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BIOGRAPHICAL SKETCH
Principal Investigator/Program Director (Last, first, middle):
NAME
POSITION TITLE
Michael E. Baker, Ph.D.
Research Biochemist
Baker, Michael E.
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
YEAR(s)
FIELD OF STUDY
(if applicable)
Lehigh University, Bethlehem, PA
Rensselaer Polytechnic Institute, Troy, NY
University of Chicago, Chicago, IL
Cornell University, Ithaca, NY
B.S.
M.S.
Ph.D.
1960
1964
1965
1968
Metallurgy
Materials Science
Chemistry
Materials Science
RESEARCH AND PROFESSIONAL EXPERIENCE:
Professional Experience
1960-1961
Metallurgist, Pratt & Whitney Aircraft, Middletown, Conn
1968-1971
NIH Fellow, Genetics Dept, Laboratory of Dr. Eric Shooter
Chair Dept of Neurobiology 1975-1987, Stanford University, Stanford, CA
1971-1975
Senior Postdoctoral Fellow, Laboratory of Dr. Robert Holley, Nobel Laureate 1968,
Salk Institute, San Diego, CA.
1976-1987
Assistant Research Biochemist, Univ. of California, San Diego
1988-1999
Associate Research Biochemist, Univ. of California, San Diego
2000-present Research Biochemist, Univ. of California, San Diego
Honors and Awards
1968-1971
NIH Postdoctoral Fellowship
1971-1974
Senior Dernham Fellowship, California Cancer Society
Summer -2002
Japan Society for the Promotion of Science, Senior Fellow at Hoshi University, Tokyo
Selected Publications
78. Grundy WN., Bailey TL., Elkan CP., Baker ME. Hidden Markov model analysis of motifs in steroid dehydrogenases
and their homologs. Biochem. Biophys Res Commun. 231, 760-766, 1997.
80. Grundy, WN., Bailey, T.L., Elkan, C.P., Baker, M.E. Meta-MEME: Motif-based hidden Markov models of protein
families. CABIOS 13, 397-406, 1997.
82. Baker, M.E. Steroid receptor phylogeny and vertebrate origins. Molec Cell Endocrinol 135, 101-107 1997.
83. Baker, M.E., Medlock, K.L., Sheehan D.M. Flavonoids inhibit estrogen binding to rat alpha-fetoprotein. Proc. Soc.
Experimental Biol. & Med. 217, 317-321, 1998.
85. Fomitcheva J; Baker ME; Anderson E; Lee GY; Aziz N. Characterization of Ke 6, a new 17beta-hydroxysteroid
dehydrogenase, and its expression in gonadal tissues. J. Biol. Chem. 273, 22664-22671, 1998.
91. Baker ME, Yan L, Pear MR. Three-dimensional model of human TIP30, a coactivator for HIV-1Tat-activated
transcription, and CC3, a protein associated with metastasis suppression. Cell. Molec. Life Sci. 57, 851-858, 2000.
93. Baker ME. Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid
action. Molec. & Cellular Endocrinol. 171, 211-215, 2001.
94. Baker ME. Adrenal and sex steroid receptor evolution: Environmental implications. J. Molec. Endocrinol. 26, 119125, 2001.
96. Nakajin S, Itoda M, Ohno S, Takase N, Toyoshima S, Baker ME Deletion of 12 carboxyl-terminal residues from pig
3/,20-hydroxysteroid dehydrogenase affects steroid metabolism. Biochim Biophys Acta 1550, 175-182, 2001.
97. Baker ME Recent insights into the origins of adrenal and sex steroid receptors. J Mol Endocrinol 28, 149-152, 2002.
100. Baker ME Evolution of adrenal and sex steroid action in vertebrates: A ligand-based mechanism for complexity.
BioEssays 25, 396-400, 2003.
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Principal Investigator/Program Director BAKER, MICHAEL E.
109. Atanasov AG, Nashev LG, Tam S, Baker ME, Odermatt A. Organotins disrupt the 11beta-hydroxysteroid
dehydrogenase type 2-dependent local inactivation of glucocorticoids. Environ Health Perspect. 113, 1600-1606, 2005.
