Parasites & Pestilence:
Infectious Public Health Challenges
HB 153
Spring 2006
D. Scott Smith, MD, MSc., DTM&H
Email: ssmith@stanford.edu
Office: (650) 299-2742 Home: 650 344-8181
Office Hours: Wed 12 noon to 2pm in HumBio Bldg 80 Room 111
Teaching Assistants:
Class Website:
Or:
Where:
When:
David Berg
Natalie Ramos
Michael Howitt
Maddie Moule
ddberg@stanford.edu
nramos@stanford.edu
mhowitt@stanford.edu
mmoule@stanford.edu
www.stanford.edu/class/humbio103
http://parasites.stanford.edu
Building 200, Room 303
Office Hours Wednesdays 12noon to 2pm in Building 80, Room 111
Wednesday afternoons 2:15 – 5:05pm April 4th to June 7th, 2006
Guest Lecturers and Speakers (in order of appearance)
Karen Smith, MD, MPH
Tuberculosis Control Officer, Napa County
Brian Blackburn, MD
Clinical Asst. Professor, Department of Medicine,
Infectious Disease
Chindi A. Peavey, Ph.D.
Vector Ecologist, San Mateo County
Michele Jay-Russell, DVM, MPVM, DACVPM, Acting Chief, Veterinary Public Health
Section, California Department of Health Services
Schedule of Lecture Topics
Class
Number
Date
Topic
Lecturer
th
1. April 5 , 2006
Introduction to microbial interactions with humans
Smith
Course overview: the TDR target diseases
Global Burden of Disease
Introductions / Pictures for website
Readings: M&V Chapter 2, pp. 6-21
2/12/2016 7:38:55 AM
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2. April 12, 2006
Tissue Nematodes
Onchocerciasis (River Blindness)
Lymphatic Filariasis: The case for eradication?
Reading: M&V pp. 274-301
Trematodes
Schistosomiasis
Reading: M&V pp. 181-196
Smith
Smith
3. April 19, 2006
Blood and Tissue Protozoa
Smith
African Trypanosomiasis* (Sleeping Sickness)
American Trypanosomiasis* (Chagas’ Disease)
Reading: M&V pp. 107-127
Reading response discussion
TAs
Workshop and Lab (at Med School)
Approaching the parasitic disease project
TAs
Reading response #1 DUE (see Coursework)
4. April 26, 2006
Gastrointestinal Parasites
Smith
Ascariasis (A. lumbricoides)
Hookworm (Ancylostoma duodenale, N. americanus)
Echinococcosis (E.granulosus)
Video: Echinococcal cyst surgery
Reading: M&V pp. 240-246 (ascaris); pp 248-255 (hookworm)
pp. 224-231 (echinococcus)
M. Howitt: GI challenges in developing countries (H. pylori)
M. Moule: Oncogenesis & Parasites
5. May 3, 2006
Leprosy
Smith
Tuberculosis: A Global Perspective
Karen Smith
Review: Multidrug-resistant tuberculosis: public health
challenges, by Coker RJ, Trop Med Int Health. 2004
Jan;9(1):25-40 (see Coursework)
"ParaSite Project Updates" DUE (Check-up)
Make MidTerm Questions: due Sunday 5/7/06 at 5pm
*** May 7, 2006 Midterm Review – 8pm, Location TBA *** TAs
MidTerm “Quiz”
Malaria
A. Malaria in Emergency Response: Tsunami in Indonesia Smith
B. Vectors and Genetics of Malaria
Disease Cycles and Intervention Strategies
Reading: M&V pp. 79-106
M. Moule: Malaria & Vectors/ Insect Lifecycles.
*ParaSite Tutorial 7-9pm, Sunday May 14, 2006 and Monday May 15, 2006, in Meyer
Library, 2nd Floor Computer Lab
6. May 10, 2006
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Schedule of Lecture Topics
Class
Number
Date
Topic
7. May 17, 2006
Lecturer
Outbreak Investigation National (CDC)
Leishmaniasis*
Reading: M&V pp. 127-139
Toxoplasmosis*
Reading response discussion
Reading response #2 DUE (see Coursework)
Blackburn
Smith
TAs
8. May 24, 2006
Outbreak Investigations (lepto, rabies, Q-fever)
Jay
Medically important Arthropods
Peavy
(and emerging diseases: West Nile Virus, Lyme Disease)
Reading: M&V pp. 322-351
Web ParaSite Projects DUE
9. May 31, 2006
Bioterrorism and other Pestilence
ParaSite Project Presentations I
Lab section at the Medical School
TBA
Class
10. June 7, 2006
Selected Zoonoses: local and current challenges
ParaSite Project Presentations II
Smith
Class
Important Dates
Friday June 2nd, 6-8pm– Final Exam Review Session
place TBA
TAs
June 3th, 3 pm Saturday “Pot Luck” of Gastronomic Delights at Dr. Smith’s House
June 9th, 2006, Friday, Final Exam 12:15 – 3:15pm
Course Readings
Course Text Book: Markell and Voge's Medical Parasitology
by Edward K. Markell, David T. John, Wojciech A. Krotoski, Ninth Edition, 2006
Selected further readings:
1. Michele Barry, M.D., FACP. Diseases without Borders: Globalization's
Challenge to the ASTMH A Call for Public Advocacy and Activism.
Presidential Address, November 2002
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2. Duane J. Gubler, Sc. D. Prevention and Control of Tropical Diseases in
the 21st Century: Back to the Field
Presidential Address, December 2000.
3. Mass Treatment to Eliminate Filariais in Papua New Guinea, N Engl J Med 2002;
347:1841-1848, Dec 5, 2002
4. Plagues and Peoples, William H. McNeill
5. Man and Microbes: Disease and Plagues in History and Modern Times,
Arno Karlen
6. Communicable Diseases Manual, 2000
7. New Guinea Tapeworms and Jewish Grandmothers: Tales of Parasites and
People, Robert S. Desowitz
8. The Malaria Capers : More Tales of Parasites and People, Research and Reality
by Robert S. Desowitz
Class Format
2-3 patient case vignettes
Didactic and Socratic Lectures
Question and Answer Session and Discussion
Microscopy Sessions on relevant days
Workshops: preparing your projects
Grading
15%
15%
25%
45%
Class participation (includes emailing exam questions, class
discussion participation, reading responses)
Midterm quiz
(Web) ParaSite Project (and presentation)
Final exam
Grading will not be done on a curve, so everyone can do well if the effort is made and
there is evidence of learning.
Students will be encouraged to participate in events on campus relevant to the course
content, including lectures and rounds such as the infectious disease grand rounds at the
medical school, fellow’s lectures, and special guest speaker’s symposia.
Students are encouraged to participate in summer projects related to the content of this
course; and every effort will be made to align students with mentors and parasite projects
or research.
Letters of recommendation will be considered for those in the top 25% of the class.
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