ss the Power of
Resveratrol
The Nutraceutical that Provides Chemoprevention,
Cardioprotection, Neuroprotection and is AntiAging, Anti-Inflammatory, Promotes Weight Loss
and much, much more
Hratch L Karamanoukian, MD, FACS
Raffy L Karamanoukian, MD, FACS
Zora DeGrandpre. MS, ND
This book is not intended for purposes of self-diagnosis or
treatment. Patients should only use this book under the direct
supervision of a trained medical professional.
Copyright© 2011
HL Karamanoukian, R L Karamanoukian, Zora DeGrandpre
All Rights Reserved
ISBN: 978-
About the Authors
Hratch Karamanoukian, MD
Dr. Hratch Karamanoukian, MD is a cardiovascular and thoracic
surgeon and vein specialist with triple board certification – in general
surgery, thoracic surgery (heart and lungs) and phlebology. In 1999, Drs.
Karamanoukian, Bergsland and Salerno were the first in the U.S. to perform
beating heart robotic coronary artery bypass surgery.
Dr. Karamanoukian obtained his training at UCLA, the University of
Southern California and the University at Buffalo. He has received
numerous teaching awards during his training and is listed in 'Guide to
America's Top Surgeons' by the Consumers Research Council of America (2008-2011). He
also received the 2009 and 2010 designation from the Consumers Research Council of
America for his expertise in Venous Disorders (Phlebology).
Dr. Karamanoukian has performed NIH sponsored research (1992-1995) at the Childrens
Hospital of Buffalo in the fields of pulmonary hypertension, inhaled nitric oxide, surfactant
physiology and fetal surgery. He has also done seminal research in fetal surgery at the
Childrens Hospital with Dr. Philip L Glick, a pediatric surgeon of international stature and
pioneer in the field of fetal surgery. Childrens Hospital of Buffalo was the second center in
the United States that developed a clinical program in fetal surgery (1989) - The Buffalo
Institute of Fetal Surgery (BIFT).
Dr. Karamanoukian has published more than 140 scientific articles in peer reviewed journals
in the fields of fetal surgery, robotic surgery, beating heart surgery, pulmonary hypertension,
congenital diaphragmatic hernia, cardiovascular surgery and cardiovascular medicine. He has
authored or co-authored 15 textbooks and review books in the fields of cardiac surgery,
thoracic surgery and general surgery. His review books have helped thousands of surgery
residents pass their written and oral surgery board examinations (for the American Board of
Surgery and American Board of Thoracic Surgery). These books, titled ABSITE Combat
Manual (first and second editions), Thoracic Surgery Board Review, Red Manual for the
Surgery Boards, Blue Manual Basic Science Review (volumes 1,2 and 3) among others, are
well recognized by trainees sitting for their specialty board examinations. He has also written
Cardiac Surgery Secrets and Thoracic Surgery Secrets through Elsevier Press. Cardiac
Surgery Secrets is in 2nd Edition and has been translated into Russian, Portuguese, Spanish,
Arabic, Armenian, Chinese and Turkish editions.
Dr. Karamanoukian has also authored or coauthored books about cardiovascular health for
the lay public entitled “Doctor, How Do I Live the Heart Healthy Way?” and “Doctor, Tell
Me About High Blood Pressure and Stroke”.
Dr. Karamanoukian is Director of the Vein Treatment Center and the Center for Excessive
Sweating. The Vein Treatment Center is a National Centers of Excellence for Venous
Diseases. He has also developed a line of nutraceutical products via Uberceuticals®,, a
Leader in Vein Care and Skin Care Science. His nutraceutical products and supplements can
be purchased on www.MyVeinStore.com
Zora DeGrandpre, MS, ND
Dr. DeGrandpre is a licensed naturopathic physician with a background in
clinical and basic science research. Her original training was as an organic
chemist, specializing in drug design. Her BS, from SUNY at Buffalo, is in
Medicinal Chemistry. Dr DeGrandpre received her Master`s degree from
Roswell Park Cancer Institute where her research focused on cancer
immunology. Later, as a PhD candidate, she examined the idiotypic
relationships involved in the regulation of T-suppressor cells, a type of
regulatory immune cell.
After a number of years teaching in Buffalo area schools, Dr DeGrandpre’s moved to the West
Coast and obtained a doctorate in natural medicine, awarded by the National College of Natural
Medicine in 2007. She has served as a grant reviewer for the National Institutes of Health and
the National Center for Complementary and Alternative Medicine (NIH/NCCAM). In addition,
her expertise in natural medicine has been called upon in litigation matters, specifically on the
properties of various herbal medicines and their interactions with pharmacologic agents. She is
also the Scientific Review Editor for an upcoming foundational textbook in natural medicine.
She has published textbooks in botanical medicine, drug-herb interactions, the treatment of
alcoholism and addiction, homeopathy and other topics. Dr DeGrandpre is also a writer and
editor for academia, writing scientific grants and curricula for Integrative Medicine programs.
She also writes for industry and the public, writing articles and monographs on various
supplements, providing well-researched and documented information for both professionals and
non-professionals on various herbal medicines and supplements. She also lectures on various
topics, including diets to treat and prevent chronic disease, the use of bio-identical hormones,
mind-body medicine, and naturopathic approaches to women’s health and addictions. Her
practice, located at the historic Academy in Vancouver, Washington, focuses on natural
approaches to healing, utilizing diet, nutrition, botanical medicines, mind-body medicine and
using bioidentical hormones to achieve balance and health. She also works with patients to
minimize their use of pharmacologic medicines while maximizing their health and wellness.
