Irrungen und Wirrungen in der Vitamin D – Forschung
http://d.mp3vhs.de/vonabisw/Labor/Lb24.docx
Hello Dr. Mercola,
I had the impression, that in your talk with Dr. Kate Rheaume-Bleue in Minute 27:3o ff of the video the statement was
a little bit foggy for people with a Vitamin D 3 intake of let's say 10.000 I.U. Vitamin D3 per day.
In case, You personally would take this amount, how much Vitamin K Menachinon-7 (MK-7) would You personally
supplement?
„8.000 I.U. of Vitamin D3 as a daily supplementation need 1.000 Mikrograms (=1 mg) of Vitamin K Menachinon-7 (MK-7)" =
Statement from Minute 27:30 in Dr. Mercolas Interview with Dr. Kate RheaumeBleue = https://www.youtube.com/watch?v=Vbd8FqnVT4c -
http://www.urlaub.astrologiedhs.de/
http://www.urlaub.astrologiedhs.de/3.html
Danke.
Es beweist mir erneut, daß die Forderung nach "evidence" in der Medizin wahrscheinlich einer der größten Fehlgriffe
in der Medizingeschichte war.
Die persönliche Erfahrung wie bei Ihnen oder bei den Brasilianern sollte viel mehr Gewicht haben - natürlich kann es
schon aus ethischen Gründen in Brasilien niemals ein RCT geben.
Was für ein vorzüglich organisierter Schwachsinn ist doch unser krankheitsverursachendes gesetzliches System, mit
dümmlichen DGE-Präsidenten an der Spitze.
Dr. Strunz schrieb mir einmal: "Recht haben oder glücklich leben." - Ich entscheide mich für Letzteres.
Wir sehen uns dann in Düsseldorf.
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
1
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
Vitamin D - Research: http://www.urlaub.astrologiedhs.de/3.html
Von: Volker Schmiedel [mailto:v-schmiedel@web.de]
Gesendet: Dienstag, 25. März 2014 19:05
An: Volker H. Schendel
Betreff: Aw: MS - Heilung ?
Ich würde ihn optimal mit Selen, Vitamin D und vor allem mit Omega-3 einstellen. In
dieser Kombination glaube ich, größere Erfolge zu erzielen, als nur einen Stoff in einer
Mega-Dosis zu geben. Um zu beweisen, ob ein solches Programm funktioniert, brauchen
wir 5 Jahre Zeit und 30 Millionen Euro für eine entsprechende große kontrollierte Studie.
Das Geld hat keiner, der in diesem Bereich arbeitet, deshalb wird es eine solche Studie
nicht geben. Insofern muss jeder erst einmal das tun, was ihn am meisten überzeugt und
woran er am meisten glaubt.
LG, Dr. Volker Schmiedel
Gesendet: Dienstag, 25. März 2014 um 18:27 Uhr
Von: "Volker H. Schendel" <volker@vonabisw.de>
An: "'Volker Schmiedel'" <v-schmiedel@web.de>
Betreff: MS - Heilung ?
Hallo Dr. Schmiedel,
danke für die Rückmeldung.
Was würden Sie aber machen, wenn ein MS Patient zu Ihnen käme um geheilt zu werden,
weil er von der Methode von Prof. Dr. Cícero Galli Coimbra an der University of São Paulo,
UNIFESP
President am Autoimmunity Investigation and Research Institute gehört hat?
Bliebe da nur das "Wegschicken" und wenn ja , was würde das eigentlich bedeuten?
Mit freundlichen Grüßen
2
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
Vitamin D - Research: http://www.urlaub.astrologiedhs.de/3.html
Von: Volker Schmiedel [mailto:v-schmiedel@web.de]
Gesendet: Dienstag, 25. März 2014 18:16
An: Volker H. Schendel
Betreff: Aw: AW: F.O.M. Kongreß 12. April 2014 - CCD Congress Center Düsseldorf
(Messegelände) : Thema: "Immunmodulation"
Sehr geehrter Herr Schendel,
mit "Mega-Dosen" von Vitamin D habe ich keine Erfahrung. Ich versuche derzeit, meine
Patienten (von Rheuma bis MS) auf vermutlich optimale Spiegel von 40-60 ng/ml zu
bringen. Wenn wir das schaffen würden, wäre schon viel erreicht. Ob noch viel höhere
Spiegel noch viel mehr bringen, vermag ich nicht zu sagen und warte ab, bis ich bessere
Informationen habe. Zu Vitamin K kann ich gar nichts sagen (jedenfalls nicht bei MS).
Herzliche Grüße,
Dr. Volker Schmiedel
Gesendet: Montag, 24. März 2014 um 13:32 Uhr
Von: "Volker H. Schendel" <volker@vonabisw.de>
An: "'Volker Schmiedel'" <v-schmiedel@web.de>
Betreff: AW: F.O.M. Kongreß 12. April 2014 - CCD Congress Center Düsseldorf
(Messegelände) : Thema: "Immunmodulation"
Hallo Dr. Schmiedel,
…. Ich bin sehr an Ihrer Meinung zur MS Heilung in Brasilien und der K2 Thematik interessiert.
3
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
Vitamin D - Research: http://www.urlaub.astrologiedhs.de/3.html
Kiene H, Hamre HJ, Kienle GS. In support of clinical case reports: A system of causality assessment. Global Adv
Health Med 2013;2(2):28-39. Abstract (PubMed) Volltext (PDF)
Kienle GS, Kiene H. From Reductionism to Holism: Systems-oriented Approaches in Cancer Research. Global Adv
Health Med 2012;1(5):68-77. Volltext (PDF)
Gagnier JJ, Kienle G, Altman DG, Moher D, Sox H, Riley D, the CARE group. The CARE guidelines: consensus-based
clinical case report guideline development. Journal of Clinical Epidemiology 2014;67(1):46-51. DOI
10.1016/j.jclinepi.2013.08.003. Epub 2013 Sep 12. PubMed PMID: 24035173. Abstract (PubMed) Abstract (HTML)
Gagnier JJ, Kienle G, Altman DG, Moher D, Sox H, Riley D, the CARE Group. The CARE guidelines: consensus-based
clinical case reporting guideline development. Journal of Medical Case Reports 2013;7:223.
Abstract (PubMed) Volltext (PDF)
Gagnier JJ, Kienle G, Altman DG, Moher D, Sox H, Riley D, CARE Group. The CARE guidelines: consensus-based
clinical case reporting guideline development. Headache. 2013 Nov-Dec;53(10):1541-7. DOI 10.1111/head.12246.
PubMed PMID: 24266334. Abstract (PubMed)
Gagnier JJ, Kienle G, Altman DG, Moher D, Sox H, Riley D, CARE Group. The CARE guidelines: consensus-based
clinical case report guideline development. J Diet Suppl. 2013 Dec;10(4):381-90. DOI 10.3109/19390211.2013.830679.
PubMed PMID: 24237192. Abstract (PubMed)
Gagnier JJ, Kienle G, Altman DG, Moher D, Sox H, Riley D, CARE Group. The CARE guidelines: consensus-based
clinical case reporting guideline development. BMJ Case Rep. 2013 Oct 23;2013. pii: bcr2013201554. DOI 10.1136/bcr2013-201554. PubMed PMID: 24155002. Abstract (PubMed)
4
Kiene H, Kalisch M. Wissenschaftliche Dogmen bei der Nachzulassung von Arzneimitteln in der Bundesrepublik
Deutschland. 1. Ausgabe. Baden-Baden: Aurelia Verlag; 1995, 78 S. ISBN 3-922907-41-5.
· Kienle GS. Der sogenannte Placeboeffekt. Illusion, Fakten, Realität. Stuttgart: Schattauer Verlag; 1995, 95 S. ISBN 37945-1687-7
Kiene H. Kritik der klinischen Doppelblindstudie. München: MMV Medizin Verlag GmbH; 1993, 70 S. ISBN 3-8208-12148.
Der Wirksamkeitsnachweis für Arzneimittel - Analyse einer Illusion [Taschenbuch]
Gerhard; Burkhardt, Rainer Kienle (Autor) - Verlag: Stuttgart: Urachhaus, 1983 - 432 Seiten -
http://www.zvab.com/basicSearch.do?anyWords=Der+Wirksamkeitsnachweis+f%FCr+Arzneimittel++Analyse+einer+Illusion+&author=&title=&check_sn=on
http://www.amazon.de/Der-Wirksamkeitsnachweis-f%C3%BCr-ArzneimittelIllusion/dp/B00494T7CK/ref=sr_1_1?ie=UTF8&qid=1395399220&sr=8-1&keywords=gerhard+kienle+arzneimittel
2.) Arzneimittelsicherheit und Gesellschaft. Eine kritische Untersuchung [Broschiert]
Gerhard Kienle (Autor) - 412 Seiten - ISBN-13: 978-3794503735
Verlag: Schattauer GmbH; Auflage: 1 (Januar 1988) -
ISBN-10: 3794503732
http://www.zvab.com/refineQuickSearch.do?anyWords=gerhard+kienle+Arzneimittelsicherheit&lastXDays=1&submit=Suchen -
http://www.amazon.de/Arzneimittelsicherheit-Gesellschaft-Eine-kritischeUntersuchung/dp/3794503732/ref=sr_1_1?ie=UTF8&qid=1395399411&sr=81&keywords=gerhard+kienle+Arzneimittelsicherheit
s.a. http://www.ifaemm.de/F5_publi.htm
http://d.mp3vhs.de/vonabisw/Kiene/K1.pdf
http://d.mp3vhs.de/vonabisw/Kiene/K2.pdf
http://d.mp3vhs.de/vonabisw/Kiene/K3.pdf
Hello Helmut,
5
I suppose You're right.
