Konan Peck
CURRICULUM VITAE OF
KONAN PECK
Office Address
Institute of Biomedical Sciences
Academia Sinica
Taipei, Taiwan 115
ROC
Tel.: 886-2-2652-3072
Fax: 886-2-2785-8594
E-mail: konan@ibms.sinica.edu.tw
Born: August 21, 1958
Married with two children
Taipei, Taiwan
Education:
Ph. D., 1987, Department of Chemistry, University of Michigan-Ann Arbor
M. S., 1985, Department of Chemistry, University of Michigan-Ann Arbor
B. S., 1980, Department of Chemistry, Chung-Hsing University, Taichung
Honors:
Knoller Fellow, 1985, University of Michigan-Ann Arbor
Moses Gomberg Fellow, 1986-1987, University of Michigan-Ann Arbor
Outstanding Graduate Student Award; 1987, University of Michigan-Ann Arbor
Chung-Ming Tu Lectureship Award, 2000, Taiwan Medical Society
TECO Technology Award, 2000, TECO foundation
Outstanding Young Investigator, 2002, Biophysical Society of Taiwan
Current Position:
Research Fellow, IBMS, Academia Sinica.
Work Experiences:
Assistant/Associate Research Fellow, IBMS, Academia Sinica, 1992 - 2004.
Visiting Specialist, IBMS, Academia Sinica, Oct. 1990 - Jan. 1992.
Postdoctoral Associate (Joint Appointment), Chemistry Dept., University of
California-Berkeley & Cell Biology Dept., School of Medicine, Stanford University,
1987 - 1990.
Teaching Assistant, University of Michigan-Ann Arbor, 1983 - 1984.
Teaching Assistant, National Chung-Hsing University, 1982 - 1983.
Interim Director, Ma-Tzu Hydrogen Plant, Ministry of Defense, ROC (mandatory
military service), 1981 - 1982.
Konan Peck
Professional Services
Member, Editorial board, Journal of Genetics and Molecular Biology, 2000 – present.
Member, Director board, Taiwan Biochip Association, 2000 – 2004.
Member, Director board, Taiwan Genome and Genetics Society, 2000 – 2008.
Member, Founding committee for the Consortium for Globalization of Chinese
Medicine, 2003 – present.
Journal Reviewer: Analytical Chemistry, Bioinformatics, Biomarkers in Medicine,
Biotechniques, BMC-Bioinformatics, BMC-Biotechnology, International Journal of
Cancer, Journal of Information Science and Engineering, Journal of Biochemical and
Biophysical Methods, Journal of Virological Methods, Nanotechnology, Nucleic
Acids Research, Oncology-BASEL.
Grant Reviewer: National Science Council, Department of Health, Ministry of
Economic Affairs, Research Grants Council of Hong Kong
Invited Lectures at International Conferences and Foreign Institutions:
1. “Identification of Cell Cycle-Associated Genes by cDNA Microarray Approach
with Enzyme-Linked Colorimetry Detection”, Genome Mapping & Sequencing,
Cold Spring Harbor Laboratory, 1998, May 13 - 17, USA.
2.
“Gene Expression Analysis by cDNA Microarray with Colorimetric Detection”,
Los Alamos National Laboratory, 1998, November 2, Albuquerque, USA.
3.
“Identification of Differentially Expressed Genes by Microarray with
Colorimetric Detection”, 8th International Symposium of Society of Chinese
Bioscientists in America, 1999, August 14 - 19, Hong Kong.
4.
“Genome-Wide Gene Expression Profiling by cDNA Microarray with
Colorimetric Detection”, 11th International Genome Sequencing and Analysis
Conference, 1999, September 18 - 21, Miami, USA.
5.
“Identifying Differentially Expressed Genes by cDNA Microarray with
Colorimetric Detection”, University of California-Davis, 1999, September 28,
Davis, USA.
6.
“Application of DNA Microarray Technology to Herbal Medicine
Characterization”, The 3rd Symposium on Herbal Medicine, 2000, March 13-16,
Taipei, Taiwan.
7.
“DNA Chips and Their Applications in Genomic Biotechnology”, The 3rd East
Asian Biophysics Symposium, EABS2000, 2000, May 22 – 26, Kyongju, Korea.
8.
