The Department of Pathology
at CWRU/UHCMC
Missions:
To Heal. To Teach. To Discover.
Cutting Edge Clinical Diagnostics. Clinical and Research Education.
Basic, Translational and Clinical Research.
Pathology department roles are very much engaged
in service to and collaboration with other departments:
1. Clinical: Serve needs of patients and clinicians from other
departments for diagnostic tests.
2. Research: Many collaborations in basic, translational and
clinical research. Basic end of translational research. Tissue
based research.
3. Research education: Pathology graduate program is
explicitly designed to engage interdepartmental participation
and is well suited to many clinical faculty in Medicine given the
focus areas of disease mechanisms, cancer, immunology/I.D.
Pathology Faculty (1° at CWRU/UHCMC) June
2015
32 CWRU-employed Expt Path (1 part-time)
1 CWRU-employed Anatomy Ed
25 UHMG-employed (3 part-time)
12 Case-UHMG dual-employed (AP-9,CP-3;)
5 UHMP-employed
Department of Pathology, 2013
4 UHCMC-employed
Total 79
(includes part time & 1-yr Clin
Instruct x 2)
(Not counted: PRNs; Medical examiner’s
office, VA)
CWRU SOM
UHPS
UHCMC
P. Davis, MD, PhD
M. Nochomovitz, MD
F. Rothstein, MD
Red: Changed since last year
Blue: Department Divisions
Green: Sections
Administrative
Director
C. Zimerla (Admin
Director: CWRU &
UHMG)
(6.5 FTE CWRU; 1.5
UHMG, others UHCMC
90 res staff
~23 Postdocs
~51 PhD stud)
Education
Residency
G MacLennan MD, PhD
W. Xin, MD (AP), C.
Schmotzer, MD (CP), R,
Elliott, MD
PhD Program
J Anderson, MD, PhD
R Petersen, PhD
-ITP: B Cobb, PhD
-CBTP M Jackson, PhD
Chair of Pathology
UHC SVP Ops
C. Harding, MD, PhD
R. Dziedzicki
Division of
Experimental
Pathology
33 faculty
~90 res staff
~23 Postdocs
~51 PhD studs
Division AP
Education
J. Willis, MD
D. Landek
Division of
Anatomic
Pathology
Division of
Clinical
Pathology
G. MacLennan, MD
(24 faculty )
J. Willis, MD
Surgical
Pathology
Ziats, Kaplan
79 faculty CWRU/UH (1°)
~15 other 1° (Med Exam,
VA)
~48 secondary & ~21 adjunct
~33 PhD trainers not 1° or
2°
Administrative Director
UHCMC/UHLSF Labs
T Brantley
MD curriculum
Pathology Academic Affairs
Vice Chair-Clinical Affairs
Medical Director
Division of
Community
Hosp Path
A. Zaher, M.D.
(5 faculty)
Ahuja
Geauga
Richmond
Bedford
Hannah Gilmore, MD
Autopsy
Pathology
W. Xin, MD
Cytology
J. Wasman, MD
UHCMC/UHLSF Labs
Managerial/Technical Staff
~337 FTEs
(1° faculty, 16; 2° faculty, 3)
•Clinical Chemistry – Schmotzer, Noguez
•Microbiology – Jacobs
•Hematology - Myerson, Sandhaus, Beck
•Flow Cytometry - Meyerson, Beck
•Coagulation - Downes
•Blood Bank/Apheresis – Downes, Zhou,
Maitta, Reeves
•HLA Lab – Greenspan, Wald
•Molecular Dx - Zhou
•Clinical Immunology – Kaplan
•Point of Care Testing – Sandhaus
•Genetics - Cytogenetics & Prenatal – Pfau
- Molecular Genetics – Zhang
•CIDEM – Kerr (Peds), McCandless (CHG) 2°
•Mycology – Ghannoum (Derm) 2°
•UHTL - Quinones
Pathology Clinical Leadership
(Overall AP/CP – see section medical
directors for specific lab areas)
AP:
Greg MacLennan, Division Chief
Hannah Gilmore, Director of Surgical Pathology
CP:
Joe Willis, Division Chief
Christine Schmotzer, Associate Division Chief
Pathology Graduate Program
Mission: Research training focused on mechanisms
of disease, including basic and translational research
Constituent Training Programs (51 PhD students)*
1. Molecular & Cellular Basis of Disease Training Program
(MCBDTP): 8 students
• Director: Bob Petersen, PhD.
2. Immunology Training Program (ITP) 27 students
• Director: Brian Cobb, PhD.
• Co-Sponsors: Infectious Diseases, Global Health, Ophthalmology,
CFAR, CCF Immunology.
3. Cancer Biology Training Program (CBTP) 16 students
•
Director, Mark Jackson, PhD.
•
Co-Sponsor: Cancer Center
*INTERDEPARTMENTAL NATURE: Majority of students in Pathology
graduate program are in labs of faculty with primary appointments in other
departments. SECONDARY OR TRAINER APPOINTMENTS.
Major Research Missions:
Synergies with other departments/initiatives
1. Immunology:
• Synergy with I.D., Global Health, Ophthalmology, Gastroenterology,
Dermatology, Rheumatology
• CWRU SOM Strategic Plan – Infect Immun.
2. Cancer Biology:
• Synergy with Cancer Center, many depts
• CWRU SOM Strategic Plan – Cancer.
3. Neuropathology:
•
Synergy with Neuro Institute (Neuro Institute-BHI), Neuroscience, Peds
Heme/Onc, Cancer Center
•
CWRU SOM Strategic Plan – Neuro and Cancer.
