Name____________________________________ Score:_______________________
Choose the best answer for the following questions, then explain why the answer
you choose is correct. Each question is worth 4 pts.
1. How would insulin be produced in the secretory pathway?
a. Constitutive secretion
d. Regulated secretion
b. In the Domesticated Pathway
e. None of the above
c. In the Endocytic Pathway
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2. Vesicles travel throughout the cell along which cellular structure(s)?
a. Cytoplasm
c. Endoplasmic Reticulum
b. Plasma Membrane
d. Microtubules & Microfilaments
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3. Signal Peptides are important to secretory proteins because:
a. They direct proteins into the ER Membrane
b. They cleave the pre-protein sequence to form a mature protein
c. They direct proteins to their proper cellular destinations
d. They direct proteins into the ER lumen
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4. Stop-Transfer sequences are important to proteins because:
a. They insert proteins into the ER Membrane
b. They cleave the pre-protein sequence to form a mature protein
c. They direct proteins to their proper cellular destinations
d. They direct proteins into the ER lumen
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5. Clatherin-coated vesicles direct cellular cargo to which of the following:
a. Golgi
c. Endoplasmic Reticulum
b. Lysosomes
d. Plasma Membrane
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6. Fuzzy-coated vesicles direct cellular cargo to which of the following:
a. Golgi
c. Endoplasmic Reticulum
b. Lysosomes
d. Plasma Membrane
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7. Which of the following peptides would be a candidate for N-glycosylation?
a. Ala-Ser-Asp-Met-Pro-Val
c. Lys(OH)-Pro-Ser-Phe-Thr-Arg
b. Lys-Ser-Pro-Thr-Met-Ala
d. Lys-Pro-Asn-Arg-Thr-Pro
c. Asp-Pro-Ser-Ala-Val-Thr
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8. Which type of glycosylation occurs in the Golgi?
a. N-glycosylation
c. O-glycosylation
b. Both
d. Neither
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9. Which of the following peptides would have the most potential for Oglycosylation?
a. Ala-Ser-Asp-Met-Pro-Val
c. Lys(OH)-Pro-Ser-Phe-Thr-Arg
b. Lys-Ser-Pro-Thr-Met-Ala
d. Lys-Pro-Asn-Arg-Thr-Pro
c. Asp-Pro-Val-Ala-Val-Thr
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10. Which product synthesized by Smooth ER is least desirable?
a. Sterols
c. Benzopyrenes
b. Carbohydrates
d. Oxygen-rich by-products
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11. Which post-translational process separates discriminate and nondiscriminate cargo?
a. Glycosylation of protreins with mannose sugars in the Golgi
b. Cleaving Zymogens into active peptides
c. Storing proteins in fuzzy-coated vesicles
d. Protein folding
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12. Which is NOT involved in the proper folding of proteins in the ER?
a. Glycosyltransferases
d. Calnexin
b. Protein-Disulfide Isomerases
e. Protein disulfide isomerase
c. Glycosyltransferases (GT)
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13. Which protein sequence is a candidate to be a membrane protein?
a. Ala-Ser-Asp-Met-Pro-Val
d. Lys(OH)-Pro-Ser-Phe-Thr-Arg
b. Lys-Lys-Pro-Thr-Met-Ala
e. Lys-Pro-Asn-Arg-Thr-Pro
c. Asp-Pro-Ser-Ala-Val-Thr
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14. What is the function of IgpA and IgpB proteins in lysosomal membranes?
a. They maintain a low pH in Lysosomes
b. They prevent degredation of Lysosomal Membrane
c. They are proton-ATPase pumps
d. They transport lysosomal enzymes into the Lysosome
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15. Which is NOT part of the Endomembrane System?
a. Golgi Apparatus
d. Vacuoles
b. Lysosomes
e. Peroxisomes
c. Endosomes
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16. Proteins are targeted to specific cellular sites to which they function by:
a. Sorting Signals
d. Signal Peptides
b. Coated vesicles
c. Signal Recognition Particles
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17. Which is NOT a function of the Smooth ER?
a. Detoxification
b. Release of glycogen from glucose
c. Synthesis of lipids
d. Promoting contractions
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18. Which is NOT an ER membrane protein?
a. Oligosaccharidetransferases
c. Signal Peptidase
b. Protein Disulfide Isomerases
d. Glycosyltransferases
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19. Glycosyltransferases differ from oligosaccharidetransferases in that
Glycosyltransferases add sugars:
a. To a nucleotide sugar
c. To an oligosaccharide chain
b. To proteins
d. Lipids
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20. Which is NOT characteristic of the Golgi?
a. Consists of interconnected compartments of flatten, dislike cisternae
with dilated rims
b. Consist of 8 curved cisternae stacked like pancakes
c. Associated with vesicles and tubules
d. Function in packaging and sorting
e. Consist of cis to trans faces
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21. Which of the following does not occur in the cis- and med- Golgi?
a. Trimming of proteins
b. Cleaving and addition of sugars
c. Addition of mannose-6-phosphate
d. Binding of Pre-lysosomal enzymes to receptors on Golgi
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22. Which peptide would most likely remain in the ER lumen?
a Ala-Ser-Asp-Met-Pro-Val
d. Lys(OH)-Pro-Ser-Phe-Thr-Arg
b. Lys-Lys-Pro-Thr-Met-Ala
e. Lys-Asp-Glu-Leu-Thr-Pro-Ser
c. Asp-Pro-Ser-Ala-Val-Thr
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23. Lysosomes are NOT involved in which of the following functions?
a. Autophagy
c. Intracellular and intercellular digestions
b. Fertilization
d. Oxidative breakdown of substrates
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24.
Which is NOT characteristic of Endosomes?
a. They contain proton ATPase pumps
b. Late endosomes are located near the plasma membrane
c. Its contents are produced in the Biosynthetic-Secretory Pathway
d. Lysosomes are the terminal compartment of this pathway
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25.
Bulk-phase Endocytosis differ from Receptor-Mediated Endocytosis
in that the uptake of materials by Bulk-phase Endocytosis is
stimulated by:
a. Fluid-filled vesicles
b. The binding of molecules to membrane-bound receptors
c. Exocytosis
d. Shrinkage of the Plasma Membrane
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