“Identify Differentially Expressed Genes by cDNA Microarray with
Colorimetric Detection”, Chinese Congress of Clinical Chemistry & Laboratory
Medicine, 2000, June 11 - 15, Hong Kong.
9.
“DNA Microarray with Colorimetric Detection for Gene Expression Analysis”,
Ateliers de formation N118: Use of DNA-Chips for Transcriptome Studies, June
22 –23, 2000, La Londe-les-Maures, France.
Konan Peck
10. “DNA Microarray and its Applications in Cancer Research”, Taiwanese German
Workshop on: Cancer Causes and Prevention: Mechanisms, Preclinical and
Clinical Studies, 2000, July 24 - 26, DKFZ, Heidelberg, Germany.
11. “Massively Parallel Genetic Analysis by DNA Microarrays with Colorimetric
Detection”, 2000 International Forum on Biochip Technologies, 2000, October
11 - 14, Beijing, China.
12. “DNA Microarray and its Application in Cancer Metastasis Study”, The 3rd
HUGO Pacific Meeting and the 4th Asia-Pacific Conference on Human Genetics,
2000, October 18 - 21, Shanghai, China.
13. “Biophysical and Chemical Aspects of DNA Chip Technologies”, International
Symposium on Physical Chemistry, “Biophysical Chemistry in the New
Millenium”, 2000, November 3, Chungbuk National Univ., Chungbuk, Korea.
14. “Massively Parallel Genetic Analysis by DNA Microarray”, 2000, December 8,
Univ. of Texas, Houston, USA.
15. “cDNA Microarray and its Application in Cancer Metastasis Study”, The 3rd
Across the Taiwan Strait symposium on Cell Biology, 2001, May 16 - 18, Wuhan,
China.
16. “DNA Microarray and its Biomedical Applications”, Finnish-Taiwanese Joint
Symposium in Biotechnology and Molecular Biology, 2001, May 25 - 30,
Helsinki, Finland.
17. “DNA Microarray and its Applications in Biomedical Studies”, Genechip
symposium, 2001, June 11 - 12, HKUST, Hong Kong.
18. “cDNA Microarray and its Applications in Biomedical Sciences”, 9th
International Symposium of Society of Chinese Bioscientists in America, 2001,
August 6 –10, Taipei, Taiwan.
19. “DNA Microarray with Gene Specific Probes for Expression Analysis”, The 4th
International Conference of Asia-Pacific International Molecular Biology
Network, 2001, November 3-4, 2001, Taipei, Taiwan.
20. “Use of DNA Arrays for Genetic Analysis and Clinical Diagnosis”, Chips to
Hits, 2002, October 27 – 31, Philadelphia, PA, USA.
21. “Use of DNA Arrays for Genetic Analysis and Clinical Diagnosis”, APOCB,
2002, November 3 – 6, Taipei, Taiwan.
22. “Use of DNA Arrays for Genetic Analysis and Clinical Diagnosis”, 2002
International Forum on Biochip Technologies (IFBT), 2002, November 9 – 13,
Beijing, China.
23. “Developments of High Throughput Instruments and Tools for Genome
Research”, The 6th International Conference of Asia-Pacific International
Molecular Biology Network, 2003, November 12 – 13, 2003, Tokyo, Japan.
24. “Genome Technologies for Genetic Analysis and Microbial Detection’, The 2nd
Taiwan-America Biotech Conference & Exhibition, 2003, November 13 – 15,
Taipei, Taiwan.
Konan Peck
25. “Quality Control of Herbal Medicines With Genome Technologies”, Consortium
for Globalization of Chinese Medicine, 2003, December 14 – 16, Hong Kong.
26. “Quality Assessment and Standardization of Herbal Medicines by Genomics
Approach”, Lu-Zhou Medical College, 2004, September 15, Lu-Zhou, China
27. “A Technology Pipeline for Gene Expression Analysis”, University of
California-Davis, 2005, July 15, Davis, USA.
28. “High Throughput Genome Technology Development Core”, Palo Alto
Research Center, 2005, July 18, Palo Alto, USA.
29. “Aptamer Microarrays for Identifying Differentially Expressed Proteins”, Joint
6th Human Genome Organization (HUGO) Pacific Meeting & 7th Asia-Pacific
Human Genetics Conference (HUGO-AP 2006), 2006, March 6-10, Taipei,
Taiwan.
