RASS Annual
Business Meeting &
Reception
Monday, March 7, 2005
6:00 p.m. – 7:30 p.m.
New Orleans Convention Center
Room 229
Laissez Le Bon Temps Rouler!
Agenda
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Accomplishments for 2004-2005 (A. Jarabek)
 Status of RASS
 Introduction of new officers
RASS Best Abstract Award (M. Gargas)
RASS Best Student Abstract Award (M. Gargas)
RASS Best Manuscript Awards (K. Krishnan)
 Advancing Risk Assessment
 Demonstrating Risk Assessment Application
Web page revisions and logo contest (D. Proctor)
Next Year: Programs and Activities (K. Krishnan)
Open Session for Membership Input
 Ideas to better serve RASS membership
 2004 nomination of symposia workshops, continuing education, etc.
Concluding comments by Incoming President (K. Krishnan)
Panel Discussion: Dose-dependent Transitions in Mechanisms of
Toxicity
Status of RASS: 2005
Annual Meeting
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How many members belong: 384 (↑ of 100)
Budget (December 2004): $11,645
Members registered to attend meeting as of March 1: ??
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Additional revenue: $4,900 (estimate)
Annual meeting expenditure: $2000 (estimate)
Sponsored CE Courses: 6
Sponsored Symposia: 6
Secondary endorsements: 26
Precedent set with historical highlight: Vinyl Chloride
RASS 2004-2005
Accomplishments
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Emphasize the role of specialty sections
Monthly Telecon Series – the State of our Science
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November: NAS report on use of human studies
December: Dose-response assessment: Past & Present
 Rory Conolly, CIIT Centers for Health Research
January: Dose-response assessment: Future
 Rory Conolly and Rusty Thomas, CIIT CHR
February: HESI Panel on Dose-dependent transition
Coming yet this Spring:
 April 13: Bruce Hope, OR DEP on bioterrorism risk assessment
 May 11: Michael Liebman, Windber Institute: Discovery and
Data mining in health care
 June 8: Woodrow Setzer, US EPA, NHEERL: OP modeling
Special thanks to Merck for generous offer of telecon system
RASS 2004-2005
Accomplishments
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Updated RASS home page
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Student membership and SAC liaison
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User friendly Information sharing
Event broadcasting
Logo contest
Letter soliciting student volunteer sent out
Student to be determined ASAP for 2006
Consider a Contemporary Concepts in Toxicology
(CCT) workshop
RASS 2005 CCT Workshop
Probabilistic Risk Assessment (PRA) —
Bridging Components Along the Exposure-Dose-Response Continuum
July 25 ─ 27, 2005
Omni Shoreham Hotel
Washington DC
Deadline for poster submission is May 12, 2005
For more information visit www.toxicology.org
2005-2006 RASS Officers
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President
Vice President
Vice President-Elect
Secretary/Treasurer
Councilor (2 year)
Councilor (1 year)
Past President
Kannan Krishnan
Mike Gargas
Jennifer Orme-Zavaleta
Lynne Haber
Teresa Leavens
Deborah Proctor
Annie Jarabek
Outgoing Officers
to Whom We Owe
Many Thanks…
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Councilor
Secretary/Treasurer
Past President
Lorenz Rhomberg
Steve DiZio
Ed Sargent
Other Grande Gratitude to
Jeanne Galbo
CIIT Centers for Health Research
RASS Best Abstract
Competition
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276 Abstracts with keyword “risk assessment”
reviewed by chair of committee
137 Vetted by Awards Committee
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Scored based on criteria:
 Originality
 Quality / Clarity
 Relevance to the risk assessor
No vote for member with conflict of interest on
any abstract
RASS 2005 Best Abstract
Awards Committee
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Mike Gargas, The Sapphire Group, Inc. (Chair)
John Christopher, Cal EPA
Michael Dourson, TERA, Inc.
Annie Jarabek, CIIT CHR / US EPA
RASS 2005
Best Abstract
“Top Ten” Blue Ribbon Winners
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377. A Framework/Approach for Incorporating PBPK Modeling into
Cumulative Risk Assessment of Chemical Mixtures. R. Yang; J.
Dennison; J. Lipscomb
381. Risk Assessment in Nephrotoxicology Sensitivity of Renal Tests. P.
Potnis; A. Maier; T. Guidotti
402. Incorporation of Trichloroacetic Acid Plasma Binding in Human and
Mouse in Trichloroethylene Risk Assessment. D. Keys; M. Lumpkin; J.
