SOM Table 1: Previously associated phenotypes and

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SOM Table 1: Previously associated phenotypes and references for the variants genotyped in this
study.
SNP
Phenotype
Study Ref
rs6541281
MDD
1
rs3738401
MDD
1
rs12044355
LOAD
2
rs1340982
MDD
1
rs1538979
BPD, SCZ
3
rs2492367
MDD
4
rs1322784
ASP
5
rs6675281
MDD
4
rs1000731
MDD
4
rs999710
SCZ
6
rs967433
MDD
1
rs821577
MDD; BPD, SCZ
1,3
rs821597
MDD
1,4
rs821616
MDD
1
rs821633
BPD, SCZ
3
rs2806465
MDD
1
rs3737597
SCZ
6
Abbreviations: BPD, bipolar disorder; MDD , major depressive disorder; SCZ, schizophrenia; ASP,
Asperger’s syndrome; LOAD late onset Alzheimer’s disease.
SOM Table 1 references:
1. Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto
K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A,
Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Sawa A, Kunugi H. Impact of the DISC1
Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling.
Hum Mol Genet. 2006 Oct 15;15(20):3024-33.
2. Beecham GW, Martin ER, Li YJ, Slifer MA, Gilbert JR, Haines JL, Pericak-Vance MA. Genomewide association study implicates a chromosome 12 risk locus for late-onset Alzheimer
disease. Am J Hum Genet. 2009 Jan;84(1):35-43.
3. Hennah W, Porteous D. The DISC1 pathway modulates expression of neurodevelopmental,
synaptogenic and sensory perception genes. PLoS One. 2009;4(3):e4906.
4. Schosser A, Gaysina D, Cohen-Woods S, Chow PC, Martucci L, Craddock N, Farmer A, Korszun
A, Gunasinghe C, Gray J, Jones L, Tozzi F, Perry J, Muglia P, Owen MJ, Craig IW, McGuffin P.
Association of DISC1 and TSNAX genes and affective disorders in the depression case-control
(DeCC) and bipolar affective case-control (BACCS) studies. Mol Psychiatry. 2010
Aug;15(8):844-9.
5. Kilpinen H, Ylisaukko-Oja T, Hennah W, Palo OM, Varilo T, Vanhala R, Nieminen-von Wendt
T, von Wendt L, Paunio T, Peltonen L. Association of DISC1 with autism and Asperger
syndrome. Mol Psychiatry. 2008 Feb;13(2):187-96.
6. Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L.
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia:
the SzGene database. Nat Genet. 2008 Jul;40(7):827-34.
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