Long-acting Vitamin C Release pellet
Effectively provide enough Vit C and maintain
24-hour physiological function.
Chemical properties
Levorotary Vit C
Scientific name
L-ascorbate or
L-ascorbic acid
Molecular formula
C6H8O6
Molecular weight
176.14
Ceiling effect of oral
Vit C is 95mg once by
oral absorption.
United States vitamin C recommendations
Recommended Dietary
90 mg/day
Allowance(adult male)
Recommended Dietary Allowance
75 mg/day
(adult female)
Tolerable Upper Intake Level (adult
2000mg/day
male and female)
1. Overdose of Vit C will result of the osmotic
water-retaining effect of the unabsorbed portion in the
gastrointestinal tract (similar to cathartic osmotic
laxatives).
Compare the maximum plasma concentration (Cmax) with different Vit C oral dosage.
Changing of plasma concentration for oral dosage in
human body
Changing of plasma concentration when uptake 200mg
and 1250mg by oral or injection (IV)
The difference between the plasma concentration of
400mg and 1000mg daily dosage is less. The Vit C
is rapidly eliminated when the dosage is over 400mg.
Up taking 200mg or 1250mg by oral (-○-) or injection
(-●-) gradually toward to the same concentration in
8~12 hours
Alteration of plasma concentration between gap
junctions in varies oral dosage of Vit C.
Vit C recommended dosage and usage.
1. Uptake 200mg~400mg of Vit C at a
time, three time per day or
2. Uptake 500mg long-acting Vit C
pellet once per day
3. higher dosage (>500mg) does not
result better effect, because it excess
the ability of GI absorption and
accelerate Vit C metabolism and
elimination.
Daily oral dose of 300mg Vit C reaches Cmax varied
from different tissues.
Medray honeycomb-structure pellet benefits
1. Pharmaceutics Improvement
(Patent Appling)
Powder
or
Microencapsulating
powder
Actives (Solid or Liquid)
Pellet with
Protecting layer
Advantage:
Protect from oxidation, light and
humidity to have longer lasting
products.
Dual mechanism design of pellet
formulation regulates Vit C release
and dissolution.
Secondary structure unit
Protective Mem.
Anti-oxidation/moisture
Functional Mem.
Delayed-release
membrane
2. Pharmacokinetics Improvement
Long-acting Vit C pellet has the following properties of pharmacokinetics.
a. Oxidation stable.
b. Pellets could easily pass the pylorus, and is not restricted by stomach evacuation.
c. Vit C pellet release steadily at Duodenum, Jejunum and Ileum(about 5 Meter) 8-12 hours and
maintain efficient plasma concentration for 12-16 hours
d. Release steadily to avoid side effect from high Vit C conc. for mucosa irritation and in plasma.
e. Different vitamin C plasma concentration play a different mechanism of metabolism elimination.
According to clinical PK data, Vit C will be metabolized and elimination faster at 70-90μM. So
administration of 500mg to 2000mg vitamin C may not achieve comparative efficacy.
3. Phramcodynamics Improvement
Long-acting Vit C pellet provide sustained and suitable plasma concentration and steadily maintain
the better physiology performance.
a. Vit C is the key coenzyme to assist proline and lysine for Hydroxylation of Collagen and is also
important for consisting triple collagen spiral. Therefore, Vit C has the significant role for
maintaining and developing of skin, cartilage, bone, enamel, and endothelium. To maintain proper
connective tissue functions also requires Vit C because collagen is used to form connective tissue
between cells.
b. Vit C involve in metabolism of Tyrosine, which influences the neural transmission of
epinephrine、dopamine、tryptophan and functions of endocrine.
c. Vit C assists synthesis of Carnitine and influences cell transportation and fatty acid for entering
mitochondrion to produce ATP, which is the energy source for body cells.
d. Assists Dopamine β-hydroxlase to synthesize epinephrine, steroid hormone, and norepinephrine for
sustaining body functions
e. Involve in synthesis and stability of hormonal peptide
f. Enhance wound healing and increase receptiveness of stress from injury and infection.
Recommended Group
1.
2.
3.
4.
Group with highly consume vitamin C: smoking, pregnant, athletic, staying up or overly stressed.
Assisting of infection、fever、inflammation and cicatrization.
Ease symptoms of gout and hyperuricemia
Anti-aging of skin and the joint and anti-melanin and whitening the skin.
5. Significantly reduced the frequency of the common cold but not the duration or severity