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J Egypt Soc Parasitol. 2008 Dec;38(3):991-1006.
Genetic polymorphism of glutathione-Stransferase (GST-M1 and GST-T1) in
schistosomiasis -associated bladder cancer
in Egyptian patients.
El Nouby KA, Abd El Hameed AH, Negm OE, Hamouda HE, El Gamal OM, Ismail GM.
Source
Department of Parasitology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Abstract
This work was carried out on three groups, 30 Egyptian patients with Schistosoma
haematobium (S. haematobium) with bladder cancer (15), and without bladder cancer
(15), as well as 15 normal individuals as a control. All the individuals were subjected to
measurement of serum level of GST by using ELISA technique and genotyping for GSTM1 & GST-T1 using PCR technique. The results proved that GST serum level was
significantly deceased in S. haematobium patients with bladder cancer as compared to the
other groups. The PCR results for the GST-M1 & GST-T1 genotyping showed 4
categories, (M1+ve/T1+ve, M1+ve/T1-ve, M1-ve/T1+ve, M1-ve/T1/-ve). There was a
significant decrease in enzyme levels in patients with GST-M1-ve/T1-ve as compared to
the other categories. Besides, there was a significant increased risk for bladder cancer
development in patients with combined gene deletion (OR = 40) which represented
mainly in S. haematobium patients with bladder cancer (53.3% = M1-ve/TI-ve).
PMID:
19209780
[PubMed - indexed for MEDLINE]