Table 4: Immunological responses* among HIV-2 –infected patients
Study
(Author, year)
CD4 count
Baseline
Median
[IQR]
82
[52-188]
90
[10-360]
134
[93 - 205]
CD4 count
Month-6
Median
[IQR]
154
[68-275]
230
[40-380]
NR
CD4 count
Month-12
Median
[IQR]
163
[132-244]
270
[60-410]
NR
CD4 count
Month -24
Median
[IQR]
NR
Delta of CD4 count
cells/mm3
Slope of CD4 count
(first period)
Slope of CD4 count
(second period)
Comments
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
Matheron, 2006 (44)
136
[57-244]
177
[98-328]
181
[123-290]
221
[133-374]
M6 : +53 (+10; +86)
M12: +41 (+9;+92)
M24 : +62 (9;120)
NR
NR
Ndour, 2006 (53)
204
[12-1029]
267
[163-381]
NR
NR
NR
NR
NR
NR
NR
NR
Month-12
+200 cells/mm3
NR
13 patients
(Group II)
Median of CD4 count at the
last visit
327 [202 -408]
At 12 months
No PI : +40 (+18; +97)
PI : (+41 (+8,+86)
P(0.67)
NR
<2 months
25 (7;42)
cells/µl/months
226
[124-359]
NR
NR
NR
>2 months
-3 (-38;+32)
cells/µl/year
PI group
106 cells/µl/year
Adje-Touré, 2003(35)
Van Der Ende, 2003 (28)
Mullins 2004(52)
Drylewicz, 2008 (12)
Ruelle, 2008(45)
M6 : +71 [11-116]
M12: +122 [61-159]
M24 + 132 [110-275]
<3 months
24.3 (7.1; 41.4)
cells/µl/months
Without PI
-25 cells/µl/year
>3 months
+8.50 (+5.3;+11.7)
cells/µl/year
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
PI
278 [248-307]
NNRTIs
268 [175-293]
NR
NR
<3 months
NNRTIs: -41 (-123 ;40)
cells/µl/year
>3 months
+8.50 (+5.3;+11.7)
cells/µl/year
Benard, 2009 (26)
142 [59-259]
Jallow, 2009 (32)
Gottlieb, 2009 (29)
Landman, 2009 (54)
116 [10-300]
200 [12-562]
130
[16-290]
NR
NR
NR
NR
Borget, 2009 (55)
Harries, 2010 (17)
NR
NR
NR
NR
Drylewicz, 2010 (36)
111
[31-171]
178 [77-232]
PI containing regimens :
+89 cells/mm3 [-31; 323]
PI sparing regimens
-53 cells/mm3 [-62; 57]
1
Slope of % of CD4 count
was reported
NR
NR
After a median follow up of
2.6 years (0.3-7.6) CD4
count was 338 [102-654]
NR
NR
Table 4: Immunological responses* among HIV-2 –infected patients (continued)
Study
(Author, year)
CD4 count
Baseline
Median
[IQR]
202 [2-1124]
CD4 count
Month-6
Median
[IQR]
NR
CD4 count
Month-12
Median
[IQR]
NR
96 [73-111]
(3NRTIs) / PI
(114) / 78
3NRTIs / PI
(102) / 171
3NRTIs / PI
(91) / 254
Peterson (18)
2011
140 [50-310]
NR
NR
Benard, 2011 (15)
191 [90-275]
PI regimen
170 [72-275]
3NRTIs
216 [150-287]
NR
181 [96-200]
NR
Smith 2010 (42)
Chiara, 2010 (43)
Peterson, 2012 (56)
CD4 count
Month -24
Median
[IQR]
NR
Delta of CD4 count
cells/mm3
Slope of CD4 count
(second period)
NR
NR
NR
NR
64% CD4 increase and
37% cd4 decline in followup
NR
NR
NR
NR
NR
NR
M6: + 120 cells
M12: + 115 cells
M24: + 285 cells
M36: +280
NR
<3 months
PI : +12
cells/µl/months
3NRTIs : +
cells/µl/months
3-12 months
PI : +76 cells/µl/y
3NRTIs : -60
cells/µl/y
NR
NR
NR
NR
+8 [-100;+181]
cells/mm3/year
PI regimen
327
3NRTIs
191
NR
Slope of CD4 count
(first period)
* Included only the study who reported immunological responses
NR: Not Reported
2
Comments
>=200 cells/mm3
PI : +52 cells/µl/y
3NRTIs : -99 cells/µl/y
NR
3