Global Pharmaceuticals Marketing Channel Reference EDITION 2015 ABOUT IMS HEALTH IMS Health is a leading global information and technology services company providing clients in the healthcare industry with comprehensive solutions to measure and improve their performance. End-to-end proprietary applications and configurable solutions connect 10+ petabytes of complex healthcare data through the IMS OneTM cloud-based master data management platform, providing comprehensive insights into diseases, treatments, costs and outcomes. The company’s 15,000 employees blend global consistency and local market knowledge across 100 countries to help clients run their operations more efficiently. Customers include pharmaceutical, consumer health and medical device manufacturers and distributors, providers, payers, government agencies, policymakers, researchers and the financial community. As a global leader in protecting individual patient privacy, IMS Health uses anonymous healthcare data to deliver critical, real-world disease and treatment insights. These insights help biotech and pharmaceutical companies, medical researchers, government agencies, payers and other healthcare stakeholders to identify unmet treatment needs and understand the effectiveness and value of pharmaceutical products in improving overall health outcomes. Additional information is available at www.imshealth.com IMS Health Global Pharmaceuticals Marketing Channel Reference 2015 extract Global Overview About This Publication Snapshots With the acquisition of the Cegedim marketing channel audits and the CSD Global and Local Promotion Databases, IMS Health now offers marketing channel performance metrics in 35 countries. Leveraging the acquired promotional databases of Cegedim, this publication provides an overview of 2014 pharmaceutical industry marketing trends worldwide and at the country level. The following metrics are highlighted in this edition: • Investment by marketing channel • Investment by corporation, brand, therapy area • Digital channel investment • Sales force rep equivalents (FTE) • Tablet detailing Please refer to the following pages for an overview of IMS Health’s promotion data assets and the methodology section of the appendix (page 204). Please contact your IMS Health sales representative for further information and questions about this report. IMS Health Global Pharmaceuticals Marketing Channel Reference 2015 extract 1 Table of Contents 04 Marketing Channel Measurement 06 Global Overview 08 Review of the Year 20 Key Countries 171 Other Countries 204Appendix 204 Marketing Channel Audits Methodology 22 212 OneKey 222 Abbreviations & Glossary IMS Health Global Pharmaceuticals Marketing Channel Reference 2015 extract Global Overview Snapshots 20 Key Countries 21USA 31France 41Germany 51Italy 61Spain 71UK 81Japan 91China 101Brazil 111Mexico 121Russia 131Turkey 141Poland 151Australia 161 South Korea 171 Other Countries 172 174 176 178 180 182 Denmark Finland Norway Sweden Belgium Czech Republic 184 186 188 190 192 194 Greece Ireland Portugal Romania Canada Colombia 196 India 198 Taiwan 200 Algeria 202 Morocco IMS Health Global Pharmaceuticals Marketing Channel Reference 2015 extract 3 3 MARKETING CHANNEL MEASUREMENT Marketing Channel Measurement is a key asset of IMS Health’s Global Services organisation. WHAT? • Monitored Promotional Sales Force and Marketing Channels • Interaction & Investment levels • Recalled messages • Measured impact and effectiveness • GPs and all major specialist groups • Share of Voice, Share of Investment and much more! WHERE? Cegedim + IMS Health promotion assets: The essentials • USA, Canada, Japan, EU5, Brazil, Russia, India, China, Turkey • Argentina, Colombia, Mexico • Australia, Korea, Taiwan, New Zealand • Denmark, Finland, Norway, Sweden •B elgium, Czech Republic, Greece, Ireland, Poland, Portugal, Romania • Algeria, Egypt, Morocco, Saudi Arabia 44 IMS IMS Health Health Global Global Pharmaceuticals Pharmaceuticals Marketing Marketing Channel Channel Reference Reference 20152015 extract and threats HOW? • Determine best marketing practice • Plan and adapt your promotional strategy •O nline daily diary questionnaire with over 30,000 panellists WHEN? WHY? • Benchmark your brands and competitors • I dentify competitive strengths, weaknesses, opportunities •M onthly & quarterly database updates recruited with OneKey physician database where available (see appendix) •G lobal or local database access, online analytics tools, flat files, bespoke reports… • Ad-hoc / Zoom style questions can be added quickly (10-30 days following update month / quarter) • Weekly bespoke reports available •B ack data? Of course! 