But there is a little bit of Medical - Science available, unfortunately only in German:
1.) Der Wirksamkeitsnachweis für Arzneimittel - Analyse einer Illusion [Taschenbuch]
Gerhard; Burkhardt, Rainer Kienle (Autor) - Verlag: Stuttgart: Urachhaus, 1983 - 432 Seiten -
http://www.zvab.com/basicSearch.do?anyWords=Der+Wirksamkeitsnachweis+f%FCr+Arzneimittel++Analyse+einer+Illusion+&author=&title=&check_sn=on
http://www.amazon.de/Der-Wirksamkeitsnachweis-f%C3%BCr-ArzneimittelIllusion/dp/B00494T7CK/ref=sr_1_1?ie=UTF8&qid=1395399220&sr=8-1&keywords=gerhard+kienle+arzneimittel
2.) Arzneimittelsicherheit und Gesellschaft. Eine kritische Untersuchung [Broschiert]
Gerhard Kienle (Autor) - 412 Seiten ISBN-13: 978-3794503735
Verlag: Schattauer GmbH; Auflage: 1 (Januar 1988) -
ISBN-10: 3794503732 -
http://www.zvab.com/refineQuickSearch.do?anyWords=gerhard+kienle+Arzneimittelsicherheit&lastXDays=1&submit=Suchen -
http://www.amazon.de/Arzneimittelsicherheit-Gesellschaft-Eine-kritischeUntersuchung/dp/3794503732/ref=sr_1_1?ie=UTF8&qid=1395399411&sr=81&keywords=gerhard+kienle+Arzneimittelsicherheit
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
Vitamin D - Research: http://www.urlaub.astrologiedhs.de/3.html
Von: Helmut Butzkueven [mailto:butz@unimelb.edu.au]
Gesendet: Donnerstag, 20. März 2014 11:33
An: Volker H. Schendel
Betreff: *** GMX Spamverdacht *** Re: AW: AW: MS and Vitamin D 3
Dear Volker
Very philosophical, but as we are now talking about diametrically opposed world views, that’s a better conversation
over a beer than by email.
6
Best of luck with your further explorations
Helmut
From: "Volker H. Schendel" <volker@vonabisw.de>
Date: Thursday, 20 March 2014 8:12 pm
To: Site License <butz@unimelb.edu.au>
Cc: "walach@europa-uni.de" <walach@europa-uni.de>, "v-schmiedel@web.de" <v-schmiedel@web.de>
Subject: AW: AW: MS and Vitamin D 3
Hello Helmut,
I think, the main problem could be, that Medical approaches are only been studied in clinical trials. But the idea, that
science is a cumulatively enriched stock of Knowledge is not necessarily true. Our knowledge of the world would be
thus - at least as far as it goes at present - irrevocable and uncorrectable. If the development of the historiography of
science and the Philosophy of science of the past had earnings , then it this , that the cumulative view of the scientific
process could be wrong .
Due to the nature of scientific ways , the Consensus - building processes are not satisfying, because we have not in
any Discipline a fundamental theory, which we definitely know, that it is true. Historically extraordinarily successful
Theories end up being wrong.
If then doctors in Brasil help with MS. What should be the international reaction in the medical establishment? -
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
Vitamin D - Research: http://www.urlaub.astrologiedhs.de/3.html
Von: Helmut Butzkueven [mailto:butz@unimelb.edu.au]
Gesendet: Donnerstag, 20. März 2014 05:04
An: Volker H. Schendel
Betreff: Re: AW: MS and Vitamin D 3
actuallythat’s easy too, we have in fact done a similar thingaiming for SERUM level of vitamin D – (check our
Neurology paper) you could do the same think aiming to avoid hypercalcemia
The hard thing is funding and willing partners- ittook us 3 years.
From: "Volker H. Schendel" <volker@vonabisw.de>
Date: Thursday, 20 March 2014 5:30 am
To: Site License <butz@unimelb.edu.au>
Subject: AW: MS and Vitamin D 3
7
Hello Helmut,
I Suppose, now I have to disagree - if the treatment of the MS patients has an individual approach - meaning every
patient gets his or her maximised dosage in the area between 50.000 I.U. Vitamin D 3 per day for six months controlled
individually against hypercalcemia and supplemented for example with 360 mcg Vitamin K 2 (personal advice of Dr.
Cees Vermeer from the research group in Maastricht, Holland, Netherlands) how could you formulate a design
protocol, if a general applied dose of Vitamin D 3 in the verum-group is forbidden?
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Von: Helmut Butzkueven [mailto:butz@unimelb.edu.au]
Gesendet: Mittwoch, 19. März 2014 19:02
An: Volker H. Schendel
Betreff: Re: MS and Vitamin D 3
Dear Volker- completely disagree- trial design really easy, but it takes commitmentand money etc.
Wehavebased our design on all available quality evidence, theprotocol was evolved over 2 years and the trial has
started so this is not exactly modifiable now.
Best
Helmut
From: "Volker H. Schendel" <volker@vonabisw.de>
Date: Thursday, 20 March 2014 3:17 am
To: Site License <butz@unimelb.edu.au>
Subject: MS and Vitamin D 3
Hello Helmut,
according to my preliminary research results, the protocol of research by Dr. Coimbra in Brazil is designed to
supplement vitamin D 3 (probably supplemented by high doses of K2) in the maximum individual dosis for each
patient from 50,000 IU D3 or higher every day consecutively for more than 6 months, strictly administered with
constant controls against hypercalcemia. From this research approach this is totally unsuitable for anything other than
personal health and healing reports.
8
Scientific studies could not follow a Research Design of this kind..
This means IMHO that Dr. Coimbra rated higher the success in healing his patients than RCT standards. As you can
see , there's the ethical problem? - All the Australian and New Zealand MS Studies with Vitamin D 3 are probably much
too low in the daily dose.
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Sehr geehrter Herr Schendel,
vielen Dank für Ihre Anfrage.
Leider kann ich diese Aussage bzgl. 25(OH)Vit. D weder bestätigen noch ausschließen, weil wir die LC-MS Messung
nicht als Analysemethode benutzen und somit keinen direkten Vergleich haben.
Wir benutzen die Bestimmung durch ein Immunoassay der Firma Diasorin.
Es gibt jedoch Literatur über den Vergleich von verschiedenen LC-MS mit verschiedenen anderen Methoden (RIA,
Immunoassays).
In der Studie von Farrell CJL et al, State-of-the-Art Vitamin D Assays, Clinical Chemistry, 58:3, 531-542, 2012 hat der
Immunoassay von Diasorin die beste Vergleichbarkeit mit der LC-MS (superior agreement).
Weiterhin wurde die Aussage bestätigt, dass die Immunoassays keine guten Ergebnisse bei niedrigen Vit. DKonzentrationen bringen, allerdings nur bei Werten unter 8 µg/l (8 ng/ml), die nicht so sehr klinisch relevant sind.
Diesen Artikel schicke ich Ihnen im Anhang.
Für weitere Fragen stehe ich Ihnen gerne zur Verfügung.
Mit freundlichen Grüßen
Hippokratis Messaritakis
FA für Mikrobiologie, Virologie und Infektionsepidemiologie
9
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Hallo Herr Geßwein,
habe heute vormittag mein 25 = OH Vitamin D3 in zwei verschiedenen Labors testen lassen
Labor 1: 36 ng / ml - ich glaube EIA Immuno Assay
Labor 2: 44 ng/ml
- Elecsys Immuno Assay von Roche
Ganz schöne Streubreite bei nur 9o Minuten zwischen den beiden Blutabnahmen.
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
10
http://www.vonabisw.de/48.html
Von: Lorenz Gesswein [mailto:praxis@hp-gesswein.de]
Gesendet: Montag, 17. März 2014 16:24
An: 'Volker Schendel'
Betreff: WG: WG: Presseanfrage zur Genauigkeit von Immuno - Assays
Hallo Herr Schindel,
ich gebe Ihnen noch kurz vor dem 12.04. bekannt, ob ich nach Düsseldorf kommen kann! Dann wäre um 13.00 Uhr am
Stand der Husaren-Apothke gut. -
Siehe auch unten Antwort von Herrn Geiger, Prof. für Klinische Chemie (früher Uni München).
Herzliche Grüße,
Lorenz Geßwein
Lorenz Geßwein
Heilpraktiker
Am Zinnbruch 34
53129 Bonn
Telefon: (0228) 360 25 733
Telefax: (0228) 360 25 734
E-Mail: praxis@hp-gesswein.de
Internet: www.hp-gesswein.de
Aktuelles Interview: www.netzwerk-frauengesundheit.com
Von: rd.lab@t-online.de [mailto:rd.lab@t-online.de]
Gesendet: Sonntag, 16. März 2014 17:15
An: Lorenz Gesswein
Betreff: Re: WG: Presseanfrage zur Genauigkeit von Immuno - Assays
11
Lieber Herr Geßwein,
vielen Dank für die Information.
Wie ich Ihnen ja schon angedeutet habe, gibt es bei den Immunoassays immer noch keine Standardisierung bzw.
Normierung, und Sie sehen es ja selbst in der Information. Da wir bei der RD möglichst mit validen Tests arbeiten, bin
ich immer auf der Suche nach Informationen über die Tests. Vor kurzem habe ich eine Literaturstelle gefunden,
die auch einen Vergleich zwischen den kommerziell erhältlichen Tests beschrieben hat, und wir sind mit dem Test, den
wir anwenden, "ganz gut weggekommen !". Also, es empfiehlt sich, den Test eigentlich immer im ausgewählten Labor
zu machen. Dann relativieren sich die Einflüsse und man erhält Werte, die man vergleichen kann.
Noch ein schönes Restwochenende und
beste Grüsse
Ihr
Reinhard Geiger
"Lorenz Gesswein" <praxis@hp-gesswein.de> schrieb:
Lieber Herr Geiger,
noch einmal kurz etwas zu Ihrer Info (die Anlage).
