Literatur zu
Zystoides Makulaödem nach Kataraktoperation
Teil 1: Epidemiologie, Pathophysiologie, Risikofaktoren
Teil 2: Klinik, Diagnostik, Therapie
Michael Witteborn, Stefan Mennel, Thomas Bertelmann
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Abe T, Hayasaka S, Nagaki Y et al (1999) Pseudophakic cystoid macular edema treated with
high-dose intravenous Methylprednisolon. J Cataract Refract Surg 25: 1286–1288
Ah-Fat FG, Sharma MK, Majid MA et al (1998) Vitreous loss during conversion from
conventional extracapsular cataract extraction to phacoemulsification. J Cataract Refract Surg
24: 801–805
Ahluwalia BK, Kalsra SC, Parmar IP et al (1988) A comparative study of the effect of
antiprostaglandins and steroids on aphakic cystoid macular oedema. Indian J Ophthalmol 36:
176–178
Arevalo JF, Garcia-Amaris RA, Roca JS et al (2007) Primary intravitreal bevacizumab for the
management of pseudophakic cystoid macular edema. Pilot study of the Pan-American
Collaborative Retina Study Group. J Cataract Refract Surg 33: 2098–2105
Arevalo JF, Maia M, Flynn HW et al (2008) Tractional retinal detachment following
intravitreal bevacizumab (Avastin) in patients with severe proliferative diabetic retinopathy.
Br J Ophthalmol 92: 213–216
Arevalo JF, Maia M, Garcia-Amaris RA et al (2009) Intravitreal bevacizumab for refractory
pseudophakic cystoid macular edema: the Pan-American Collaborative Retina Study Group
results. Ophthalmology 116: 1481–1487
Augustin A, Löwenstein A, Kuppermann BD (2010) Macular edema. General
pathophysiology. Dev Ophthalmol 47: 10–26
Ayyala RS, Cruz DA, Margo CE et al (1998) Cystoid macular edema associated with
latanoprost in aphakic and pseudophakic eyes. Am J Ophthalmol 126: 602–604
Barone A, Russo V, Prascina F et al (2009) Short-term safety and efficiacy of intravitreal
bevacizumab for pseudophakic cystoid macular edema. Retina 29: 33–37
Bencic G, Vatavuk Z, Mandic Z (2006) Pars plana vitrectomy and intravitreal triamcinolone
for chronic pseudophakic cystoid macular edema. Acta Med Croatica 60: 93–96
Benhamou N, Massin P, Haouchine B et al (2003) Intravitreal triamcinolone for refractory
pseudophakic macular edema. Am J Ophthalmol 135: 246–249
Bertelmann T, Kicova N, Messerschmidt-Roth A et al (2011) The vitreomacular interface in
retinal vein occlusion. Acta Ophthalmol 89: e327–e331
Bito LZ, Salvador EV (1972) Intraocular fluid dynamics: the site and mechanism of
prostaglandin transfer across the blood intraocular fluid barriers, part 3. Exp Eye Res 14: 233–
241
Bito LZ (1974) The effects of experimental uveitis on anterior uveal prostaglandin transport
and aqueous humor composition. Invest Ophthalmol 13: 959–966
Bonnet M (1972) Le syndrome d’Irvine-Gass. Arch Opht 32: 801–814
Borne MJ, Tasman W, Regillo C et al (1996) Outcomes of vitrectomy for retained lens
fragments. Ophthalmology 103: 971–976
Callanan D, Fellmann RL, Savage JA (1998) Latanoprost-associated cystoid macular edema.
