CURRICULUM VITAE
Personal Data
Name:
Niall S. Kenneth PhD
Position:
Research Investigator
Address:
Pathology Department
North Campus Research Complex
Building 520
Huron Parkway
Ann Arbor, MI.
48109-2800
Tel:
734-615-1902 (lab) 734-489-2856 (cell)
Email:
niallk@umich.edu
Nationality: British
Education
1997 – 2002 BSc (hons) 1st Class Biochemistry, University of Dundee, United Kingdom
2002 – 2006 PhD Biochemistry and Molecular Biology, University of Glasgow, United
Kingdom
Research Experience
2000 – 2001 Internship 1 Year placement in industry, gaining experience in setting up
high throughput screens to develop novel therapeutics.
AstraZeneca, Cancer and Infection Department, Alderly Edge, UK.
2002 – 2006 Graduate Student Identifying co-activator proteins required for the
activation of RNA-polymerase III transcription by c-Myc.
Advisor – Professor Robert J White, Institute of Biomedical and Life
Sciences, University of Glasgow, UK.
2007 – 2010 Post-Doctoral Research Fellow Investigating the interplay between the
Nuclear Factor-kappaB (NF-B) and the Hypoxia Inducible Factor (HIF)
transcription factors in response to different activating stimuli.
Advisor – Dr Sonia Rocha, Wellcome Centre for Gene Regulation and
Expression, University of Dundee, UK.
2010 –
Post-Doctoral Research Fellow/ Research Investigator Defining the roles
of the Inhibitor of Apoptosis (IAP) proteins in the regulation of NF-B
transcription.
Advisor – Dr Colin S Duckett, Department of Pathology, University of
Michigan, Ann Arbor, MI, USA.
Teaching Experience
2002 – 2006 Undergraduate Teaching Assistant Assisted in the practical laboratory
classes for undergraduates in Genetics, Molecular Biology and
Biochemistry.
Institute of Biomedical and Life Sciences, University of Glasgow, UK.
2007- 2010 Post Doctoral Research Fellow Co-supervised undergraduate and
graduate students in various research projects.
Wellcome Trust Centre for Gene Regulation and Expression, University of
Dundee, UK.
2011
Postdoctoral Short-Course on College Teaching in Science and
Engineering Completed this course, as part of a select group of thirtytwo advanced Postdoctoral Scholars, to teach effectively as future faculty
members.
Center for Research on Learning and Teaching (CRLT), University of
Michigan, USA.
Reviewing Activities
In the past 24 months I have reviewed manuscripts for Molecular Cell, Cell Death and
Differentiation, Biochemical Journal and FEBS Letters
Publications
1. Felton-Edkins ZA, Kenneth NS, Brown TR, Daly NL, Gomez-Roman N, Grandori C,
Eisenman RN, White RJ. Direct regulation of RNA polymerase III transcription by
RB, p53 and c-Myc. Cell Cycle. 2003 May-Jun;2(3):181-4. 12734418
2. Fairley JA, Kantidakis T, Kenneth NS, Intine RV, Maraia RJ, White RJ. Human La is
found at RNA polymerase III-transcribed genes in vivo. Proc Natl Acad Sci U S A.
2005 Dec 20;102(51):18350-5. 16344466
3. Ernens I, Goodfellow SJ, Innes F, Kenneth NS, Derblay LE, White RJ, Scott PH.
Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene
transcription in cardiomyocytes. Nucleic Acids Res. 2006 Jan 10;34(1):286-94.
16407335
4. Gomez-Roman N, Felton-Edkins ZA, Kenneth NS, Goodfellow SJ, Athineos D,
Zhang J, Ramsbottom BA, Innes F, Kantidakis T, Kerr ER, Brodie J, Grandori C,
White RJ. Activation by c-Myc of transcription by RNA polymerases I, II and III.
Biochem Soc Symp. 2006;(73):141-54. 16626295
5. Kenneth NS, Ramsbottom BA, Gomez-Roman N, Marshall L, Cole PA, White RJ.
TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription.
Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14917-22. 17848523
6. van Uden P*, Kenneth NS*, Rocha S. Regulation of hypoxia-inducible factor1alpha by NF-kappaB Biochem J. 2008 Jun 15;412(3):477-84. 18393939 (* - Joint
first author)
7. Kenneth NS, Marshall L, White RJ. Recruitment of RNA polymerase III in vivo.
Nucleic Acids Res. 2008 Jun;36(11):3757-64. 18487626
8. Kenneth NS, Rocha S. Regulation of gene expression by hypoxia. Biochem J. 2008
Aug 15;414(1):19-29. 18651837
9. Kenneth NS, Mudie S, van Uden P, Rocha S. SWI/SNF regulates the cellular
response to hypoxia. J Biol Chem. 2009 Feb 13;284(7):4123-31. 19097995
10. Kenneth NS, White RJ. Regulation by c-Myc of ncRNA expression. Curr Opin
Genet Dev. 2009 Feb;19(1):38-43. 19179065
11. Kenneth NS, Mudie S, Rocha S. IKK and NF-kappaB-mediated regulation of
Claspin impacts on ATR checkpoint function. EMBO J. 2010 Sep 1;29(17):296678. 20657549
12. Newton IP, Kenneth NS, Appleton PL, Näthke I, Rocha S. Adenomatous polyposis
coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection. Mol
Biol Cell. 2010 Nov 1;21(21):3630-8. 20844082
13. van Uden P, Kenneth NS, Webster R, Müller HA, Mudie S, Rocha S. Evolutionary
conserved regulation of HIF-1β by NF-κB.
PLoS Genet. 2011 Jan
27;7(1):e1001285. 21298084
14. Fairley JA, Mitchell LE, Berg T, Kenneth NS, von Schubert C, Silljé HH, Medema
RH, Nigg EA, White RJ. Direct regulation of tRNA and 5S rRNA gene transcription
by Polo-like kinase 1. Mol Cell. 2012 Feb 24;45(4):541-52.
15. Kenneth NS, Younger JM, Hughes ED, Marcotte D, Barker PA, Saunders TL,
Duckett CS. An inactivating caspase 11 passenger mutation originating from the
129 murine strain in mice targeted for c-IAP1. Biochem J. 2012 Apr
15;443(2):355-9. 22332634
16. Kenneth NS, Mudie S, Naron S, Rocha S. TfR1 interacts with the IKK complex and
is involved in IKK-NF-κB signalling. Biochem J. 2013 Jan 1;449(1):275-84.
23016877
17. Kenneth NS, Duckett CS. IAP proteins: regulators of cell migration and
development. Curr Opin Cell Biol. 2012 Dec;24(6):871-5. 23219152
18. Hucks GE*, Kenneth NS*, Kocab AJ, McCollom AL, Duckett CS. Copper is a
potent inhibitor of the canonical and non-canonical NF-kappaB pathways.
Biochem J. In review. (*-joint first author).