Herzliche Grüße,
Lorenz Geßwein
Lorenz Geßwein
Heilpraktiker
Am Zinnbruch 34
53129 Bonn
Telefon: (0228) 360 25 733
Telefax: (0228) 360 25 734
E-Mail: praxis@hp-gesswein.de
Internet: www.hp-gesswein.de
Aktuelles Interview: www.netzwerk-frauengesundheit.com
12
Von: Volker H. Schendel [mailto:volker@vonabisw.de]
Gesendet: Donnerstag, 13. März 2014 18:53
An: Volker H. Schendel
Betreff: WG: Presseanfrage zur Genauigkeit von Immuno - Assays
zu Ihrer Information.
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Von: Kramer, Jan [mailto:j.kramer@ladr.de]
Gesendet: Donnerstag, 13. März 2014 10:05
An: volker@vonabisw.de
Betreff: WG: Presseanfrage zur Genauigkeit von Immuno - Assays
Sehr geehrter Herr Schendel,
herzlichen Dank für Ihre Anfrage.
Tatsächlich gibt es Inter-Assay Varianzen zwischen unterschiedlichen Methoden.
Der freigegebene direkte Messbereich des von uns verwendeten Tests liegt bei 10-375 nmol/l.
Die Intra-Assay Varianz bei 0,1-3,8%. Somit ist die Aussage, wird immer dieses gleiche Testverfahren verwendet, auch
für z.B. das Therapie-Monitoring sehr gut.
Die Inter-Assay Varianz beträgt 6,0-9,8%. Zur Varianz der Testverfahren untereinander habe ich Ihnen auch eine kurze
Präsentation von mir beigelegt (Folie 1 und 2). Aus meiner Sicht relativ akademische Diskussion und wer legt denn
eigentlich wirklich den „Goldstandard“ fest?
Auch wenn aktuell sicherlich die Bestimmung des 25-Vitamin D als Aussagekräftigster Parameter für den Vitamin D
Status eines Menschen gelten kann, stellt sich dennoch die Frage, ob in Zukunft bessere Parameter, wie das freie
„bioverfügabere“ Vitamin D gemessen werden sollte. Siehe auch Folie 3 meiner Präsentation sowie zur gesamten
Thematik „Challenges in describing vitamin D status and activity“ auch Vogeser et al., 2014 J Lab Med 38(1): 1-10.
Aktuell zeigen allerdings die noch nicht-automatisiert verfügbaren Teste untereinander eine Varianz von >20% für das
freie Vitamin D. Auch die Intra-Assay Varianz dieser Teste ist noch nicht abschließend für die Routine getestet.
Mit freundlichen Grüßen,
Jan Kramer
Priv.-Doz. Dr. med. Jan Kramer
Facharzt für Innere Medizin, Hämostaseologie
Facharzt für Laboratoriumsmedizin
13
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Von: Kurtz, Jessica
Gesendet: Mittwoch, 12. März 2014 16:01
An: Kramer, Jan
Cc: Wollenberg, Peter
Betreff: WG: Presseanfrage zur Genauigkeit von Immuno - Assays
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Assistentin der Geschäftsleitung
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Von:Volker H. Schendel [mailto:volker@vonabisw.de]
Gesendet: Mittwoch, 12. März 2014 10:53
An: #-Info-Adressen
Betreff: Presseanfrage zur Genauigkeit von Immuno - Assays
Sehr geeehrte Damen und Herren,
In einem hiesigen Labor erhielt ich die Information, daß Immuno-Assays bei sehr niedrigen 25-OH-Vitamin D3
Blutwerten Probleme machen können hinsichtlich der Meßgenauigkeit, während ab ca. 50 ng/ml = 125 nmol/l die
Ergebnisse dicht am LC-MS/MS Meßwert liegen. Haben Sie diesbezüglich ähnliche Erfahrungen.
Zur Erläuterung: bei der Referenzmethode LC-MS/MS wird der Analyt vor der eigentlichen Bestimmung des Vitamin D
aus dem Serum bzw. Plasma extrahiert, so dass mögliche Effekte durch die (Protein)matrix eliminiert werden.
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
-RD Laboratorien GmbH
Mühlstr. 8, D 86911 Diessen
Tel. 08807-911 51 Fax 08807-911 53
Geschäftsführer: Prof. Dr. Dr. Reinhard Erich Geiger
Amtsgericht Augsburg; HRB-Nr. 14562
That was my impression too. But considering the pain spared for his patients - for me , thats human science - remains
the hope, that the message goes around the world.
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
15
Von: Brant Cebulla [mailto:bcebulla@vitamindcouncil.org]
Gesendet: Mittwoch, 19. März 2014 00:05
An: 'Volker H. Schendel'
Betreff: RE: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero Coimbra with
daily intake of 50.000 I.U. Vitamin D 3
Volker,
I believe the strategy of Dr. Coimbra’s is to supplement as high as he can without inducing hypercalcemia. All he’s
trying to do is supplement with vitamin D as high as he can, without any harmful effects. He’s not saying that a certain
dose works but certain other doses do not.
Brant Cebulla
Development Director
Office: (805) 439-1075
Connect with us
From: Volker H. Schendel [mailto:volker@vonabisw.de]
Sent: Tuesday, March 18, 2014 11:06 AM
To: 'Brant Cebulla'
Subject: AW: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero Coimbra with
daily intake of 50.000 I.U. Vitamin D 3
Hello Brant Cebulla
does that mean, they supplement with 50.000 I.U. per day and consecutive in 6 months and cure their patients from MS
- they just don't have a theory - but when they supplement with less than 50.000 I.U., their patients remain ill?
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
16
Von: Brant Cebulla [mailto:bcebulla@vitamindcouncil.org]
Gesendet: Dienstag, 18. März 2014 18:44
An: 'Volker H. Schendel'
Betreff: RE: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero Coimbra with
daily intake of 50.000 I.U. Vitamin D 3
Volker,
We have exchanged emails with Dr. Coimbra. They don’t know why 50,000 IU is important any more than we do. They
have access to all the same literature we do.
Regards,
Brant Cebulla
Development Director
Office: (805) 439-1075
Connect with us
From: Volker H. Schendel [mailto:volker@vonabisw.de]
Sent: Tuesday, March 18, 2014 7:02 AM
To: 'Brant Cebulla'
Subject: AW: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero Coimbra with
daily intake of 50.000 I.U. Vitamin D 3
Hello Brant Cebulla,
do you have direct communication with the Brasilian Researchers, because according to the video-documentation , they seem
to know, why 50.000 I.U. per day for more than 6 consecutive months is important, to cure MS.
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
17
http://www.vonabisw.de/48.html
Von: Brant Cebulla [mailto:bcebulla@vitamindcouncil.org]
Gesendet: Montag, 17. März 2014 20:01
An: 'Volker H. Schendel'
Betreff: RE: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero Coimbra with
daily intake of 50.000 I.U. Vitamin D 3
Volker,
I think vitamin D is very important in MS.
Dr. Coimbra is doing interesting work with some very interesting and hopeful case reports. He hasn’t published much
of his data to date, unfortunately, but he and his patients report remarkable results.
I would love to see some pilot trials to quantify the effect of extremely high dose vitamin D in MS. Until then, it’s hard to
know if there is any extra benefit in supplementing with extremely high doses verse just 5-10,000 IU/day.
Cheers,
Brant Cebulla
Development Director
Office: (805) 439-1075
Connect with us
From: Volker H. Schendel [mailto:volker@vonabisw.de]
Sent: Monday, March 17, 2014 5:43 AM
To: rmh-mwu@mh.org.au
Subject: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero Coimbra with daily
intake of 50.000 I.U. Vitamin D 3
Hello,
could I get a comment from You to the Research in Multiple Sclerosis (MS) cure by the Brasilian Research Group
around Dr. Cicero Coimbra with daily intake of 50.000 I.U. Vitamin D 3
documented here:
http://www.youtube.com/watch?v=erAgu1XcY-U
18
Sincerely
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Admittedly, it was only 12 patients with MS, but Vieth et al pushed it up to 40,000iu/day and saw no adverse effects on
calcium levels etc. however, longer term safety concerns have been raised, e.g. Cardiac artery calcification.
Safety of vitamin D3 in adults with multiple sclerosis.
Kimball SM1, Ursell MR, O'Connor P, Vieth R.Am J Clin Nutr. 2007 Sep;86(3):645-51.
Author information
Abstract
BACKGROUND:
Vitamin D3 may have therapeutic potential in several diseases, including multiple sclerosis. High doses of vitamin D(3) may be
required for therapeutic efficacy, and yet tolerability--in the present context, defined as the serum concentration of 25hydroxyvitamin D [25(OH)D] that does not cause hypercalcemia--remains poorly characterized.
OBJECTIVE:
The objective of the study was to characterize the calcemic response to specific serum 25(OH)D concentrations.
DESIGN:
In a 28-wk protocol, 12 patients in an active phase of multiple sclerosis were given 1200 mg elemental Ca/d along with
progressively increasing doses of vitamin D3: from 700 to 7000 microg/wk (from 28 000 to 280 000 IU/wk).
RESULTS:
Mean (+/- SD) serum concentrations of 25(OH)D initially were 78 +/- 35 nmol/L and rose to 386 +/- 157 nmol/L (P < 0.001).
Serum calcium concentrations and the urinary ratio of calcium to creatinine neither increased in mean values nor exceeded
reference values for any participant (2.1-2.6 mmol/L and <1.0, respectively). Liver enzymes, serum creatinine, electrolytes,
serum protein, and parathyroid hormone did not change according to Bonferroni repeated-measures statistics, although
parathyroid hormone did decline significantly according to the paired t test. Disease progression and activity were not affected,
but the number of gadolinium-enhancing lesions per patient (assessed with a nuclear magnetic brain scan) decreased from the
initial mean of 1.75 to the end-of-study mean of 0.83 (P = 0.03).
