EXCELLENCE & INNOVATION IN ACADEMIC PATHOLOGY & LABORATORY MEDICINE
WWW.LMP.FACMED.UTORONTO.CA
Vol. 14 #3– 2012
LMPAnnual Reunion & Banquet.
From (top) left to right: Katie Babcock, Dr. Richard Hegele, Christine Kreutzer, Rama Ponda, Zamiha Premji,
(seated) Teresa Trimboli, Robin Wilcoxen, Louella D’Cunha, Joanne D’Angelo, Paula Nixon & Sue Sarju Balaga
COMMENTS FROM THE CHAIR
INVESTIGATING DISEASE. IMPACTING HEALTHCARE.
The Department of Laboratory Medicine and Pathobiology (LMP) occupies a
special place at the interface between basic biomedical science and healthcare.
This location provides an incredible opportunity to make major advances in
understanding of the causes and mechanisms of disease and translating new
knowledge into improved health outcomes for patients and populations.
As part of the implementation of the LMP Strategic Plan 2010-2015, we held the
“LMP Tagline Challenge”, in which the entire department was invited to submit
suggestions for a concise and memorable turn of phrase that embodies the
mission and aspirations of LMP. I was personally overwhelmed by the
response—over 200 entries were submitted for a chance to win an iPad 3. One
cannot help but be impressed by the level of engagement shown by our faculty,
students, trainees and staff. Congratulations to Ghassan Awad Elkarim, one of our students in the
Undergraduate Arts and Science Pathobiology Specialist Program, on winning the iPad 3. It bodes well
for the future of our department to have someone at such an early stage
understand what LMP is all about!
Inside This Issue:
The 2011-12 academic year has been marked by consistent high level
Awards & Honors……..pg 2
performance and accomplishment in the spheres of education, research,
Appointments………….pg 3
creative professional activity and service. Objective evidence for this can be
Announcements……….pg 4
found in the diversity of LMP faculty who were promoted to the rank of Full
Research……………….pg 4
Professor at the University of Toronto during the most recent promotions cycle.
Education……………….pg 5
Congratulations to Drs. Hong Chang, Michael Ohh and Patricia Shaw on their
Hospital Reports……….pg 7
promotions.
Publications………….…pg 11
Photos…………………..pg 16
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
Starting this fall, each LMP faculty member who is
promoted to Full Professor will deliver a “Professorial
Lecture” to the whole department, as part of the LMP
Weekly Seminar Series held on Monday afternoons at
4 p.m. I guarantee you will be impressed by the
incredible accomplishments of these individuals and
their fascinating stories that resulted in each of them
achieving an international reputation with distinction.
LMP does not take the summer off. Our Summer
Student program is well subscribed and students get
the opportunity to work with exceptional faculty on a
wide range of projects. The LMP Summer Student
Research Day is scheduled for August 16th and
everyone is invited to attend and view the posters and
interact with the students who have worked so hard
over their term. I know you will be amazed by the
quantity and quality of research occurring throughout
the department and the caliber of students.
Investigating Disease. Impacting Healthcare. LMP
focuses on real solutions to real problems. That’s what
makes our department such a special place and
thanks to all who contribute to advancing our mission.
With best wishes for the summer.
Richard G. Hegele, MD, FRCPC, PhD
Professor and Chair
AWARDS AND HONORS
LMP 2012 ANNUAL REUNION & BANQUET
Allan Gornall Testimonial Award
Qi Jiang
Allan Pollard Postdoctoral Clinical Chemistry Travel
Award
Julie Shaw
Danny Ghazarian Resident Teaching Award
Scott Boerner & Alden Chesney
Distinguished Service Award
Tony Mazzulli
Graduate Teaching/Education Award
Terence Colgan
Harry Gotlieb Award in Undergraduate Medical
Pathology
Larissa Liontos
John B. Walter Teaching Prize
George Yousef
Linda & Avrum Gotlieb Award
Tao (Tony) Liu
Norman Bethune Award
Julianne Kus
Stuart Allan Hoffman Memorial Prize
Andrea Conroy
Third Year Specialist Pathobiology Award
Michael Wong
Undergraduate Teaching/Education Award
Heyu Ni
Wolfgang Vogel Memorial Travel Award
Nicole White
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Vol. 14 #3- 2012
FACULTY
 Khosrow Adeli has been awarded the 2012 Canadian
Society of Clinical Chemist Award.
 Sahar Al-Haddad received the Dr. Arthur Vandenbroucke
Award for Teaching to Laboratory Technologists and
Technicians from the Department of Laboratory Medicine
at St. Michael’s Hospital.
 Jagdish Butany received the 2011 Colin Woolf Award for
Longterm Contributions to Continuing Education. The
award recognizes and promotes the importance of
innovative research in continuing education for health
professionals.
 Terence Colgan was awarded the President’s Meritorious
Award for service to the American Society of Colposcopy
and Cervical Pathology at the Society’s Biennial meeting in
San Francisco on March 17th, 2012.
 Eleftherios Diamandis has been honoured as a Fellow of
the American Association for the Advancement of Science
for his contributions to the field of genomics and
pathobiology of serine proteases, particularly the kallikrein
family, and their application as diagnostic cancer
biomarkers.
 Richard Hegele received the Award of Merit from the
Society for Cardiovascular Pathology.
 Jason Karamchandani is the recipient of the Teaching
Award for Excellence in PBL Teaching from the FitzGerald
Academy
 Jeffrey Lee received the 2012 Connaught New
Researcher Award.
 Donald Low was presented with a Council Award. Dr.
Low's research group is recognized internationally for their
Canadian population-based surveillance programs for the
study of antimicrobial resistance and infectious diseases.
 Larissa Matukas received the Dr. Bernadette Garvey
Award for Teaching to Residents, Graduate Students and
Fellows from the Department of Laboratory Medicine at St.
Michael’s Hospital.
 Katerina Pavenski received the Dr. Kalman Kovacs
Award for Teaching to Undergraduate Medical Students
from the Department of Laboratory Medicine at St.
Michael’s Hospital.
 Douglas Templeton is the recipient of the 2012
Excellence in Undergraduate Teaching in the Life Sciences
Award. The award recognizes sustained excellence in
teaching, coordination, and/or development lecture or
seminar courses in Arts and Science offered by the Basic
Sciences Departments in the Faculty of Medicine.
 Ming-Sound Tsao has been awarded the Canadian
Cancer Society's O. Harold Warwick Prize.
 Dan Winer received the Dr. Hubert Wolfe Award in
Endocrine Pathology.
STUDENTS AND TRAINEES
 Jennifer Sacco, MSc won second place in the 2012
Laurence Becker Symposium Poster Competition.
Alberta Innovates Health Solutions Clinical Fellowship
Incentive Award
Vijay Ramaswamy (Michael Taylor)
CIHR CGS Doctoral
Pawel Buczkowicz (Cynthia Hawkins)
Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
CIHR Doctoral Research Award
Eric Shikatani (Husain Mansoor)
CIHR Fellowship
Vijay Ramaswamy (Michael Taylor)
CIHR Vanier Canada Graduate Scholarship
Xin Kevin Wang (Michael Taylor)
Jayesh Salvi (Karim Mekhail)
Samantha Greer (Michael Ohh)
Gordon Cressy Student Leadership Master’s Award
Nisa Mullaithilaga (Chen Wang)
Graduate Student Research Day 2012 Award Winners
MSc:
 Patrick Mott (Alan Lazarus)
 Nadia Okolowsky (Paul Hamel)
 Andrea Savio (Bharati Bapat)
 Alex Tam (Yeni Yucel)
PhD:
 Olga Brashavitskaya (Carol Swallow)
 Alexander Falkenhagen (Sadhna Joshi)
 Nisha Kanwar (Susan Done)
 Paul Nagy (Isabelle Aubert)
 Punit Saraon (Eleftherios Diamandis)
 Bunty Singh (Ren Ke Li)
 Joanna Smeeton (Norman Rosenblum)
NSERC CGS Master’s
Tayyaba Jiwani (Norman Rosenblum)
Queen Elizabeth II Graduate Scholarship in Science and
Technology – Heat and Stroke Foundation of Ontario
Marsel Lino (Khosrow Adeli)
Allan Siu (Myron Cybulsky)
University of Toronto Fellowship
Farshad Azimi (Jeff Lee)
Brian Golbourn (James Rutka)
John Lee (Philip Marsden)
Michael Norris (Theo Moraes)
Jonathan Torchia (Annie Huang)
Postgraduate Trainee 2012 Research Day:
Clinical Awards
 First Place: Michael Sidiropoulos
 Second Place: Manal Tadros
 Third Place: Shawn Winer
Research Awards
 First Place: Nicole White
 Second Place: Julianne Kus
 Third Place: Andrei Drabovich
APPOINTMENTS
CLAMPS EXECUTIVE COUNCIL 2012-2013
President: Stephen McCarthy
Vice-President Academic: Eric Shikatani
Vice-President Social: Evgenia Bloch
Secretary: Henry Cheng
Treasurer: Ekaterina Olkhov
LMPSU EXECUTIVE COUNCIL 2012-2013
President: Desmond She
Vice President Academic: Ghassan El-Karim
Vice-President Financial: William Fung
Vice-President Social Coordinator: Anastasia Bosc
Communications Officers: Darren Benedict, David Dai,
Carl Ren
Social Committee: Florence Chen, Jennifer Lee, Tom Lu
Vol. 14 #3- 2012
LMP NEW STAFF APPOINTMENTS
We have 8 new faculty members who have joined the
Department:
Cameron Ackerley
The Hospital for Sick Children
Rank: Lecturer
Effective: February 1, 2012
Shelley Boyd
St. Michael’s Hospital
Rank: Assistant Professor
Effective: March 1, 2012
Matthew Cesari
Sunnybrook Health Sciences Centre
Rank: Assistant Professor
Effective: May 1, 2012
David Farrell
Ontario Agency for Health & Promotion
Rank: Associate Professor
Effective: April 1, 2012
Mary Ann George
The Hospital for Sick Children
Rank: Assistant Professor
Effective: March 1, 2012
Guangming Han
Sunnybrook Health Sciences Centre
Rank: Assistant Professor
Effective: March 15, 2012
Michael Pickup
Ontario Forensic Pathology Service
Rank: Assistant Professor
Effective: February 1, 2012
Michael Roehrl
Toronto General Hospital (UHN)
Rank: Associate Professor
Effective: June 1, 2012
Kun-Young Sohn
Credit Valley Hospital for Sick Children
Rank: Lecturer
Effective: March 1, 2012
LMP STAFF PROMOTIONS
Hong Chang
Rank: Professor
Effective: July 1, 2012
Lili-Naz Hazrati
Rank: Assistant Professor
Effective: May 3, 2012
Michael Ohh
Rank: Professor
Effective: July 1, 2012
Nades Palaniyar
Rank: Associate Professor
Effective: July 1, 2012
Patricia Shaw
Rank: Professor
Effective: July 1, 2012
Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
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LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
ANNOUNCEMENTS
LMP Tagline Winner
Vol. 14 #3- 2012
 Wednesdays
 Hematopathology Review, 9-10 AM, MSH 6-412 (1st
Wednesday of the month).