30. “A Pipeline of Aptamer Technologies for Biomarker Discovery”, International
Cancer Biomarker Consortium (ICBC) meeting, 2008, February 20-22,
Honolulu, Hawaii, USA.
31. “Development of Genomics/Proteomics Hybrid Technology for Cancer
Biomarker Discovery”, Joint 7th Human Genome Organization (HUGO) Pacific
Meeting & 8th Asia-Pacific Human Genetics Conference (HUGO-AP 2008),
2008, April 2-5, Cebu, Philippines.
32. “Fabrication of oligonucleotide probes for detection of nucleic acids and
proteins “ , The 8th Taiwan-Japan Microelectronics Symposium 2008 Bioelectronics and Green Electronics, 2008, December 22-23, Hsinchu, Taiwan.
33. “Aptamer Technology for Cell-specific Cancer Therapy”, International Joint
Symposium on “Cell Fate Regulation Research: Molecular Basis and
Therapeutic Potentials, 2009, April 8-10, Kumamoto, Japan.
Konan Peck
Publications
Journal Articles:
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Konan Peck, Fotios K. Fotiou and Michael D. Morris, “Characterization of the
Photothermal Deflection Densitometer”, Anal. Chem., 1985, 57, 1359–1362.
Konan Peck and Michael D. Morris, “Sensitive Photothermal Densitometer for
Quantitation of Coomassie Brilliant Blue Stained Proteins in Polyacrylamide
Gels”, Anal. Chem., 1986, 58, 507–509.
Michael D. Morris and Konan Peck, “Photothermal Effects in Chemical Analysis”,
Anal. Chem., 1986, 58, 811A–822A.
Konan Peck and Michael D. Morris, “Photothermal Quantification of Nanogram
Quantities of Coomassie Brilliant Blue Stained Proteins in Denaturing
Polyacrylamide Gels”, Anal. Chem., 1986, 58, 2876–2879.
Konan Peck and Michael D. Morris, “Optical Properties of the Retroreflective
Array in Spectroscopy Instrumentation”, Rev. Sci. Instrum., 1987, 58, 189–196.
Konan Peck and Michael D. Morris, “Thermo-optic Behavior of Polyacrylamide
Electrophoresis Gels”, Appl. Spectrosco., 1988, 42(5), 513–515.
Konan Peck, Tshenge Demana and Michael D. Morris, “Rapid Scanning Thermal
Lens/Laser Transmission Densitometer”, Appl. Theo. Electroph., 1988, 1, 41–45.
Konan Peck and Michael D. Morris, “Optical Errors in a Liquid Chromatography
Absorbance Cell”, J. Chromatogr., 1988, 448, 193–201.
Konan Peck, Lubert Stryer, Alexander N. Glazer, and Richard A. Mathies,
“Single-Molecule Fluorescence Detection: Autocorrelation Criterion and
Experimental Realization with Phycoerythrin”, Proc. Natl. Acad. Sci. U. S. A.,
1989, 86, 4087–4091.
Richard A. Mathies, Konan Peck, and Lubert Stryer, “High Sensitivity Single
Molecule Fluorescence Detection”, Proc. Intl. Soc. Opt. Eng. – SPIE, 1990, 1205,
52–59.
Richard A. Mathies, Konan Peck, and Lubert Stryer, “Optimization of
High-Sensitivity Fluorescence Detection”, Anal. Chem., 1990, 62, 1786–1791.
Alexander N. Glazer, Konan Peck, and Richard A. Mathies, “A Stable
Double-Stranded DNA-Ethidium Homodimer Complex: Application to Picogram
Fluorescence Detection of DNA in Agarose Gels”, Proc. Natl. Acad. Sci. U. S. A.,
1990, 87, 3851–3855.
Hays S. Rye, Mark A. Quesada, Konan Peck, Richard A. Mathies, and Alexander
N. Glazer, “High-Sensitivity Two-Color Detection of Double-Stranded DNA with
a Confocal Fluorescence Gel Scanner Using Ethidium Homodimer and Thiazole
Orange”, Nucleic Acids Res., 1991, 19, 327–333.
Chin-Tarng Lin, Chung-Chung Chen, Shu-Wen How, Whei-Ming Huang, and
Konan Peck, “Localization of HPV-16 DNA Sequence in CaSki Cells by Electron
Microscopic Hybridocytochemistry”, J. Histochem. Cytochem., 1992, 40,
467–473.