Am J Ophthalmol 126: 134–135
Cervera E, Diaz-Llopis M, Udaondo P et al (2008) Intravitreal pegaptanib sodium for
refractory pseudophakic macular edema. Eye 22: 1180–1182
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
Chandler P (1954) Complications after cataract extraction: clinical aspect. Tr Am Acad Ophth
58: 382–396
Chee SP, Ti SE, Sivakumar M (1999) Postoperative inflammation: extracapsular cataract
extraction versus phacoemulsification. J Cataract Refract Surg 25: 1280–1285
Cheng T, Cao W, Wen R et al (1998) Prostaglandin E2 induces vascular endothelial growth
factor and basic fibroblast growth factor mRNA expression in cultured rat Muller cells. Invest
Ophthalmol Vis Sci 39: 581–591
Cohen SM, Davis A, Cukrowski C (2006) Cystoid macular edema and pars plana vitrectomy
for retained lens fragments. J Cataract Refract Surg 32: 1521–1526
Dellaporte A (1955) Fundus changes in postoperative hypotony. Am J Ophthalmol 40: 781–
789
Deuter CM, Gelisken F, Stübiger N et al (2001) Successful treatment of chronic pseudophakic
macular edema (Irvine-Gass-syndrome) with interferon alpha: a report of three cases. Ocul
Immunol Inflamm 19: 216–218
Dick HB, Schwenn O, Krummenauer F et al (2000) Inflammation after sclerocorneal versus
clear corneal tunnel phacoemulsification. Ophthalmology 107: 241–247
Diestelhorst M, Aspacher F, Konen W et al (1991) The effect of flubiprofen 0.03% eye drops
on the blood aqueous barrier in extracapsular cataract extraction with IOL implantation. Int
Ophthalmol 15: 69–73
Drolsum L, Haaskjold E (1995) Causes of decreased visual acuity after cataract extraction. J
Cataract Refract Surg 21: 59–63
Estafanous MF, Lowder CY, Meisler DM et al (2001) Phacoemulsification cataract extraction
and posterior chamber lens implantation in patients with uveitis. Am J Ophthalmol 131: 620–
625
Federman JL, Annesley WH Jr, Sarin LK et al (1980) Vitrectomy and cystoid macular edema.
Ophthalmology 87: 622–628
Ferrari TM, Cavallo M, Durante G et al (1999) Macular edema induced by
phacoemulsification. Doc Ophthalmol 97: 325–327
Flach AJ, Dolan BJ, Irvine AR (1987) Effectiveness of ketorolac tromethamine
0.5%ophthalmic solution for chronic aphakic and pseudophakic cystoid macular edema. Am J
Ophthalmol 103: 479–486
Flach AJ, Graham J, Kruger L et al (1998) Quantitative assessment of postsurgical breakdown
of the blood aqueous barrier following administration of ketorolac tromethamine solution: a
double-masked, paired comparison with vehicle-placebo solution study. Arch Ophthalmol
106: 344–347
Flach AJ, Stegman RC, Graham J et al (1990) Prophylaxis of aphakic cystoid macular edema
without corticosteroids. A paired-comparison, placebo-controlled double-masked study.
Ophthalmology 97: 1253–1258
Flach AJ (1998) The incidence, pathogenesis and treatment of cystoid macular edema
following cataract surgery. Trans Am Ophthalmol Soc 96: 557–634
Foster RE, Lowder CY, Meisler DM et al (1992) Extracapsular cataract extraction and
posterior chamber intraocular lens implantation in uveitis patients. Ophthalmology 99: 1234–
1241
Fung WE (1982) Surgical therapy for chronic aphakic cystoid macular edema.
Ophthalmology 89: 898–901
Fung WE (1985) Vitrectomy for chronic aphakic cystoid macular edema: results of a national,
collaborative, prospective, randomized investigation; the Vitrectomy-ACME Study Group.
Ophthalmology 92: 1102–1111. Discussion by T Hanson 1111
Gass JDM, Norton EWD (1969) Follow-up study of cystoid macular edema following
cataract extraction. Trans Am Acad Ophthalmol Otolaryngol 73: 665–682
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52.
53.
54.
55.
56.
57.
58.
59.
60.
61.