 Hematopathology Journal Club/Critical Appraisal, 9-10
nd
am, MSH 6-412 (2 Wednesday of the month).
 Hematopathology Interesting Cases, 9-10 am, MSH 6rd
412 (3 Wednesday of the month).
 Thursdays
 University of Toronto Transfusion Rounds, 12-1 PM, (3rd
Thursday of the month). Check website for venue details
at www.transfusionontario.org.
 Fridays
 The Centre for Forensic Science & Medicine 2011/12
Seminar Series: Controversies in Forensic Science and
Medicine: Towards Resolution in the 21st Century. 1:303:00 PM, Health Science Centre, 155 College St. Rm.
106. (last Friday of the month from November–May).
www.forensics.utoronto.ca/events
Surgical Pathology Update in Kuwait 2012
Ghassan Awad Elkarim with his iPad 3
Ghassan: “LMP is not only a program that I am enrolled in, but also
a family that I am happy to be a part of!”
 Eleftherios Diamandis has been elected to Fellowship in
the Canadian Academy of Health Sciences.
 Avrum Gotlieb has been approved by the Academic
Board of his extension as Acting Vice Dean, Graduate
Affairs. Dr. Gotlieb will continue in this role until December
31, 2012.
 Golnar Rasty has been appointed as an Executive
Committee Member at Iranian Pathology Association of
North America; a subcommittee of USCAP.
 Gino Somers has been appointed as Chair of the
Pathology and Molecular Diagnostics Committee, for the
Pediatric Oncology Group of Ontario.
 Linda Sugar has been appointed as PGME Accreditation
In April, Surgical Pathology Update was a success in Kuwait and
offered as a University of Toronto program. It was co-directed by
Golnar Rasty and Hala El-Zimaity. Speakers also included:
Oyedele Adeyi, Andrew Evans, Naomi Miller, Robert Riddell,
Brendan Dickson and John Srigley.
Consultant.
 Glenn Taylor was named President Elect of the Society
for Pediatric Pathology on March 18, 2012.
LMP ADMINISTRATIVE ANNOUNCEMENTS
 Welcome to Katie Babcock who has joined the LMP
Administrative Team as our Web and Communications
Coordinator, for a two year term, on April 9th.
MEETING CALENDAR
 Canadian Association of Pathologists Conference,
Calgary, AB, July 21-24, 2012. www.cap-acp.org
RESEARCH
SEMINARS / COURSES / ROUNDS
GRANTS AWARDED
 Mondays
 Adeli K. Mechanisms of Hepatic VLDL Overproduction in
 Postgraduate Seminars/Recent Advances in
th
Pathology, 2-4 PM, TGH, Pathology Conference Rm, 11
Flr, Eaton Wing.
 Graduate Student Presentation Seminars, 3-4 PM, MSB
2172.
 LMP Seminars in Molecular Pathobiology, 4-5 PM, MSB
2172.
 Tuesdays
 Postdoctoral Training Program Journal Club, 11-1 PM,
MSH 6-412.
4
Insulin Resistant States. Heart and Stroke Foundation of
Ontario Operating Grant. ($299,437) 3 years.
 Adeli K. Translational Control of Apolipoprotein B mRNA.
NSERC. ($200,000).
 Bendeck M. Cadherins and the Regulation of Smooth
Muscle Cell Function. Heart & Stroke Foundation of
Canada. ($330,258).
Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
 Blasutig I. Validation of Five Candidate Pancreatic Cancer
Biomarkers. National Cancer Institute’s Early Detection
Research Network (USA). ($50,000) 2 years.
 Cybulsky M. Reverse Transmigration of Arterial Intimal
Dendritic Cells. Heart & Stroke Foundation of Canada.
($289,521). 5 years.
 Cybulsky M. Initiation of Atherosclerosis: Mechanisms and
Cell Biology. Heart & Stroke Foundation of Canada, Career
Investigator Awards. ($83,000).
 El-Shawarby M, Khalifa M, Tamimi D, Seth A. Molecular
Genetics of Breast Cancer in Eastern province of Saudi
Arabia: A Pilot Study. University of Dammam ($422,000) 1
year.
 Fish JE. Modulation of Vegf Receptor Activity and
Angiogenesis by Slit/Robo Signalling. Heart & Stroke
Foundation of Canada. ($275,790).
 Fish JE. Regulation of Cardiovascular Disease by
MicroRNA. Ontario Ministry of Research & Innovation Early
Research Award. ($140,000).
 Girardin S. Bacterial Invasion and Mitochondrial
Dysfunction. NSERC. ($240,000).
 Lee J. Development of Novel Technologies for the
Expression of Human and Viral Proteins. University of
Toronto Connaught Fund. ($10,000) 1 year.
 Lingwood C. Underlying Mechanisms of Regulation of
Glycosphingolipid Synthesis in Cells. NSERC. ($170,000).
 Ni H. Novel Mechanisms of Platelet Aggregation: Roles of
Fibronectin and other Non-Classical Beta3 Integrin Ligands
in Thrombosis and Hemostasis. Heart & Stroke Foundation
of Canada. ($272,190).
 Rand M. The Procoagulant Surface of Activated Platelets:
Development and Persistence in Vtiro and in Vivo. Heart &
Stroke Foundation of Canada. ($160,544).
 Somers G. The Role of the Novel CIC-DUX4
Rearrangement in Pediatric Sarcomagenesis. Hospital for
Sick Children, Garron Family Cancer Centre. ($46,907) 1
year.
 Templeton D. Cadmium, Cell Signalling and the
Cytoskeleton. NSERC. ($130,000).
 Wang Q, Prud’homme GJ. GABAergic Signaling as a
Potential New Target for Beta-Cell Regeneration. Juvenile
Diabetes Research Foundation International.
($500,000US) 2 years.
 Waters V, Yau Y, Speert D, Guttman D, Aaron S,
Stephenson A, Ratjen F, Tullis E, McKinney M, Lavoie
A, Wilcox P, Chilvers M, Freitag A, Stanojevic S,
Fisman D, Zlosnik J. The Role of Clonal Pseudomonas
Aeruginosa in Cystic Fibrosis Patients in Canada. The
Canadian Cystic Fibrosis Foundation Team Grant.
($169,994) 2 years.
 Winer DA. Mechanisms of B Lymphocyte Dysregulation in
Insulin Resistance. Canadian Diabetes Association –
Clinician Scientist Award. ($275,000) 5 years.
 Winer DA. B Lymphocyte Dysregulation in the Metabolic
Syndrome. Canadian Diabetes Association – Operating
Grant. ($275,000) 3 years.
 Yang B. Expression and Function of Proteoglycan
Versican Regulated my MiroRNA’s. NSERC. ($240,000).
 Yang B. The Roles of MicroRNAs in Regulating Cell
Activities and Angiogenesis. Heart & Stroke Foundation of
Canada, Career Investigator Awards. ($83,000) 5 years.
Vol. 14 #3- 2012
 Yousef GM. miRNA Target Validation Studies. Switch
Gear Grant Program. ($3000) 1 year.
 Yucel Y, Weinreb R. Sirtuins in Glaucomatous Optic
Neuropathy. National Institutes of Health (NIH) (USA).
($84,533) 3 years.
 Xu Y, Zhang L. Role of Immune Cell OGRI in Prostate
Cancer Development and the Mechanisms Involved.
National Institutes of Health ($2,185,805US) 5 years.
CIHR RESULTS
 Adeli K. Role of Mesenteric Fat and Ceramides in Insulin
Resistance. (CIHR)-China. ($225,000) 2 years.
 Beauchemin N. Jothy S, Metrakos PP. CEACAM1 in
Colon Cancer Progression and Metastasis. ($834,100) 5
years.
 Cybulsky M. Reverse Transmigration of Arterial Intimal
Dendritic Cells. ($608,918) 5 years.
 Done SJ. Towards a Better Understanding of Breast
Cancer Intratumoural Heterogeneity. ($403,829). 3 years.
 Fish JE. Modulation of Vegf Receptor Activity and
Angiogenesis by Slit/Robo Signalling. ($625,836).
 Fish JE. Metabolic Syndrome and Atherosclerosis: Role of
microRNAs. CIHR Team Grant. ($1,313,025).
 Mahuran DJ. Treating Parkinson's Disease with Drugs that
Increase Lysosomal B-Glucocerebrosidase Activity.
($150,000).
 Mahuran DJ. Enzyme Enhancement Therapy for GM1
Gangliosidosis. ($821,637).
 Ni H. Novel Mechanisms of Platelet Aggregation: Roles of
Fibronectin and Other Non-Classical 3 Integrin Ligands in
Thrombosis and Hemostasis. ($638,411) 5 years.
 Ni H. Pathogenesis of Fetal and Neonatal Alloimmune
Thrombocytopenia and Mechanisms of IVIG and Anti-FcRn
Therapies. ($557,347) 4 years.
 Ohh M. Molecular Characterization of JMML. ($782,020).
 Semple JW. Identification of Host Immune Factors
Responsible for the Initiation and/or Modulation of
Transfusion Related Acute Lung Injury (TRALI). CIHR &
Canadian Blood Services. ($749,000) 3 years.
 Winer DA. Defining Adaptive Immune Mechanics of Insulin
Resistance. ($603,000) 5 years.
 Yousef GM. The Role of miRNAs in Renal Cell Carcinoma
Pathogenesis and their Clinical Utility as Tumor Markers.
($493,169) 3 years.
 Yucel Y. Karrow N, Gupta N. (Co-PI’s). Lymphatics as a
Novel Target to Treat Glaucoma. ($579,963) 5 years.
 Zhang L, Pintilie M, Tsao MS, Zheng G, Waddell T.
Development of Personalized Immunotherapy to Treat
Lung Cancer Using Gamma-Delta-T Cells. ($785,005) 5
years.
EDUCATION
RESIDENTS AND FELLOWS SECTION
Postgraduate Trainee Research Day
LMP would like to congratulate participants of the sixth
annual LMP Postgraduate Research Day. Led by the
Director of Postgraduate Research, Dr. George Yousef, the
day celebrated the achievements of LMP’s residents and
post-doctoral fellows.
Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
5
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
Vol. 14 #3- 2012
The theme of the day was “Personalized Medicine: A New
Landscape for Laboratory Medicine Practice”. With 32 poster
and 6 podium presentations and almost 100 attendees, the
event emphasized LMP’s broad scope and solid track record
of sustained excellence in research encompassing basic,
translational and clinical science.