Lee-Young Chau, Konan Peck, Hsueh-Heng Yen, and Jiunn-Yau Wang,
“Agonist-Induced Down Regulation of Platelet-Activating Factor Receptor Gene
Expression in U937 Cells”, Biochem. J., 1994, 301(3), 911–916.
Ta-Chau Chang, Chien-Chih Chiang, Shiow-Hwa Chou, and Konan Peck,
“Thermally Activated Hole Filling of Dye and Dye-Oligonucleotide Doped in
Konan Peck
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Polymer Films”, J. Phys. Chem., 1995, 99, 6620–6627.
Ta-Chau Chang, Chien-Chih Chiang, Shiow-Hwa Chou, and Konan Peck,
“Temperature-Annealing-Cycling Hole Spectra of Dye and Dye-Oligonucleotide
Doped in Polymer Films”, J. Lumin., 1995, 64, 75–79.
Ta-Chau Chang, Chien-Chih Chiang, and Konan Peck, “Hydrogen Bond Effect on
the Chromophore-Oligonucleotide Conformational Structure Studied by
Non-Photochemical Hole Burning Spectroscopy”, J. Am. Chem. Soc., 1995, 117,
7576–7577.
Jeremy J. W. Chen and Konan Peck, “Non-radioisotopic Differential Display
Method to Directly Visualize and Amplify Differential Bands on Nylon
Membrane”, Nucleic Acids Res., 1996, 24(4), 793–794.
Ta-Chau Chang, Chien-Chih Chiang, and Konan Peck, “Conformational
Structures of Dye-Oligonucleotides Studied by Satellite Holes”, in OSA TOPS on
Biomedical Optical Spectroscopy and Diagnostics, Eva Sevick-Muraca & David
Benaron (eds.), Optical Society of America, 1996, 3, 245-249.
Konan Peck, Shu-Li Wung, Gau-Shuoh Chang, Jeffrey J. Y. Yen, and You-Zung
Hsieh, “Restriction Mapping of Genes by Capillary Electrophoresis with Laser
Induced Fluorescence Detection”, Anal. Chem., 1997, 69(7), 1380-1384.
Konan Peck, Yuh-Pyng Sher, Jin-Yuan Shih, Steve R. Roffler, Cheng-Wen Wu,
and Pan-Chyr Yang, “Detection and Quantitation of Circulating Cancer Cells in
the Peripheral Blood of Lung Cancer Patients”, Cancer Res., 1998, 58(13),
2761-2765.
Jeremy J. W. Chen, Reen Wu, Pan-Chyr Yang, Jane-Yu Huang, Yuh-Pyng Sher,
Meng-Hsuan Han, Wei-Chen Kao, Pei-Jung Lee, Trai Fu Chiu, Fu Chang,
Yi-Wen Chu, Cheng-Wen Wu, and Konan Peck, “Profiling Expression Patterns &
Isolating Differentially Expressed Genes by cDNA Microarray System with
Colorimetry Detection”, Genomics, 1998, 51(3), 313-324.
Ching-Tung Kuo, Chien-Chih Chiang, Jenwei Yu, Konan Peck, and Ta-Chau
Chang, “Satellite Hole Investigation of Binding Mechanism of
Dipyrrometheneboron Difluoride (BODIPY) Derivative and Oligonucleotide in
Glycerol-Water Glass”, J. Chem. Soc., Faraday Trans., 1998, 94(14), 1989-1994.
Francois Bertucci, Karine Bernard, Beatrice Loriod, Yi-Chung Chang, Samuel
Granjeaud, Daniel Birnbaum, Catherine Nguyen, Konan Peck, “Sensitivity issues
in DNA array-based expression measurements and performance of Nylon
microarrays for small samples”, and Bertrand R. Jordan, Human Molecular
Genetics, 1999, 8(9), 1715-1722.
Ta-Chau Chang, Ching-Tung Kuo, Chien-Chih Chiang, Ji-Yen Cheng,
Cheng-Sheng Yan, and Konan Peck, “Investigation of guanine-rich DNA
telomeric structure by a covalently linked BODIPY dye”, Phys. Chem. Chem.
Phys., 1999, 1(16), 3783-3787.