Gass JD, Norton EW (1966) Cystoid macular edema and papilledema following cataract
extraction. A fluorescein funduscopic and angiographic study. Arch Ophthalmol 76: 646–661
Gehring JR (1968) Macular edema following cataract extraction. Arch Ophthalmol 80: 626–
631
Guex-Crosier Y (1999) The pathogenesis and clinical presentation of macular edema in
inflammatory diseases. Doc Ophthalmol 97: 297–309
Harbour JW, Smiddy WE, Rubsamen PE et al (1995) Pars plana vitrectomy for chronic
pseudophakic cystoid macular edema. Am J Ophthalmol 120: 302–307
Hauer Y, Barkay S (1964) Vitreous detachment in aphakic eyes. Brit J Ophthalmol 48: 341–
343
Haut J, van Effenterre G, Le Mer Y et al (1989) Oedeme maculaire cystoide, decollement de
la retine, et decollement du vitre. Bull Soc Opht France 8–9: 1035–1038
Heier JS, Topping TM, Baumann W et al (2000) Ketorolac versus prednisolone versus
combination therapy in the treatment of acute pseudophakic cystoid macular edema.
Ophthalmology 107: 2034–2038; discussion 2039
Henderson BA, Kim JY, Ament CS et al (2007) Clinical pseudophakic cystoid macular
edema. Risk factors for development and duration after treatment. J Cataract Refract Surg 33:
1550–1558
Herrmann WA, Heimann H, Helbig H (2010) Kataraktoperation. Effekt auf den hinteren
Augenabschnitt. Ophthalmologe 107: 975–986
Irvine SR (1953) A newly defined vitreous syndrome following cataract surgery, interpreted
according to recent concepts of the structure of the vitreous. Am J Ophthalmol 36: 599–619
Italian Diclofenac Study Group (1997) Efficiacy of diclofenac eyedrops in preventing
postoperative inflammation and long-term cystoid macular edema. J Cataract Refract Surg 23:
1183–1189
Jaffe NS, Allen AW, Johnson JC et al (1979) Cystoid macular edema in aphakic and
pseudophakic eyes. The Miami study group. Am J Ophthalmol 88: 45–48
Jaffe NS, Light DS (1966) Vitreous changes produced by cataract surgery: A study of 1058
aphakic eyes. Arch Ophthalmol 76: 541–553
Jaffe NS (1967) Vitreous traction at the posterior pole of the fundus due to alterations in the
vitreous posterior. Tr Am Acad Ophth Otol 71: 642–652
Jampel HD, Brown A, Roberts A et al (1992) Effect of paracentesis upon the blood-aqueous
barrier of cynomolgus monkeys. Invest Ophthalmol Vis Sci 33: 165–171
Jampol LM (1985) Pharmacologic therapy of aphakic and pseudophakic cystoid macular
edema. 1985 update. Ophthalmology 92: 807–810
Jampol LM (1982) Pharmacologic therapy of aphakic cystoid macular edema; a review.
Ophthalmology 89: 891–897
Jonas JB, Kreissig I, Degenring RF (2003) Intravitreal triamcinolone acetonide for
pseudophakic cystoid macular edema. Am J Ophthalmol 136: 384–386
Kapusta MA, Chen JC, Lam WC (1996) Outcomes of dropped nucleus during
phacoemulsification. Ophthalmology 103: 1184–1187
Katzen LE, Fleischman JA, Trokel S (1983) YAG laser treatment of cystoid macular edema.
Am J Ophthalmol 95: 589–592
Kent D, Vinores SA, Compachiaro PA (2000) Macular oedema: the role of soluble mediators.
Br J Ophthalmol 84: 542–545
Kicova N, Bertelmann T, Irle S et al (2012) Evaluation of a posterior vitreous detachment: A
comparison of biomicroscopy, b-scan ultrasonography and optical coherence tomography to
surgical findings with chromodissection. Acta Ophthalmol 90: e264-8
Kraff MC, Sanders DR, Jampol LM et al (1985) Effect of an ultraviolet-filtering intraocular
lens on cystoid macular edema. Ophthalmology 92: 366–369
62.
63.
64.
65.
66.
67.
68.
69.
70.
71.
72.
73.
74.
75.
76.
77.
78.
79.
80.
81.
82.
83.
