Online resource 1
Potentially adverse reactions of nitrofurantoin with corresponding ICD-9 code
Type of adverse reaction1,2
ICD-9
code
Description of ICD-9 code
General adverse events
Overdosing
E857
Adverse effects (in general)
E931.9
Accidental poisoning by other anti-infectives;
flucytosine and nitrofurantoin derivatives
Adverse effects by other and unspecified antiinfectives; flucytosine and nitrofurantoin derivatives
Pulmonary reactions
Common pulmonary reactions
519.9
Unspecified disease of respiratory system
Respiratory Disease (chronic) NOS
516.33
Acute interstitial pneumonitis
516.30
Idiopathic interstitial pneumonia, not otherwise
specified. Idiopathic fibrosing alveolitis
Idiopathic non-specific interstitial pneumonitis
Acute cellular interstitial lung
disease/pneumonia
Subacute interstitial pneumonia.
Pulmonary infiltrates and eosinophilia.
Eosinophilic pneumonia
Organising pneumonia ( BOOP - AFOP)
516.32
518.3
516.8
Desquamative interstitial pneumonia (DIP
pattern)
Pulmonary fibrosis
516.37
Diffuse alveolar damage (DAD):
ARDS is a clinical syndrome associated
518.82
516.31
Pulmonary eosinophilia
Other specified alveolar and parietoalveolar
pneumonopathies
Endogenous lipoid pneumonia; Interstitial pneumonia;
Lymphoid interstitial pneumonia due to known
underlying cause; Lymphoid interstitial pneumonia
NOS; Non-specific interstitial pneumonia due to
known underlying cause; Non-specific interstitial
pneumonia NOS; Organizing pneumonia due to known
underlying cause; Organizing pneumonia NOS
Desquamative interstitial pneumonia
Idiopathic pulmonary fibrosis
Cryptogenic fibrosing alveolitis
Other pulmonary insufficiency, not elsewhere
classified
1
with a variety of pathological findings.
These include pneumonia, eosinophilic
pneumonia, cryptogenic organizing
pneumonia, acute fibrinous organizing
pneumonia, and diffuse alveolar damage
(DAD). Of these, the pathology most
commonly associated with ARDS is DAD.
Acute severe pulmonary oedema / ARDS
Acute respiratory distress
Acute respiratory insufficiency
Adult respiratory distress syndrome
518.4
Diffuse alveolar haemorrhage (ANCA)
786 (3)
Acute bronchospasm
519.11
Bronchospasm and angioedema
(anaphylaxis)
517.8
995.0
995.1
Pleural effusion
511.9
Pulmonary vasculitis
417.8
Peritracheal/mediastinal haemorrhage and
upper airway obstruction
Skin rash, eosinophilia, and internal organs
involvement including pneumonia
(DRESS)
786.3
Isolated acute chest pain
786.50
518.3
Acute edema of lung, unspecified
Acute pulmonary edema NOS; pulmonary edema
postoperative
786.3 Haemoptysis
Cough with haemorrhage
Pulmonary haemorrhage
Acute bronchospasm
Bronchospasm NOS
Lung involvement in other diseases classified
elsewhere
Other anaphylactic reaction {Allergic
shock}{Anaphylactic reaction}{Anaphylactic
shock}{Anaphylaxis} NOS or due to adverse effect of
correct medicinal substance properly Administered;
Anaphylactoid reaction NOS
Angioneurotic edema, not elsewhere classified
Giant urticaria; Allergic angioedema
Unspecified pleural effusion
Pleural effusion NOS; Pleurisy: exudative,
serofibrinous, serous, with effusion NOS
Other specified diseases of pulmonary circulation:
•Pulmonary:arteritis endarteritis
•Rupture of pulmonary vessel
•Stricture of pulmonary vessel
Haemoptysis
Pulmonary eosinophilia
Eosinophilic asthma
Löffler's syndrome
Pneumonia: allergic + eosinophilic
Tropical eosinophilia
Unspecified chest pain
2
786.52