Key highlights of the day included a presentation by keynote
speaker George J. Netto, MD, Director of Surgical Pathology
Molecular Diagnostics at Johns Hopkins University, an
engaging video about the future of pathology and a new
poster presentation format which allowed students to interact
directly with a small panel of judges. Students were further
engaged in an open discussion with departmental Chair, Dr.
Richard Hegele and the Program Director of Anatomical
Pathology, Dr. Simon Raphael.
The winners of this year’s Research Day are listed on page
2.
The breadth and depth of the research was impressive. The
first place winner of the clinical award, Michael Sidiropoulos,
presented on the ability to more accurately distinguish
between malignant melanoma and benign moles using
fluorescence microscopy. Nicole White, first place winner of
the research award, presented on the potential earlier and
more accurate diagnosis of kidney cancer by studying
dysregulated miRNAs.
The success of LMP’s poster presentations is clearly evident
by the number of those accepted at national and
international conferences. LMP is confident that presenters
at this year’s event will achieve the same success and that
their work will provide a strong foundation for future
research.
We would like to thank all of the LMP trainees who
participated in the event by giving oral and poster
presentations. A diverse range of research topics was
represented, and without them, the day would certainly not
have been possible. We would also like to thank the faculty
who served as judges as well as our sponsors, Springer and
Ideal Scientific, who contributed generously to our event.
We would also like to thank Paula Nixon for her
organizational and logistical support from the initial planning
stages to the event itself.
We would like to call for volunteers to participate in next
year’s planning committee. Interested individuals should
contact pathology.residency@utoronto.ca.
Sincerely,
The 2012 Postgraduate Research Day Committee including
Clarissa Cassol, Lorna Mirham, Ghassan Allo, Ingo Von
Both, Ron Francis, Joerg Schwock, Rosalind Silverman,
Nicole White, Julie Shaw, Jennifer Shea, Paula Nixon and
George Yousef.
New Trainees
The Department of Laboratory Medicine & Pathobiology
would like to extend a warm welcome to our new trainees
starting July 1, 2012:
Anatomical Pathology: Dina Boles, Svetlana Carrigan,
Ahmed Shahata, David Kolin, Al-Raheem Peerani and
Blerta Starova
Neuropathology: Andrew Gao
Hematopathology: Larissa Liontos
Forensic Pathology: Angela Guenther, Ashwyn
Rajagopalan
Clinical Chemistry: Joshua Raizman, Tracy Teodoro
Medical Microbiology: Danielle Brabant
Clinical/Research Fellows: Areej, Alnemer, Jesse Babwah,
Gillian Bethune, Michelle Downes, Isabelle Gagne,
Hector LiChang, Soledad Martinez, Anapat Sanpavat,
Keiyan Sy, Carlos Parra-Herran, Ann Treacy
We would also like to extend our congratulations to our
graduating trainees:
Residents: Jesse Babwah, Michael, Bonert, Will Dubinski,
Hala Faragalla, Angela Guenther, Michael Sidiropoulos,
Keiyan Sy
Postdoctoral Diploma Trainees: Julie Shaw
New Chief Resident
On behalf of Dr. Simon Raphael, the Anatomical Pathology
Residency Program would like to congratulate and welcome
Dr. Will Chen as the 2012 Chief Resident.
We would like to thank Dr. Michael Sidiropoulos for all of his
hard work over the past year and wish him the best in his
future endeavors.
 Tania Petruzziello (James Brunton) Molecular
Compiled by Paula Nixon
FORENSIC PATHOLOGY
The Centre of Forensic Science and Medicine at the
University of Toronto has completed a report on its first three
years (2008-2011) of supporting academic forensic activities
in Toronto. The document is available to view on-line at
www.forensics.utoronto.ca
Compiled by Sue Sarju Balaga
GRADUATE STUDENTS SECTION
Thesis Defenses - MSc
 Yasha Amani Andabili (Ben Alman) Possible Role of
Ostteoblasts in Regulating the Initiation of Endochral
Repair Process During Fracture Healing.
 Bradley Frew (Jeremy Mogridge) Proteolyric Processing
of Nlrplb in FIIND Domain is Required for Inflammasome
Activity.
 Sumaiya Marium (Philip Marsden) Rule of Notch
Signalling Network in gene Patterns of Angiogenic EC in
3D matrix and 2D confluent monolayer.
Thesis Defenses - PhD
 Zina Jeyapalan (Burton Yang) Modulation of micro-RNA
Functions by the 3' Untranslated Regions of CD44 and
Tumour Suppressor Candidate 2.
Mechanisms of E.Coli Shiga Toxin Pathogenesis.
 Ioannis Prassas (Eleftherios Diamandis)
Investigating the Anti-Cancer Properties of Cardiac
Glycosides.
 Dea Shahnias (Dylan Pillai) Targeting Plasmodium
Falciparum Heat Shock Pretein 90 (PFHSP90): A Strategy
to Reverse Antimalarial Resistance.
Compiled by Rama Ponda & Zamiha Premji
6
Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
HOSPITAL REPORTS
HOSPITAL FOR SICK CHILDREN
Announcement
Filling the gaps: New diagnostic tool reflects today’s
diverse Canadian paediatric population
When a child undergoes blood tests to diagnose a specific
medical condition, obtaining accurate test results is the key
to help determine the best treatment options and provide the
necessary care. Accurate reference values provide the
“normal” result for a healthy child in the general population
and until now, these reference values in Canada have had
significant demographic gaps, and much of the current data
is outdated.
Over the past four years, Dr. Khosrow Adeli, Department of
Paediatric Laboratory Medicine at SickKids and Professor,
LMP, has led a national project to develop a new,
comprehensive database of 40 biochemical markers in an
ethnically-diverse Canadian paediatric population, involving
nearly 2,200 healthy children and teens. This Laboratory
Initiative on Paediatric Reference Intervals (CALIPER)
Project is now available to hospitals and paediatricians, and
will soon be available to the general public. This new
national database is reported in a recent online publication of
Clinical Chemistry. Next steps will include testing for an
additional 30 biochemical markers, and using transference
studies to run tests on different equipment in various
hospitals across Canada, to help ensure consistent results,
regardless of the patient’s geographic location.
For more information about the CALIPER Project, or to
participate, visit www.caliperproject.com
Presentations
 Adissu HA, McKerlie C, Fang H, Khokha R, Wood GA.
Role of inflammation and metalloproteinase activity in
promoting invasive prostate cancer. Canadian Cancer
Research Conference. Toronto, November 2011.
 Adissu HA, Sunter D, Estabel J, Tuck E, Hooks Y,
Carragher D, Clarke K, Newbigging S, Jones N, Morikawa
L, White JK, McKerlie C. The utility of complete
histopathology analysis in a high-throughput primary
phenotyping screen: lessons from the microscope. The
Hospital for Sick Children Physiology & Experimental
Medicine Research Program Scientific Retreat, Toronto,
March 2012.
 Bellis M, Ngan B. Cutaneous adnexal tumors in children
and adolescents: a 26 year review from a single pediatric
hospital. Annual Meeting of the Society of Pediatric
Pathology Meeting held in conjunction with USCAP.
Vancouver, BC, March 2012.
 Taylor G: (co-moderator) Session on perinatal pathology.
Annual Meeting of the Society for Pediatric Pathology held
in conjunction with USCAP. Vancouver, BC, March 2012.
 Wang Y, McKerlie C, Newbigging S, Morikawa L. Perfusion
and fixation of mouse. The Hospital for Sick Children
Research Institute Retreat. Toronto November 2011.
Vol. 14 #3- 2012
 White JK, Sunter D, Adissu H, Estabel J, Tuck E, Hooks Y,
Carragher D, Clarke K, Newbigging S, Jones N, Morikawa
L, McKerlie C. Utility of complete histopathological analysis
in the high-throughput Sanger Mouse Genetics Project
primary phenotyping screen. Wellcome Trust Scientific
Conference on Mouse Models of Disease: Linking in vivo
observations to pathology endpoints. Hinxton, Cambridge,
UK, February 2012.
Invited Lectures
 McKerlie C: Interesting phenotypes from the primary
screen pathology pilot. EUMODIC 5th AGM. Geneva,
Switzerland, November 2011.
 McKerlie C: A mouse for every gene: challenges and
opportunities in genome-wide functional annotation.
University of Manitoba, Faculty of Medicine Edge of
Science Signature Lecture Series. Winnipeg, January
2012.
 McKerlie C: Mouse line production and phenotyping at the
Toronto Centre for Phenogenomics. Institut Clinique de la
Souris & Institut de Génétique et de Biologie Moléculaire et
Cellulaire (IGBMC). Strasbourg, France, February 2012.
 Somers G: Pediatric sarcoma development - lessons
learned in the great white north. Royal Children’s Hospital.
Melbourne, Victoria, Australia, May 2012.
 Somers G: Molecular events in sarcoma development insights gained while shoveling snow. Peter MacCallum
Cancer Institute. Melbourne, Victoria, Australia, May 2012.
MOUNT SINAI HOSPITAL
Invited Lectures
 Kandel R: Bone and soft tissue pathology - challenges in
the diagnosis of bone and soft tissue tumors. USCAP.
Vancouver, BC, March 2012.
 Kandel R: An update on research topics and future
directions in intervertebral disc research. Orthopaedic
Research Society Annual Meeting. San Francisco, CA,
February 2012.
 Kandel R: (Moderator). Intervertebral disc: stem cells & cell
line. Orthopaedic Research Society Annual Meeting 2012.
San Francisco, CA, February 2012.
 Keating S: What’s so special about perinatal pathology?
Forensic Pathologists of Ontario. April 2012.
Compiled by Marie Maguire
ST. MICHAEL’S HOSPITAL
Presentations
 Abadir A, Streutker C, Brezden-Mazley C, Grin A, Kim Y.
Intestinal metaplasia and the risk of gastric cancer in an
immigrant Asian Population. Canadian Digestive Diseases
Week. Montreal, PQ, February 2012.
 Jothy S. Alterations of the renal glomerular podocyte as a
cause of clinico-pathological emergencies. Department of
Pathology and Molecular Medicine, Queen’s University.
Kingston, ON, February 2012.
 Karamchandani J. Pericardial glial nodule. Canadian
Association of Neuropathologists Annual Meeting.
Vancouver, BC, September 2011.
Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
7
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
Vol. 14 #3- 2012
 Leytin V. Platelet apoptosis mediated by platelet surface
receptors. Institute of Clinical Biochemistry and
Pathobiochemistry. University of Würzburg. Würzburg,
Germany , November 2011.