Tse-Ming Hong, Konan Peck, Jeremy J.W. Chen, Shuenn-Chen Yang, Yen-Chu
Chen, Cheng-Wen Wu, and Pan-Chyr Yang, “Profiling the Down Stream Genes
of Tumor Suppressor PTEN in Lung Cancer Cells by cDNA Microarray”, Am. J.
Respir. Cell Mol. Biol., 2000, 23, 355-363.
Tse-Ming Hong, Jeremy J.W. Chen, Konan Peck, Pan-Chyr Yang, and
Cheng-Wen Wu, “p53 amino acids 339-346 represent the minimal p53 repression
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domain”, J. Biol. Chem., 2001, 276(2), 1510-1515.
Sunny Ang, Cha-Ze Lee, Konan Peck, Michelle Sindici, Udayakumar
Matrubutham, Martin A. Gleeson, and Jin-Town Wang, “Acid-Induced Gene
Expression in Helicobacter pylori: Study in Genomic Scale by Microarray”, Infect.
Immun., 2001, 69(3), 1679-1686.
Ken Yoneda, Konan Peck, Mary Mann-Jong Chang, Ken Chmiel, Yuh-Pyng Sher,
Jeremy Chen, Pan-Chyr Yang, Yin Chen, and Reen Wu, “Development of
High-density DNA Microarray Membrane for Profiling Smoke- and Hydrogen
Peroxide-induced Genes in a Human Bronchial Epithelial Cell Line”, Am. J.
Respir. Crit. Care Med., 2001, 164: S85-S89.
Jeremy J.W. Chen, Konan Peck, Tse-Ming Hong, Shuenn-Chen Yang, Yuh-Pyng
Sher, Jin-Yuan Shih, Reen Wu, Steve R. Roffler, Cheng-Wen Wu, Pan-Chyr
Yang, “Global Analysis of Gene Expression in Invasion by a Lung Cancer
Model”, Cancer Res., 2001, 61: 5223-5230.
Wei Huang, Yuh-Pyng Sher, Konan Peck, Y.C. Fung, “Correlation of gene
expression with physiological functions: Examples of pulmonary blood vessel
rheology, hypoxic hypertension, and tissue remodeling”, Biorheology, 2001,
38(2,3), 75-87.
Wei Huang, Yuh-Pyng Sher, David Delgado-West, Jonathan T. Wu, Konan Peck,
and Yuan Cheng Fung, “Tissue Remodeling of Rat Pulmonary Artery in Hypoxic
Breathing. I. Changes of Morphology, Zero-Stress State, and Gene Expression”,
Annals of Biomedical Engineering, 2001, 29: 535-551.
Jin-Yuan Shih, Shuenn-Chen Yang, Tse-Ming Hong, Ang Yuan, Jeremy J. W.
Chen, Chong-Jen Yu, Yih-Leong Chang, Yung-Chie Lee, Konan Peck,
Cheng-Wen Wu, and Pan-Chyr Yang, “Collapsin Response Mediator Protein-1
and the Invasion and Metastasis of Cancer Cells”, J. Natl. Cancer Inst., 2001, 93:
1392-1400.
Wei Huang, Yuh-Pyng. Sher, Konan Peck, and Y. C. Fung, “Matching gene
activity with physiological functions”, Proc. Natl. Acad. Sci. USA, 2002, 99:
2603-2608.
Ling-Huei Yih, Konan Peck, and Te-Chang Lee, “Changes in gene expression
profiles of human fibroblasts in response to sodium arsenite treatment”,
Carcinogenesis, 2002, 23: 867-876.
Ji-Yen Cheng, Hung-Hui Chen, Yu-Shu Kao, Wei-Chen Kao, and Konan Peck,
“High throughput parallel synthesis of oligonucleotides with 1,536-channel
synthesizer”, Nucleic Acids Res. 2002, 30: e93.
Song Li, Jianmin Lao, Benjamin P.C. Chen, Yi-shuan Li, Yihua Zhao, Julia Chu,
Kuang-Den Chen, Tsui-Chun Tsou, Konan Peck, and Shu Chien, “Genomic
analysis of smooth muscle cells in three-dimensional collagen matrix”, FASEB J.,
2003, 17:97-99.
Pei-chin Chang and Konan Peck, “Design and assessment of a fast algorithm for
identifying specific probes for human and mouse genes”, Bioinformatics, 2003, 19:
1311-1317.