Kraff MC, Sanders DR, McGuigan L et al (1990) Inhibition of blood-aqueous humor barrier
breakdown with diclofenac: a fluorophotometric study. Arch Ophthalmol 108: 380–383
Krebs I, Brannath W, Glittenberg C et al (2007) Posterior Vitreomacular Adhesion: A
Potential Risk Factor for Exsudative Age-related Macular Degeneration? Am J Ophthalmol
144: 741–746
Kremer M, Baikoff G, Charbonnel B (1932) The release of prostaglandins in human aqueous
humour following intraocular surgery. Effect of indomethacin. Prostaglandins 23: 695–702
Krishna R, Meisler DM, Lowder CY et al (1998) Long-term follow-up of extracapsular
cataract extraction and posterior chamber intraocular lens implantation in patients with
uveitis. Ophthalmology 105: 1765–1769
Kumagai K, Ogino N, Furukawa M et al (2002) Vitrectomy for pseudophakic cystoid macular
edema. Nippon Ganka Gakkai Zasshi 106: 297–303
Kuppermann BD, Blumenkranz MS, Haller JA et al (2007) Randomized controlled study of
an intravitreous dexamethasone drug delivery system in patients with persistant macular
edema. Arch Ophthalmol 125: 309–317
La Heij EC, Hendrikse F, Kessels AG et al (2001) Vitrectomy results in diabetic macular
oedema without evident vitreomacular traction. Graefe’s Arch Clin Exp Ophthalmol 239:
264–270
Lanzetta P, Menchini U, Virgili G et al (1998) Scleral fixated intraocular lenses: an
angiographic study. Retina 18: 515–520
Lardenoye CWTA, van Schooneveld MJ, Treffers WF et al (1998) Grid laser
photocoagulation for macular oedema in uveitis or the Irvine-Gass syndrome. Br J
Ophthalmol 82: 1013–1016
Lobo CL, Faria PM, Soares MA et al (2004) Macular alterations after small incision cataract
surgery. J Cataract Refract Surg 30: 752–760
Lobo C (2012) Pseudophakic cystoid macular edema. Ophthalmologica 227: 61-67
Löwenstein A, Zur D (2010) Postsurgical cystoid macular edema. Dev Ophthalmol 47: 148–
159
Martinez MR, Ophir A (2011) Pseudophakic cystoid macular edema associated with
extrafoveal vitreoretinal traction. Open Ophthalmol J 5: 35–41
Mennel S, Meyer CH, Schmidt JC (2011) The role of the vitreous in the pathogenesis of agerelated macular degeneration. Klin Monatsbl Augenheilkd 228: 460–464
Metge P, Bonnefoy-Mandirac C, Chauvet G (1983) Barriere hemato-aqueuse et syndrome
d’Irvine Gass. Bull Soc Opht France 1: 145–148
Michels RG, Green WR, Maumeree AE (1971) Cystoid macular edema following cataract
extraction (the Irvine-Gass syndrome): a case studied clinically and histopathologically.
Ophthalmic Res 2: 217–221
Milch FA, Yannuzzi LA (1987) Medical and surgical treatment of aphakic cystoid macular
edema. Int Ophthalmol Clin 27: 205–217
Miyake K, Ibakari N (2002) Prostaglandins and cystoid macular edema. Surv Ophthalmol 47
(Suppl 1): 203–218
Miyake K, Masuda K, Shirato S et al (2000) Comparison of diclofenac and fluorometholone
in preventing cystoid macular edema after small incision cataract surgery: a multicentered
prospective trial. Jpn J Ophthalmol 44: 58–67
Miyake K (1978) Prostaglandins as a causative factor of the cystoid macular edema after lens
extraction. Folia Ophthalmol Jpn 29: 447–450
Miyake Y, Miyake K, Shiroyama N (1993) Classification of aphakic cystoid macular edema
with focal macular electroretinograms. Am J Ophthalmol 116: 576–583
Moroi SE, Gottfredsdottir MS, Schteingart MT et al (1999) Cystoid macular edema associated
with latanoprost therapy in a case series of patients with glaucoma and ocular hypertension.
Ophthalmology 106: 1024–1029
84.
85.
86.
87.
88.
89.
90.
91.
92.
93.
94.
95.
96.
97.
98.
99.
100.
101.
102.
103.
104.
105.
106.