 Leytin V. Apoptosis in the anucleate platelet. Blood
ANATOMIC PATHOLOGY POSITION
St. Michael's Hospital is a large and vibrant teaching hospital in the heart
of Toronto. The physicians and staff of St. Michael's Hospital provide
compassionate care to all who walk through its doors as well as
outstanding medical education to future healthcare professionals in more
than 20 academic disciplines. Critical care and trauma, heart disease,
neurosurgery, diabetes, cancer care and care of the homeless and
vulnerable populations in the inner city are among the Hospital's
recognized areas of expertise. Through the Keenan Research Centre and
the Li Ka Shing Knowledge Institute, research at St. Michael's Hospital is
recognized, respected and put into practice around the world. Founded in
1892, the Hospital is fully affiliated with the University of Toronto.
The Department of Laboratory Medicine at St. Michael’s Hospital invites
applications for a full time, faculty position as an Anatomic Pathologist in
the Division of Pathology. The successful candidate will receive an
academic appointment in the Department of Laboratory Medicine and
Pathobiology, University of Toronto, with the appropriate academic rank.
The starting date is September 4, 2012, but is flexible.
Applicants must have a M.D. degree and be certified in Anatomic
Pathology by the Royal College of Physicians and Surgeons of Canada, or
equivalent. Requirements include formal training and experience in
general surgical pathology and cytopathology. The position involves
diagnostic service, teaching, and development of a collaborative research
program in clinical, applied or basic research. The diagnostic service is in
the areas of surgical pathology and cytopathology.
The Division of Pathology has 14 pathologists and is affiliated with 4 other
divisions in the Department of Laboratory Medicine. A molecular biology
laboratory is associated with anatomic pathology, as well as automated
immunohistochemistry and electron microscopy services.
The University of Toronto is strongly committed to diversity within its
community and especially welcomes applications from visible minority
group members, women, Aboriginal persons, persons with disabilities,
members of sexual minority groups and others who may contribute to the
further diversification of ideas.
Please forward a letter of interest, a list of references, including your
curriculum vitae to:
Dr. Serge Jothy, Chief, Department of Laboratory Medicine
St. Michael’s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8
Tel: (416) 864-5972 Fax: (416) 864-5648 E-Mail: jothys@smh.ca
 Kovacs K. Endocrine research and its creativity.
International symposium to develop practitioners for holistic
cancer care. Endocrine organ and stem cell-tissue
development and tumorigenesis. Japan, November 2011.
 Lazarus A. Role of FcRn and CD44 in the treatment of
ITP. Bayer Healthcare. San Francisco, CA, February 2012.
 Lazarus A. A new potential therapeutic for experimental
ITP. Toronto Platelet Immunobiology Group Seminar.
Toronto, January 2012.
 Lazarus A. How does IVIg work in autoimmunity and can
we replace it with something better? Centre For Blood
Research. Vancouver, BC, November 2011.
 Lazarus A. Advances in the understanding of the
mechanism of action of IVIg. CSL Berhing Sponsored
Educational Talk. National Webcast Presentation, October
2011.
8
Center of Wisconsin and Blood Research Institute.
Milwaukee, WI, November 2011.
 Leytin V. The platelet: apoptosis in bypass of death
receptors. Immunforum, Klinisk
 Immunologi & Transfusionsmedicin (KIT). Lund, Sweden,
January 2012.
 Munoz DG. Recent advances in central nervous system
tumors. Arab Health Congress. Dubai, January 2012.
 Ni H. Platelets in atherothrombosis: Emerging links
between lipoprotein metabolism and platelet function.
China-Canada Symposium on Atherosclerosis and
Cardiovascular Diseases. Beijing, China, September 2011.
 Ni H. Does specificity of anti-platelet antibody dictate the
efficacy of ITP therapy? The first affiliated hospital, Anhui
Medical University. Hefei, China, September 2011.
 Ni H. Thrombosis and thrombocytopenia: lessons from
animal models and human patients. University of
California. San Diego, CA, October 2011.
 Ni H. Integrin ligands in thrombosis and hemostasis:
exploring roles of apolipoprotein A-IV and plasma
fibronectin. The Scripps Research Institute. La Jolla, CA,
December 2011.
 Ni H. Does specificity of anti-platelet antibody dictate the
efficacy of ITP therapy? 2011 American Society of
Hematology Annual Meeting. San Diego, CA, December
2011.
 Ni H. Pathogenesis of fetal and neonatal alloimmune
thrombocytopenia: lessons from murine models.
Immunology Research Group, Institute of Medical Biology,
Faculty of Health Sciences. The University of Tromsø.
Norway, January 2012.
 Ni H. Platelets are versatile cells: new links between
lipoprotein metabolism and atherothrombosis. SUNY
Downstate Medical Center. New York, February 2012.
 Ni H. Platelets are versatile cells: new links between
apolipoprotein A-IV and atherothrombosis. Seminars in
Lipoprotein Metabolism, Atherosclerosis & Nutrition.
Columbia University. New York, February 2012.
 Pavenski, K. Transfusion management of a massively
bleeding patient. Ontario Transfusion Coordinators
Meeting. Toronto, November 2011.
 Pavenski K. Management of a massively bleeding patient:
facts and arguments from the 2011 MTCC. Transfusion
Medicine Symposium. London, ON, November 2011.
 Pavenski K. An update in transfusion medicine: transfusion
triggers, urgent anticoagulant reversal and deadly
reactions. Ross Memorial Hospital Transfusion Medicine
Rounds. Lindsay, ON, December 2011.
 Prud’homme G.J, Glinka Y, Mohammed N. Role of
neuropilin-1 in breast cancer stem cells. 2nd International
Conference on Stem Cells and Cancer. Puna, India,
October 2011.
 Prud'homme GJ, Glinka Y. Neuropilin-1 promotes NFkappaB signalling and mammosphere formation by human
breast cancer stem cells. Canadian Cancer Conference.
Toronto, November 2011.
Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
 Semple JW, Kim M, Hou J, Lee J, Tabuchi A, Kuebler WM,
Chai Z-W, Lazarus AH. Intravenous Gammaglobulin (IVIg)
Therapy Prevents Antibody-Mediated Transfusion Related
Acute Lung Injury (TRALI) by Directly Inhibiting Recipient
Neutrophil Activation in a Murine Model. The American
Society of Hematology 53rd Annual Meeting. San Diego
CA, December 2011.
 Streutker C, Bresden-Mazley C. Her2 Testing in Gastric
Carcinoma. Cancer Care Ontario Gastric Cancer Advisory
Board. Toronto, December 2011.
 Yousef GM. The miRNA regulation of kallikreins: there is a
whole new world out there. 4th International Symposium on
Kallikreins and Kallikrein-related Peptidases. Rhodes
Island, Greece, September 2011.
 Yousef GM. The future of kallikreins. 4th International
Symposium on Kallikreins and Kallikrein-related
Peptidases. Rhodes Island, Greece, September 2011.
 Yousef GM. miRNAs: a new paradigm in kidney cancer
research. Semmelweis University Medical School.
Budapest, Hungary, September 2011.
 Yousef GM. Kidney cancer: the new landscape. Updates
in Surgical Pathology Conference. Taiba Hospital. Kuwait,
January 2012.
 Yousef GM. Personalized medicine: rekindling an old
flame. Updates in Surgical Pathology Conference. Taiba
Hospital. Kuwait, January 2012.
 Yousef GM. miRNA in renal cell carcinoma: the journey to
clinical applications. 2nd Western New York and Southern
Ontario Kidney Cancer Symposium. Buffalo, NY, May
2012.
American Association of Blood Banks Annual Meeting San Diego, CA, October 22-25, 2011.
 Cserti-Gazdewich CM, Pendergrast J, Dharman A,
Pavenski K, Krok E, Lin Y, Callum J, Colavecchia C, Reis
M. Minor incompatible group O platelet management
strategies: alternative practices and outcomes within a
multi-center collaborative.
 Krok E, Naassan A, Anderson M, Pavenski K. Incidence
of passive sensitization and hemolysis following high dose
IVIG treatment.
 Krok E, Naassan A, Pavenski K. Utilization of massive
transfusion protocol in non-trauma patients: a single
institution chart review.
 Moayedi Y, Venos E, Pavenski K, Trinkaus M. A
retrospective chart review of Octaplex administration
practices at St. Michael's Hospital.
 Ni H. Lessons gained from the mouse models of fetal and
neonatal alloimmune thrombocytopenia. 9107-TC recent
developments in fetal and neonatal alloimmune
thrombocytopenia.
 Pavenski K, Naassan A. Massive transfusion protocol in
obstetrical patients: a single center retrospective review.
23rd European Congress of Pathology - Helsinki,
Finland, August 27- September 1, 2011.
 Kovacs K. Mixed endocrine and non-endocrine tumors in
the pituitary.
 Moshkin O, Scheithauer BW, Horvath E, Jentoft M,
Collins PC, Syro LV, Kovacs K. Tumefactive
postmenopausal gonadotroph cell hyperplasia.
 Scheithauer BW, Horvath E, Abel T, Deal C, Robitaille Y,
Osamura R, Kovacs K. Pituitary blastoma: confirmation of
an entity.
Vol. 14 #3- 2012
12th International Pituitary Meeting & 10th International
Workshop - Santorini, Greece, October 5-8, 2011.
 Cusimano M, Rotondo F, Scheithauer BW, Horvath E,
Kovacs K. Aggressive Crookecell adenoma of the
pituitary.
 Kovacs K. Mixed endocrine-nonendocrine tumors in the
pituitary.
 Lloyd RV, Scheithauer BW, Horvath E, Kovacs K. Stem
cells in the normal pituitary and in pituitary adenomas.
 Lombardero M, Quintanar-Stephano A, Horvath E, Kovacs
K, Scheithauer BW. Effect of thyroxin on cell morphology
and hormone secretion of pituitary grafts in rats.
 Moshkin O, Rotondo F, Scheithauer BW, Soares M, Coire
C, Smyth HS, Horvath E, Kovacs K. Atypical bronchial
carcinoid metastatic to the sella turcica.
 Natar AG, Syro LV, Scheithauer BW, Kovacs K, Horvath
E, Rotondo F, Cusimano M. Necrotizing
infundibuloneurohypophysitis.
 Nose V, Ezzat S, Horvath E, Kovacs K, Laws ER, Lloyd
RV, Lopes MBS, Asa SL. Protocol for the examination of
specimens from patients with primary pituitary tumors.
 Rotondo F, Cusimano M, Scheithauer BW, Rotondo A,
Syro LV, Kovacs K. Ghrelin the pituitary.
 Sav A, Syro LV, Scheithauer BW, Rotondo F, Horvath E,
Kovacs K. Silent somatotroph adenoma: a morphologic,
immunohistochemical and electron microscopic study: a
case report.
 Scheithauer BW, Lloyd RV, Abel T, Deal C, Robitaille Y,
Osamura RY, Lloyd RV, Kovacs K. Pituitary blastoma: an
entity within a tumor syndrome.
 Sidiropoulos M, Syro LV, Scheithauer BW, Penagos LC,
Uribes H, Ramirez MP, Horvath E, Rotondo F, Kovacs K.