Sung-Liang Yu, Huei-Wen Chen, Pan-Chyr Yang, Konan Peck, Min-Hui Tsai,
Jeremy J.W. Chen, Fang-Yue Lin, “Differential gene expression in gram-negative
and gram-positive sepsis”, Am. J. Respir. Crit. Care Med., 2004,
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169(10):1135-1143.
Huei-Wen Chen, Sung-Liang Yu, WJ Chen, Pan-Chyr Yang, CT Chien, HY Chou,
HN Li, Konan Peck, CH Huang, Fang-Yue Lin, Jeremy J. W. Chen and YT Lee,
“Dynamic changes of gene expression profiles during postnatal heart development
in mice”, Heart, 2004, 90(5): 927-934.
Cheng-Chung Chou, Chun-Houh Chen, Te-Tsui Lee, and Konan Peck,
“Optimization of probe length and the number of probes per gene for optimal
microarray analysis of gene expression”, Nucleic Acids Res., 2004, 32: e99.
Yuh-Pyng Sher, Jin-Yuan Shih, Pan-Chyr Yang, Steve R. Roffler, Yi-Wen Chu,
Cheng-Wen Wu, Chia-Li Yu, and Konan Peck, “Prognosis of Non-Small Cell
Lung Cancer Patients by Detecting Circulating Cancer Cells in the Peripheral
Blood with Multiple Marker Genes”, Clin. Cancer Res., 2005, 11: 173-179.
(selected as one of significant publications of Academia Sinica, 2005~2006)
Huey-Jiuan Juang, Te-Chang Lee, Rong-Nan Huang, Jeou-Yuan Chen, and
Konan Peck, “Identification of p53-regulated Genes in Human Cancer Cells
by Genome-wide Transcription Profiling with cDNA Microarray” J. Genetics
and Mol. Biol., 2005, 16: 63-71.
Mu-Chin Shih, Konan Peck, Wen-Ling Chan, Yen-Ping Chu, Jui-Chang Chen,
Chang-Hai Tsai, Jan-Gowth Chang, “SARS-CoV Infection Was from at Least
Two Origins in the Taiwan Area”, Intervirology, 2005, 48:124-132.
Jau-Ling Huang, Hui-Tsu Lin, Yu-Ming Wang, Yi-Chien Yeh, Konan Peck,
Bai-Ling Lin, Huan-Wun Liu, Ann Chen, Chang-Shen Lin, “Rapid and sensitive
detection of multiple genes from the SARS-Coronavirus using quantitative
RT-PCR with dual systems”, J Med Virol., 2005, 77:151-158.
Chin-Hung Liu, Konan Peck, Jin-Ding Huang, Min-Shung Lin, Chiu-Hsiung
Wang, Wen-Pin Hsu, Hong-Wen Wang, Hui-Ling Lee, Ming-Liang Lai,
“Screening CYP3A SNPs in a Han Chinese Population With a Genotyping Chip”,
Pharmacogenomics, 2005, 6:731-747.
Yian A Chen, Cheng-Chung Chou, Xinghua Lu, Elizabeth H Slate, Konan Peck,
Wenying Xu, Eberhard O Voit, Jonas S Almeida, “A multivariate prediction
model for microarray cross-hybridization”, BMC Bioinformatics, 2006, 7:101.
Cheng-Chung Chou, Te-Tsui Lee, Chun-Houh Chen, Hsiang-Yun Hsiao, Yi-Ling
Lin, Mei-Shang Ho, Pan-Chyr Yang, Konan Peck, “Design of microarray probes
for virus identification and detection of emerging viruses at the genus level”,
BMC Bioinformatics, 2006, 7:232.
Andrey Semenyuk, Mathilda Ahnfelt, Camilla Estmer, Yong-Hao, Andras Földesi,
Yu-Shu Kao, Hong Huei Chen, Wei-Chen Kao, Konan Peck, Marek Kwiatkowski,
“Cartridge-based high-throughput purification of oligonucleotides for reliable
oligonucleotide arrays”, Anal. Biochem., 2006, 356:132-141.