Dr. DeGrandpre is also a Reiki Master and certified Healing Touch practitioner and has a
particular interest in traditional native healing, and travels around the country, listening and
learning to Native American elders. She holds a 2nd degree black belt in Isshinryu karate. Dr
DeGrandpre and her husband share 8 children and 11 grandchildren, a golden retriever named
Leto and a cat named WMD. More information can be found at HazelDellNaturalHealth.com. Dr
DeGrandpre can be contacted at DrZoraMSND@gmail.com.
Table of Contents
About the Authors _________________________________________________________ 3
Hratch Karamanoukian, MD ___________________________________________________ 3
Zora DeGrandpre, MS, ND _____________________________________________________ 5
Introduction ________________________________________Error! Bookmark not defined.
Fighting inflammation ___________________________________ Error! Bookmark not defined.
Chapter 1 __________________________________________Error! Bookmark not defined.
A Closer Look at Aging __________________________________ Error! Bookmark not defined.
Longevity Is Changing ___________________________________ Error! Bookmark not defined.
The Link between Calorie Restriction and Longevity _________ Error! Bookmark not defined.
How do caloric restriction or resveretrol work as anti-aging approaches? Error! Bookmark not defined.
Does Eating Fish Really Help? _________________________________ Error! Bookmark not defined.
Fruits and Veggies- What They Can Offer ________________________ Error! Bookmark not defined.
The Importance of Exercise ___________________________________ Error! Bookmark not defined.
Strength Training ___________________________________________ Error! Bookmark not defined.
Aerobic Exercise ____________________________________________ Error! Bookmark not defined.
Summary __________________________________________________ Error! Bookmark not defined.
Chapter 2 __________________________________________Error! Bookmark not defined.
A Closer Look at Sirtuins and the SIRT1gene family __________ Error! Bookmark not defined.
SIRT1 Benefits _____________________________________________ Error! Bookmark not defined.
Are There Foods That Can Activate Sirtuins Such As SIRT1? ________ Error! Bookmark not defined.
Summary __________________________________________________ Error! Bookmark not defined.
Chapter 3 __________________________________________Error! Bookmark not defined.
What Is Resveratrol? ____________________________________ Error! Bookmark not defined.
The Benefits of Resveratrol ___________________________________ Error! Bookmark not defined.
Summary__________________________________________________ Error! Bookmark not defined.
Chapter 4 __________________________________________Error! Bookmark not defined.
Resveratrol Safety and Side Effects ________________________ Error! Bookmark not defined.
Pay Attention to Dosage ______________________________________ Error! Bookmark not defined.
Some information and tips for choosing reputable supplements ________ Error! Bookmark not defined.
What Are the Side Effects? ____________________________________ Error! Bookmark not defined.
A Note about Safety _________________________________________ Error! Bookmark not defined.
Summary __________________________________________________ Error! Bookmark not defined.
Chapter 5 __________________________________________Error! Bookmark not defined.
Where Is Resveratrol Found In Nature? ____________________ Error! Bookmark not defined.
Grapes ____________________________________________________ Error! Bookmark not defined.
Peanuts ___________________________________________________ Error! Bookmark not defined.
Blueberries and Cranberries ___________________________________ Error! Bookmark not defined.
Dark Chocolate _____________________________________________ Error! Bookmark not defined.
Other Sources ______________________________________________ Error! Bookmark not defined.
Summary __________________________________________________ Error! Bookmark not defined.
Chapter 6 __________________________________________Error! Bookmark not defined.
Resveratrol Supplements- What They Offer and How to Choose Error! Bookmark not defined.
Read the Label! _____________________________________________ Error! Bookmark not defined.
Watch Out for Fake Endorsements ______________________________ Error! Bookmark not defined.
If It Sounds Too Good to Be True…… __________________________ Error! Bookmark not defined.
Look for Type and Purity _____________________________________ Error! Bookmark not defined.
Look Out for Emodin ________________________________________ Error! Bookmark not defined.
Read ALL of the Ingredients ___________________________________ Error! Bookmark not defined.
Summary __________________________________________________ Error! Bookmark not defined.
Chapter 7 __________________________________________Error! Bookmark not defined.
Natural or Supplemental- Which Is Best? ___________________ Error! Bookmark not defined.
Natural Food-Based Resveratrol Only ___________________________ Error! Bookmark not defined.
Supplemental Resveratrol Only ________________________________ Error! Bookmark not defined.
Using Foods and Supplements Together __________________________ Error! Bookmark not defined.
A Word on Supplements ______________________________________ Error! Bookmark not defined.
Summary __________________________________________________ Error! Bookmark not defined.
Chapter 8 __________________________________________Error! Bookmark not defined.
Making the Most of Resveratrol with a Healthy Lifestyle ______ Error! Bookmark not defined.
What Changes Can or Should I Make? ___________________________ Error! Bookmark not defined.
Improved Diet ______________________________________________ Error! Bookmark not defined.
Greater Physical Activity _____________________________________ Error! Bookmark not defined.
Healthy Lifestyles ___________________________________________ Error! Bookmark not defined.
Positive Interactions _________________________________________ Error! Bookmark not defined.
Epigenetics ________________________________________________ Error! Bookmark not defined.
Summary __________________________________________________ Error! Bookmark not defined.
Conclusion _________________________________________Error! Bookmark not defined.
References Cited: ____________________________________Error! Bookmark not defined.