Neal RE, Bettelheim FA, Lin C et al (2005) Alterations in human vitreous humor following
cataract extraction. Exp Eye Res 80: 337–347
Nguyen QD, Tatlipinar S, Shah SM et al (2006) Vascular endothelial growth factor is a
critical stimulus for diabetic macular edema. Am J Ophthalmol 142: 961–969
Nicholls JVV (1956) Concurrence of macular edema with cataract extraction. Arch
Ophthalmol; 55: 595–604
Nicholls JVV (1954) Macular edema in association with cataract extraction. Am J
Ophthalmol 37: 665–672
Norton AL, Brown WJ, Carlson M et al (1975) Pathogenesis of aphakic macular edema. Am J
Ophthalmol 80: 96–101
Pendergast SD, Margherio RR, Williams GA et al (1999) Vitrectomy for chronic
pseudophakic cystoid macular edema. Am J Ophthalmol 128: 317–323
Peyman GA, Canakis C, Livir-Rallatos C et al (2002) The effect of internal limiting
membrane peeling on chronic recalcitrant pseudophakic macular edema: A report of two
cases. Am J Ophthalmol 133: 571–572
Pollack A, Leiba H, Bukelman A et al (1992) The course of diabetic retinopathy following
cataract surgery in eyes previously treated by laser photocoagulation. Br J Ophthalmol 76:
228–231
Radetzky S, Walter P, Fauser S et al (2004) Visual outcome of patients with macular edema
after pars plana vitrectomy and indocyanine green assisted peeling of the internal limiting
membrane. Graefe’s Arch Clin Exp Ophthalmol 242: 273–278
Ray S, Damico DJD (2002) Pseudophakic cystoid macular edema. Semin Ophthalmol 17:
167–180
Reese AB, Jones IS, Cooper WC (1966) Macular changes secondary to vitreous traction. Tr
Am Ophth Soc 64: 123–134
Reis A, Birnbaum F, Hansen LL et al (2007) Successful treatment of cystoid macular edema
with valdecoxib. J Cataract Refract Surg 33: 682–685
Rho DS (2003) Treatment of acute pseudophakic cystoid macular edema: Diclofenac versus
ketorolac. J Cataract Refract Surg 29: 2378–2384
Rossetti L, Autelitano A (2000) Cystoid macular edema following cataract surgery. Curr Opin
Ophthalmol 11: 65–72
Rowen S (1999) Preoperative and postoperative medications used for cataract surgery. Curr
Opin Ophthalmol 10: 29–35
Ruiz RS, Saatci OA (1991) Visual outcome in pseudophakic eyes with clinical cystoid
macular edema. Ophthalmic Surg 22: 190–193
Runkle EA, Antonetti DA (2011) The blood-retinal barrier: Structure and functional
significance. In: The blood-brain and other neural barriers: Reviews and Protocols, Methods
in molecular Biology (Hrsg: Sukriti N) Humana Press, Springer Science, New York
Schepens CL, Avila MP, Jalkh AE et al (1984) Role of the vitreous in cystoid macular edema.
Surv Ophthalmol 28: 499–504
Schepens CL(1955) Fundus changes caused by alterations of the vitreous body. Am J
Ophthalmol 39: 631–635
Scholl S, Kirchhof J, Augustin AJ (2010) Pathophysiology of macular edema.
Ophthalmologica 224 (Suppl 1): 8–15
Schubert HD (1989) Cystoid macular edema: the apparent role of mechanical factors. In: The
ocular effects of prostaglandins and other eicosanoids (Hrsg: Bito LZ, Stjernschantz J) S.