Bruckner; J. Fisher
404. Monte Carlo Analysis of Sources of Variability in Chloroform-induced
Hepatic Cytolethality and Regenerative Proliferation in B6c3f1 Mice. Y.
Tan; R. Conolly
349. An integrated QSAR-PBPK model for simulating pharmacokinetics of
chemicals in mixtures. K. Price; K. Krishnan
847. A Harmonized PBPK Model for Trichloroethylene Risk Assessment.
T. Covington; H. Clewell; J. Fisher; D. Keys; C. Hack; J. Zhao
RASS 2005
Best Abstract
“Top Ten” Blue Ribbon Winners
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866. Validation of a Human Physiologically-Based Pharmacokinetic
Model for Vinyl Acetate Against Human Nasal Dosimetry Data. P.
Hinderliter; K. Thrall; R. Corley; L. Bloemen; B. Matthew
1096. Assessment of neurotoxicity using zebrafish as a model
organism. N. Roy; C. Ton; Y. Lin; C. Parng
1304. A Mechanistic Model of Lifetime Cancer Risk for Inhalation
Exposures to Reactive Gases. J. Kimbell; D. Kalisak; R. Conolly; F.
Miller; A. Jarabek
1934. Evaluation of Systemic Toxicity in Mixtures of Trichloroethylene
(TCE), Heptachlor (HEPT), and Di(2-ethylhexyl)phthalate (DEHP)
Assessed in a 5x5x5 Design. J. Simmons; S. Yeatts; J. Zhao; C.
Gennings; A. McDonald; R. MacPhail
2110. Improved Dosimetric Adjustment Factors for Interspecies
Extrapolation of Inhaled, Poorly Soluble Particles. B. Asgharian; O.
Price; A. Jarabek; F. Miller
RASS 2005
Best Abstract Award
Winner
Abstract 2110. (Thursday March 10)
Improved Dosimetric Adjustment
Factors for Interspecies Extrapolation
of Inhaled, Poorly Soluble Particles.
B. Asgharian, O. Price, A.M. Jarabek
and F.J. Miller.
CIIT Centers for Health Research
RASS 2005 Best Student Abstract
Competition
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Submission process
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Student submits abstract and extended abstract (up to 5
pages)
Advisor provides letter of recommendation
Review process – vetted by Award Committee
based on criteria:
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Originality
Clarity
Role of Student
Special thanks to
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Taylor and Francis
Burdock Group, Inc.
RASS 2005 Best Student Abstract
Nominees
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62. Decreased Acetaminophen and Bromobenzene-induced Hepatotoxicity and Lethality in
Type 2 Diabetic Mice. M. Mitra; S. Sawant; A. Dnyanmote; J. Latendresse; A. Warbritton;
H. Mehendale, University of Louisiana.
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197. Rat Kidney injury molecule-1 (rKim-1) ELISA: A sensitive assay for early detection of
kidney tubular injury in preclinical toxicity studies. V. Vaidya; T. Ichimura; J. Bonventre ,
Harvard Medical School, Brigham and Women’s Hospital.
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259. PBPK modeling of inter-child differences in pharmacokinetics on the basis of subjectspecific data on hepatic CYP2E1 levels. A. Nong; D. McCarver; R. Hines; K. Krishnan,
University of Montreal.
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731. Role of Toxicokinetics in the Bioactivation-mediated Liver Injury of Thioacetamide in
Ad Libitum Fed and Diet Restricted Rats. J. Chilakapati; M. Korrapati; H. Mehendale,
University of Louisiana.
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2095. Characterization of Deltamethrin (Dlt) Metabolism in Adult Male Sprague-dawley
Rats. S. Anand; W. Haines; J. Bruckner; J. Fisher; S. Muralidhara; D. Hunter; S. Padilla,
University of Georgia.
RASS 2005 Best Student Abstract
Award Committee
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Mike Gargas, The Sapphire Group, Inc. (Chair)
Lisa Sweeney, The Sapphire Group, Inc.
Jim McDougal, Wright State University
James Holder, US EPA NCEA
RASS 2005 Best Student Abstract
Winner
Abstract 197.
Rat Kidney injury molecule-1 (rKim-1) ELISA: A
sensitive assay for early detection of kidney
tubular injury in preclinical toxicity studies.
V. Vaidya, T. Ichimura, and J. Bonventre
Harvard Medical School,
Brigham and Women’s Hospital.
