Supplementary Figures Captions
Supplementary Figure S1. Appetite drive (in a 10min period) in the novelty suppressed feeding test.
Error bars denote SEM. *P<0.05, **P<0.01, ***P<0.001; n=10 to 15 per group.
Supplementary Figure S2. Average swimming velocity in the water maze trials. Error bars denote
SEM. *P<0.05, **P<0.01, ***P<0.001; n=10 to 15 per group.
Supplementary Figure S3. MAM effect on weight variation. Error bars denote SEM. *P<0.05,
**P<0.01, ***P<0.001; n=10 to 15 per group.
Supplementary Figure S4. Closed-arms entries in EPM test. Error bars denote SEM. *P<0.05,
**P<0.01, ***P<0.001; n=10 to 15 per group.
Supplementary Figure S5. Latency to immobility in FST. Error bars denote SEM. *P<0.05,
**P<0.01, ***P<0.001; n=10 to 15 per group.
Supplementary Figure S6. Performance on memory acquisition trials on the 4 days preceding the behavioral flexibility test (5th day). (a) Depicts the effect of MAM in memory acquisition performance of control and uCMS rats; (b) depicts the ADs effect; (c) depicts the effect of MAM co-administration along with ADs. Error bars denote SEM. *P<0.05, **P<0.01, ***P<0.001; n=10 to 15 per group.
Supplementary Figure S7. Effects of MAM on density and morphology of spines from newborn neurons. (a) Effect of MAM administration on spine density in newborn neurons (Golgi/BrdU
+ cells); (b) MAM administration mimics the increase of thin spines produced by uCMS exposure, which is reversed by ADs administration. Error bars denote SEM.
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*P<0.05,
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**P<0.01,
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***P<0.001; n=10 to 15 per group.