Primary melanoma of the sellar region.
 Syro LV, Ortiz LD, Scheithauer BW, Uribe H, Penagos LC,
Fadul CE, Rotondo F, Horvath E, Kovacs K. Treatment of
pituitary neoplasms with temozolomide.
Complied by Dorothy Avery
SUNNYBROOK HEALTH SCIENCES CENTRE &
WOMEN’S COLLEGE HOSPITAL
Presentations
 Feigenberg T, Covens A, Ismiil N, Ghorab Z, Dube v, Saad
RS, Khalifa MA, Nofech Mozes. Is routine appendectomy
at the time of primary surgery for mucinous ovarian tumors
helpful? SGO 43rd Annual Meeting. Austin, TX, March
2012.
 Muise-Helmericks RC, Demcheva M, Zhang A, Bacopulos
S, Amemiya Y, Vournakis J, Seth A. Short Poly-N-Acetyl
glucosamine (sNAG) Nanofibers regulate gene expression
in endothelial cells and keratinocytes. Human Genome
Meeting. Sydney, Australia, March 2012.
 Pennell N, Cheung M, Alden C, Buckstein R, Ghorab Z,
Davidson C, Berinstein NL. First evidence of high
incidence of complete and sustained molecular remission
and maintenance of immuno responses in patients
receiving consolidation with Y90 ibritumomab tiuxetan post
R-CHOP for newly diagnosed advanced stage high and
intermediate risk follicular lymphoma. ASH Annual
Meeting. San Diego, CA, December 2011.
 Sade S. Primary cutaneous CD4-positive small/medium
pleomorphic T-cell lymphoma. Toronto Dermatological
Society Meeting. February 2012.
Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
9
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
The Canadian Cancer Research Conference – Toronto,
ON, Nov 27-30, 2011.
 Benatar T, Tang W, Amemiya Y, Evdokimova V, Seth A.
IGFBP7 reduces breast cancer growth by induction of
senescence and apoptosis pathways..
 Chaterjee S, Badiani K, Seth A, Murphy L, Raouf A.
Estrogen signaling suppresses the expression of tumor
suppressor gene, IGFBP7.
 Chow A, SivanathanL, Amemiya Y, Seth A, Emmenegger
U. Molecular profiling of resistance to metronomic
cyclophosphamide chemotherapy.
 Du WW, Yang BB, Seth A, Yee AJ. Tumor specific
expression of Versican/PG-M G3 domain promotes breast
cancer cell invasion and bone metastasis.
 Evdokimova V, Tognon CE, Benatar T, Sornsen PHB,
Seth A. IGFBP7 blocks IGF1 receptor activation by IGF1
while enhancing insulin receptor signaling and sensitivity.
 Gordanpour A, Nam RK, Stanimirovic A, Sugar L, Seth A.
Higher expression of miR-182 is associated with prostate
cancer aggressiveness.
United States and Canadian Academy of Pathology
Annual Meeting – Vancouver, BC, March 17-23, 2012.
 Babwah J, Khalifa MA, Rowsell C. Analysis of addendum
reports in anatomic pathology as a quality improvement
initiative.
 Chan S, Sherman C, Gabril M, Zbieranowski I, Sugar L,
Yousef G, Bjarnason G. Xp11.2 translocations in adult
renal cell carcinomas with clear cell and papillary features.
 Grin A, Hsieh ET, Brezden-Masley C, Streuker CJ.
Gastric biopsies are appropriate for assessment of Her2:
a correlation study with resection specimens.
 Hsieh E, Henry P, Kwok K, Hanna W. HER2/neu testing
in 207 gastric and gastroesophageal junction
adenocarcinomas: immunohistochemistry and silver in situ
hybridization (SISH) provide effective brightfield methods
for clinical HER2 testing.
 Kaur H, Eiriksson L, Saad R, Khalifa M, Dubé V, Ghorab
Z, Covens A, Barbera L, Ismiil N. Prognostic significance
of primary tumour factors in stage III high grade
endometrial cancer.
 Keith J, Ang LC, Dickson B, Bilbao J, Croul S. Synovial
sarcoma of the nervous system: a clinicopathologic study
of 9 patients.
 Nafisi H, Ghorab Z, Ismiil N, Saad R, Dubé V, Khalifa MA.
p16 expression in early müllerian serous carcinogenesis.
 Saad RS, El-Sayed A, Shehata A, Mashour M, Hanna W.
Immunophenotype profile of breast carcinoma brain
metastases in comparison to their breast primaries.
 Saad RS, Shehata AF, Silverman JF, Ismiil N, Ghorab Z.
Is it possible to differentiate endometrial serous carcinoma
from endometrioid type in liquid-based preparation? a
cytomorphologic study.
 Sidiropoulos M, Hanna W, Raphael S, Jakate K, Ghorab
Z. Merkel cell carcinoma immunoreactivity with Pax5.
 Wang T, Rowsell C, Hsieh E, J Ramsay, C Streutker.
Immunohistochemical profiles of small intestinal
adenocarcinomas.
Invited Lectures
 Rowsell C: Overview of the CAP cancer checklist for
exocrine pancreas. Webex presentation. Cancer Care
Ontario and Canadian Association of Pathologists.
December 2011.
Compiled by Lesley Nicholson
10
Vol. 14 #3- 2012
UNIVERSITY HEALTH NETWORK
Announcements
 Dan Winer received the Castleman Award for the top
paper published in Human Pathology Research for a young
pathologist.
 Lili Hazrati has won this year's IMS Course Lecturer
Award. This award is presented annually for a sustained
contribution of three years or more to excellence in
lecturing in an IMS graduate course. Dr. Hazrati was
nominated by students in the MSC1006H - Introduction to
Anatomical Organization of the Brain. The award was
presented at IMS Scientific Day held on May 15, 2012.
Presentations
United States and Canadian Academy of Pathology
Annual Meeting – Vancouver, BC, March 17-23, 2012.
 Abi Daoud MS, Nuin P, Chen J, Zhang X, Feilloter H, Tron
VA. microRNAs as prognostic biomarkers in malignant
malanoma.
 Allo G, Mackay H, Rouzbahman M, Shaw PA, Bernardini
M, Clarke BA. ARID1A gene expression in high-grade
endometrial carcinomas.
 Bellis M, Victor JC, Rouzbahman M, Rasty G. The
prognostic significance and outcome of patients with grade
1 stage 1 endometrioid endometrial adenocarcinoma
involving the lower uterine segment.
 Bilodeau EA, Weinreb I, Dacic S, Muller S, Barker B,
Seethala RR. Clear cell odontogenic carcinomas show
EWSR1 rearrangements: a novel finding & biologic link to
salivary clear cell carcinomas.
 Bonert M, Craddock KJ. An in silico approach to finding
the expected frequency of coincidental overlaps for in situ
hybridization using dual-colour fusion probes.
 Cassol CA, Asa SL. Cell cycle regulators in
pheochromocytomas (PCTs) and paragangliomas (PGLs)
and correlation with SDHx status and FGFR4 genotype.
 Chen M, Brandwein J, Craddock KJ, Chang H. Prognostic
factors in unfavourable-risk acute myeloid leukemia in the
absence of monosomal karyotype.
 Conklin CMJ, Craddock KJ, Have C, Tsao MS, Couture C,
Ionescu DN. Immunohistochemistry may not be a reliable
screening tool for identification of ALK rearrangement
(ALKR) in non-small cell lung carcinoma (NSCLC).
 Dubinski W, Ghazarian D. Endoglin: an adjunct diagnostic
marker to differentiate between benign and atypical
vascular lesions/proliferations arising in the breast postradiation therapy.
 George SHL, Milea A, Shaw PA. Proliferation in the
normal tubal epithelium is a hallmark of the follicular phase
not BRCA1 mutation status.
 Goswami RS, Atenafu EG, Waldron L, Xuan Y, Xu W,
Reis PP, Kuruvilla J, Good DJ, Bailey DJ, Lai R, Church A,
Lam WS, LeBrun DP, Sehn LH, Farinha P, Gascoyne RD,
Crump MR, Jurisica I, Kamel-Reid S. Identification of a
novel prognostic microRNA signature in mantle cell
lymphoma.
 Lai J, Magro CM. Acral nevi as possible precursors to
acral melanomas?
 Li G, Al Daoud N, Evans AJ, Van der Kwast TH. Utility of
triple antibody cocktail stain in radical prostatectomy
specimens with crushed surgical margins.
 Mete O, Erovic B, Irish J, Asa SL. Identification of new
target proteins in parathyroid carcinomas.
Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
 Milea A, George SHL, Berman H, Gauthier M, Shaw PA.
Significance of alterations of the RB1 pathway in high
grade serous carcinoma.
 Moreno JC, Nair R, Miller NA, BJ Youngson, V Iakovlev, D
McCready, SJ Done. DCIS heterogeneity: an integrated
RNA-miRNA analysis.
 Ofek E, Waddell TK, Keshavjee S, Hwang Dm. Diffuse
pulmonary exogenous lipoid pneumonitis – an indicator of
inhalational exposure to aerosolized oils?
 Rasty G, Kamel-Ried S. Fluorescence in situ hybridization
(FISH) for detection of MAML2 rearrangement in patients
with adenosquamous carcinoma of uterine cervix.
 Saha MN, Jiang J, Chang H. A novel small molecule
MIRA-1 induces cytotoxicity in multiple myeloma cells
harbouring wild-type or mutant p53.
 Saha MN, Koh S, Chang H. Preclinical evaluation of small
molecule p53 activating agent prima-1met in waldenstrom
macroglobulinemia.
 Schaeffer DF, Hafezi-Bakhtiari S, Cino M, Hirschfi GM, ElZimaity H. Inflammatory bowel disease associated with
primary sclerosing cholangitis has different phenotypes:
PSC-IBD vs. IBD-PSC.
 Shiau CJ, Babwah J, da Cunha Santos G, Boerner SL,
Geddie WR, Kamel-Reid S, Wei C,Hwang DM, Tsao MS.
Selection of samples for epidermal growth factor receptor
(EGFR) mutation analysis in non-squamous non-small cell
lung carcinoma.
 Siddiqui RF, Baptista AC, Ross C, Good DJ, Sheridan B,
Bailey DJ, Craddock KJ. “Double Hit” aggressive B-Cell
Neoplasms with B-ALL phenotypes: role of FISH in the
diagnosis.
 Sidiropoulos M, Hindi Z, Al-Habeeb A, Ghazarian D,
Craddock KJ. Fluorescence in situ hybridization (FISH)
reliably distinguishes tumour cells of benign melanocytic
nevi from those of metastatic melanoma.
 Siniavskaia I, Hafezi-Bakhtiari S, Adeyi O. Low
proliferation/apoptosis ratio in early biopsies predicts
adverse outcome in cardiac death donor liver allografts.