RASS Annual Best Manuscript
Competition
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Nominations by membership
Review of relevant journals published in past year
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Chosen by Vice-President & Awards Committee
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Toxicological Sciences
Toxicology & Applied Pharmacology
Human & Ecological Risk Assessment
Regulatory Toxicology & Pharmacology
Risk Analysis
“Top ten” fully vetted
Scoring criteria: merit, clarity, and impact
No vote on manuscript for committee member if
any conflict of interest
RASS 2005 Award
Best Manuscript Advancing Risk
Assessment Science
Awards Committee
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Kannan Krishnan, Univ. Montreal (Chair)
Mel Andersen, CIIT CHR
Marcy Banton, Lyondell
Mike Gargas, The Sapphire Group, Inc.
Annie Jarabek, CIIT CHR / US EPA
William Slikker, NCTR
2005 RASS “Top Ten” Papers
ADVANCING SCIENCE OF RISK ASSESSMENT
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5.
Ashani Y and Pistinner S. (2004). Estimation of the upper limit of human
butrylchloinesterase dose required for protection against organophosphates
toxicity: a mathematically based toxicokinetic model. Toxicological Sciences
77: 358-367.
Conolly RB and Lutz WK. (2004). Nonmonotonic dose response
relationships: mechanics basis, kinetic modeling and implications for risk
assessment. Toxicological Sciences 77: 153-157.
Dorne JL, Walton K, Renwick AG. (2004). Human variability in the renal
elimination of foreign compounds and renal excretion-related uncertainty
factors for risk assessment. Food Chem. Toxicol. 42(23): 275-98.
Englehardt JD (2004) Predictive Bayesian dose-response assessment for
appraising absolute health risk from available information. Human and
Ecological Risk Assessment 10: 69-78.
Gaylor DW and Aylward LL. (2004). An evaluation of benchmark dose
methodology for noncancer continuous data health effects in animals due to
exposed to dioxin. Regulatory Toxicology and Pharmacology 40: 9-17.
2005 RASS “Top Ten” Papers
ADVANCING SCIENCE OF RISK ASSESSMENT
6.
7.
8.
9.
10.
Gaylor DW, Lutz WK and Conolly RB. (2004). Statistical analysis of
nonmonotonic dose-response relationships: research design and analysis of
nasal cell proliferation in rats exposed to formaldehyde. Toxicological
Sciences 77: 158-164.
Toyoshiba H, Yamanaka T, Sone H, Parham FM, Walker NJ, Martinez J,
Portier CJ. (2004). Gene interaction network suggests dioxin induces a
significant linkage between aryl hydrocarbon receptor and retinoic acid
receptor beta. Environ. Health Perspect. 112(12): 1217-24.
Razzaghi M and Kodell R. (2004) Quantitative risk assessment for
developmental neurotoxic effects. Risk Analysis 24: 1673.
Clark LH, Setzer RW and Barton HA. (2004) Framework for evaluation of
physiologically-based pharmacokinetic models for use in safety or risk
assessment. Risk Analysis 24: 1697.
Calabrese EJ (2004). Hormesis: from marginalization to mainstream: a case
for hormesis as the defaul dose-response model in risk assessment. Toxicol.
Appl. Pharmacol. 197: 125-136.
Risk Assessment Specialty Section
2005
Best Paper Advancing the
Science of
Risk Assessment
Toyoshiba H, Yamanaka T, Sone H, Parham FM, Walker
NJ, Martinez J, Portier CJ. (2004). Gene interaction
network suggests dioxin induces a significant linkage
between aryl hydrocarbon receptor and retinoic acid
receptor beta. Environ. Health Perspect. 112(12): 121724.
RASS 2005 Award
Best manuscript demonstrating
application of risk assessment
Awards Committee
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Kannan Krishnan, Univ. Montreal (Chair)
Steve DiZio, Cal EPA
Lynne Haber, TERA
Deborah Proctor, Exponent
Resha Putzrath, EPA Forum
Ed Sargent, Merck
2005 RASS “Top Ten” Papers
APPLICATION OF RISK ASSESSMENT
1. Babich MA, Chen SB, Greene MA, Kiss CT, Porter WK, Smith TP, Wind ML,
Zamula WW. (2004). Risk assessment of oral exposure to diisononyl phthalate
from children’s products. Regul. Toxicol. Pharmacol. 40(2): 151-67.
2. Booze TF, Reinhardt TE, Quiring SJ and Ottmar RD. (2004). A screening level
assessment of the health risks of chronic smoke exposure for wildland
firefighters. Journal of Occupational and Environmental Hygiene 1: 296-305.
3. Conolly RB, Kimbell JS, Janszen D, Schlosser PM, Kalisak D, Preston J
and Miller FJ. (2004). Human respiratory tract cancer risks of inhaled
formaldehyde: dose response predictions from biologically-motivated
computational modeling of as combined rodent and human dataset.