CONCLUSIONS:
Patients' serum 25(OH)D concentrations reached twice the top of the physiologic range without eliciting hypercalcemia or
hypercalciuria. The data support the feasibility of pharmacologic doses of vitamin D3 for clinical research, and they provide
objective evidence that vitamin D intake beyond the current upper limit is safe by a large margin.
From: "Volker H. Schendel" <volker@vonabisw.de>
Date: Wednesday, 19 March 2014 7:25 am
To: Site License <butz@unimelb.edu.au>
Subject: AW: AW: AW: AW: WG: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr.
Cicero Coimbra with daily intake of 50.000 I.U. Vitamin D 3
19
I'd like to agree, that Vitamin D is pretty safe - but I'm not a member of the Medical Profession - and in this profession,
You'd not find many colleagues, who would say, that 50.000 I.U. of Vitamin D 3 every day for more than six months to
cure MS is a safe protocol.
And then, MS to cure might not fall in the category " come and gone" - isn't it an ethical task, to find out, wether these
bloody Brasilians got the breakthrough?
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Von: Helmut Butzkueven [mailto:butz@unimelb.edu.au]
Gesendet: Dienstag, 18. März 2014 21:02
An: Volker H. Schendel
Betreff: Re: AW: AW: AW: WG: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr.
Cicero Coimbra with daily intake of 50.000 I.U. Vitamin D 3
Firstly, it’s pretty safe and availableand cheap so anyone who wants to can just take it? I prefer to generate evidence.
Remember so many “cures’ have come and gone….
From: "Volker H. Schendel" <volker@vonabisw.de>
Date: Wednesday, 19 March 2014 5:14 am
To: Site License <butz@unimelb.edu.au>
Subject: AW: AW: AW: WG: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero
Coimbrawith daily intake of 50.000 I.U. Vitamin D 3
Hello Helmut,
I'm pretty sure , there is no chance for a RCT with Dr. Cicero Coimbra's approach. But then, according to the President
of the German official Chamber of the Medical Profession (Bundesärztekammer), only 40 % of the official medicine is
evidence based.
" Professor Dr. Jörg-Dietrich Hoppe, Präsident der Bundesärztekammer, auf dem Dialogforum Pluralismus in der Medizin: https://www.aekno.de/page.asp?pageID=8736&noredir=True - …Maximal 40 Prozent der Medizin sei evidenzbasiert und
finde sich früher oder später in wissenschaftlichen Leitlinien wieder, sagte Hoppe bei der Feier zum zehnjährigen Jubiläum des
Forums in der Hauptstadt. "
So let's assume, there never will be RCT to cure MS with the brasilian approach. Where does that leave the patients,
who are ill and don't know, that in Brasil, they would be cured?
20
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Von: Helmut Butzkueven [mailto:butz@unimelb.edu.au]
Gesendet: Dienstag, 18. März 2014 16:22
An: Volker H. Schendel
Betreff: Re: AW: AW: WG: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero
Coimbra with daily intake of 50.000 I.U. Vitamin D 3
Hi Volker
Do you know if Dr Coimbra has published any results?
(not on youtube, but in the medical literature/medicalconferences)
Ortrialdesigns? Ours are in the international trial registries.
Ifyougoogle “curefor MS” there are today 63,300,000 hits. If youadd “curefor MS vitamin D, you still get 2,200,000
So the task of knowing all informationsourcesand pieces of data is very hard- actuallyimpossible. Maybe a better task
for a journalist than an MS researchdoctor
Best
Helmut
From: "Volker H. Schendel" <volker@vonabisw.de>
Date: Wednesday, 19 March 2014 2:06 am
To: Site License <butz@unimelb.edu.au>
Subject: AW: AW: WG: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero
Coimbrawithdaily intake of 50.000 I.U. Vitamin D 3
Hello Helmut,
that's what I expected. Being a Journalist and not a member of the medical Profession. Wouldn't it be a sensible idea,
to get into contact with Dr. Cicero Coimbra, considering, that the film
http://www.youtube.com/watch?v=erAgu1XcY-U
reports total cure of MS?
MitfreundlichenGrüßen
Volker H. Schendel - Ministerialrat a.D.
21
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Von: Helmut Butzkueven [mailto:butz@unimelb.edu.au]
Gesendet: Dienstag, 18. März 2014 15:58
An: Volker H. Schendel
Cc: Lisa Melton
Betreff: Re: AW: WG: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero
Coimbra with daily intake of 50.000 I.U. Vitamin D 3
Hi Volker
Weareexaminingdaily doses of 1000,5000 or 10000 versus placebo, in a standard randomised, controlled design. There
is a french group with a similartrial design (endpoint- new lesions/relapses )examining 100,000 units/every 2 weeks
versus placebo. So no, no data on doses of 50,000 IU/day will be generated from these trials.
Best
helmut
From: "Volker H. Schendel" <volker@vonabisw.de>
Date: Wednesday, 19 March 2014 12:53 am
To: Site License <butz@unimelb.edu.au>
Subject: AW: WG: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero
Coimbrawithdailyintake of 50.000 I.U. Vitamin D 3
Hello Helmut,
Is my assumption correct, that Your Australian approach is miles away and below from the Brasilian Medical Approach
with the Intention to cure MS with 50.000 I.U. per day for six consecutive months ?
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
22
Von: Helmut Butzkueven [mailto:butz@unimelb.edu.au]
Gesendet: Dienstag, 18. März 2014 02:59
An: Volker H. Schendel
Cc: Lisa Melton
Betreff: Re: WG: Research in Multiple Sklerose (MS) curebythebrasilianReearch Group araound Dr. Cicero Coimbra with
dailyintake of 50.000 I.U. Vitamin D 3
DearMr Schendel
MS research Australia is conducting a trialof different doses of vitamin D to suppressdiseaseactivity in early MS.
The MSRA coordinator is Lisa Melton, she can provide you with press information ifyouwish.
Best
Helmut
From: "Volker H. Schendel" <volker@vonabisw.de>
Date: Monday, 17 March 2014 11:45 pm
To: Site License <butz@unimelb.edu.au>
Subject: WG: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero
Coimbrawithdailyintakeof 50.000 I.U. Vitamin D 3
Hello,
could I get a comment from You to the Research in Multiple Sclerosis (MS) cure by the Brasilian Research Group
around Dr. Cicero Coimbra with daily intake of 50.000 I.U. Vitamin D 3
documentedhere:
http://www.youtube.com/watch?v=erAgu1XcY-U
Sincerely
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
23
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Sehr geehrter Herr Messaritakis
danke für das Feedback.
Nach meinen vorläufigen Rechercheergebnissen ist das Protokoll der Forschung von Dr. Coimbra in Brasilien so
angelegt, daß er Vitamin D 3 (vermutlich ergänzt um hohe Dosen von K2) in der individuell bei jedem Patienten
maximalen Supplementierungsdosis von möglichst 50.000 I.U. D3 oder höher jeden Tag konsekutiv für idR mehr als
Monate verabreicht mit ständigen Kontrollen gegen Hypercalcemia. Vom Forschungsansatz ungeeignet für etwas
Anderes als individuelle Kranken- und Heilungsberichte.
Wissenschaftliche Studien könnten so nicht vorgehen.
Das bedeutet m.E. , daß er Heilerfolge bei seinen Patienten höher bewertet, als RCT Standards. Wie sehen Sie das
ethisch? - Die von Ihnen in Bezug genommenen neuen Versuche liegen vermutlich deutlich zu niedrig im Dosisbereich.
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Von: Messaritakis Hippokratis [mailto:messaritakis@ganzimmun.de]
Gesendet: Mittwoch, 19. März 2014 11:22
An: Volker H. Schendel
Betreff: AW: Ihre Anfrage vom 12.03.2014 bzgl. Vit. D
Sehr geehrter Herr Schendel,
24
es könnte sein, dass das Vitamin D hochdosiert zusammen mit einer Interferon-Therapie eine Wirkung bei Patienten
mit MS zeigt. Das wird aber gerade jetzt untersucht durch die SOLAR-Studie. Die Ergebnisse liegen noch nicht vor.
Diesbezüglich schicke ich Ihnen im Anhang einen Artikel aus dem Deutschen Ärzteblatt. Ist also ein Thema, worüber
noch diskutiert wird, und ich glaube dass wir bald aussagekräftige Ergebnisse haben werden.
Was das Vitamin D allgemein angeht, gibt es genügend Hinweise, dass eine Gabe von Vitamin D keinen Einfluss auf
Herz-Kreislauf-Erkrankungen und Krebs hat. Den entsprechenden Artikel schicke ich Ihnen auch noch dazu. Es sieht
also danach aus, dass das Vitamin D nur bei bestimmten Situationen helfen kann. Eine sicher Indikation wäre z.B. die
Osteodystrophie bei chronischen Nierenpatienten, wo allerdings die aktive Form 1,25(OH)2-Vit. D verabreicht wird.
Weitere Fragen beantworte ich Ihnen gerne.
Viele Grüße
Hippokratis Messaritakis
FA für Mikrobiologie, Virologie und Infektionsepidemiologie
Von: Volker H. Schendel [mailto:volker@vonabisw.de]
Gesendet: Dienstag, 18. März 2014 15:27
An: Messaritakis Hippokratis
Betreff: AW: Ihre Anfrage vom 12.03.2014 bzgl. Vit. D
Hallo Herr Messaritakis,
wie finden Sie the Research in Multiple Sclerosis (MS) cure by the Brasilian Research Group around Dr. Cicero
Coimbra with daily intake of 50.000 I.U. Vitamin D 3
documented here:
http://www.youtube.com/watch?v=erAgu1XcY-U
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Von: Messaritakis Hippokratis [mailto:messaritakis@ganzimmun.de]
Gesendet: Donnerstag, 13. März 2014 13:26
25
An: volker@vonabisw.de
Betreff: Ihre Anfrage vom 12.03.2014 bzgl. Vit. D
Sehr geehrter Herr Schendel,
vielen Dank für Ihre Anfrage.
