Section 1 Fundamentals of Nutrition Copyright © 2003 Delmar Learning, a Thomson Learning company Chapter 7 Vitamins Copyright © 2003 Delmar Learning, a Thomson Learning company Objectives Chapter 7 State one or more functions of each of the thirteen vitamins discussed Identify at least two food sources of each of the vitamins discussed Identify some symptoms of, or diseases caused by, deficiencies of the vitamins discussed Copyright © 2003 Delmar Learning, a Thomson Learning company 3 Facts Organic (carbon-containing) compounds that are essential in small amounts for body processes. Do not provide energy. Enable the body to use the energy provided by fats, carbohydrates, and proteins. Megadoses can be toxic. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 4 Vitamin types (13) Fat soluble (4): A, D, E, K Water soluble (9): • • Chapter 7 Vitamin C Vitamin B complex which includes: thiamin (B1), riboflavin (B2), niacin, vitamin B6, folate, vitamin B12 (cobalamin), pantothenic acid, biotin Copyright © 2003 Delmar Learning, a Thomson Learning company 5 Requirements Vitamin allowances given by weight in milligrams (mg) or micrograms (mcg or g) Dietary reference intake (replacing recommended dietary allowance) UL–tolerable upper limits–maximum level of daily intake unlikely to cause adverse effects Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 6 Vitamin Deficiency People prone to vitamin deficiency • • • • • Chapter 7 Alcoholics Poor and incapacitated elderly Clients with serious diseases that affect appetite Mentally retarded Children receiving inadequate care Copyright © 2003 Delmar Learning, a Thomson Learning company 7 Deficiency of Fat-soluble Vitamins Chronic malabsorption diseases • • • Chapter 7 Cystic fibrosis Celiac disease Crohn’s disease Copyright © 2003 Delmar Learning, a Thomson Learning company 8 Stop and Share Match the following terms with the correct definition. 1. Avitaminosis 2. Hypervitaminosis a. Concentrated form of vitamins b. Without vitamins 3. Vitamin supplement c. Condition caused by ingestion of excess vitamins Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 9 Stop and Share Answers: 1. b 2. c 3. a Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 10 Avoiding Vitamin Loss Buy fresh, unbruised vegetables and fruits and use them raw when possible. Prepare fresh vegetables and fruits just before serving. Heat canned vegetables quickly and in their own liquid. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 11 Avoiding Vitamin Loss Follow package directions when cooking frozen vegetables or fruit. Steam, or use as little water as possible. Cover pan and cook for a short period of time. Save cooking liquid for soups, stews, and gravy. Store in a cool, dark place. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 12 Fat-Soluble Vitamins Chapter 7 Vitamins A, D, E, K Copyright © 2003 Delmar Learning, a Thomson Learning company 13 Vitamin A Preformed (retinol) • Active form of vitamin A Carotenoids • Inactive form of vitamin A found in plants Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 14 Functions of Vitamin A Antioxidant; protects cells from destruction by oxygen. Maintains healthy eyes and skin, normal growth and reproduction, and a healthy immune system. Helps prevent infection. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 15 Sources of Vitamin A Preformed vitamin A Carotenoids (retinol) (provitamin A or beta-carotene) Fat-containing animal foods: liver, butter, cream, whole milk, cheeses Chapter 7 Green leafy vegetables & fruits, carrots, sweet potatoes, squash, spinach, broccoli, mango, cantaloupe, pumpkin Copyright © 2003 Delmar Learning, a Thomson Learning company 16 Vitamin A Requirements Commonly listed as retinol equivalents (RE) A retinol equivalent is 1 g retinol or 6 g beta-carotene Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 17 Stop and Share What are the signs and symptoms you may expect to see with too much vitamin A? …too little? Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 18 Stop and Share Excess Deficit • • Chapter 7 Birth defects, hair loss, dry skin, headaches, nausea, dryness of mucous membranes, liver damage, and bone and joint pain Night blindness; dry, rough skin; increased susceptibility to infections; and blindness or xerophthalmia Copyright © 2003 Delmar Learning, a Thomson Learning company 19 Vitamin D Prohormone–converted to a hormone in the body. D2 (ergocalcifenol) is formed in plants. D3 (cholecalciferol) is formed in humans from cholesterol in the skin. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 20 Sources of Vitamin D Sunlight Milk, fish liver oils, egg yolk, butter, fortified margarine Most milk in the U.S. has 10 g of vitamin D concentrate added per quart. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 21 Vitamin D Requirements Newborns through 51 years • 5.0 g (200 IU) 51-70 years • 10.0 g (400 IU) 70+ years • 15.0 g (600 IU) Pregnant and lactating women • Chapter 7 5.0 g (200 IU) Copyright © 2003 Delmar Learning, a Thomson Learning company 22 Stop and Share What are the signs and symptoms you may expect to see with too much vitamin D? …too little? Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 23 Stop and Share Excess Deficit • • Chapter 7 Deposits of calcium and phosphorus in soft tissues, kidney and heart damage, and bone fragility Poor bone and tooth formation, rickets which causes malformed bones and pain in infants Copyright © 2003 Delmar Learning, a Thomson Learning company 24 Stop and Share Deficit • • Chapter 7 Osteomalacia (softening of bones) Osteoporosis (brittle, porous bones) Copyright © 2003 Delmar Learning, a Thomson Learning company 25 Vitamin E Tocopherols • • Alpha (most biologically active) Beta, delta, gamma Tocotrienols Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 26 Functions of Vitamin E Antioxidant Prevention of hemolytic anemia among premature infants Enhance immune system Retard spoilage of commercial foods Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 27 Sources of Vitamin E Vegetable oils: corn, soybean, safflower, and cottonseed, and products made from them such as margarine Wheat germ, nuts, green leafy vegetables Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 28 Vitamin E Requirements Given as -TE (alpha-tocopherol equivalents) 1 mg of -TE = 1 IU Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 29 Stop and Share Your client asks you if it is possible to take too much vitamin E. How would you advise the client? What signs and/or symptoms can result from too little vitamin E? Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 30 Stop and Share Chapter 7 Excess Deficit • • Relatively nontoxic, fatsoluble vitamin. Excess stored in adipose tissue. Avoid long-term megadoses. Serious neurological defects can occur from malabsorption. Copyright © 2003 Delmar Learning, a Thomson Learning company 31 Vitamin K Made up of several compounds essential to blood clotting. Vitamin K1 (phylloquinone) Vitamin K2 (menaquinone) Synthetic Vitamin K (menadione) Vitamin K is destroyed by light alkalis. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 32 Functions of Vitamin K Formation of prothrombin; clotting of blood Candidates likely to receive Vitamin K • • • • • Chapter 7 Newborns immediately after birth Clients who suffer from faulty fat absorption After extensive antibiotic therapy Antidote for an overdose of anticoagulant Clients being treated for hemorrhage Copyright © 2003 Delmar Learning, a Thomson Learning company 33 Sources of Vitamin K Green leafy vegetables such as broccoli, cabbage, spinach, and kale. Dairy products such as eggs, meats, fruits, and cereals. Bacteria in small intestine synthesizes some vitamin K but must be supplemented by dietary sources. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 34 Vitamin K Requirements Measured in micrograms. 0-6 months • 2 g/day 6-12 months • 2.5 g/day Men • 120 g/day Women (same during pregnancy or lactation) • Chapter 7 90 g/day Copyright © 2003 Delmar Learning, a Thomson Learning company 35 Stop and Share What signs and/or symptoms can result from too much vitamin K? … too little? Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 36 Stop and Share Excess Deficit • • Chapter 7 Anemia can result from excessive amounts of synthetic vitamin K Defective blood coagulation, which increases clotting time and makes client prone to hemorrhage Copyright © 2003 Delmar Learning, a Thomson Learning company 37 Water-soluble Vitamins Chapter 7 Vitamin B complex Vitamin C Copyright © 2003 Delmar Learning, a Thomson Learning company 38 Vitamin B Complex: Thiamin Thiamin B1 Essential for nerve and muscle action, and metabolism of carbohydrates and some amino acids. Sources include unrefined and enriched cereals, yeast, wheat germ, lean pork, organ meats, and legumes. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 39 Vitamin B Complex: Thiamin Average adult female requires 1.1 mg/day. Average adult male requires 1.2 mg/day. Deficiency symptoms include loss of appetite, fatigue, nervous irritability, and constipation. Beriberi is a disease caused by extreme deficiency of vitamin B1. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 40 Vitamin B Complex: Riboflavin Riboflavin B2 Necessary for: the metabolism of carbohydrates, protein, and fats; tissue maintenance (especially the skin around the mouth); and healthy eyes. Sources include milk, meats, poultry, fish, enriched breads, cereals, broccoli, spinach, and asparagus. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 41 Vitamin B Complex: Riboflavin Average adult female requires 1.1 mg/day. Average adult male requires 1.3 mg/day. Deficiency can result in cheilosis (a condition characterized by sores on the lips and cracks at the corners of the mouth); glossitis (inflammation of the tongue); dermatitis; and eye strain in the form of itching, burning, and eye fatigue. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 42 Vitamin B Complex: Niacin Generic name for nicotinic acid and nicotinamide. A coenzyme in energy metabolism. Sources include meats, poultry, fish, peanuts, legumes. Milk and eggs are sources of tryptophan (precursor). Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 43 Vitamin B Complex: Niacin Measured in niacin equivalents (NE). 1 NE = 1 mg of niacin or 60 mg of tryptophan (an amino acid that is a precursor of niacin). Average adult female requires 14 mg/NE. Average adult male requires 16 mg/NE. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 44 Vitamin B Complex: Niacin Excessive amounts of niacin may cause flushing due to vascular dilation, GI problems, itching, and liver damage. May be used as a cholesterol-lowering agent under close supervision of a physician due to adverse side effects, which include liver damage and peptic ulcers. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 45 Vitamin B Complex: Niacin Deficiency symptoms include weakness, anorexia, indigestion, anxiety, and irritability. Pellagra is an extreme deficiency causing sores on the skin, diarrhea, anxiety, confusion, irritability, poor memory, dizziness, and untimely death. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 46 Vitamin B Complex: B6 Pyridoxine, pyridoxal, pyridoxamine Essential for protein metabolism and absorption, and aids in release of glucose from glycogen. Serves as catalyst in conversion of tryptophan to niacin; helps synthesize neurotransmitters such as serotonin and dopamine. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 47 Vitamin B Complex: B6 Sources include poultry, fish, liver, kidney, potatoes, bananas, spinach, and unrefined whole grains (oats and wheat). Deficiency symptoms include irritability, depression, and dermatitis. Deficiency in infants can cause various neurological symptoms and abdominal problems. Toxicity is rare; may cause temporary neurological problems. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 48 Vitamin B Complex: B6 Measured in milligrams. Average adult female requires 1.3-1.5 mg/day. Average adult male requires 1.3-1.7 mg/day. Need increases as protein increases. Oral contraceptives interfere with metabolism of vitamin B6 and can result in a deficiency. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 49 Vitamin B Complex: Folate Folate, folacin, and folic acid are chemically similar compounds, and names are used interchangeably. Needed for DNA synthesis, protein metabolism, formation of hemoglobin. Sources include cereals fortified with folate, green leafy vegetables, legumes, sunflower seeds, fruits such as orange juice and strawberries. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 50 Vitamin B Complex: Folate Measured in micrograms. Average adult female requires 400 g/day. Average adult male requires 400 g/day. Increased need during pregnancy and growth. 600 g/day required one month before conception through first six weeks of pregnancy. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 51 Vitamin B Complex: Folate Deficiency linked to neural tube defects in fetus such as spina bifida (spinal cord or spinal fluid bulge through the back) and anencephaly (absence of the brain). Other signs include inflammation of mouth and tongue, poor growth, depression and mental confusion, problems with nerve functions, megaloblastic anemia. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 52 Vitamin B Complex: Folate Excess can mask vitamin B12 deficiency and inactivates phenytoin, an anticonvulsant drug used by epileptics. FDA limits amount in over-the-counter supplements to: • • • Chapter 7 100 g for infants 300 g for children 400 g for adults Copyright © 2003 Delmar Learning, a Thomson Learning company 53 Vitamin B Complex: B12 Cobalamin–contains mineral cobalt. Stored in body three to five years. Involved in folate metabolism, maintenance of the myelin sheath, and healthy red blood cells. To be absorbed, must bind with intrinsic factor in stomach. Pernicious anemia may result from loss of intrinsic factor. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 54 Vitamin B Complex: B12 Sources include animal foods, especially organ meats, lean meat, seafood, eggs, dairy products. Average adult requires 2.4 g/day. Increased need during pregnancy and lactation. Amount absorbed will depend on current need. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 55 Vitamin B Complex: B12 Deficiency is rare and may be due to congenital problems of absorption or years of a vegetarian diet with no animal foods. Symptoms inclued megaloblastic anemia, pernicious anemia (if intrinsic factor absent), anorexia, glossitis, sore mouth, tongue, pallor, depression, dizziness, weight loss, neurological system damage. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 56 Vitamin B Complex: Pantothenic Acid Involved in metabolism of carbohydrates, fats, proteins. Essential for synthesis of neurotransmitter acetylcholine and steroid hormones. Sources include meats, poultry, fish, eggs, whole grain cereals, and legumes. Thought to be synthesized by the body. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 57 Vitamin B Complex: Pantothenic Acid Food and Nutrition Board has provided an estimated intake of 5 mg a day for normal adults. Toxicity from excess not confirmed. Natural deficiencies unknown. Signs include weakness, fatigue, burning sensation in feet (deficiencies produced experimentally). Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 58 Vitamin B Complex: Biotin Coenzyme in synthesis of fatty acids and amino acids. Sources include liver, egg yolk, soy flour, cereals, yeast. Synthesized in intestine by microorganisms, amount available for absorption unknown. Food and Nutrition Board suggests adequate intake of 30 g for adults. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 59 Vitamin B Complex: Biotin Toxicity from excess unknown. Deficiency symptoms include nausea, anorexia, depression, pallor, dermatitis, increase in serum cholesterol. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 60 Vitamin C Ascorbic acid Has antioxidant properties and protects food from oxidation. Role in formation of collagen. Aids in absorption of nonheme iron. May be involved with formation or functioning of norepinephrine, some amino acids, folate, leukocytes, the immune system, allergic reactions. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 61 Vitamin C Sources include citrus fruits, melon, strawberries, tomatoes, potatoes, red and green peppers, cabbage, broccoli. Average female adult requires 75 mg/day. Average male adult requires 90 mg/day. Stress and cigarette smoking increase need. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 62 Stop and Share What disease results from a deficiency in vitamin C? What are the associated signs and/or symptoms? What results from excess? Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 63 Stop and Share Scurvy: disease characterized by gingivitis, easy bruising, pinpoint hemorrhages of the skin, poor wound healing, sore joints and muscles, weight loss. Extreme cases result in death. Found in sailors who lived without fresh fruits and vegetables. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 64 Stop and Share Deficiency of Vitamin C: bleeding gums, loose teeth, tendency to bruise easily, poor wound healing, scurvy. Excess: diarrhea, nausea, cramps, excessive absorption of food iron, rebound scurvy (when megadoses are stopped abruptly) and possibly oxalate kidney stones. Generally considered nontoxic. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 65 Vitamin Supplementation Balanced diet provides nutritional needs of healthy people. No amount of vitamins will build muscles. Vitamins do not provide energy; they help to release the energy provided by nutrients. Heart disease, cancer and the common cold cannot be cured by vitamin supplements. Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 66 Conclusion Organic compounds that regulate body functions and promote growth. Each vitamin has a specific function. Well-balanced diet provides sufficient vitamins to fulfill body requirements. Fat-soluble vitamins: A, D, E, K Water-soluble vitamins: B complex, C Chapter 7 Copyright © 2003 Delmar Learning, a Thomson Learning company 67