4. Other areas corresponding to clinical subspecialty
areas and small basic science focus areas.
National NIH Grant Ranking
#10 of 87 US NIH-funded Pathology depts (FY14)
(up from #13 in 2012, #11 in 2013)
Rank
From the BLUE RIDGE INSTITUTE for MEDICAL RESEARCH
Name
1 UNIVERSITY OF PENNSYLVANIA
2 JOHNS HOPKINS UNIVERSITY
3 EMORY UNIVERSITY
4 NEW YORK UNIVERSITY SCHOOL OF MEDICINE
5 COLUMBIA UNIVERSITY HEALTH SCIENCES
6 UNIVERSITY OF WASHINGTON
7 WASHINGTON UNIVERSITY
8 UNIVERSITY OF MICHIGAN
9 UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
10 CASE WESTERN RESERVE UNIVERSITY
11 UNIVERSITY OF CALIFORNIA SAN DIEGO
12 UNIVERSITY OF MINNESOTA
13 STANFORD UNIVERSITY
14 UNIVERSITY OF ALABAMA AT BIRMINGHAM
15 UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
16 UNIVERSITY OF CHICAGO
17 YALE UNIVERSITY
18 VANDERBILT UNIVERSITY
19 UNIVERSITY OF UTAH
20 UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Blue Ridge Institute for Medical Research (brimr.org)
• Grants, direct plus indirect costs
BRIMR.ORG
Pathology
$43,750,152
$42,912,905
$32,519,648
$27,467,594
$27,428,155
$24,738,513
$24,520,915
$19,237,961
$13,224,486
$12,909,287
$12,886,758
$11,954,531
$11,207,005
$11,167,114
$9,115,125
$9,079,419
$8,660,311
$8,443,632
$8,443,253
$8,346,780
Faculty changes in Experimental
Pathology July 2014-June 2015
1. Selected Arrivals: Sam Xiao, Rafick Sekaly
Goals: Research and Graduate Education
1. Build research and graduate training, primarily in Immunology,
Cancer and Neuropathology, but including selected other areas that
fit with department strengths and missions and SOM strategic plan.
2.Foster research grant success. Build successful collaborative
teams.
3. Faculty recruitment in:
a. Cancer research (general, Hemepath, GI Path)
b. Immunology research
4.Renew training grants. (Note interdepartmental participation).
5.Contribute to institutional planning for Tissue Procurement,
Biobanking with Cancer Center, UH CCRT.
Mission: Clinical Diagnostics
Recent Faculty Changes in Anatomic Path,
Clinical Path
1. Selected AP faculty recruitments 2014-2015: Sarah White
(surgical/breast path), Dan Cowden (renal path service
restart/cytology), Shahrazad Saab (surgical/peds/renal path).
2. Selected AP recruits summer/fall 2015: Qinghu Ren
(surgical/GU path), Holly Harper (surgical path + Ahuja).
3. CP recruits 2014-2015: Jaime Noguez (Clin Chem).
4. CP recruits summer 2015: Navid Sadri (cancer genomics),
Goals: Clinical Faculty Recruitment
1. Clinical Microbiology Director replacement.
2. Hematopathology replacement.
3.Surgical pathology replacement (Avril effort)
4. Surgical pathology Instructor replacement (2)
5. Immunology research (~3 positions over next 2 years).
6. Physician-scientist recruitments (CRI package):
Hematopathology, GI pathology (probably in later year)
Overview of selected 2015-2016 goals
UHMG/UHCMC Pathology
•
•
•
IT/LIS and Informatics: Complete recruitment and organization
of LIS team. Improve test reporting and ordering, develop data
mining and dashboard functions, apply to test
utilization/appropriate test ordering for patient care improvement
and budget savings, develop informatics to apply to genomics.
AP: Enhance sub-specialty service logistics and AP residency
training organization. Tune newly launched renal pathology
service.
CP: Establish Next Gen Sequencing in clinical labs for Cancer
Genomics. Enhance Mol/Gen Dx. New automated microbiology
system.
AP subspecialty services
Full Services:
1
GU
2
Lung, ENT
3
GI Large
4
GI Biopsy
5
Breast
6
Gyn Surgicals
7
Frozen section
8
Non-Gyn cytology
9
Gyn Cytology
10
Pediatric Pathology
Partial services:
11
Bone, soft tissue, skin
12
Neuropathology
13
Transplant/Renal
14
Eye Pathology
16
Autopsy
17
Medical liver
18
Cardiac Pathology
Weight
1
1
1
1
1
1
1
1
1
1
Total services
12.3
0.3
0.6
0.5
0.1
0.4
0.3
0.1
Goals: Clinical Interactions
1. Interdepartmental interactions: Foster engagement of
clinicians with pathologists to enhance patient care,
test interpretation, utilization and reporting to meet
clinical needs.
2. Clinical colleagues urged to reach out to Pathology:
a. When considering changes or additions to
programs that involve laboratory/diagnostic
needs.
b. To engage pathologists in discussion of test
utilization and interpretation.
c. We need to work together to define new test
needs/opportunities, e.g. design gene panels for
NGS cancer genomics.
Goals: Research Interactions
1. Interdepartmental research interactions: Promote
interdepartmental collaborations in basic,
translational, clinical research.
2. Graduate Program (PhD, MD-PhD students).
3. ITP Retreat.
4. Tissue procurement. For tissue-based research,
pathologist is often needed to select cases, select
appropriate blocks and areas, tissue; connection to
pathology collaborators is important; reach out to
Greg MacLennan or me. Effort support on grants
when possible.