Yuh-Pyng Sher, Cheng-Chung Chou, Ruey-Hwang Chou, Han-Ming Wu,
Wun-Shaing Wayne Chang, Chun-Houh Chen, Pan-Chyr Yang, Cheng-Wen Wu,
Chia-Li Yu, Konan Peck, “Human Kallikrein 8 Protease Confers A Favorable
Clinical Outcome in Non-Small Cell Lung Cancer by Suppressing Tumor Cell
Invasiveness”, Cancer Res., 2006, 66:11763-11770.
Maria J. Chen, Pinwen Peter Chiou, Patrick Lin, Chun-Mean Lin, S. Siri, Konan
Peck, Thomas T. Chen, “Suppression of growth and cancer-induced angiogenesis
Konan Peck
of aggressive human breast cancer cells (MDA-MB-231) on the chorioallantoic
membrane of developing chicken embryos by E-peptide of pro-IGF-I”, J. Cell
Biochem., 2007, 101:1316-1327.
53. Konan Peck, Lin-Chi Chen, Shin-Cheng Tzeng, Yu-Shu Kao, Wei-Chen Kao,
“DNA aptamer for molecular recognition and protein expression profiling”, J.
Genetics and Mol. Biol., 2008, 19: 263-269.
54. Yeh-Hsing Lao, Konan Peck, Lin-Chi Chen, “Enhancement of aptamer
microarray sensitivity through spacer optimization and avidity effect”, Anal.
Chem., 2009, 81: 1747–1754.
55. Yi-Chung Chang, Wei-Chen Kao, Wei-Ya Wang, Wan-Yi Wang, Ruey-Bing
Yang, Konan Peck, “Identification and characterization of oligonucleotides
that inhibit Toll-like receptor 2-associated immune responses”, FASEB J.,
2009, doi: 10.1096/fj.09-129312.
Book Chapters:
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Konan Peck and Yuh-Pyng Sher, “cDNA Microarrays on Nylon Filter Membrane
With Colorimetric Detection”, in DNA Microarrays: Gene Expression
Applications ed. Bertrand R. Jordan, Springer-Verlag, 35-54, 2001.
Konan Peck and Yuh-Pyng Sher, “Application of Enzyme Colorimetry for cDNA
Microarray Detection”, in BioChip Technology, eds. Jing Cheng & Larry J.
Kricka, Harwood Academic Publishers, 325-340, 2001.
Mary M. J. Chang, Yin Chen, Yu Hua Zhao, Reen Wu, Ching Li, and Konan Peck
“High-Density DNA Microarray Membranes to Study Gene Expression Patterns
Associated with Human Airway Epithelial Cell Differentiation in Culture”, in
Cilia and Mucus: From Development to Respiratory Defense, eds. Matthias
Salathe, Marcel Dekker, Inc., New York, 225-238, 2001.
Cheng-Chung Chou and Konan Peck “DNA chips”, in Micro Electro Mechanical
Systems: Technology & Application, eds. National Science Council, 1117-1120,
2003. (in Chinese)
Cheng-Chung Chou and Konan Peck “Design and Fabrication of Spotted Long
Oligonucleotide Microarrays for Gene Expression Analysis”, in Methods in
Molecular Biology – Microarrays: Synthesis Methods, eds. Jang B. Rampal,
Humana Press, 213-225, 2007.
Review Articles:
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Konan Peck, “Single Fluorescent Molecule Detection Method”, Instrum. Today,
1991, 12(6), 10–18. (in Chinese)
Ji-Yen Cheng, “Fabrication of oligonucleotide microarray and its applications in
genetic assay”, Instrum. Today, 2001, 22(5), 8–19, (in Chinese)
Cheng-Chung Chou and Konan Peck, “DNA microarrays and their applications”,
Instrum. Today, 2002, 23(5), 5-13. (in Chinese)
Konan Peck, “Kallikreins and Cancer”, in Encyclopedia of Cancer 2nd ed. ed.
Manfred Schwab, Springer, Heidelberg, 2008, 1587-1590.
Konan Peck
Published Patents
1. Michael D. Morris, Joseph T. K. Pang, and Konan Peck, “Liquid Chromatography
Absorbance Detector”, 1989, US# 4,795,262.
2. Michael D. Morris, Konan Peck, Reed A. Schick, and Steven Parad, “Optoelectric
Electrophoresis Analysis System”, 1989, WO# 8901620.
3. Michael D. Morris and Konan Peck, “Photothermal Densitometer for Reading
Electrophoresis Gels”, 1990, US# 4,938,593.