277–291. Wiley,
Schulze S, Hoerle S, Mennel S et al (2008) Vitreomacular traction and exsudative age-related
macular degeneration. Acta Ophthalmol 86: 470–481
Sebag J (1992) Anatomy and pathology of the vitreo-retinal interface. Eye 6: 541–552
107. Sebag J, Balzac EA (1984) Pathogenesis of cystoid macular edema: an anatomic
consideration of vitreoretinal adhesion. Surv Ophthalmol 28: 493–498
108. Shelsta HN, Jampol LM (2011) Pharmacologic therapy of pseudophakic cystoid macular
edema. 2010 update. Retina 31: 4–12
109. Solomon LD (1995) Efficiacy of topical flubiprofen and indomethacin in preventing
pseudophakic cystoid macular edema. Flubiprofen-CME Study Group I. J Cataract Refract
Surg 21: 73–81
110. Spitzer MS, Ziemssen F, Yoeruek E et al (2008). Efficiacy of intravitreal bevacizumab in
treating postoperative pseudophakic cystoid macular edema. J Cataract Refract Surg 34: 70–
75
111. Stark WJ Jr, Maumenee AE, Fagadau W et al (1984) Cystoid macular edema in
pseudophakia. Surv Ophthalmol 28 (Suppl ): 442-451
112. Stefánsson E (2009) Physiology of vitreous surgery. Graefe’s Arch Clin Exp Ophthalmol 247:
147–163
113. Steinert RF, Wasson PJ (1989) Neodynium YAG laser anterior vitreolysis for Irvine-Gass
cystoid macular edema. J Cataract Refract Surg 15: 304–307
114. Stern AL, Taylor DM, Dalburg LA et al (1981) Pseudophakic cystoid maculopathy: a study of
50 cases. Ophthalmology 88: 942–946
115. Suttorp-Schulten MS, Riemslang FC, Rothova A et al (1997) Long-term effect of repeated
hyperbaric oxygen therapy on visual acuity in inflammatory cystoid macular edema. Br J
Ophthalmol 81: 329
116. Tach AB, Dugel PU, Flindall RJ et al (1997) A comparison of retrobulbar versus sub-Tenon’s
corticosteroid therapy for cystoid macular edema refractory to topical medications.
Ophthalmology 104: 2003–2008
117. Taylor DM, Sachs SW, Stern AL (1984) Aphakic cystoid macular edema. Longterm clinical
observations. Surv Ophthalmol 28: 437–441
118. Thomas MA, O’Grady GE, Swartz SL (1985) Prostaglandin levels in human vitreous. Br J
Ophthalmol 69: 275–279
119. Tolentino FI, Schepens CL (1965) Edema of posterior pole after cataract extraction. Arch
Ophthalmol 74: 781–786
120. Tranos PG, Wickremasinghe SS, Stangos NT et al (2004) Macular edema. Surv Ophthalmol
49: 470–490
121. Ursell PG, Spalton DJ, Whitcup SM et al (1999) Cystoid macular edema after
phacoemulsification: relationship to blood-aqueous barrier damage and visual acuity. J
Cataract Refract Surg 25: 1492–1497
122. Vinores SA, Derevjanik NL, Ozaki H et al (1999) Cellular mechanisms of blood retinal
barrier dysfunction in macular edema. Doc Ophthalmol 97: 217–228
123. Wand M, Gaudio AR (2002) Cystoid macular edema associated with ocular hypotensive
lipids. Am J Ophthalmol 133: 403–405
124. Weisz JM, Bressler NM, Bressler SB et al (1999) Ketorolac treatment of pseudophakic
cystoid macular edema identified more than 24 months after cataract extraction.
Ophthalmology 106: 1656–1659
125. Welch RB, Cooper JC (1958) Macular edema, papilledema, and optic atrophy after cataract
extraction. Arch Ophthalmol 59: 665–675
126. Williams GA, Haller JA, Kuppermann BD et al (2009) Dexamethasone posterior-segment
drug delivery system in the treatment of macular edema resulting from uveitis or Irvine-Gass
syndrome. Am J Ophthalmol 147: 1048–1054
127. Winslow RL, Taylor BC, Harris WS (1978) A one-year follow-up of cystoid macular edema
following intraocular lens implantation. Ophthalmology 85: 190–196
128. Wolter JR (1981) Cystoid macular edema in vitreo-retinal traction. Ophthalmic Surg 12: 900–
904
129. www.wikipedia.org
130. Young PW, Shea M (1980) Pars plana vitrectomy in the management of the Irvine-Gass
syndrome. Can J Ophthalmol 15: 172–175
131. Bertelmann T, Witteborn MCP, Mennel S (2012) Das pseudophakiebedingte zystoide
Makulaödem. Klin Monatsbl Augenheilkd 229: 798-811