1) If there are two alleles at a locus,
and one of them has a frequency of
0.4
• A) The other has a frequency of 0.6
• B) Heterozygote frequency would be 0.48
assuming Hardy-Weinberg conditions
• C) The homozygous recessive genotype
frequency would be 0.36 (assuming H-W)
• D) All of the above
• E) A and B above, but not C or D
2) Mutation selection balance
• A) predicts that deleterious mutations will
have an equilibrium frequency of zero
• B) predicts that selection will be weak
• C) predicts that mutation rate changes to
balance selection
• D) predicts that selection and mutation rate
could balance at some non-zero equilibrium
frequency of a deleterious allele
• E) Answers B and D are correct
3) underdominance
• A) Means that homozygotes have higher
fitness than heterozygotes
• B) Means that heterozygotes have lower
fitness than homozygotes
• C) Means that heterozygotes have lower
fitness than one of the homozygous
genotypes but not the other
• D) Means that w11 > w12 < w22
• E) all of the above except C
4) If there is selection against a recessive allele “a”
whose frequency is given as “q”; assume H-W
conditions other than selection (i.e. only selection)
• A) the allele will increase in frequency slowly at
first, but then decline rapidly
• B) delta q will = [(q2 waa + pq wAa)/wmean ] – q
• C) the allele will drop to a very low frequency but
never disappear
• D) the equilibrium frequency of the alternative
allele is 1.5
• E) all of the above
5) With overdominance, highest mean
fitness occurs
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A) when all alleles are dominant
B) when all alleles are at equal frequency
C) when one allele is lost
D) when the population evolves that trait
E) when heterozygote fitness is higher than
homozygote fitness