4. Richard A. Mathies, Konan Peck, and Lubert Stryer, “High Sensitivity Fluorescent
Single Particle and Single Molecule Detection Apparatus and Method”, 1990,
WO# 9014589; 1990, US# 4,979,824; 1996, EP# 426829B1.
5. Richard A. Mathies, Konan Peck, “Laser Excited Confocal Fluorescence Gel
Scanner”, 1992, US# 5,091,652;1994, JP#6-341955; 1996, EP# 440342B1.
6. Konan Peck, Pan-Chyr Yang, Shu-Li Wung, “Methods for Rapid Antimicrobial
Susceptibility Testing”, 1998, US# 5,789,173, JP#10-066598; 2001, ROC#
00438889; 2002,EP# 0822261B1.
7. Alexander N. Glazer, Richard A. Mathies, Konan Peck, “Multichromophore
Fluorescent DNA Intercalation Complexes”, 1998, US# 5,763,162.
8. Konan Peck, Jeremy J. W. Chen, Pan-Chyr Yang, Reen Wu, Fu Chang, Yi-Wen
Chu, Cheng-Wen Wu, “Method for Profiling Gene Expression Pattern and
Isolation of Differentially Expressed Genes”, 2001, US# 6,218,114 B1; 2003,
ROC#00541340.
9. Alexander N. Glazer, Richard A. Mathies, Konan Peck, “Multichromophore
Fluorescent Probes Using DNA Intercalation Complexes”, 2002, US#6,428,667
B1.
10. Yung-Ching Cheng, Patrick C. Kung, Konan Peck, Yun-Shien Lee, Yuh-Pyng
Sher, “Phytomics: A genome-based approach to herbal compositions”, 2001,
WO#0166803 A2; 2003, US#20030207270 A1.
11. Konan Peck, Jih-Yeng Cheng, “Apparatus and Methods for Chemical Synthesis”,
2005, US#6,867,050 B2; ROC# I232867.
12. Pan-Chyr Yang, Jin-Yuan Shih, Jeremy J. W. Chen, Konan Peck, Cheng-Wen Wu,
Tse-Ming Hong, Shuenn-Chen Yang, “Collapsin response mediator protein-1”,
2003, EP#1271153 A2, 2006, ROC#I252314, 2008, US#7,354,709 B2.
13. Jeremy J. W. Chen, Pan-Chyr Yang, Konan Peck, Tse-Ming Hong, Shuenn-Chen
Yang, Cheng-Wen Wu, “Metastasis-Associated Genes”, 2003, EP#1285970 A2,
US#20030054387 A1.
14. Konan Peck, Yuh-Pyng Sher, Jin-Yuan Shih, Pan-Chyr Yang, Cheng-Wen Wu,
“Rapid Efficacy Assessment Method for Lung Cancer Therapy”, 2009,
US#7,507,534 B2.
Technology Transfers
1.
2.
Transfer “Laser Excited Confocal Fluorescence Gel Scanner”, USP# 5,091,652,
exclusively to GE Healthcare, Mountain View, CA, USA.
Transfer “High Sensitivity Fluorescent Single Particle and Single Molecule
Konan Peck
3.
4.
5.
6.
7.
8.
9.
Detection Apparatus and Method”, USP# 4,979,824, field exclusively to LI-COR,
Inc., Lincoln, Nebraska, USA.
Transfer “Method for Profiling Gene Expression Pattern and Isolation of
Differentially Expressed Genes”, USP# 6,218,114, non-exclusively to Taiwan
Genome Sciences, Inc. and 4 other companies.
Transfer “Method for Constructing High-density Non-redundant Gene Arrays”
non-exclusively to Taiwan Genome Sciences, Inc. and 2 other companies.
Transfer “Methods for Rapid Antimicrobial Susceptibility Testing”, USP#
5,789,173, to Cold Spring Biotech, Inc.
Transfer “Metastasis-Associated Genes” to AdvPharma, Inc.
Transfer “Human Gene-specific DNA Microarray” to Univ. of Connecticut and
other academic institutions.
Transfer “High Sensitivity Fluorescent Single Particle and Single Molecule
Detection Apparatus and Method”, USP# 4,979,824, field exclusively to Singulex,
Hayward, CA, USA.
Transfer “Acites Fluid of Anti-CRMP-1” to Millipore Corp.