110. Sciotti MA, Tam, S, Wermuth B, Baker, ME. Differences in catalytic activity between rat testicular and ovarian
carbonyl reductases are due to two amino acids. FEBS Lett. 580, 67-71, 2006.
113. Baker ME Evolution of metamorphosis: role of environment on expression of mutant nuclear receptors and other
signal-transduction proteins. Integr Comp. Biol. 46, 808-814, 2006.
114. Ollikainen N, Chandsawangbhuwana C, Baker ME. Evolution of the thyroid hormone, retinoic acid, ecdysone and
liver X receptors. Integr Comp Biol. 46, 815-826, 2006.
115. Baker ME, Chandsawangbhuwana C, Ollikainen N, Structural analysis of the evolution of steroid specificity in the
mineralocorticoid and glucocorticoid receptors. BMC Evol Biol, 7:24, 2007.
116. Nashev LG, Chandsawangbhuwana C, Balazs Z, Atanasov AG, Dick B, Frey FJ, Baker ME, Odermatt A. Hexose-6phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and
7beta-hydroxy-neurosteroids. PLoS ONE, 2:e561, 2007.
117. Baker ME Amphioxus, a primitive chordate, is on steroids: evidence for sex steroids and steroidogenic enzymes.
Endocrinology 148, 3551-3553, 2007.
118. Baker ME, Chandsawangbhuwana C. Analysis of 3D models of octopus estrogen receptor with estradiol: Evidence
for steric clashes that prevent estrogen binding. Biochem Biophys Res Commun. 361, 782-788, 2007.
120. Baker ME, Chandsawangbhuwana C. Motif analysis of amphioxus, lamprey and invertebrate estrogen receptors:
toward a better understanding of estrogen receptor evolution. Biochem Biophys Res Commun. 371, 724-728, 2008.
122. Baker ME. Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor:
Implications for estrogen receptor evolution. Biochem Biophys Res Commun. 375, 623-627, 2008.
123. Gumy C, Chandsawangbhuwana C, Dzyakanchuk AA, Kratschmar DV, Baker ME, Odermatt A. Dibutyltin disrupts
glucocorticoid receptor function and impairs glucocorticoid-induced suppression of cytokine production. PLoS ONE 3,
e3545, 2008.
124. Balázs Z, Nashev LG, Chandsawangbhuwana C, Baker ME, Odermatt A. Hexose-6-phosphate dehydrogenase
modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1. Mol Cell
Endocrinol 301, 117-122, 2009
125. Baker ME, Ruggeri B, Sprague LJ, Eckhardt-Ludka C, Lapira J, Wick I, Soverchia L, Ubaldi M, Polzonetti-Magni
AM, Vidal-Dorsch D, Bay S, Gully JR, Reyes JA, Kelley KM, Schlenk D, Breen EC, Sásik R, Hardiman G. Analysis of
endocrine disruption in Southern California coastal fish using an aquatic multispecies microarray. Environ Health
Perspect. 117, 223-230, 2009
126. Wu W, Baker ME, Early SA, Bush KT, Nigam SK. Analysis of a large cluster of SLC22 transporter genes,
including novel USTs, reveals species-specific amplification of subsets of family members. Physiol Genomics 38:116124, 2009..
127. Baker ME, Chang DJ. 3D model of amphioxus steroid receptor complexed with estradiol. Biochem Biophys Res
Commun. 386, 516-520, 2009.
128. Baker ME, Chang DJ, Chandsawangbhuwana C. 3D model of lamprey estrogen receptor with estradiol and 15alphahydroxy-estradiol. PLoS ONE;4, e6038, 2009.
129. Markov GV, Tavares R, Dauphin-Villemant C, Demeneix BA, Baker ME, Laudet V Independent elaboration of
steroid hormone signaling pathways in metazoans. Proc Natl Acad Sci USA. 106, 11913-11918, 2009.