Leider kann ich diese Aussage bzgl. 25(OH)Vit. D weder bestätigen noch ausschließen, weil wir die LC-MS Messung
nicht als Analysemethode benutzen und somit keinen direkten Vergleich haben.
Wir benutzen die Bestimmung durch ein Immunoassay der Firma Diasorin.
Es gibt jedoch Literatur über den Vergleich von verschiedenen LC-MS mit verschiedenen anderen Methoden (RIA,
Immunoassays).
In der Studie von Farrell CJL et al, State-of-the-Art Vitamin D Assays, Clinical Chemistry, 58:3, 531-542, 2012 hat der
Immunoassay von Diasorin die beste Vergleichbarkeit mit der LC-MS (superior agreement).
Weiterhin wurde die Aussage bestätigt, dass die Immunoassays keine guten Ergebnisse bei niedrigen Vit. DKonzentrationen bringen, allerdings nur bei Werten unter 8 µg/l (8 ng/ml), die nicht so sehr klinisch relevant sind.
Diesen Artikel schicke ich Ihnen im Anhang.
Für weitere Fragen stehe ich Ihnen gerne zur Verfügung.
Mit freundlichen Grüßen
Hippokratis Messaritakis
FA für Mikrobiologie, Virologie und Infektionsepidemiologie
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Hello Helmut,
I Suppose, now I have to disagree - if the treatment of the MS patients has an individual approach - meaning every
patient gets his or her maximised dosage in the area between 50.000 I.U. Vitamin D 3 per day for six months controlled
individually against hypercalcemia and supplemented for example with 360 mcg Vitamin K 2 (personal advice of Dr.
Cees Vermeer from the research group in Maastricht, Holland, Netherlands) how could you formulate a design
protocol, if a general applied dose of Vitamin D 3 in the verum-group is forbidden?
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Von: Helmut Butzkueven [mailto:butz@unimelb.edu.au]
Gesendet: Mittwoch, 19. März 2014 19:02
An: Volker H. Schendel
Betreff: Re: MS and Vitamin D 3
Dear Volker- completely disagree- trial design really easy, but it takes commitment and money etc.
We have based our design on all available quality evidence, the protocol was evolved over 2 years and the trial has
started so this is not exactly modifiable now.
Best
Helmut
From: "Volker H. Schendel" <volker@vonabisw.de>
Date: Thursday, 20 March 2014 3:17 am
To: Site License <butz@unimelb.edu.au>
Subject: MS and Vitamin D 3
27
Hello Helmut,
according to my preliminary research results, the protocol of research by Dr. Coimbra in Brazil is designed to
supplement vitamin D 3 (probably supplemented by high doses of K2) in the maximum individual dosis for each
patient from 50,000 IU D3 or higher every day consecutively for more than 6 months, strictly administered with
constant controls against hypercalcemia. From this research approach this is totally unsuitable for anything other than
personal health and healing reports.
Scientific studies could not follow a Research Design of this kind..
This means IMHO that Dr. Coimbra rated higher the success in healing his patients than RCT standards. As you can
see , there's the ethical problem? - All the Australian and New Zealand MS Studies with Vitamin D 3 are probably much
too low in the daily dose.
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Dear Volker Schendel ,
Thank you for your recent correspondence.
It is important to constantly evaluate emerging research and allow our understanding of nature to remain fluid and
dynamic. As our understanding of nutrition and physiology evolves, paradigm shifts may change our understanding of
scientific theory as it applies to human health. Anecdotes and case reports serve a role in allowing us to question
accepted norms, but should not represent the basis or rationale for making suggestions regarding safe and
responsible healthcare or disease prevention. The collective body of scientific evidence should always be considered
when reviewing individual reports regarding health.
As we discussed in a prior email correspondence, although certain cases of excessive Vitamin D ingestion suggest
that such dosages may be tolerable for many people over a short term, they do not suggest that it would be safe or
necessary for most people to ingest such quantities long-term. 25-hydroxy vitamin D blood levels exceeding 100 ng/dL
have been linked to increased risk of cardiovascular events. Life Extension suggests 25-hydroxy-vitamin D levels be
maintained between 50 and 80 ng/dL. Most people require between 5000-8000 IU of Vitamin D3 daily to attain this level.
In rare instances, doses of less than 5,000 IU result in blood levels greater than 100 ng/mL. In other instances, some
people may require doses higher than 8000 IU daily to achieve optimal levels.
All individuals react differently to particular dosages of any compound. Vitamin D may not always be fully absorbed or
metabolized effectively and differences in body weight and vitamin D storage may also affect blood concentrations.
Regular blood work is important to ensure vitamin D blood concentrations stay within a safe range.
While the aforementioned adverse outcomes are not always seen in every individual, they are still potential risks. A
risks and benefits analysis should always be conducted prior to any therapeutic intervention.
Here is an article Life Extension published regarding the potential dangers of excessive Vitamin D blood levels:
http://www.lef.org/magazine/mag2012/may2012_New-Study-Warns-Against-Excessive-Vitamin-D-Intake_01.htm
28
If you have any additional questions, please email us or call the advisor helpline at (800) 226-2370; international
customers
Dear Volker Schendel ,
Thank you for your recent correspondence.
The first document you provided is simply a collection of user-generated reviews for the eBook you previously linked
to. Life Extension has not reviewed the content of the eBook by Jeff T Bowles. Based on the description of the book, it
appears to be a report about the author’s self-administration of extremely high doses of vitamin D. We were not able to
locate any peer-reviewed studies by the author that might validate or support his book’s contents.
Vitamin D has a significant amount of research regarding its role in immune regulation. As Multiple Sclerosis is a
disease characterized by autoimmune-related demyelination of nerve cells, it is not surprising that Vitamin D may play
a supportive role in nerve function. In our Multiple Sclerosis protocol, we write the following:
“Mainstream medicine has failed to recognize the pivotal role of vitamin D in regulating the overactive immune system
in MS patients.
Greater than 30 years have passed since vitamin D was originally hypothesized to be an important environmental
determinant of the prevalence of MS (Goldberg 1974; Craelius 1978). During the three decades following the initial
linking of vitamin D and MS, evidence has continued to mount. It is now known that MS occurs more frequently in
individuals with lower blood levels of vitamin D. A study published in the prestigious Journal of the American Medical
Association found that, compared to those with the highest vitamin D blood levels, those with the lowest blood levels
were 62% more likely to develop MS.
MS attacks occur less frequently during seasons corresponding with the highest exposure to sunlight; since vitamin D
synthesis depends upon exposure of the skin to sunlight, the summer months also bring the highest blood levels of
vitamin D (Tremlett 2008). A recent study has quantified the impact of vitamin D blood levels on risk for MS relapse –
for each 4 ng/ml increase in 25-hydroxy vitamin D in the blood, the risk for MS relapse is reduced by 12%. The
investigators who conducted this study concluded that “Clinically, raising 25-hydroxy vitamin D levels by [20 ng/ml]
could halve the hazard of a relapse” (Simpson 2010).
Vitamin D mediates these disease-modifying effects through complex and powerful interactions with the immune
system. Hostile immune cells, which attack the myelin sheath, are calmed upon exposure to vitamin D. In fact, when
aggressive immune cells taken directly from MS patients are exposed to the active form of vitamin D, the cells divide
and reproduce much more slowly, indicating that vitamin D has the ability to impede the aberrant autoimmunity that is
a driving force in MS.
However, vitamin D does more than just arrest damaging immune cells; it also supercharges protective immune cells.
T-reg cells are specialized components of the immune system that help keep immunity balanced. If too few T-reg cells
are present, the immune system becomes overactive, as in autoimmune diseases like MS. Vitamin D increases the
number of protective T-reg cells, restoring equilibrium to an overactive immune system (Correale 2009).
In a randomized controlled trial, supplementation with doses of vitamin D ranging from 10,000 IU to 40,000 IU daily over
the course of 52 weeks resulted in a reduction in relapses and a reduction in the number of aggressive immune cells in
patients with MS (Burton 2010).
Despite robust findings across a range of studies on the link between vitamin D and MS, mainstream medicine and the
federal government have only just recently begun to realize the need to initiate federally funded trials. A large scale,
randomized, controlled clinical trial to assess the effects of vitamin D in MS is now recruiting; the study is expected to
be complete in 2014 (ClinicalTrials.gov [NCT01285401]).”
The above information and cited studies may be referenced from our protocol, available at the following link:
http://www.lef.org/protocols/neurological/multiple_sclerosis_01.htm
It is important to constantly evaluate emerging research and allow our understanding of nature to remain fluid and
dynamic. As our understanding of nutrition and physiology evolves, paradigm shifts may change our understanding of
scientific theory as it applies to human health. Anecdotes and case reports serve a role in allowing us to question
accepted norms, but should not represent the basis or rationale for making suggestions regarding safe and
responsible healthcare or disease prevention. The collective body of scientific evidence should always be considered
when reviewing individual reports regarding health.
29
As we discussed in a prior email correspondence, although certain cases of excessive Vitamin D ingestion suggest
that such dosages may be tolerable for many people over a short term, they do not suggest that it would be safe or
necessary for most people to ingest such quantities long-term. 25-hydroxy vitamin D blood levels exceeding 100 ng/dL
have been linked to increased risk of cardiovascular events. Life Extension suggests 25-hydroxy-vitamin D levels be
maintained between 50 and 80 ng/dL. Most people require between 5000-8000 IU of Vitamin D3 daily to attain this level.
