infection – Inflammation of epididymis or testes • Female-related – Scarring from STDs – Pelvic inflammatory disease – Inadequate diet – No ovulation or menstrual cycle – Endometriosis – Abnormal shape of uterus or cervix – Hormonal imbalances – Cysts in ovaries – Older than 40 years © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-59 Infertility (cont.) • Tests – Semen analysis – Monitoring of morning body temperature – Blood hormone measurements – Endometrial biopsy – Urine analysis for LH – Hysterosalpingogram – Laparoscopy • Treatments – Surgical repair of abnormalities – Fertility drugs – Hormone therapies – Artificial insemination – In vitro fertilization – Use of surrogate © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-60 Apply Your Knowledge Indicate whether each cause of infertility is male-related (M), female-related (F), or both (B). ANSWER: M Retrograde ejaculation ___ M Mumps infection ___ F Inadequate diet ___ B Scarring from STDs ___ F ___ Pelvic inflammatory disease F ___ Hormone imbalances M ___ Use of some medications ___ F Being over 40 years old Very good! © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-61 Sexually Transmitted Diseases STD Cause AIDS HIV virus causes AIDS; described in Chapter 21 Chlamydia Caused by bacterium; most commonly reported; often no symptoms in female Genital warts Caused by HPV; not everyone infected has symptoms Gonorrhea Bacterial cause © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-62 Sexually Transmitted Diseases (cont.) STD Cause Herpes simplex Caused by viruses; type I causes cold sores; type II commonly known as genital herpes; may be passed from mother to child during childbirth Pubic lice Parasitic infestation; commonly called crabs Syphilis Caused by bacteria; decreasing in women but increasing in males who have sex with other males Trichomoniasis Caused by protozoan parasite; also called trichomonas infection or “trich” © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-63 Apply Your Knowledge Match: ANSWER: D Most commonly reported STD in the U.S. ___ A. F Two types; both caused by a virus ___ B. E Crabs ___ C. C Increasing incidence in males ___ D. A Common bacterial STD; can also grow in mouth E. ___ B Caused by HPV virus ___ F. S Gonorrhea U Genital warts P Syphilis E Chlamydia R Pubic lice ! Herpes simplex © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-64 In Summary 27.1 The organs of the male reproductive system include the testes, responsible for sperm and hormone production, and the accessory organs of vas deferens, seminal vesicles, prostate and bulbourethral glands, scrotum, and penis. 27.2 Spermatogenesis begins in the seminiferous tubules of the testes. They mature in the epididymis first as spermatogonia, then as spermatocytes, and finally as spermatids. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-65 In Summary (cont.) 27.3 Semen is a mixture of seminal fluid, prostatic fluid, sperm cells, and lubricating bulbourethral fluid. 27.4 Erection occurs during sexual arousal, causing penile engorgement with blood. Ejaculation occurs when semen and its sperm cells are forced out of the body through the urethra. 27.5 Testosterone is responsible for the male secondary sex characteristics and maturation of the male reproductive organs. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-66 In Summary (cont.) 27.6 The diseases of the male reproductive system vary widely between simple inflammation and cancers. The more common diseases and disorders, with their varied symptoms and treatments, are outlined in the Pathophysiology section of this chapter, immediately following the A&P of the male reproductive system. 27.7 The organs of the female reproductive system include the ovaries, fallopian tubes, uterus, and vagina. The external accessory organs include the mons pubis, labia majora and minora, clitoris, urethral meatus, vaginal orifice, Bartholin’s glands, perineum, and mammary glands. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-67 In Summary (cont.) 27.8 Ova originate from the primordial follicles within the ovaries present during fetal development, which produce the oocyte and follicular cells responsible for oogenesis. 27.9 Estrogen is responsible for female secondary sex characteristics. Both estrogen and progesterone stimulate the uterine lining to thicken in preparation for pregnancy and inhibit uterine contractions during pregnancy. 27.10 Ovulation occurs when the anterior pituitary releases a surge of LH, causing the release of a mature ovum. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-68 In Summary (cont.) 27.11 The follicular cells become the corpus luteum, which releases more progesterone, which causes the uterine lining to become more vascular and glandular to prepare for the pregnancy. 27.12 The female menstrual cycle causes periodic changes in the uterine lining. After a menstrual period, the body prepares for the next ovulatory cycle with increasing levels of estrogen and progesterone. If pregnancy does not occur, these levels drop, causing the uterine lining to break down and resulting in the next menstrual period. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-69 In Summary (cont.) 27.13 Menopause is the cessation of the menstrual cycle related to normal aging of the ovaries. 27.14 The diseases of the female reproductive system vary widely between simple inflammation and cancers. The more common diseases and disorders, with their varied symptoms and treatments, are outlined in the Pathophysiology section of this chapter, immediately following the A&P of the female reproductive system. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-70 In Summary (cont.) 27.15 Fertilization occurs with the union of a sperm cell and ovum; usually occurs within the fallopian tubes, but may occur anywhere in the female reproductive tract. 27.16 The fertilized ovum, now a blastocyst, implants in the endometrial wall of the uterus. 27.17 The embryonic period occurs from week 28 of the pregnancy, and the fetal period is from week 9 through delivery. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-71 In Summary (cont.) 27.18 Hormonal changes stimulate the uterine lining and inhibit FSH and LH production to prevent ovulation. Mammary glands are stimulated and enlarged, uterine contractions are inhibited, and the pelvic ligaments loosen in preparation for delivery. 27.19 Some of the contraceptive methods include coitus interruptus; barrier methods; chemical barriers; oral contraceptives; injectable, implantable and insertable contraceptives; and intrauterine devices. Their mechanisms are discussed in detail within the chapter. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-72 In Summary (cont.) 27.20 The causes of infertility are varied, with about 15% of infertility for unknown causes. A number of infertility tests and treatments are discussed within the chapter. 27.21 There are many sexually transmitted diseases, all passed between sexual partners (heterosexual and same-sex partners alike). Their symptoms, treatments, and sequelae for both sexes are discussed in detail in the Pathophysiology section devoted to STDs at the end of this chapter. © 2011 The McGraw-Hill Companies, Inc. All rights reserved. 27-73 End of Chapter 27 The reproduction of mankind is a great marvel and mystery. ~Martin Luther © 2011 The McGraw-Hill Companies, Inc. All rights reserved.