1
MICROBAN OVERVIEW
Cipherlab Co. Ltd
August 3rd 2010
2
Agenda
Overview of Microban.
•
Microban Overview: Who we are and what we do.
•
Microban Value Proposition: How Microban creates value for its partners.
Why use Microban additives?
•
Microban Technology: Choice of antimicrobial / test methods / How
antimicrobials function: What are the benefits?
•
3
Microban Support: How we help our partners.
MICROBAN OVERVIEW
4
Microban International, Ltd.
Microban is the world’s leading provider of safe, durable and effective built-in
antibacterial solutions.
Microban Americas
 Charlotte, USA
 Montreal, Canada
 Sao Paulo, Brazil
 Mexico City, Mexico
Microban Europe
 Cannock, U.K.
 Frankfurt, Germany
 Milan, Italy
 Barcelona, Spain
Microban Asia Pacific
 Hong Kong
 Shenzhen, China
5
Microban Manufacturing & Warehousing Footprint
Microban supports customers on a regional level with local manufacturing and
export of its additive systems, and is expanding its manufacturing base to Asia.
North America
 Charlotte, USA
(Polymers & Formulations)
 Export to EU, Central &
South America, and Asia
(Polymers & Formulations)
Europe

Liverpool, U.K. (Polymers)
Asia Pacific
 Hong Kong – Warehouse
(Polymers & Formulations)
 Shenzhen, China
(Polymers)
6
BUILT-IN TO MORE THAN
750 PRODUCTS
BY OVER
150 LEADING MANUFACTURERS
AROUND THE WORLD
7
Microban Partners - Selection
Microban is privileged to help these and other industry-leading companies around the world
improve and differentiate their products.
8
Our impressive reach towards consumers
Microban – we are up to the challenge
 In the Home
 Hospitals, Clinics, Surgeries
 Hotel, Restaurants, Catering Venues
 Offices, Waiting Rooms, Care Homes
 Supermarkets, Shopping Centres
 Other Public Venues
 Airports, Public Transport Venues
 Gyms, Leisure, Pools & Spa Centres
 Museums, Schools, Universities
and, we are looking at new areas all of the time...
9
Example product materials we already treat
10
MICROBAN VALUE PROPOSITION
11
Microban Value Proposition
We help our partners strengthen their businesses by creating a valuable point-ofdifferentiation for their products through a compelling ingredient brand.
For companies trying to strengthen their businesses and address core business challenges.
Microban represents an alternative business strategy that brings value by providing a compelling
and enduring point of product differentiation …
And we do this by providing a complete ingredient brand solution including:
• The leading antimicrobial brand
• Innovative technical solutions
• Patent protection (when available)
• Regulatory support
• Ingredient branding marketing expertise
12
The power of Microban ingredient branding
Since 1996, Microban have been driving consumer product sales through
innovation, improved quality, product longevity & enhanced consumer appeal
13
•
Extend Product Life – The life of a product will
be extended when using Microban – we restrict
typical microbial and fungal degradation
•
Visible Cleanliness – Product cleanliness is
improved with our antimicrobial and / or antifungal
solution
•
Invisible Cleanliness – Microbes are invisible.
Their growth is proven to be significantly
controlled by Microban technology
•
Odour Reduction – Microbes can cause noxious
odours. Using Microban naturally reduces odours
and improves product appeal for consumers
MICROBAN TECHNOLOGY
14
Microban Technology
•
Plastics
– Antimicrobial is incorporated during extrusion for thermoplastics or by addition to
liquid resin for thermosets
– Full range of plastics, from polyolefins to polystyrenes and polycarbonate to
unsaturated polyesters and acrylics
•
Textiles
– Incorporated via standard textile processes such as the dye bath or in surface
finishes such as softeners and permanent press finishes
•
Coatings
– Mixed with latex or solvent-based resins
– Addition rates into the coating depend on the application rate of the coating on
the substrate
•
Ceramics
– Secondary glaze on tile surfaces
•
Metals
– Epoxy powder coatings or nickel / chrome electroplating
15
Choice of Antimicrobial
The available choices for antimicrobials will depend on:
•
Efficacy desired
– Antibacterial
– Anti-fungal
•
Processing
– Process conditions, particularly temperature
– Materials used for part
•
•
•
Properties desired (e.g, clarity)
Cost
Regulatory approvals
– Approval for specific use
– Food & water contact approvals, if needed for water.