Toxicological Sciences 82: 279-296.
4. Farrrow S. (2004). Using risk assessment, benefit-cost analysis, and real
options to implement a precautionary principle. Risk Anal. 24(3): 727-35.
5. Himmelstein MW, Carpenter SC, Evans MV, Hinderliter PM, Kenyon EM.
(2004). Kinetic modeling of beta-chloroprene metabolism: II. The application of
physiologically based modeling for cancer dose response analysis. Toxicol. Sci.
79(1): 28-37.
2005 RASS “Top Ten” Papers
APPLICATION OF RISK ASSESSMENT
6.
7.
8.
9.
10.
Kirman CR,, Sweeney LM, Teta MJ, Sielken RL, Valdez-Flores C, Albertini
RJ and Gargas ML. (2004). Addressing nonlinearity in the exposure-response
relationship for a genotoxic carcinogen: cancer potency estimates for ethylene
oxide. Risk Analysis 24: 1165.
Renwick AG. (2004). Establishing the upper end of the range of adequate
and safe intakes for amino acids: a toxicologist’s viewpoint. J. Nutr. 134(6
Suppl): 1617S-1624S.
Schoen A, Beck B, Sharma R and Dubé E. (2004) Arsenic toxicity at low
doses: epidemiological and model of action considerations. Toxicology and
Applied Pharmacology 198: 253-267.
Sweeney LM, Andersen ME and Gargas ML. (2004). Ethyl acrylate risk
assessment with a hybrid computational fluid dynamics and physiologicallybased nasal dosimetry model. Toxicological Sciences 79: 394-403.
Tsuji JS, Benson Rj, Schoof RA, Hook GC. (2004). Health effect levels for
risk assessment of childhood exposure to arsenic. Regul. Toxicol. Pharmacol.
39(2): 99-110.
Risk Assessment Specialty Section
2005
Best Paper Demonstrating the
Application of
Risk Assessment
Kirman CR,, Sweeney LM, Teta MJ, Sielken RL, ValdezFlores C, Albertini RJ and Gargas ML. (2004).
Addressing nonlinearity in the exposure-response
relationship for a genotoxic carcinogen: cancer potency
estimates for ethylene oxide. Risk Analysis 24: 1165.
RASS Web Page Update
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RASS Description, Goals and Activities
Links
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Monthly Telecons
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Dates and Downloads
History of RASS
Current and Previous Officers and all Presidents
Annual Meeting
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Best Abstract Awards
Best Student Abstracts
RASS Endorsed Symposia, etc.
RASS Web Page Update (continued)
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Links
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Annual Meeting
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Best Manuscript Awards from 2004 and 2005
Upcoming Events
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Information regarding reception
Information regarding Panel Discussion Tonight
CCT on Probabilistic Risk Assessment
Links to other sites and meetings of interest
Just Getting Started
Seeking Your Input
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Logo Contest
History of RASS
Feedback on
Web Page
Pictures
Graphics
Send to DProctor@Exponent.com
Logo Contest
First Entry
Logo Contest
Second Entry
Logo Contest
Third Entry
Logo Contest
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Extended for 1 week after SOT (3/17/05)
Email Your Entries to Deb Proctor
(Dproctor@Exponent.com)
Computer and drawing skills are not required
Prepares will be Anonymous
RASS Membership will vote by email
Winner by End of March
Proof that Ability to Draw is
Not a Requirement
RASS 2005/06
Program & Activities
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Submission of symposia and continuing education proposals
 Need your input & ideas
 Evaluate venue attributes that best suit topic:
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Provide endorsements:
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Symposium
Workshop
Continuing Education
Four primary endorsements
Help fully develop proposals
Follow-up Contemporary Concepts in Toxicology (CCT) program
 PRA proposal
 Program development and funding formula
RASS 2005/06
Program & Activities (cont.)
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Post-doc and graduate student memberships in RASS
 Risk assessment programs
 Institutional contacts
 Enrolment
RASS Newsletter
 Bi-monthly, electronic
 Update on activities, hot issues, announcements,
opportunities, …
 Membership participation
Teleconference presentations
 Risk assessment tools
 Topics TBD by YOU — please let us know!
RASS 2005 Reception
Conclusion
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Open Forum
Panel Discussion: Dose-dependent
transitions in mechanisms of toxicity
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William Slikker, US FDA NCTR
Ray David, Eastman Kodak
Rory Conolly, CIIT Centers for Health Research
Dale Hattis, Clark University
William Farland, US EPA ORD
David Jacobson-Kram, US FDA CDER