Acute chest pain and interstitial lung
disease
Allergic reactions
Common
786.5
995.3
995.20
995.27
995.29
Anaphylactic reaction
995.0
Pruritus
698.9
Urticaria
Angioedema
708.0
995.1
Erythema multiforme
Fever
695.1
780.60
Painful respiration. Pain: anterior chest wall, pleuritic;
Pleurodynia
Symptoms involving respiratory system and other chest
symptoms
786.5 Chest pain
Allergy unspecified, not elsewhere classified
Allergic reaction NOS; Hypersensitivity NOS;
Idiosyncrasy NOS
Unspecified adverse effect of unspecified drug,
medicinal, and biological substance
Unspecified adverse effect of unspecified medicinal
substance properly administered
Other drug allergy
Allergic reaction NEC (due) to correct medical
substance properly administered; Drug allergy NOS;
Drug hypersensitivity NOS; Hypersensitivity (due) to
correct medical substance properly administered
Unspecified adverse effect of other drug, medicinal,
and biological substance
Unspecified adverse effect of medicinal substance
NEC properly administered
Other anaphylactic reaction
{Allergic shock}{Anaphylactic
reaction}{Anaphylactic shock}{Anaphylaxis} NOS or
due to adverse effect of correct medicinal substance
properly administered; Anaphylactoid reaction NOS
Unspecified pruritic disorder
Itch NOS; Pruritus NOS
Allergic urticaria
Angioneurotic edema, not elsewhere classified,
Allergic angioedema
Erythema multiforme
Fever, unspecified
Chills with fever; Fever NOS; Fever of unknown origin
(FUO); Hyperpyrexia NOS; Pyrexia NOS; Pyrexia of
unknown origin
Liver damage
3
Jaundice
782.4
Hepatomegaly
789.1
Blood dyscrasias
Haemolytic anemia
283.0
283.1
283.9
Thrombocytopenia
287.5
287.30
287.39
287.49
Severe haemorrhagic diathesis
287.9
Allergic agranulocytosis
288.09
Neutropenia
288.03
288.00
284.1
Pancytopenia
Neuropathy
356.4
356.8
356.9
357.6
357.9
Jaundice, unspecified, not of newborn
Cholemia NOS; Icterus NOS
Hepatomegaly
Enlargement of liver
Autoimmune haemolytic anemias
Autoimmune haemolytic disease (cold type) (warm
type); Chronic cold hemagglutinin disease; Cold
agglutinin disease or hemoglobinuria; Haemolytic
anemia: cold type (secondary) (symptomatic), druginduced, wart type (secondary) (symptomatic)
Non-autoimmune haemolytic anemias
Acquired haemolytic anemia, unspecified
Acquired haemolytic anemia NOS; Chronic idiopathic
haemolytic anemia
Thrombocytopenia, unspecified
Primary thrombocytopenia, unspecified
Megakaryocytic hypoplasia
Other primary thrombocytopenia
Other secondary thrombocytopenia
Thrombocytopenia (due to): dilutional, drugs,
extracorporeal circulation of blood, massive blood
transfusion, platelet alloimmunization, secondary NOS
Unspecified haemorrhagic conditions
Haemorrhagic diathesis (familial)
Other neutropenia
Agranulocytosis; Neutropenia: immune, toxic
Drug induced neutropenia
Neutropenia, unspecified
Pancytopenia
Idiopathic progressive polyneuropathy
Other specified idiopathic peripheral neuropathy.
Supranuclear paralysis
Unspecified idiopathic peripheral neuropathy
Polyneuropathy due to drugs
Unspecified inflammatory and toxic neuropathies
Other inflammatory and toxic neuropathy
4
357.89
1: Aronson JK. Meyler's side effects of drugs. ed. 15th: Elsevier science BV; 2006.
2: Holmberg L, Boman G, Bottiger LE, Eriksson B, Spross R, Wessling A. Adverse reactions to nitrofurantoin.
Analysis of 921 reports. Am J Med. 1980;69:733-8.
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