– Approved use limits
16
Benefit – Improved Cleanliness
2 log reduction in average CFUs
No of swabs / count range
40
- Treated boning knives
- Untreated boning knives
35
30
25
20
Reduction in samples with high levels of contamination
15
10
5
0
<103
Total Viable Count cfu/swab
<109
Results from field study conducted in Sainsbury food preparation facilities. Sainsbury is a major British
supermarket chain.
• Does not necessarily lead to sterile surfaces
• Provides continuous action as compared to disinfection
• Does not readily transfer to skin, food, or other contact surfaces
17
Average bioburden wo/ cleaning
Average bioburden w/ cleaning
0
2
4
6
8
10
12
14
Over a 24 Hour Period
18
Clean & disinfect
Clean & disinfect
Level of Bioburden on Product Surface
Effect of Disinfection
16
18
20
22
24
Average bioburden
wo/ cleaning
Average Bioburden w/antimicrobial
0
2
4
6
8
10
12
14
Over a 24 Hour Period
19
Additional “dirt”
Additional “dirt”
Additional “dirt”
Additional “dirt”
Level of Bioburden on Product Surface
Effect of Antimicrobial Treatment
16
18
20
22
24
Level of Bioburden on Product Surface
Antimicrobial Treatment vs. Disinfection
Average Bioburden w/o cleaning
Average Bioburden – w/ Disinfectants
Average Bioburden w/ Antimicrobials
0
2
4
6
8
10
12
14
16
Over a 24 Hour Period
Disinfectants
Microban® Antimicrobial Technology
20
18
20
22
24
Microban Efficacy Demonstration
Unprotected Surface
2 hours
16 hours
20 hours
24 hours
20 hours
24 hours
Surface with Microban® Antimicrobial Protection
2 hours
16 hours
This information is based upon standard laboratory tests and is provided for comparative purposes to substantiate antimicrobial
activity for non-public health applications. Microban technology is not designed to replace good hygiene practices or protect users
21 disease causing microorganisms. Antimicrobial action limited to product surface.
from
Antibacterial Test Methods
Qualitative Test Method
•
3 main methods covering bacterial and Fungal resistance.
–
AATCC TM 30 pt III (plastics materials – Fungal growth)
–
AATCC TM 147 (bacterial test method mainly for textile materials)
–
Kirby Bauer / Zone Diffusion (plastics materials – bacterial growth)
•
Results expressed as a Zone of Inhibition or measurement of inhibition area (mm).
•
Observations are also noted for Surface growth (fungal tests) and graded according to
% coverage
•
Qualitative test methods show a product is able to inhibit the growth of the test organism
(bacteriostatic or fungistatic activity)
22
Antibacterial Test Method Summary
Quantitative Test Method
•
•
Two main standards employed :
–
ISO 22196 / JIS Z 2801 (Japanese Industrial standard)
–
AATCC TM 100
Results expressed as a % reduction value and Log Kill e.g. 99.9% = 3 Log reduction
after recovery of viable organisms following a 24hr period.
–
Samples results are expressed verses the initial population of bacteria or verses untreated
control (when available)
•
Quantitative test methods show a product is able to actively kill the test organism
(bactericidal or fungicidal activity)
–
23
Results obtained will also distinguish between bacteriostatic and bactericidal activity.
Antibacterial Microban Actives: Mode of Action
Cationic
CHLOROPHENOXY
Metal
Zinc
Pyrithione
ions
Antimicrobials
Based
ANTIMICROBIALS
• Antimicrobials
Copper
Disrupts
or
ion
Silver
transport
ions
gradients
with
across
theion
the
thiolcell
(-SH)
• combine
Multiple routes
Disrupts
normal
groups in gradients,
membrane
amino
interfering
acidswith
and
transport
• Combine
with
disrupt enzyme
cellular
respiration
catalysis
interfering
with nutrient
protein/enzyme
amino
and function
and energy
• intake
React
with
enzymatic
acids and disrupt the
production.