 Srigley J, Evans AJ, Yurcan M, Hunter A, Hart J, Mazuryk
J, McKnight L, Raby M, Irish J, Chin J, McGowan T,
McLeod R, Fleshner N. Improving margin status in radical
rrostatectomies through performance measurement and
multidisciplinary knowledge transfer (KT) activities: a
population level approach to quality improvement.
 Torlakovic EE, Young G, Cheung C, Dirnhofer S, Tzankov
A. The presence of langerhans cells is positively
correlated with the extent of eosinophilia in classical
hodgkin lymphoma.
 Trudel D, Kron K, Liu L, Trachtenberg J, Fleshner N,
Bapat B, Van der Kwast TH Absence of ERG expression
predicts early prostate cancer biochemical recurrence
when combined with DNA methylation status of a
development-associated gene.
 Van der Kwast TH, Aldaoud N, Collette L, Sykes J, Bolla
M, Bristow RG. Biopsy diagnosis of intraductal carcinoma
is prognostic in intermediate and high risk prostate cancer
patients treated by radiation.
 Vang R, Visvanathan K, Gross A, Maambo E, Gupta M,
Kuhn E, Li R, Ronnett BM, Seidman JD, Yemelyanova A,
Shih I-M, Shaw PA, Soslow RA, Kurman RJ. Validation of
an algorithm for the diagnosis of serous tubal
intraepithelial carcinoma.
 White NMA, Khella HWZ, Grigull J, Adzovic S, Youssef
YM, Honey RJ, Stewart R, Pace KT, Bjarnason GA, Jewett
MAS, Evans AJ, Gabril M, Yousef GM. miRNA profiling in
metastatic renal cell carcinoma reveals a tumor
suppressor effect for miR-215.
Vol. 14 #3- 2012
 Yang Y, Ning Y, Chang H. Identification of micro RNAs
within chromosome 1p minimal deletion region associated
adverse outcomes in multiple myeloma.
Compiled by Yvonne Bedford
PUBLICATIONS
 Adeli K. Closing the gaps in pediatric reference intervals:
The CALIPER initiative. Clin Biochem. 2011;44(7);480-2.
 Al-Maghraby H, Ghorab Z, Khalbuss W, Wong J,
Silverman JF, Saad RS. The diagnostic utility of CK5/6
and p63 in fine-needle aspiration of the breast lesions
diagnosed as proliferative fibrocystic lesion. Diagn
Cytopathol. 2012;Feb;40(2):141-7.
 Babwah J, Khalifa MA, Rowsell C. Analysis of addendum
reports in anatomic pathology as a quality improvement
initiative. Mod Pathol. 2012;Feb; 25(Supp 2):2063.
 Bacopulos S, Amemiya Y, Zubovits J, Burger A, Seth AK.
Effects of partner proteins on BCA2 RING ligase activity.
BMC Cancer. 2012;Feb; 8;12(1):63.
 Baron M, Gomez-Tortosa E, Bochdanovits Z, Gobernado I,
Rabano A, Munoz DG, Heutink P, Jimenez-Escrig A.
Extended kindred with recessive late-onset alzheimer
disease maps to locus. Alzheimer Dis Assoc Disord.
2012;26:91-95.
 Beeson CC, Beeson GC, Buff H, Eldridge J, Zhang A, Seth
A, Demcheva M, Vournakis JN, Muise-Helmericks RC.
Integrin-dependent Akt1 activation regulates PGC-1
expression and fatty acid oxidation. J Vasc Res.
2012;Jan;13;49 (2):89-100.
 Bhaduri M, Khalifa M, Tomlinson G, Glanc P.
Sonohysterography: the utility of diagnostic criteria sets.
AJR Am J Roentgenol. 2012 Jan;198(1):W83-8.
 Bredlau A-L, Semple JW, Segel G. Management of
immune thrombocytopenic purpura in children: potential
role of novel agents. Pediatric Drugs. 2011;13:1-11.
 Chan S, Sherman C, Gabril M, Zbieranowski I, Sugar L,
Yousef G, Bjarnason G. Xp11.2 translocations in adult
renal cell carcinomas with clear cell and papillary features.
Mod Pathol. 2012;Feb;25 (Supp 2):814.
 Chan SM, Gabril MY, Zbieranowski IJ, Sugar LM, Yousef
GM, Bjarnson GA, Sherman CG. Xp11.2 translocations in
adult renal cell carcinomas with clear cell and papillary
features. Mod Pathol. 2012;25:196A.
 Chan SS, Lee L, Chin J, Gomez JA, Moussa M, Yousef
GM, Gabril MY. Should fuhrman grading in clear cell renal
cell carcinomas be based on nucleoli only? Mod Pathol.
2012;25:195A.
 Colantonio DA, Kyriakopoulou L, Chan MK, Daly CH, Brinc
D, Venner AA, Pasic MD, Armbruster D and Adeli K.
Closing the gaps in pediatric laboratory reference intervals:
a CALIPER database of 40 biochemical markers in a
healthy and multiethnic population of children. Clin Chem.
2012 Feb 27.
 Crow AR, Suppa SJ, Chen X, Mott PJ, Lazarus AH. The
neonatal Fc receptor (FcRn) is not required for IVIg or antiCD44 monoclonal antibody-mediated amelioration of
murine immune thrombocytopenia. Blood. 2011;118:64036406.
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11
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
 Darlington P, Haugom-Olsen H, von Sivers K, Wahlström
J, Runold M, Svjatoha V, Porwit A, Eklund A, Grunewald J.
T cell phenotypes in bronchoalveolar lavage fluid, blood
and lymph nodes in pulmonary sarcoidosis - indication for
an airborne antigen as the triggering factor in sarcoidosis. J
Intern Med. 2012 Mar 31.
 Du WW, Yang BB, Shan SW,Yang BL, Deng Z, Jeyapalan
Z, Lee DY, Shatseva TA, Seth A, Yee AJ. Versican G3
domain modulates breast cancer cell apoptosis: a
mechanism for breast cancer cell response to
chemotherapy and EGFR therapy. PLoS One.
2011;6(11):e26396. Epub 2011 Nov 9.
 Dubinski W, Gabril M, Iakovlev VV, Scorilas A, Youssef
YM, Faragalla H, Kovacs K, Rotondo F, Metias S,
Arsanious A, Plotkin A, Girgis AH, Streutker CJ, Yousef
GM. Assessment of the prognostic significance of endoglin
(CD105) in clear cellrenal cell carcinoma using automated
image analysis. Hum Pathol. 2011. [Epub ahead of print]
 Dubinski W, Petraki C, Youssef Y, Yousef GM. Evaluation
and prognostic significance of human tissue kallikreinrelated peptidase 10 (KLK10) in colorectal cancer. Mod
Pathol. 2012; 25:159A.
 Farr S, Adeli K. Incretin-based therapies for treatment of
postprandial dyslipidemia in insulin-resistant states. Curr
Opin Lipidol. 2012;Feb;23(1):56-61.
 Fendler A, Jung M, Stephan C, Honey RJ, Stewart RJ,
Pace KT, Erbersdobler A, Samaan S, Jung K, Yousef GM.
miRNAs can predict prostate cancer biochemical relapse
and are involved in tumor progression. Int J Oncol. 2011;
39:1183-1192.
 Fernandes BF, Weisbrod D, Yücel YH, Follwell M, Krema
H, Laperriere N, Herdarian M, Xu W, Payne D, McGowan
H, Simpson ER, Saghal A. Neovascular glaucoma after
stereotactic radiotherapy for juxtapapillary choroidal
melanoma: Histopathologic and dosimetric findings.
International Journal of Radiation Oncology Biology
Physics. 2011; 80: 377-384.
 Ford McIntyre MS, Gao JF, Li XJ, Naeini BM, L. Zhang.
Consequences of double negative regulatory T cell and
antigen presenting cell interaction on immune response
suppression. Int. Immunopharmacol. 2011:11:597–603.
 Gao JF, Ford McIntyre MS, Diao J, Juvet SC, Li XJ,
Vanama RB, Mak TW, Cattral MS, Zhang L. Regulation of
antigen expressing dendritic cells by double negative
regulatory T cells. Eur. J. Immunol. 2011;41:2699-2708.
 Ghazi AA, Boustani I, Amouzegar A, attarian H, Pourafkari
M, Gashti HN, Sabetian T, Tirgari N, Ghazi S, Kovacs K.
Postpartum hypercalcemia secondary to a neuroendocrine
tumor of pancreas: a case report and review of literature.
Iran J Med Sci. 2011;36:217-221.
 Gordanpour A, Nam R, Sugar L, Seth AK. MicroRNAs and
gene fusions in prostate cancer: from biomarkers to
molecularly-based therapeutics. Prostate Cancer and
Prostatic Diseases. 2012 Feb 14. doi: 10.1038/pcan. [Epub
ahead of print]
 Grin A, Hsieh ET, Brezden-Masley C, Streuker CJ. Gastric
biopsies are appropriate for assessment of Her2: a
correlation study with resection specimens. Mod Pathol.
2012;Feb;25 (Supp 2):667.
 Gu P, Fang JG, DSouca C, Kowalczyk A, Chou KY, Zhang
L. Trogocytosis of CD80 and CD86 by induced regulatory T
cells. Cell Mol. Immunol. 2012 Mar;9(2):136-46. doi:
10.1038/cmi.2011.62. Epub 2012 Feb 6.
12
Vol. 14 #3- 2012
 Hammond EH, Hanna W, Nofech- Mozes SNM.
Neighbourly collaboration to improve breast predictive
factors testing in North America. Can J of Path.
2012;4(1):32-37.
 Hsieh E, Henry P, Kwok K, Hanna W. HER2/neu testing in
207 gastric and gastroesophageal junction
adenocarcinomas: immunohistochemistry and silver in situ
hybridization (SISH) provide effective brightfield methods
for clinical HER2 testing. Mod Pathol. 2012;Feb;25 (Supp
2):674.
 Iakovlev VV, Gabril M, Dubinski W, Scorilas A, Youssef
YM, Faragalla H, Kovacs K, Rotondo F, Metias S,
Arsanious A, Plotkin A, Girgis AH, Streutker CJ, Yousef
GM. Microvascular density as an independent predictor of
clinical outcome in renal cell carcinoma: an automated
image analysis study. Lab Invest. 2012;92:46-56.
 Ilina MV, Kepron CA, Taylor GP, Perrin DG, Kantor PF,
Somers GR. Sudden unexpected death due to
undiagnosed heart disease in infancy and childhood: a
retrospective autopsy study. Pediatrics. 2011;128:e513e520.
 Jakate K, Wong K, Sirbovan J, Hanna W. Cutaneous
myoepithelioma arising within hidradenoma of the scalp. J
Cutan Pathol. 2012;Feb;39(2):279-85.
