Post-doctoral position at INSERM UMR1011-Lille
Functional genomics of obesity-related diseases
Research project: Our laboratory studies obesity-related diseases including diabetes and nonalcoholic fatty liver disease. We are using functional genomics to define how the
transcriptional regulatory programs of key metabolic organs (liver, adipose tissue…) are
altered to promote these diseases. Using a combination of transcriptomic, cistromic and
epigenomic analyses of in-vitro cellular and animal models, we aim to define the role exerted
by nuclear receptors in the pathophysiology of these obesity-related diseases.
Candidate profile: We are seeking a highly motivated post-doc who will both be able to
manage experiments and be strongly involved in bioinformatical analyses related to his/her
projects. Therefore, the successful candidate will have to work in close interaction with both
bioinformaticians and biologists from our laboratory in order to identify novel regulatory
pathways involving nuclear receptors in obesity-related diseases.
The successful candidate should have a PhD in molecular biology with a solid background in
the study of transcriptional regulation. His/her project will involve performing ChIP,
(h)MeDIP and RNA expression analyses on both cell-lines and mouse tissues. Moreover,
he/she should have experience and interest for analyses of genomic data issued from highthroughput sequencing technologies or microarrays. Previous experiences with galaxy-based
tools for the analysis of genomic data would be an asset.
For further details visit our website (http://www.u1011.lille.inserm.fr/) and contact Drs J.
Eeckhoute
(jerome.eeckhoute@inserm.fr)
claude.lefebvre@inserm.fr).
or
P.
Lefebvre
(philippe-