130. Baker ME Evolution of 11beta-hydroxysteroid dehydrogenase-type 1 and 11beta-hydroxysteroid dehydrogenasetype 3. FEBS Lett. 584, 2279-2284, 2010
131. Baker ME. 11beta-hydroxysteroid dehydrogenase-type 2 evolved from an ancestral 17beta-hydroxysteroid
dehydrogenase-type 2. Biochem Biophys Res Commun. 399, 215-220, 2010.
132. Baker ME. Origin and diversification of steroids: co-evolution of enzymes and nuclear receptors. Mol Cell
Endocrinol. 334, 14-20, 2011.
133. Baker ME, Asnaashari P, Chang DJ, McDonnell S. 3D models of lamprey progesterone receptor complexed with
progesterone, 7-hdyroxy-progesterone and 17-hydroxy-progesterone. Steroids. 76, 169-176, 2011.
134. Baker ME. Insights from the structure of estrogen receptor into the evolution of estrogens: Implications for
endocrine disruption. Biochem Pharmacol. 82, 1-8, 2011.
135. Odermatt A, Da Cunha T, Penno CA, Chandsawangbhuwana C, Reichert C, Wolf A, Dong M, Baker ME. Hepatic
reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1. Biochem
J. 436, 621-629, 2011.
136. Andrieu T, Bertolini R, Nichols SE, Setoud R, Frey FJ, Baker ME, Frey BM. A novel steroidal antiandrogen
targeting wild type and mutant androgen receptors. Biochemical Pharmacol. 82, 1651–1662, 2011.
137. Baker ME, Uh KY, Asnaashari P. 3D models of lamprey corticoid receptor complexed with 11-deoxycortisol and
deoxycorticosterone. Steroids 76, 1451-1457, 2011.
138. Baker ME, Uh KY. Evolutionary analysis of the segment from helix 3 through helix 5 in
vertebrate progesterone receptors. J Steroid Biochem Mol Biol. 132, 32-40, 2012.
139. Baker ME, Uh KY, Chandsawangbhuwana C. 3D models of human ERα and ERβ
complexed with 5-androsten-3β,17β-diol. Steroids 77, 1192-1197, 2012
140. Baker ME, Chandsawangbhuwana C. 3D models of MBP, a biologically active metabolite
of bisphenol A, in human estrogen receptor α and estrogen receptor β. PLoS One. 2012, 7, e46078.
141. Baker ME. What are the physiological estrogens? Steroids 78, 337-340, 2013.
142. Weinstain R, Kanter J, Friedman B, Ellies LG, Baker ME, Tsien RY. Fluorescent ligand
for human progesterone receptor imaging in live cells. Bioconjug Chem. 24, 766-771, 2013.
143. Baker ME, Funder JW, Kattoula SR. Evolution of hormone selectivity in glucocorticoid and mineralocorticoid
receptors. J Steroid Biochem Mol Biol. 137, 57-70, 2013
144. Baker ME, Vidal-Dorsch DE, Ribecco C, Sprague LJ, Angert M, Lekmine N, Ludka C, Martella A, Ricciardelli E,
Bay SM, Gully JR, Kelley KM, Schlenk D, Carnevali O, Sášik R, Hardiman G. Molecular analysis of endocrine
disruption in hornyhead turbot at wastewater outfalls in southern california using a second generation multi-species
microarray.PLoS One 2013 8, e75553.
145. Nashev LG, Atanasov AG, Baker ME, Odermatt A. Cysteine-10 on 17 β-Hydroxysteroid Dehydrogenase 1 Has
Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals. Int J
Cell Biol. 2013;2013:769536, 2013
146. Chandsawangbhuwana C, Baker ME 3D models of human ERα and ERβ complexed with coumestrol Steroids 80,
37–43, 2014.
147. Kattoula SR, Baker ME Structural and evolutionary analysis of the co-activator binding domain in vertebrate
progesterone receptors. J Steroid Biochem Mol Biol. 141, 7-15, 2014.
148. Baker ME, Hardiman G. Transcriptional analysis of endocrine disruption using zebrafish and massively parallel
sequencing. J Molecular Endocrinology 52, R241-R256, 2014.