 Juvet SC, Zhang L. Double negative regulatory T cells in
transplantation and autoimmunity: recent progress and
future directions (an invited review). J. Molecular Cell
Biology. 2012;4:48-58.
 Karamchandani J, Vogel H, Fischbein N, Gibbs I, Edwards
MS, Harsh G. Extravascular papillary endothelial
hyperplasia mimicking neoplasm following radiosurgery.
Neurosurgery. 2011 September [Epub ahead of print]
 Kaur H, Eiriksson L, Saad R, Khalifa M, Dubé V, Ghorab Z,
Covens A, Barbera L, Ismiil N. Prognostic significance of
primary tumour factors in stage III high grade endometrial
cancer. Mod Pathol. 2012;Feb;25(Supp 2):1176.
 Keith J, Ang LC, Dickson B, Bilbao J, Croul S. Synovial
sarcoma of the nervous system: a clinicopathologic study
of 9 patients. Mod Pathol. 2012;Feb;25(Supp 2):1798.
 Keith J, Bilbao J, Baskin R. JC virus granular neuronopathy
and rhombencephalic progressive multifocal
leukoencephalopathy: case report and review of the
literature. Neuropath.2012 Oct [Epub ahead of print]
 Khella HW, White NM, Faragalla H, Gabril M, Boazak M,
Dorian D, Khalil B, Antonios H, Bao TT, Pasic MD, Honey
RJ, Stewart R, Pace KT, Bjarnason GA, Jewett MA, Yousef
GM. Exploring the role of miRNAs in renal cell carcinoma
progression and metastasis through bioinformatic and
experimental analyses. Tumour Biol. 2012;33:131-140.
 Khella HWZ, White NMA, Faragalla H, Gabril M, Boazak
M, Dorian D, Khalil B, Bao TT, Pasic MD, Honey RJ,
Stewart R, Pace KT, Bjarnson GA, Jewett M, Yousef GM.
Exploring the role of miRNAs in renal cell carcinoma
progression and metastasis through bioinformatic and
experimental analyses. Mod Pathol. 2012;25:218A.
 Kim M, Johnston MG, Gupta N, Moore S, Yücel YH. A
model to measure lymphatic drainage from the eye. Exp
Eye Res. 2011; 93:586-91.
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LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
 Kirshenbaum GS, Clapcote SJ, Duffy S, Burgess C,
Petersen J, Jarowek KJ, Yücel YH, Cortez MA, Snead OC,
Vilsen B, Peever J, Ralph MR, Roder JC. Mania-like
behavior induced by genetic dysfunction of the neuronspecific Na+,K+- ATPase α3 sodium pump. Proc Natl Acad
Sci U S A. 2011;108:18144-18149.
 Kollmus H, Post R, Brielmeier M, Fernandez J, Fuchs H,
McKerlie C, Montoliu L, Otaegui PJ, Rebelo M, Riedesel H,
Ruberte J, Sedláček R, Habré d´Angelis M, Schughart K.
Analysis of structural and functional concepts employed in
mouse phenotyping and archiving facilities. Transgenic
Res. 2011;Oct;20;(5):1155.
 Kuiper JW, Plötz FB, Groeneveld AJ, Haitsma JJ, Jothy S,
Vaschetto R, Zhang H, Slutsky AS. High tidal volume
mechanical ventilation-induced lung injury in rats is greater
after acid instillation than after sepsis-induced acute lung
injury, but does not increase systemic inflammation: an
experimental study. BMC. Anesthesiol. 2011;11:26.
 Kushwah R, Oliver J, Duan C, Zhang L, Keshavjee S, Hu
J: Induction of immunological tolerance towards adenoviral
vectors using a novel dendritic cell based strategy. J.
Virology.2012;Jan 18.
 Leytin V. Apoptosis in the anucleate platelet. Blood Rev.
2012;26:51-63.
 Liang Y, Qiu H, Glinka Y, Lazarus AH, Ni H, Prud’homme
GJ, Wang Q. Immunity against a therapeutic
xenoprotein/Fc construct delivered by gene transfer is
reduced through binding to the inhibitory receptor FcγRIIb.
J Gene Med. 2011;13:470-477.
 Lichner Z, Mejia-Guerrero S, Ignacak M, Krizova A, Bao T,
Girgis A, Youssef Y, Youssef GM. Pleotrophic action of
renal cell carcinoma-dysregulated microRNAs on hypoxia
related signalling pathways. Mod Pathol. 2012;25:463A.
 Lichner Z, Mejia-Guerrero S, Ignacak M, Krizova A, Bao
TT, Girgis AH, Youssef YM, Yousef GM. Pleiotropic action
of renal cell carcinoma-dysregulated miRNAs on hypoxiarelated signaling Ppthways. Am J Pathol. 2012 [Epub
ahead of print]
 Ly T, Gupta N, Weinreb RN, Kaufman PL, Yücel YH.
Dendrite plasticity of the lateral geniculate nucleus in
primate glaucoma. Vision Research. 2011;51:243-50.
 Manoranjan B, Syro LV, Scheithauer BW, Ortiz LD,
Horvath E, Salehi F, Kovacs K, Cusimano M.
Undifferentiated sarcoma of the sellar region. Endocr
Pathol. 2011; 22:159-164.
 Merims S, Dokouhaki P, Joe B, Zhang L. Human Vδ1 T
cells regulate immune responses by targeting autologous
immature dendritic cells. Hum Immunol. 2011;72:32-38.
 Merims S, Li XJ, Joe B, Dokouhaki P, Han M, Wang ZY,
Childs RW, Gupta V, Minden MD, Zhang L. Anti leukemia
effect of ex vivo expanded DNT cells from AML patients: a
potential novel autologous T cell adoptive immunotherapy.
Leukemia. 2011;25:1415-1422.
 Morris S, Parkin P, Science M, Subbarao P, Yau Y,
O’Riordan S, Barton M, Allen U, Tran D. A retrospective
cross sectional study of risk factors and clinical spectrum of
children admitted to hospital with pandemic H1N1 influenza
as compared to influenza A. BMJ Open. 2012;2:e000310.
 Moshkin O, Syro LV, Scheithauer BW, Ortiz LD, Fadul CE,
Uribe H, Gonzalez R, Cusimano M, Horvath E, Rotondo F,
Kovacs K. Aggressive silent corticotroph adenoma
progressing to pituitary carcinoma. The role of
temozolomide therapy. Hormones. 2011;10:162-167.
Vol. 14 #3- 2012
 Nafisi H, Ghorab Z, Ismiil N, Saad R, Dubé V, Khalifa MA.
p16 expression in early müllerian serous carcinogenesis.
Mod Pathology. 2012;Feb; 25(Supp 2):1215.
 Nam RK, Zhang W, Siminovitch K, Shlien A, Kattan MW,
Klotz LH, Trachtenberg J, Lu Y, Zhang J, Yu C, Toi A,
Loblaw DA, Venkateswaran V, Stanimirovic A, Sugar L,
Malkin D, Seth A, Narod SA. New variants at 10q26 and
15q21 are associated with aggressive prostate cancer in a
genome-wide association study from a prostate biopsy
screening cohort. Cancer Biol Ther. 2011;Dec;1;12(11).
 Naples M, Baker C, Lino M, Iqbal J, Hussain MM and Adeli
K. Ezetimibe ameliorates intestinal chylomicron
overproduction and improves glucose tolerance in a dietinduced hamster model of insulin resistance. Am J Physiol
Gastrointest Liver Physiol. 2012 Feb 16.
 Nassiri F, Cusimano MD, Scheithauer BW, Rotondo F,
Fazio A, Yousef GM, Syro LV, Kovacs K, Lloyd RV.
Endoglin (CD105): a review of its role in angiogenesis and
tumor diagnosis, progression and therapy. Anticancer
Res. 2011;31:2283-2290.
 Nofech-Mozes S, Ismiil N, Dubé V, Saad RS, Ghorab Z,
Grin A, Ackerman I Khalifa MA. Interobserver agreement
for endometrial cancer characteristics evaluated on Biopsy
material. Obst ans Gyn Int. 2012;Article ID 414086:6.
 Nofech-Mozes S, Ismiil N, Dube V, Saad RS, Khalifa MA,
Moshkin O, Ghorab Z. Immunohistochemical
characterization of primary and recurrent adult granulosa
cell tumors. Int J Gynecol Pathol. 2012;Jan;31(1):80-90.
 Nofech-Mozes S, Jorden T, Hanna WM, Khalifa MA.
Synoptic reporting on breast cancer biomarkers: a novel
quality improvement module. Can J Path. 2012;4(4):11-15.
 Pavenski K, Freedman J, Semple JW: HLA
alloimmunization against platelet transfusions:
pathophysiology, significance, prevention and
management. Tissue Antigens. 2012;79:237-245.
 Petraki C, Dubinski W, Scorilas A, Saleh C, Pasic MD,
Komborozos V, Khalil B, Gabril MY, Streutker C,
Diamandis EP, Yousef GM. Evaluation and prognostic
significance of human tissue kallikrein-related peptidase 6
(KLK6) in colorectalcancer. Pathol Res Pract. 2012;
208:104-108
 Quinn KL, Henriques M, Taubchi A, Han B, Yang H, Cheng
ST, Yu H, Luo A, Charbonney E, Tullis E, Lazarus AH,
Robinson LA, Ni H, Peterson BR, Kuebler WM, Slutsky AS,
Zhang H. Human neutrophil peptides mediate endotheliamonocyte interaction, foam cell formation and platelet
activation. Arterioscler Thromb Vasc Biol. 2011;31:20702079.
 Quintanar-Stephano A, Organista-Esparza A, ChaviraRamirez R, Kovacs K, Berczi I. Effects of
neurointermediate pituitary lobectomy and desmopressin
on acute experimental autoimmune encephalomyelitis in
lewis rats. Neuroimmunomodulation. 2012;19:148-157.
 Raftopoulos SC, Efthymiou M, Streutker CJ, May GR.
Education and imaging. Gastrointestinal: Atypical
hyperplastic gastric polyposis: a case report and brief
review of the literature. J Gastroenterol Hepatol.
2011;26:1693.
 Rakovitch E, Nofech-Mozes S, Hanna W, Narod S, Spayne
J, Thiruchelvam D, Saskin R, Paszat L. Her2/neu and ki-67
expression predict non-invasive recurrence following
breast conserving therapy for ductal carcinoma in situ. Br J
Cancer. 2012 Feb 23 [Epub ahead of print]
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LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
 Rizoli S, Nascimento B Jr, Key N, Tien HC, Muraca S,
Pinto R, Khalifa M, Plotkin A, Callum J. Disseminated
intravascular coagulopathy in the first 24 hours after
trauma: the association between ISTH score and
anatomopathologic evidence. J. Trauma. 2011;Nov;71(5
Suppl 1):S441-7.
