Using of 1-alkoxyalkyl-4- substituted piperidols in the synthesis of
biologically active compounds
S.S. Ibrayeva1, Т.G. Bimurzayeva2, Zh.N. Kadyr1, А.О. Таzhigulovа1
1 Kazakh-British Technical University, 050000, Kazakhstan, Almaty, Tole bi Str., 59
2 Institute of Chemical Sciences named after A.B. Bekturov, 050010, Kazakhstan,
Almaty, Walikhanov Str., 106
е-mail: symba_t@mail.ru
The main conclusion was drawn from the analysis of biological activity data of previously
synthesized N-alkoxyalkyl-4-ethynylpiperidols-4 is the identity of their skeleton. There are Nalkoxyalkyl-4-oxypiperidine moiety and triple bond in all structures. It has been shown that the
nature of the substitutes at the triple bond and at nitrogen atom is responsible for the compounds
activity.
The novel biologically active compounds generation involved Favorsky reaction leading to
the formation of ethynylcarbinols. In the molecules of last the combination of two functional groups
(triple bond and a hydroxy group) able to further transformations expands their applicability:
Such the combined system of modifications of N-alkoxyalkyl-4-ethynylpiperidols-4
involving several chemical reactions has undeniable advantages, since these transformations result
in the obtaining of homologous series of potentially biologically active compounds and the ability
to identify the "structure-activity" relationship is appeared.