In rare instances, doses of less than 5,000 IU result in blood levels greater than 100 ng/mL. In other instances, some
people may require doses higher than 8000 IU daily to achieve optimal levels.
All individuals react differently to particular dosages of any compound. Vitamin D may not always be fully absorbed or
metabolized effectively and differences in body weight and vitamin D storage may also affect blood concentrations.
Regular blood work is important to ensure vitamin D blood concentrations stay within a safe range. While the
aforementioned adverse outcomes are not always seen in every individual, they are still potential risks. A risks and
benefits analysis should always be conducted prior to any therapeutic intervention.
Here is an article Life Extension published regarding the potential dangers of excessive Vitamin D blood levels:
http://www.lef.org/magazine/mag2012/may2012_New-Study-Warns-Against-Excessive-Vitamin-D-Intake_01.htm
Thanks for Your ideas.
" the basis or rationale for making suggestions regarding safe and responsible healthcare or disease prevention" is
naturally also a question of the Philosophy of Science. In that "Anything Goes" in the Sense of Prof. Paul Feyerabend
might be more leading to a good future.
Scientific evidence in medicine, often according to the rules of RCT's might be misleading.
But I agree totally to " Regular blood work is important to ensure vitamin D blood concentrations stay within a safe
range."
The problem in so called scientific medicine is the neglecting of the personal experience of the doctors. which is more
worth, than statistic. But there we might not come to a consensus.
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Von: CustomerService@lifeextension.com [mailto:CustomerService@lifeextension.com]
Gesendet: Mittwoch, 19. März 2014 20:17
An: volker@vonabisw.de
Betreff: Case:[2860999] - AW: Supplementing Vitamin D3
Dear Volker Schendel ,
Thank you for your recent correspondence.
30
It is important to constantly evaluate emerging research and allow our understanding of nature to remain fluid and dynamic. As
our understanding of nutrition and physiology evolves, paradigm shifts may change our understanding of scientific theory as it
applies to human health. Anecdotes and case reports serve a role in allowing us to question accepted norms, but should not
represent the basis or rationale for making suggestions regarding safe and responsible healthcare or disease prevention
. The collective body of scientific evidence should always be considered when reviewing individual reports regarding health.
As we discussed in a prior email correspondence, although certain cases of excessive Vitamin D ingestion suggest that such
dosages may be tolerable for many people over a short term, they do not suggest that it would be safe or necessary for most
people to ingest such quantities long-term. 25-hydroxy vitamin D blood levels exceeding 100 ng/dL have been linked to
increased risk of cardiovascular events. Life Extension suggests 25-hydroxy-vitamin D levels be maintained between 50 and 80
ng/dL. Most people require between 5000-8000 IU of Vitamin D3 daily to attain this level. In rare instances, doses of less than
5,000 IU result in blood levels greater than 100 ng/mL. In other instances, some people may require doses higher than 8000 IU
daily to achieve optimal levels.
All individuals react differently to particular dosages of any compound. Vitamin D may not always be fully absorbed or
metabolized effectively and differences in body weight and vitamin D storage may also affect blood concentrations. Regular
blood work is important to ensure vitamin D blood concentrations stay within a safe range.
While the aforementioned adverse outcomes are not always seen in every individual, they are still potential risks. A risks and
benefits analysis should always be conducted prior to any therapeutic intervention.
Here is an article Life Extension published regarding the potential dangers of excessive Vitamin D blood levels:
http://www.lef.org/magazine/mag2012/may2012_New-Study-Warns-Against-Excessive-Vitamin-D-Intake_01.htm
If you have any additional questions, please email us or call the advisor helpline at (800) 226-2370; international customers dial
001-954-202-7660. We will be happy to assist you.
Hello and thanks.
According to my preliminary research results, the protocol of research by Dr. Coimbra in Brazil is designed to
supplement vitamin D 3 (probably supplemented by high doses of K2) in the maximum individual dosis for each
patient from 50,000 IU D3 or higher every day consecutively for more than 6 months, strictly administered with
constant controls against hypercalcemia. From this research approach this is totally unsuitable for any research
studyy design other than personal health and healing reports.
Scientific studies could not follow a Research Design of this kind..
This means probably that Dr. Coimbra rated higher the success in healing his patients than RCT standards. As you can
see , there's the ethical problem? -
I doubt , there is a chance for a RCT with Dr. Cicero Coimbra's approach. But then, according to the President of the
German official Chamber of the Medical Profession (Bundesärztekammer), only 40 % of the official medicine is
evidence based.
" Professor Dr. Jörg-Dietrich Hoppe, Präsident der Bundesärztekammer, auf dem Dialogforum Pluralismus in der Medizin: https://www.aekno.de/page.asp?pageID=8736&noredir=True - …Maximal 40 Prozent der Medizin sei evidenzbasiert und
finde sich früher oder später in wissenschaftlichen Leitlinien wieder, sagte Hoppe bei der Feier zum zehnjährigen Jubiläum des
Forums in der Hauptstadt. "
If the treatment of the MS patients has an individual approach - meaning every patient gets his or her maximised
dosage in the area between 50.000 I.U. Vitamin D 3 per day for six months controlled individually against
hypercalcemia and supplemented for example with 360 mcg Vitamin K 2 (personal advice of Dr. Cees Vermeer from
the research group in Maastricht, Holland, Netherlands in his internet interview with Dr. Mercola) how valid could this
research be, if a general applied dose of Vitamin D 3 in the verum-group is forbidden?
31
But could it be, that the healing of MS patients in Brasil is more important than following scientific rules and should
this be a reason for Lifeextension to get into contact with the Brasilian Doctors?
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Von: CustomerService@lifeextension.com [mailto:CustomerService@lifeextension.com]
Gesendet: Mittwoch, 19. März 2014 20:32
An: volker@vonabisw.de
Betreff: *** GMX Spamverdacht *** Case:[2859507] - WG: Presseanfrage zur Supplementierung von Vitamin D3
Dear Volker Schendel ,
Thank you for your recent correspondence.
The first document you provided is simply a collection of user-generated reviews for the eBook you previously linked
to. Life Extension has not reviewed the content of the eBook by Jeff T Bowles. Based on the description of the book, it
appears to be a report about the author’s self-administration of extremely high doses of vitamin D. We were not able to
locate any peer-reviewed studies by the author that might validate or support his book’s contents.
Vitamin D has a significant amount of research regarding its role in immune regulation. As Multiple Sclerosis is a
disease characterized by autoimmune-related demyelination of nerve cells, it is not surprising that Vitamin D may play
a supportive role in nerve function. In our Multiple Sclerosis protocol, we write the following:
“Mainstream medicine has failed to recognize the pivotal role of vitamin D in regulating the overactive immune system
in MS patients.
Greater than 30 years have passed since vitamin D was originally hypothesized to be an important environmental
determinant of the prevalence of MS (Goldberg 1974; Craelius 1978). During the three decades following the initial
linking of vitamin D and MS, evidence has continued to mount. It is now known that MS occurs more frequently in
individuals with lower blood levels of vitamin D. A study published in the prestigious Journal of the American Medical
Association found that, compared to those with the highest vitamin D blood levels, those with the lowest blood levels
were 62% more likely to develop MS.
MS attacks occur less frequently during seasons corresponding with the highest exposure to sunlight; since vitamin D
synthesis depends upon exposure of the skin to sunlight, the summer months also bring the highest blood levels of
vitamin D (Tremlett 2008). A recent study has quantified the impact of vitamin D blood levels on risk for MS relapse –
for each 4 ng/ml increase in 25-hydroxy vitamin D in the blood, the risk for MS relapse is reduced by 12%. The
investigators who conducted this study concluded that “Clinically, raising 25-hydroxy vitamin D levels by [20 ng/ml]
could halve the hazard of a relapse” (Simpson 2010).
Vitamin D mediates these disease-modifying effects through complex and powerful interactions with the immune
system. Hostile immune cells, which attack the myelin sheath, are calmed upon exposure to vitamin D. In fact, when
aggressive immune cells taken directly from MS patients are exposed to the active form of vitamin D, the cells divide
and reproduce much more slowly, indicating that vitamin D has the ability to impede the aberrant autoimmunity that is
a driving force in MS.
However, vitamin D does more than just arrest damaging immune cells; it also supercharges protective immune cells.
32
T-reg cells are specialized components of the immune system that help keep immunity balanced. If too few T-reg cells
are present, the immune system becomes overactive, as in autoimmune diseases like MS. Vitamin D increases the
number of protective T-reg cells, restoring equilibrium to an overactive immune system (Correale 2009).
In a randomized controlled trial, supplementation with doses of vitamin D ranging from 10,000 IU to 40,000 IU daily over
the course of 52 weeks resulted in a reduction in relapses and a reduction in the number of aggressive immune cells in
patients with MS (Burton 2010).
Despite robust findings across a range of studies on the link between vitamin D and MS, mainstream medicine and the
federal government have only just recently begun to realize the need to initiate federally funded trials. A large scale,
randomized, controlled clinical trial to assess the effects of vitamin D in MS is now recruiting; the study is expected to
be complete in 2014 (ClinicalTrials.gov [NCT01285401]).”
The above information and cited studies may be referenced from our protocol, available at the following link:
http://www.lef.org/protocols/neurological/multiple_sclerosis_01.htm
It is important to constantly evaluate emerging research and allow our understanding of nature to remain fluid and
dynamic. As our understanding of nutrition and physiology evolves, paradigm shifts may change our understanding of
scientific theory as it applies to human health. Anecdotes and case reports serve a role in allowing us to question
accepted norms, but should not represent the basis or rationale for making suggestions regarding safe and
responsible healthcare or disease prevention. The collective body of scientific evidence should always be considered
when reviewing individual reports regarding health.
As we discussed in a prior email correspondence, although certain cases of excessive Vitamin D ingestion suggest
that such dosages may be tolerable for many people over a short term, they do not suggest that it would be safe or
necessary for most people to ingest such quantities long-term. 25-hydroxy vitamin D blood levels exceeding 100 ng/dL
have been linked to increased risk of cardiovascular events. Life Extension suggests 25-hydroxy-vitamin D levels be
maintained between 50 and 80 ng/dL. Most people require between 5000-8000 IU of Vitamin D3 daily to attain this level.
In rare instances, doses of less than 5,000 IU result in blood levels greater than 100 ng/mL. In other instances, some
people may require doses higher than 8000 IU daily to achieve optimal levels.
All individuals react differently to particular dosages of any compound. Vitamin D may not always be fully absorbed or
metabolized effectively and differences in body weight and vitamin D storage may also affect blood concentrations.
Regular blood work is important to ensure vitamin D blood concentrations stay within a safe range. While the
aforementioned adverse outcomes are not always seen in every individual, they are still potential risks. A risks and
benefits analysis should always be conducted prior to any therapeutic intervention.
Here is an article Life Extension published regarding the potential dangers of excessive Vitamin D blood levels:
http://www.lef.org/magazine/mag2012/may2012_New-Study-Warns-Against-Excessive-Vitamin-D-Intake_01.htm
If you have any additional questions, please email us or call the advisor helpline at (800) 226-2370; international
customers dial 001-954-202-7660. We will be happy to assist yo
Hello Lisa,
thanks for Your feedback.
The basis or rationale for making suggestions regarding safe and responsible healthcare or disease prevention is
naturally also a question of the Philosophy of Science. In that "Anything Goes" in the Sense of Prof. Paul Feyerabend
might be more leading to a good future. - Scientific evidence in medicine, often according to the rules of RCT's might
be misleading. - But I agree totally to " Regular blood work is important to ensure vitamin D blood concentrations stay
within a safe range." - The problem in so called scientific medicine is the neglecting of the personal experience of the
doctors. which is more worth, than statistic. But there we might not come to a consensus.
I doubt , there is a chance for a RCT with Dr. Cicero Coimbra's approach. But then, according to the President of the
German official Chamber of the Medical Profession (Bundesärztekammer), only 40 % of the official medicine is
evidence based.
" Professor Dr. Jörg-Dietrich Hoppe, Präsident der Bundesärztekammer, auf dem Dialogforum Pluralismus in der
Medizin: - https://www.aekno.de/page.asp?pageID=8736&noredir=True - …Maximal 40 Prozent der Medizin sei
33
evidenzbasiert und finde sich früher oder später in wissenschaftlichen Leitlinien wieder, sagte Hoppe bei der Feier zum
zehnjährigen Jubiläum des Forums in der Hauptstadt. "
If the treatment of the MS patients has an individual approach - meaning every patient gets his or her maximised
dosage in the area between 50.000 I.U. Vitamin D 3 per day for six months controlled individually against
hypercalcemia and supplemented for example with 360 mcg Vitamin K 2 (personal advice of Dr. Cees Vermeer from
the research group in Maastricht, Holland, Netherlands in his internet interview with Dr. Mercola) how valid could this
research be, if a general applied dose of Vitamin D 3 in the verum-group is forbidden? - But could it be, that the
healing of MS patients in Brasil is more important than following scientific rules and should this be a reason for you
and your team to get into direct contact with the Brasilian Doctors?
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Von: Lisa Melton [mailto:lmelton@msra.org.au]
Gesendet: Donnerstag, 20. März 2014 00:00
An: 'Volker H. Schendel'
Cc: Helmut Butzkueven
Betreff: RE: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero Coimbra with
daily intake of 50.000 I.U. Vitamin D 3
Dear Volker
In relation to MS, there is a great deal of evidence to suggest that both sun exposure and vitamin D levels independently affect
the risk of developing MS. The data is very much correlative/circumstantial. To date there have been no clinical trials of
sufficient size and good design to provide the necessary evidence that vitamin D can prevent MS in those at high risk, or treat
MS for those with established disease.
Despite this there is a great deal of advice (both on the web and from GPs etc) that people with MS should take vitamin D
supplements. However, without properly designed clinical trials we cannot know whether vitamin D supplements are safe and
effective in reducing a person's risk of developing MS or whether it can reduce the risk and severity of relapses in people with
established MS. And we also don't know what is the most appropriate dose of vitamin D for people with MS.
As a result of this, MS Research Australia, together with a consortium of highly experienced MS neurologists, endocrinologists
and epidemiologists is now running a clinical trial in Australia and New Zealand to determine whether vitamin D can reduce the
risk of developing MS (in people with a first demyelinating event), whether it is safe and what is the correct dose
(http://www.mstrials.org.au/PrevANZ-Trial ).
The PrevANZ trial has been very carefully designed and is based on previous data from other smaller clinical trials and on a
pilot study conducted in Australia. With the doses being tested we expect to raise the serum vitamin D of the majority of
participants by a clinically significant level. We will be correlating the outcomes both with the dose taken and the serum level
achieved to obtain an accurate understanding of what serum level is necessary to achieve a therapeutic benefit. In parallel we
will also be controlling for sun exposure, diet and lifestyle factors that may confound the results.
As Helmut mentioned there is also a trial underway in France with a similar approach, but using a dosing regimen of 100,000
I.U. per fortnight.
It is not clear from the information you have sent whether Dr Coimbra is conducting a randomised controlled trial of his treatment
protocol. However, this is what would be required to obtain evidence for the safety and efficacy of this approach.
Kind regards
Lisa
34
Dr Lisa Melton
BSc, PhD
Research Development Manager
MS Research Australia
02 8484 1306 • 1300 356 467
lmelton@msra.org.au • www.msra.org.au
Level 26 Northpoint • 100 Miller Street • North Sydney NSW 2060
From: Volker H. Schendel [mailto:volker@vonabisw.de]
Sent: Thursday, 20 March 2014 3:19 AM
To: Lisa Melton
Subject: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero Coimbra with daily
intake of 50.000 I.U. Vitamin D 3
Hello Lisa,
according to my preliminary research results, the protocol of research by Dr. Coimbra in Brazil is designed to
supplement vitamin D 3 (probably supplemented by high doses of K2) in the maximum individual dosis for each
patient from 50,000 IU D3 or higher every day consecutively for more than 6 months, strictly administered with
constant controls against hypercalcemia. From this research approach this is totally unsuitable for anything other than
personal health and healing reports.
Scientific studies could not follow a Research Design of this kind..
This means IMHO that Dr. Coimbra rated higher the success in healing his patients than RCT standards. As you can
see , there's the ethical problem? - All the Australian and New Zealand MS Studies with Vitamin D 3 are probably much
too low in the daily dose.
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
35
http://www.vonabisw.de/48.html
Von: Lisa Melton [mailto:lmelton@msra.org.au]
Gesendet: Mittwoch, 19. März 2014 05:57
An: 'Helmut Butzkueven'; Volker H. Schendel
Betreff: RE: AW: WG: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero
Coimbra with daily intake of 50.000 I.U. Vitamin D 3
Dear Volker
You can read more details of our Australian vitamin D trial here http://www.msra.org.au/prevanz
Let me know if you have any further questions, that I might be able to help with
Regards
Lisa
Dr Lisa Melton
BSc, PhD
Research Development Manager
MS Research Australia
02 8484 1306 • 1300 356 467
lmelton@msra.org.au • www.msra.org.au
Level 26 Northpoint • 100 Miller Street • North Sydney NSW 2060
From: Helmut Butzkueven [mailto:butz@unimelb.edu.au]
Sent: Wednesday, 19 March 2014 1:58 AM
To: Volker H. Schendel
Cc: Lisa Melton
Subject: Re: AW: WG: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero
Coimbra with daily intake of 50.000 I.U. Vitamin D 3
Hi Volker
We are examining daily doses of 1000,5000 or 10000 versus placebo, in a standard randomised, controlled design.
There is a french group with a similar trial design (endpoint- new lesions/relapses ) examining 100,000 units/every 2
weeks versus placebo. So no, no data on doses of 50,000 IU/day will be generated from these trials.
36
Best
helmut
From: "Volker H. Schendel" <volker@vonabisw.de>
Date: Wednesday, 19 March 2014 12:53 am
To: Site License <butz@unimelb.edu.au>
Subject: AW: WG: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero Coimbra
with daily intake of 50.000 I.U. Vitamin D 3
Hello Helmut,
Is my assumption correct, that Your Australian approach is miles away and below from the Brasilian Medical Approach
with the Intention to cure MS with 50.000 I.U. per day for six consecutive months ?
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Von: Helmut Butzkueven [mailto:butz@unimelb.edu.au]
Gesendet: Dienstag, 18. März 2014 02:59
An: Volker H. Schendel
Cc: Lisa Melton
Betreff: Re: WG: Research in Multiple Sklerose (MS) cureby the brasilian Reearch Group araound Dr. Cicero Coimbra
with daily intake of 50.000 I.U. Vitamin D 3
DearMr Schendel
MS research Australia is conducting a trialof different doses of vitamin D to suppress disease activity in early MS.
The MSRA coordinator is Lisa Melton, she can provide you with press information ifyou wish.
Best
Helmut
From: "Volker H. Schendel" <volker@vonabisw.de>
Date: Monday, 17 March 2014 11:45 pm
37
To: Site License <butz@unimelb.edu.au>
Subject: WG: Research in Multiple Sklerose (MS) cure by the brasilian Reearch Group araound Dr. Cicero Coimbrawith
daily intake of 50.000 I.U. Vitamin D 3
Hello,
could I get a comment from You to the Research in Multiple Sclerosis (MS) cure by the Brasilian Research Group
around Dr. Cicero Coimbra with daily intake of 50.000 I.U. Vitamin D 3
documentedhere:
http://www.youtube.com/watch?v=erAgu1XcY-U
Sincerely
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Hallo Herr Schendel,
Vitamin D3 hat eine sehr breite Wirkung. Abgesehen davon, dass manche Leute bei medizinischen Erfolgsberichten
zum Übertreiben neigen, gehe ich davon aus, dass diese positiven Berichte wahrheitsgemäß sind!
J Wissen Sie, was Midi-Chlorianer sind? J
„Midi-Chlorianer sind eine mikroskopisch kleine Lebensform, die sich in allen lebenden Zellen befindet. Und
wir leben in Symbiose mit ihnen. Das sind Lebensformen, die zum gegenseitigen Vorteil eng miteinander
leben. Ohne die Midi-Chlorianer könnte kein Leben existieren und wir hätten auch keine Kenntnis von der
38
Macht. Ohne Unterlass sprechen sie zu uns und teilen uns den Willen der Macht mit. Wenn du gelernt hast
deine Gedanken zum Schweigen zu bringen, wirst du auch hören, was sie sagen.“
— Qui-Gon Jinn zu Anakin Skywalker (Quelle)
Midi-Chlorianer sind sozusagen die intrazellulären Rezeptoren Der Macht. Hochdosiertes Vitamin D3 erhöht die Anzahl
der Midi-Chlorianer (ebenso wie S-Acetylglutahion). Es stärkt also auch Jedis!
Herzlicher Gruß,
Lorenz Geßwein
Many Thanks for Your feedback..
What Do you think of the here reported Cases:
http://www.amazon.com/MIRACULOUS-RESULTS-EXTREMELY-SUNSHINE-EXPERIMENT-ebook/productreviews/B005FCKN2S/ref=cm_cr_pr_btm_link_1?ie=UTF8&showViewpoints=0&sortBy=byRankDescending
= http://d.mp3vhs.de/vonabisw/Labor/Lb21.docx
and could I get a comment from You to the Research in Multiple Sclerosis (MS) cure by the Brasilian Research Group
around Dr. Cicero Coimbra with daily intake of 50.000 I.U. Vitamin D 3 for more than 6 consecutive months
documented here:
http://www.youtube.com/watch?v=erAgu1XcY-U
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
Von: CustomerService@lifeextension.com [mailto:CustomerService@lifeextension.com]
Gesendet: Montag, 17. März 2014 22:07
An: volker@vonabisw.de
Betreff: *** GMX Spamverdacht *** Case:[2859507] - WG: Presseanfrage zur Supplementierung von Vitamin D3
39
Dear Volker Schendel ,
Thank you for your recent correspondence.
Although these cases of excessive Vitamin D ingestion suggest that such dosages may be tolerable for many people
over a one or two year period, they do not suggest that it would be safe or necessary for most people to ingest such
quantities long-term. 25-hydroxy vitamin D blood levels exceeding 100 ng/dL have been linked to increased risk of
cardiovascular events. Life Extension suggests 25-hydroxy-vitamin D levels be maintained between 50 and 80 ng/dL.
Most people require between 5000-8000 IU of Vitamin D3 daily to attain this level. In rare instances, doses of less than
5,000 IU result in blood levels greater than 100 ng/mL. In other instances, some people may require doses higher than
8000 IU daily to achieve optimal levels. Regular blood work is important to ensure vitamin D blood concentrations stay
within a safe range.
Here is an article Life Extension published regarding the potential dangers of excessive Vitamin D blood levels:
http://www.lef.org/magazine/mag2012/may2012_New-Study-Warns-Against-Excessive-Vitamin-D-Intake_01.htm
Life Extension has not reviewed the content of the eBook by Jeff T Bowles. Based on the description of the book, it
appears to be a report about the author’s self-administration of extremely high doses of vitamin D. We were not able to
locate any peer-reviewed studies by the author that might validate or support his book’s contents.
Dear Volker Schendel ,
Thank you for your recent correspondence.
Although these cases of excessive Vitamin D ingestion suggest that such dosages may be tolerable for many people over a one
or two year period, they do not suggest that it would be safe or necessary for most people to ingest such quantities long-term.
25-hydroxy vitamin D blood levels exceeding 100 ng/dL have been linked to increased risk of cardiovascular events. Life
Extension suggests 25-hydroxy-vitamin D levels be maintained between 50 and 80 ng/dL. Most people require between 50008000 IU of Vitamin D3 daily to attain this level. In rare instances, doses of less than 5,000 IU result in blood levels greater than
100 ng/mL. In other instances, some people may require doses higher than 8000 IU daily to achieve optimal levels. Regular
blood work is important to ensure vitamin D blood concentrations stay within a safe range.
Here is an article Life Extension published regarding the potential dangers of excessive Vitamin D blood levels:
http://www.lef.org/magazine/mag2012/may2012_New-Study-Warns-Against-Excessive-Vitamin-D-Intake_01.htm
Life Extension has not reviewed the content of the eBook by Jeff T Bowles. Based on the description of the book, it appears to
be a report about the author’s self-administration of extremely high doses of vitamin D. We were not able to locate any peerreviewed studies by the author that might validate or support his book’s contents.
If you have any additional questions, please email us or call the advisor helpline at (800) 226-2370; international customers dial
001-954-202-7660. We will be happy to assist you.
Hallo Herr Schendel,
… „angemessene Schlussfolgerungen“? Die habe ich für meine Praxis gezogen. Aber die allermeisten Patienten folgen
mir nicht. Ich bin nur HP, und „2.000 IE Vitamin D3 ist ja schon doppelt so viel wie die Standarddosis, die Ärzte
empfehlen!“ Ich sage dann immer: „Unser Kinderarzt hat unseren Kindern vor 30 Jahren, als sie Säuglinge waren,
1.000 IE Vitamin D3 pro Tag verordnet. Denken Sie mal darüber nach.“
Auch das hier wird von mir dringendst empfohlen. Wer bei der Bestellung meinen Namen erwähnt, bekommt sogar
30% Rabatt auf den Nettopreis. Wer befolgt meinen Rat? Fast keiner! Die Leute haben ein schlafendes Bewusstsein!
Die träumen auch noch von diesem Ideal! Grundlegender dargestellt hier!
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Herzliche Grüße,
Lorenz Geßwein
Lorenz Geßwein
Heilpraktiker
Am Zinnbruch 34
53129 Bonn
Telefon: (0228) 360 25 733
Telefax: (0228) 360 25 734
E-Mail: praxis@hp-gesswein.de
Internet: www.hp-gesswein.de
Aktuelles Interview: www.netzwerk-frauengesundheit.com
Von: Volker H. Schendel [mailto:volker@vonabisw.de]
Gesendet: Dienstag, 18. März 2014 15:22
An: 'Lorenz Gesswein'
Betreff: AW: Fallberichte zu monatelangen extrem hohen Supplementierungen von Vitamin D 3
Hallo Herr Geßwein,
wenn diese Fälle echt sind, wer zieht dann die angemessenen Schlußfolgerungen?
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
41
Von: Lorenz Gesswein [mailto:praxis@hp-gesswein.de]
Gesendet: Montag, 17. März 2014 17:12
An: 'Volker H. Schendel'
Betreff: AW: Fallberichte zu monatelangen extrem hohen Supplementierungen von Vitamin D 3
Hallo Herr Schendel,
Vitamin D3 hat eine sehr breite Wirkung. Abgesehen davon, dass manche Leute bei medizinischen Erfolgsberichten
zum Übertreiben neigen, gehe ich davon aus, dass diese positiven Berichte wahrheitsgemäß sind!
J Wissen Sie, was Midi-Chlorianer sind? J
„Midi-Chlorianer sind eine mikroskopisch kleine Lebensform, die sich in allen lebenden Zellen befindet. Und
wir leben in Symbiose mit ihnen. Das sind Lebensformen, die zum gegenseitigen Vorteil eng miteinander
leben. Ohne die Midi-Chlorianer könnte kein Leben existieren und wir hätten auch keine Kenntnis von der
Macht. Ohne Unterlass sprechen sie zu uns und teilen uns den Willen der Macht mit. Wenn du gelernt hast
deine Gedanken zum Schweigen zu bringen, wirst du auch hören, was sie sagen.“
— Qui-Gon Jinn
zu Anakin Skywalker (Quelle)
Midi-Chlorianer sind sozusagen die intrazellulären Rezeptoren Der Macht. Hochdosiertes Vitamin D3 erhöht die Anzahl
der Midi-Chlorianer (ebenso wie S-Acetylglutahion). Es stärkt also auch Jedis!
Herzlicher Gruß,
Lorenz Geßwein
Lorenz Geßwein
Heilpraktiker
Am Zinnbruch 34
53129 Bonn
Telefon: (0228) 360 25 733
Telefax: (0228) 360 25 734
E-Mail: praxis@hp-gesswein.de
42
Internet: www.hp-gesswein.de
Aktuelles Interview: www.netzwerk-frauengesundheit.com
Von: Volker H. Schendel [mailto:volker@vonabisw.de]
Gesendet: Montag, 17. März 2014 16:36
An: Udo Böhm
Betreff: Fallberichte zu monatelangen extrem hohen Supplementierungen von Vitamin D 3
Hallo Dr. Böhm,
würden Sie solche Fallberichte:
Fallberichte: http://www.amazon.com/MIRACULOUS-RESULTS-EXTREMELY-SUNSHINE-EXPERIMENT-ebook/productreviews/B005FCKN2S/ref=cm_cr_pr_btm_link_1?ie=UTF8&showViewpoints=0&sortBy=byRankDescending
= http://d.mp3vhs.de/vonabisw/Labor/Lb21.docx
ernst nehmen?
Mit freundlichen Grüßen
Volker H. Schendel - Ministerialrat a.D.
Freier Wissenschaftsjournalist
Langrederhof 5
30455 Hannover
Tel.: 0511 / 215 99 44 (mit AB)
http://www.vonabisw.de/48.html
43