4000 BC - 3000 BC • Believed that illness and disease were caused by supernatural spirits and demons. • Ceremonies were used to drive out evil spirits. • Herbs and plants were used for medication. • Skeletal evidence has been found demonstrating trepanation . • Average life span = 20 years. Trepanation Unearthed in Peru; 6000 BC. Unearthed in Peru; 7000 BC 2000 BC – 300 BC Ancient Egypt • Earliest known health records. • Offerings to gods for healing. Ancient papyrus • Imhotep (2700 BC) first recognized physician. • Use of blood-letting and leeches as treatment. • Herbs and plants used as medicine • Average life span = 20 to 30 years. Imhotep 1700 BC – 220 AD Ancient Chinese Acupuncture • Monitored pulse rate to determine the condition of the body. • Believed in curing whole body by curing the spirit and nourishment: Yin and Yang • First recorded “pharmacy” of herbs. • Use of acupuncture and acupressure. • Began searching for organic causes of disease. • Average life span = 20 to 30 years. 1200 BC – 200 BC Ancient Greeks Hippocrates • The start of the Hippocratic tradition “will cause no harm to the patient”. • Believed illness the result of natural causes. • Introduction of massage therapy and continued use of herbal therapy. • Introduced concept that good diet and cleanliness prevented disease. • Average life span = 25 to 35 years. 753 BC – 410 AD Ancient Romans • First to organize medical care for wounded soldiers. Surgical hooks • Early hospitals allowed for separation of well and sick. • Beginning of public health and sanitation systems. • Diet, exercise and medication used to treat disease. • Average life span = 25 to 35 years. Various surgical tools • Renewed interest in work of Greeks and Romans. • Medical universities open in the 9th century. • Pandemic of bubonic plague occurred. • Chemistry advances in pharmacology. • Average life span = 20 to 35 years. 800 – 1400 AD Middle Ages Doctor dressed for visiting patient believed to suffer from Black Death. 1350 – 1650 AD Renaissance David, by Michelangelo Circle Man, by da Vinci • Dissection of the human body allowed for better understanding of anatomy and physiology • Michelangelo and da Vinci used dissection to give their art a more realistic look. • Invention of the printing press allowed knowledge to be spread to others. • Three important contributors; Vesalius, Servetus, and Bacon • Average life span = 30 to 40 years. 16th and 17th Centuries • Not many discoveries or advances. •Ambroise Pare (1510-1590) •Anton van Leeuwenhoek (1578-1723) • Causes of disease still unknown. • Many died from infection and childbirth fever. • Apothecaries made, prescribed, and sold medications. • Average life span = 35 to 45 years. Mortar & pestle Ambroise Pare 1510-1590 • Father of Modern Surgery • Introduced amputation to battlefield care of wounded soldiers. • Began using ligatures to stop bleeding and bind arteries instead of boilingoil cauterization. • Promoted use of artificial limbs. Anton van Leeuwenhoek 1632-1723 • Developed one of the most important inventions of all time – the microscope! • Began using the lenses to observe the microscopic world. • Discovered bacteria, protists, rotifers, and blood cells. Early microscope Rotifer Franklin 18th Century • Fahrenheit created first mercury thermometer. • Priestly discovered the element oxygen. • Ben Franklin invented bifocals for glasses. • Lind prescribed limes to prevent scurvy. • Jenner developed first smallpox vaccine. • Average life span = 40 – 50 years. Edward Jenner 1749-1823 • Edward Jenner learned early in his medical career that if at one time one had cowpox, they would not get smallpox. • The human immunity from the infection of smallpox was tested by vaccinating patients with fluid from pustules of cowpox-infected patients and then showing that these subjects were immune to smallpox. 19th Century • Many discoveries and inventions • First use of anesthetic for surgeries. • International Red Cross was founded in 1863. • Discovery of bacterial causes of disease. • Average life span = 40 – 60 years. Important Dates • 1819: First successful human blood transfusion by James Blundell. • 1819: Rene Laennec invented the stethoscope. • 1849: Elizabeth Blackwell was the first female physician in the U.S. • 1865: First use of antiseptics during surgery by Joseph Lister. • 1892: Discovery of viruses by Dimitri Ivanfski. • 1895: X-rays discovered by Wilhelm Roentgen. Louis Pasteur 1822-1895 • Worked to disprove the idea of spontaneous generation. • Proved that microorganisms cause disease: Germ Theory of Disease • Developed pasteurization to kill microorganisms in milk. • Created a vaccine for rabies. Gregor Mendel 1822-1884 • Developed Mendel’s Laws of Inheritance. These laws established principles of heredity and dominant/recessive patterns. • Presented his finding to the medical community, but they weren’t widely accepted until the early 1900’s. You name it, it happened! • 1901: ABO blood groups identified • 1920: Health insurance plans are introduced. • 1928: Fleming discovered penicillin • 1952: Development of polio vaccine. • 1953: DNA structure described by Watson & Crick. • 1954: First kidney transplant. • 1962: First severed arm reattached. • 1963: First liver transplant. • 1964: First lung transplant. • 1968; First heart transplant. • 1970: First synthesized gene. • 1975: Amniocentesis used to diagnose birth defects in-utero. And more! Dolly Introduction of sperm into egg cytoplasm • 1978: First test tube baby. • 1981: AIDS appeared in the population. • 1982: Artificial heart is implanted in human. • 1984: HIV identified. • 1990: Gene therapy used to treat disease. • 1990’s: Human Genome The Human Genome Project Project begins • 1997: Dolly the sheep is cloned. Jarvik-7 artifical heart Potential • Cures for current diseases like AIDS. • Gene manipulation to prevent inherited diseases/Designer babies. • Slow the aging process. • Treatment for spinal cord injuries. • Increased average life • Improved transplantation span to 100+ years. techniques. • Reduced antibiotic resistance. • Computerized body parts. • Increased cloning activities.