 Rotondo F, Cusimano M, Scheithauer BW, Rotondo A,
Syro LV, Kovacs K. Ghrelin immunoexpression in pituitary
adenomas. Pituitary. 2011;14:318-322.
 Rotondo F, Rotondo A, Scheithauer BW, Cusimano M,
Latta E, Syro LV, Kovacs K. Ghrelin immunoexpression in
the human hypophysis. Appl Immunohistochem Mol
Morphol. 2012;20:77-81.
 Ruschoff J, Hanna W, Bilous M, Hofmann M, Osamura RY,
Penault-Llorca F, van de Vijver M, Viale G. Her2 testing in
gastric cancer: a practical approach. Mod Pathol. 2012
Jan [Epub ahead of print]
 Saad RS, El-Sayed A, Shehata A, Mashour M, Hanna W.
Immunophenotype profile of breast carcinoma brain
metastases in comparison to their breast primaries. Mod
Pathol. 2012;Feb;25(Supp 2):256.
 Saad RS, Ghorab Z, Khalifa MA, Xu M. CDX2 as a marker
for intestinal differentiation: its utility and limitations. World
J Gastrointest Surg. 2011;Nov;27;3(11):159-66.
 Saad RS, Mashhour M, Nofech-Mozes S, Ismiil N, Dube V,
Ghorab Z, Faragalla H, Khalifa MA. P16INK4a expression
in undifferentiated carcinoma of the uterus does not
exclude its endometrial origin. Int J Gynecol Pathol.
2012;Jan;31(1):57-65.
 Saad RS, Shehata AF, Silverman JF, Ismiil N, Ghorab Z. Is
it possible to differentiate endometrial serous carcinoma
from endometrioid type in liquid-based preparation? a
cytomorphologic study. Mod Pathol. 2012;Feb;25(Supp
2):1240.
 Saleeb R, Faragalla H, Sy K, Yousef GM, Stward R,
Streutker CJ. Malignancies arising in allograft kidneys. Mod
Pathol. 2012;25:238A.
 Salehi F, Scheithauer BW, Kovacs K, Syro LV, Sharma S,
Manoranjan B, Cusimano M. O-6-methylguanine-D
methyltransferase (MGMT) immunohistochemical
expression in pituitary corticotroph adenomas.
Neurosurgery. 2012;70:491-496.
 Salehi F, Scheithauer BW, Kros JM, Lau Q, Fealey M,
Erickson D, Kovacs K, Horvath E, Lloyd RV. MGMT
promotermethylation and immunoexpression in aggressive
pituitary adenomas and carcinomas. J Neurooncol.
2011;104:647-657.
 Sav A, Syro LV, Scheithauer BW, Rotondo F, Builes CA,
Horvath E, Kovacs K. Silent somatotroph adenoma: a
morphologic immunohistochemical and electron
microscopic study: a case report. J Med Cases.
2012;3:43-48.
 Semple JW, Kim M, Hou J, Lee YJ, Tabuchi A, Kuebler
WM, Lazarus AH. Intravenous gammaglobulin (IVIg)
therapy prevents antibody-mediated transfusion related
acute lung injury (TRALI) by directly inhibiting recipient
neutrophil activation in a murine model. Blood.
2011;118:42.
 Semple JW, Gebremeskel S, Aslam R, Ni H, Freedman J.
Thymic retention of CD4+CD25hi+FoxP3+ T regulatory
(Treg) cells is responsible for peripheral Treg deficiency
and platelet and megakaryocyte destruction in active
immune thrombocytopenia (ITP). Blood. 2011;118:523.
14
Vol. 14 #3- 2012
 Semple JW, Kim M, Hou J, McVey M, Lee YJ, Tabuchi A,
Kuebler WM, Chai Z-W, Lazarus AH. Intravenous
immunoglobulin prevents murine antibody-mediated acute
lung injury at the level of neutrophil reactive oxygen
species (ROS) production. PloS ONE. 2011;7:31357.
 Sherman C, Jani P, Marks A, Kahn H. D2-40 is expressed
on the luminal surface of pulmonary airspaces in normal
developing and adult lung but is lost in conditions
associated with intra-alveolar infiltrate. Pediatr Dev Pathol.
2011 Dec 9 [Epub ahead of print]
 Shi SY, Garcia Martin R, Duncan RE, Choi D, Lu SY,
Schroer SA, Cai EP, Luk CT, Hopperton KE, Domenichiello
AF, Tang C, Naples M, Dekker MJ, Giacca A, Adeli K,
Wagner KU, Bazinet RP, Woo M. Hepatocyte-specific
deletion of Janus kinase 2 (JAK2) protects against dietinduced steatohepatitis and glucose intolerance. J Biol
Chem. 2012 Jan 24.
 Sidiropoulos M, Hanna W, Raphael S, Jakate K, Ghorab Z.
Merkel cell carcinoma immunoreactivity with Pax5. Mod
Pathology. 2012;Feb;25 (Supp 2):548.
 Sivapragasam M, Rotondo F, Lloyd RV, Scheithauer BW,
Cusimano M, Syro LV, Kovacs K. MicroRNAs in the human
pituitary. Endocri Pathol. 2011;22:134-143.
 Tabuchi A, Kim M, Semple JW, Kuebler WM. Acute lung
injury causes pendelluft between adjacent alveoli in vivo.
Am. J. Respir. Crit. Care Med. 2011;183:A2490.
 Tam ALC, Gupta N, Zhang Z, Yücel YH. Quantum dots
trace lymphatic drainage from the mouse eye.
Nanotechnology. 2011;22:425101.
 Thon JN, Peters CG, Rowley J, Weyrich AS, Semple JW,
Aslam R, Flaumenhaft R, Italiano Jr. JE. The functional
role of TLR9 in human platelets. Blood. 2011;118:366.
 Tiller H, Killie M, Husebekk A, Skogen B, Ni H, KjeldsenKragh J, Øian P. Platelet antibodies and fetal growth:
maternal antibodies against fetal platelet antigen 1a are
strongly associated with reduced birthweight in boys. Acta
Obstetricia et Gynecologica Scandinavica (AOGS).
2012;91:79-86.
 Wang T, Rowsell C, Hsieh E, J Ramsay, C Streutker.
Immunohistochemical profiles of small intestinal
adenocarcinomas. Mod Pathol. 2012;Feb;25(Supp 2):766.
 Waters V, Stanojevic S, Atenafu EG, Lu A, Yau Y, Tullis E,
Ratjen F. Effect of pulmonary exacerbations on long-term
lung function decline in cystic fibrosis. European
Respiratory Journal. 2011 Dec 1 [Epub ahead of print]
 White NM, Khella HW, Grigull J, Adzovic S, Youssef YM,
Honey RJ, Stewart R, Pace KT, Bjarnason GA, Jewett MA,
Evans AJ, Gabril M, Yousef GM. miRNA profiling in
metastatic renal cell carcinoma reveals a tumoursuppressor effect for miR-215. Br J Cancer.
2011;105:1741-9.
 White NMA, Khella HWZ, Grigull J, Adzovic S, Youssef
YM, Honey RJ, Stewart R, Pate KT, Bjarnason GA, Jewett
MAS, Evans AJ, Gabril M, Yousef GM. miRNA profiling in
metastatic renal cell carcinoma reveals a tumor supressor
effect for miR-215. Mod Pathol. 2012;25:251A.
 White NMA, Masui O, DeSouza L, Krakovska O, Matta A,
Siu KWM, Yousef GM. Relative quantification of protein
expression in metastatic clear cell renal cell carcinoma
tissue using iTRAQ LC-MS/MS analysis. Mod Pathol.
2012;25:251A.
Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
Vol. 14 #3- 2012
 White NMA, Youssf YM, Jung K, Fendler A, Stephan C,
Gabril M, Yousef GM. The microRNA-Kallikrein axis of
interaction: a new dimension in the pathogenesis of
prostate cancer. Mod Pathol. 2012;25:468A.
 Yousef GM. Personalized Cancer Genomics: The Road
Map to Clinical Implementation. Clin Chem. 2012. [Epub
ahead of print]
 Zeng Q, Zhu L, Tao L, Bao J, Yang M, Simpson EK, Li
C, van der Wal DE, Chen P, Spring CM, Wang M, Zhang
L, Ruan C, Hou M, Xia R, Ni H. Relative efficacy of steroid
therapy in immune thrombocytopenia mediated by antiplatelet GPIIbIIIa versus GPIb antibodies. Am J Hematol.
2012;87:206-208.
 Zhang L, Thomson AW. New partners for tolerogenic
dendritic cells. Am. J. Transplant. 2011;11:2003-2004.
 Zimring JC, Lis Welniak L, Semple JW, Ness PM, Slichter
SJ, Spitalnik SL and the NHLBI Alloimmunization Working
Group. Current problems and future directions of
transfusion-induced alloimmunization: summary of an
NHLBI working group. Transfusion. 2011;51:435-441.
Books/Book Chapters
 Cines DB, Kuter DJ, Newland AC, Provan D, Semple JW.
The Handbook: Immune Thrombocytopenia. European
School of Haematology. Paris FR. Press 2011.
 Horvath E, Kovacs K. Histopathology of Pituitary Tumors.
In:Oxford Yextbook of Endocrinology and Diabetes. 2nd
Edition. Eds. Wass JAH, Steward PM. Oxford University
Press. 2011. pp 121-127.
 Kontogeorgos G, Stefaneanu L, Kovacs K, Horvath E.
Hypophyis. In: The Human Nervous System. 3rd Edition.
Eds. JK Mai, G Paxinos, Elsevier. 2012. pp 584-593.
 Semple JW. Mouse models of ITP. In The Handbook:
st
Immune Thrombocytopenia. 1 Edition. Eds. Cines DB,
Kuter DJ, Newland AC, Provan D, Semple JW. European
School of Haematology. Press 2011. Paris FR. Chapter
1.3. pp 40-54.
LMP Newsletter is a communication of the Department of
Laboratory Medicine & Pathobiology, Faculty of Medicine,
University of Toronto. Please send your submission to:
Joanne D’Angelo
Laboratory Medicine & Pathobiology
1 King’s College Circle, Rm 6231, Toronto ON M5S 1A5
Tel: 416-978-2557 Fax: 416-9787-7361
E-mail: joanne.dangelo@utoronto.ca
Next Deadline for Submissions: October 12, 2012
Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
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LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
Vol. 14 #3- 2012
GRADUATE STUDENT RESEARCH DAY
March 6, 2012
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Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
Vol. 14 #3- 2012
POSTGRADUATE RESEARCH DAY
April 17, 2012
Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
17
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
Vol. 14 #3- 2012
LMP ANNUAL REUNION & BANQUET
June 7, 2012
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Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
Vol. 14 #3- 2012
LMP ANNUAL REUNION & BANQUET
Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca
19
LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto
Vol. 14 #3- 2012
ARTS & SCIENCE RECEPTION
June 13, 2012
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Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca