Cellular Response
Adaptive
Non Adaptive
Disturbances of
growth
Degeneration
Inflammation
and repair
Neoplasia
Immune
response
Dysplasia
Necrosis

It’s a structure and function changes in
the cells and intracellular substance (C.T)
due to mild and moderate injury, not
severe enough to cause cell death.
1- Cloudy swelling:
Accumulation of
caused by ATP.
water
within
the
cells
2- Fatty changes:
Pathological accumulation of excess neutral
fat in the cells.
3-A myloid degeneration(amyloidosis):
Extracellular accumulation of amyloid
(abnormal protein)
4-Hyaline degeneration:
Microscopic change in the tissues
which become homogenous
,structure less & stain pink with eosin
have a glassy appearance.
The kidney are swollen due to entry of water , soft, bloodless and pale, the
borders are rounded.
Cells are swollen, conical in shape with fine red granular cytoplasm
and normal nuclei, lumen of cell appear as star shape.
Pale Yellow color ,enlarged of size, soft and border round
-the cell swollen & show empty vacuoles in cytoplasm of cells .It is occupied by
fat accumulation ,
-the nuclei of cell are pushed by accumulated fat against the cell membrane
,And become flattened giving the cell a signet ring appearance
Homogenous pink a myloid deposit in:
-The branches of the hepatic artery in the portal tracts which become
thickened and narrowed.
-B.M of sinusoids between lining endothelium and liver cells.
The kidney is enlarged, the cut surface is waxy with border shape &
shows light brown dots caused by amyloid deposit
Homogenous pink a myeloid deposit in wall of the arteries. The wall appear thick
and narrow lumen
a myeloid deposit in the basement membrane of glomerular capillaries
Homogenous pink a myeloid deposit in:
- wall of the arteries. It is appear thick and narrow lumen
-the basement membrane of glomerular capillaries
- the basement membrane of collecting tubules preventing waterr
reabsorbing.
Hyaline change affecting the central arterioles of the lymph follicles ,the C.T of it
,become structure less homogenous and pink with eosin and glass reflected
material. The wall of arterioles become thick and narrowed lumens