5 years is standard but we have more …just ask! IMS Health Global Source: Pharmaceuticals IMS Health Strategic Marketing DataChannel Promotion Reference Database, 2015 Year extract 2014 5 5 Global Overview 66 IMS IMS Health Health Global Global Pharmaceuticals Pharmaceuticals Marketing Marketing Channel Channel Reference Reference 20152015 extract Global Pharmaceuticals Marketing Channel Reference Global Overview Total Investment $70.7bn -1.4% vs 2013 7 Commentary Review of the year 2014 Worldwide, the use of digital channels increased by over 30% in 2014. At nearly $71 billion constant US dollars, worldwide industry investment in pharmaceuticals sales force and marketing channels dropped slightly by -1.4% in 2014. The leading 10 multinational companies – ranked by total measured promotional expenditure, showed widely varied evolution in investment during the 12 months to December 2014. For example, AstraZeneca and Johnson & Johnson increased marketing investment by double digits while others, such as Lilly and Novartis cut spending dramatically. Investment in worldwide sales force – the largest single channel by cost – was flat in 2014. Several factors are notable when analyzing the current pharmaceuticals marketing landscape: • • • 88 R eductions in sales force levels have slowed following several years of consolidation related to the “patent cliff”. H igh levels of new compound approvals over the past 4 years – reaching 50 in 2014, have driven investment in related, specialist targeted marketing S ales force “upgrades”, with a focus on an integrated “multichannel” approach and provision of rich clinical content reveal a progressive shift away from influence and advertising towards high value engagements across multiple touchpoints. IMS Health Global Pharmaceuticals Marketing Channel Reference 2015 extract Global Overview Snapshots Marketing investment did vary dramatically by geography in 2014 as the country level sections of this report will reveal. Major emerging countries saw jumps in expenditure including China (+11%) and Brazil (+20%). Likewise, Australia and Turkey both saw increases in spending of more than 10%. Russia was flat however and other major European markets saw significant cuts in spending with Germany down -11% and Spain off by -9%. Meanwhile, marketing investment in the USA returned to positive territory with measured expenditure up by nearly 3%. Worldwide, the use of digital channels including online detailing, emailing and streaming video increased yet again in 2014 with investment in these three channels up over 30% at $2.3 billion constant US dollars. Measured in-call use of tablets and other connected mobile devices, often referred to as “e-detailing” saw higher levels of penetration in smaller and emerging markets. Roughly 20% of face-to-face rep calls in Belgium are supported by such devices – the highest level of penetration across 30 audited countries. Mexico, Brazil and Denmark followed in the rankings, with 14% e-detailing penetration or higher. IMS Health Global Pharmaceuticals Marketing Source: IMS Channel Health Reference Strategic Data 2015Promotion extract Database, Year 2014 9 9 Global Overview Snapshots Sales Force Rep Equivalents 2014 $70.7bn Total Investment -1.4% vs 2013 2013 2014 440,421 444,112 Change +0.8% 0.0% CHANGE vs 2013 Detailing 10 10 -2.7% Samples IMS Source: Health Global IMS Health Pharmaceuticals Strategic Data Marketing Promotion Channel Database, Reference Year 2014 2015 -25.5% Meetings +5.0% Advertising Global Overview Global Overview Snapshots Digital Investment Detailing $2.3bn $44.2bn 3.2% 62.5% of total investment of total investment 6.3% face to face calls use a tablet as detailing support +30.9% Clinical Trials +19.7% DTC 6.3% +11.9% +32.2% Mailing/others Digital Source: IMS Health Strategic Data Promotion Database, Year 2014 11 11 Global Overview Investment by Channel Full Year 2014 2014 $70.7bn Total Investment -1.4% vs 2013 Total All Channels 12 12 IMS Source: Health Global IMS Health Pharmaceuticals Strategic Data Marketing Promotion Channel Database, Reference Year 2014 2015 Total Investment $bn % by channel % change Detailing 44.2 62.5% -0.0% Samples 7.9 11.1% -2.7% Meetings 7.8 11.1% -25.5% Advertising 0.5 0.6% +5.0% Clinical Trials 1.6 2.3% +30.9% DTC 4.6 6.5% +19.7% Mailing/Others 1.8 2.6% +11.9% Digital 2.3 3.2% +32.2% 70.7 100.0%-1.4% Global Overview Investment by Corporation, Brand & Therapy Area Digital investment by Brand – Full Year 2014 Investment by Corporation Corporations % Change Brands Investment ($K) 4,192,663 5.9% +1.7% Xarelto 1,054,745 1.5% +11.0% AstraZeneca 3,972,820 5.6% +24.6% Eliquis 1,029,254 1.5% +52.8% Merck & Co 3,467,625 4.9% -13.6% Forxiga 725,678 1.0% +630.3% GlaxoSmithKline 2,580,661 3.7% +4.0% Crestor 723,865 1.0% -16.0% Actavis 2,546,109 3.6% -2.8% Symbicort 719,248 1.0% +3.1% Boehringer Ingelheim 2,516,537 3.6% -8.9% Januvia 707,128 1.0% -17.6% Novartis 2,384,940 3.4% -21.0% Pradaxa 674,467 1.0% -9.9% Johnson & Johnson 2,265,628 3.2% +22.9% Abilify 606,875 0.9% +5.6% Takeda 1,942,219 2.7% -3.3% Lyrica 592,677 0.8% +1.1% Lilly 1,866,278 2.6% -21.3% Tradjenta 574,825 0.8% -20.0% Pfizer Investment ($K) % Investment by BRAND Investment by Therapy Area 4.6% 3.4% 3.1% 3.0% 3.0% 82.9% A10N R03F N06A B01F A10P All Others % % Change DIGITAL INVESTMENT BY brand Naramig Nexium Januvia Pradaxa Xarelto Eliquis Invokana Deberza Crestor Relvar 39,077 31,768 30,085 27,768 27,586 25,554 25,055 24,944 23,002 22,236 $k Source: IMS Health Strategic Data Promotion Database, Year 2014 1313 Global Overview Number of reps BY region and % change 2013-2014 North America Europe Top 5 71,245 70,149 76,632 73,311 -1.5% +0.8% vs 2013 444,112 -4.3% 60,143 58,067 -3.5% Other Europe +1.6% +9.5% 51,410 52,240 126,006 137,992 Latin America IMS Source: Health Global IMS Health Pharmaceuticals Strategic Data Marketing Promotion Channel Database, Reference Year 2014 2015 -4.8% Japan Asia Pacific 2013 14 14 54,984 52,353 2014 Global Overview Sales Force Rep Equivalents (FTE) FTEs Top 10 Corporations, % change & Call Quality Score – 2014 Total all corporations : 444 112 FTEs Average % change vs 2013Call Quality Score +0.8% +32.2 17,867 Pfizer -1.9% +38.5 16,594 Merck & Co -9.1% +34.3 15,912 Novartis -8.2% +31.8 15,017 AstraZeneca +8.7% +31.4 13,697 Sanofi +3.1% +33.6 12,581 GlaxoSmithKline -1.9% +34.1 11,214 Bayer +2.0% +36.3 11,045 Boehringer Ingelheim -2.1% +34.9 9,736 Johnson & Johnson +11.8% +36.7 8,812 Bristol Myers Squibb +10.3% +35.6 Source: IMS Health Strategic Data Promotion Database, Year 2014 1515 Global Overview Use of tablet detailing support by country Top 15 countries - Full year 2014 % of Face to Face calls using a Tablet as detailing support 16 16 20.5% Belgium 17.0% Mexico 16.3% Brazil 14.4% Denmark 13.8% Australia 11.5% Norway 11.3% UK 11.2% Finland 11.1% Portugal 10.8% Spain 10.1% Turkey 8.4% Sweden 7.6% USA 6.8% Ireland 6.5% Colombia 6.3% Avg All Countries IMS Source: Health Global IMS Health Pharmaceuticals Strategic Data Marketing Promotion Channel Database, Reference Year 2014 2015 Global Overview Global Overview Digital INVESTMENT Total investment and trends 2013 Total Investment e-meetings +54.3% vs 2013 2014 Total Investment $2,295m 3.2% of total investment $1,736m 282 182 661 2.4% of total investment Overall change +32.2% e-mailing +16.3% vs 2013 568 1,353 986 e-detailing +37.2% vs 2013 Source: IMS Health Strategic Data Promotion Database, Year 2014 1717 Global Overview Total Digital INVESTMENT and % Change 2014 Europe Top 5 North America +28.2% $1,275.1m +4.6% +37.9% $92.4m $15.2m +43% $890.6m Other Europe +1.7% $9.0m +32.2% vs 2013 $2.3bn 18 18 Latin America IMS Source: Health Global IMS Health Pharmaceuticals Strategic Data Marketing Promotion Channel Database, Reference Year 2014 2015 Japan +17.7% $12.8m Asia Pacific Global Overview Digital Investment Top 5 Corporations by Region - Year 2014 North America Europe Top 5 Japan Total Digital Investment $k Corporation % Share % Change Total Digital Investment $k Corporation % Share % Change Total Digital Investment $k Corporation % Share % Change 107,861 PFE 8.5 +27.0 6,900 MRK 7.5 -25.2 137,406 GSK 15.4 +85.5 87,818 NVT 6.9 +35.4 4,319 AZ 4.7 -18.6 52,482 AZ 5.9 +14.4 86,713 MRK 6.8 +35.9 3,709 GSK 4.0 +79.5 49,129 MRK 5.5 +115.9 83,858 VAL 6.6 +185.1 3,621 J&J 3.9 +12.2 48,927 PFE 5.5 +29.1 64,118 AZ 5.0 +50.7 3,259 PFE 3.5 -18.9 46,457 DSP 5.2 -11.3 Latin America Other Europe Asia Pacific Total Digital Investment $k Corporation % Share % Change Total Digital Investment $k Corporation % Share % Change Total Digital Investment $k Corporation % Share % Change 1,255 MRK 13.9 -36.1 1,297 SAN 8.6 +52.4 1,110 HMI 8.7 +716.5 760 AZ 8.4 +107.0 1,166 GSK 7.7 +92.8 1,008 PFE 7.9 +11.7 475 NVT 5.3 +143.7 1,162 PFE 7.7 +31.1 813 MRK 6.4 +23.8 413 LLY 4.6 +105.3 936 AZ 6.2 +46.0 525 NVT 4.1 +33.6 406 SAN 4.5 +42.5 849 ADA 5.6 +47.1 502 AZ 3.9 +31.8 Source: IMS Health Strategic Data Promotion Database, Year 2014 1919 IMS Health 90/92 Route de la Reine 92773 Boulogne Billancourt Cedex France For further information: Christopher Wooden Vice President, Global Sales, ChannelDynamics cwooden@fr.imshealth.com Phone: +33 1 47 79 83 00 ©2015 IMS Health Incorporated and its affiliates. 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