“APPROVED”
Vice-Chancellor for Academic Affairs
Prof.GuminskyY.J.
_________________
2015 year
Schedule of Lectures in Toxicological Chemistry
For the 5-th Year Foreign Students of the Pharmaceutical Faculty
Pharmaceutical Chemistry Department, Speciality “Pharmacy”
2015-2016, Semester IX
№
Date
1
10.09
2
24.09
3
4
08.10
22.10
5
6
7
05.11
19.11
03.12
8
17.12
9
26.12
10
31.12
Topic
MODULE 2
Hours
Substances isolated from the biological material by solvent extraction
(drugs). Physical and chemical properties.
General and special methods of the drug isolation from the biological
material. Factors which affect efficiency of the drug isolation.
Methods of the extract purification from concomitant admixtures.
The general scheme of the chemical toxicological analysis of drugs.
Directions of the chemical toxicological analysis. The scheme of drugs
isolation from biological samples in indirect chemical toxicological
analysis.
TLC-screening of drugs.
Chemical methods of drugs’ analysis.
The group of substances isolated from the biological material by the
organic solvent extraction (pesticides). General description of pesticides.
Negative pesticides influence on the environment and human health.
Classification of pesticides.
Chemical toxicological examination of biological material for
pesticides.
The group of substances isolated from the biological material by special
methods (fluoride, silicifluoride).
The group of substances examined without isolation (carbon
monooxide). Physical and chemical properties of carbon monooxide, its
toxicological value. Identification and quantitative analysis of
carboxyhemoglobine in blood. Evaluation of results.
Total
The Head of the Pharmaceutical
Chemistry Department
2
2
2
2
2
2
2
2
2
2
20
PhD Assistant professor
YuschenkoT.I.
“APPROVED”
Vice-Chancellor for Academic Affairs
Prof.GuminskyY.J.
_________________2015 year
Schedule of Practical Classes
in Toxicological Chemistry
For the 5-th Year Foreign Students of the Pharmaceutical Faculty
Pharmaceutical Chemistry Department, Speciality “Pharmacy”
2015-2016, Semester IX
№ Date
1
31.09
2
10.09
3
4
5
14.09
24.09
28.09
6
08.10
7
12.10
8
22.10
9
26.10
10 05.11
11 09.11
12 19.11
13 23.11
14 03.12
15 07.12
Topic
MODULE 2
Substances isolated from the biological material by solvent extraction (drugs).
General description of the group. Reasons of poisoning. Representatives of the group.
Physical and chemical properties.
General and special methods of the drug isolation from the biological material.
Factors which affect efficiency of the drug isolation.
Methods of the extract purification from concomitant admixtures.
The general scheme of drugs’ chemical toxicological analysis.
Directions of the chemical toxicological analysis. The scheme of drugs isolation in
case of indirect chemical toxicological analysis. The choice if the analytical method
for the chemical toxicological analysis of drugs.
Chemical toxicological analysis of acids, neutral and weak basic drugs (salicylates,
barbiturates, pyrazolone derivatives).
Chemical toxicological analysis of alkaloids and synthetic basic drugs.
(phenolthiazine, 1,4-benzodiazepine derivatives, p-aminobenzoic acid derivatives).
TLC-screening of drugs. Content Module in topics topics “The group of
substances isolated from the biological material by the polar solvent extraction”.
The group of substances isolated from the biological material by the organic
solvent extraction (pesticides). General description of pesticides, negative influence
on the environment and human health. Classification.
Physical and chemical properties, regularities of behavior in the body, toxicity of
chlorinated pesticides, and organophosphorus compounds.
Chemical toxicological examination of biological samples for the presence of
chlorinated pesticides, organophosphorus compounds, carbamic acid derivatives,
pyrethrins.
The group of substances isolated from the biological material by special methods
(fluoride, silicifluoride).
Substances examined without isolation (carbon monooxide).
Spectroscopic methods of carboxy hemoglobine analysis. Content Module in
topics “The group of substances isolated from the biological material by the
organic solvent extraction (pesticides). The group of substances isolated from
the biological material by special methods and substances examined without
isolation.”
Final control of knowledge in topics “The group of substances isolated from
the biological material by the polar solvent extraction. The group of substances
isolated from the biological material by the organic solvent extraction
(pesticides). The group of substances isolated from the biological material by
special methods and substances examined without isolation.”
Total
The Head of the Pharmaceutical
Chemistry Department
PhD Assistant Professor
YuschenkoT.I.
Hours
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
30