Metal ions in
functional
groups
cellular functions
the cell are chelated and
• transported
Disrupt cell membrane
out of the cell
integrity causing loss of ion
transport gradients
• Triclosan blocks lipid
biosynthesis and prevents
formation of vital
membrane fatty acids
24
Claims Overview
• Claims will be developed based on laboratory substantiation of
bacteriostatic/bacterocidal and/or fungistatic/fungicidal efficacy.
• In addition, claims will be formulated based on one or more of the
following key functional benefits provided by Microban protection.
– Invisible Cleanliness
– Visible Cleanliness
– Odour Control
– Product Degradation
• Microban antimicrobial technologies are designed to provide durable
antimicrobial protection. Lifetime durability claims may be used with
the appropriate substantiating data.
25
Case Study: Cosentino®
The makers of Silestone® countertops embraced Microban protection to
differentiate their product from other quartz surfaces and to steal share from
other countertop surface materials.
Primary Objective
•
To differentiate Silestone® from granite and other countertop
materials to generate demand and justify premium price.
Actions
•
Launched worldwide across their entire product line and
supported with heavy media (T.V. advertising at prime time
on Spanish and Portuguese channels) and pan European
consumer print campaigns.
•
Sponsorship of Fernando Alonso Formula One driver
supported by TV advertising on Spanish and Portuguese
channels.
Results
•
•
26
Major growth across Europe leading to 9 new sales offices
and 3 distribution warehouses opening.
Extension of product diversity from kitchen countertops to
public space interior design.
Application example: Hospital Design
Infection risk control – protecting buildings
27
•
1. Walls
•
2. Beds and
curtains
•
3. Blinds
•
4. High contact
surfaces
•
5. Flooring
•
6. Switches and
controls
•
7. Wet
environments
•
8. Computer
equipment and
reception areas
Case Study: WHIRLPOOL®
Whirlpool embraced Microban to enhance their appliances features and is
currently broadening the range of treated components across the product
Primary Objective
•
To enhance Whirlpool appliances with a range of
antibacterial features.
Action
•
Whirlpool have introduced a special air filter
device in the refrigerators which incorporates
Microban antibacterial technology.
•
Following its success, the Microban technology
has been extended to additional areas within the
refrigeration project and also across the product
mix (dishwashers and washing machines) within
the Whirlpool and Bauknecht brands.
Results
•
Significant differentiation achieved and
communicated to Whirlpool customers.
•
Market surveys showing a remarkably high
percentage of Whirlpool customers find the
treatment appealing and innovative.
28
MICROBAN SUPPORT
29
The Microban Solution
Microban provides a turnkey, ingredient branding solution, that ranges from a
technical solution through the use of the Microban brand.
30
Technical Support
Microban provides industry-leading technical services to ensure that partners get
a customised technical solution that best meets their unique product.
•
Expert research and development – dedicated staff of
engineers, microbiologists and analytical chemists.
•
The only antimicrobial solutions provider that offers over
20 different antimicrobial technologies under a single
umbrella brand.
•
One of the most advanced antibacterial laboratories in
the world.
• Bacterial and fungal microbiology laboratories
on-site at HQ in North Carolina.
• Capacity to manage all of our partners’ testing
needs. Microban micro lab completes over 30,000
tests annually.
• Close liaison with independent testing laboratories
across Europe.
• Privileged to be conducting cutting edge
antimicrobial product development for the US
Department of Defence.
31
HEALTHCARE RESEARCH
32
Healthcare Research
97% of healthcare professionals are concerned about the
presence of microbes (such as bacteria, mold and mildew)
in their healthcare facilities.
33
Healthcare Research
79% of patients are concerned about the presence of
bacteria when at a hospital.
34
Patient room products / medical devices
From initial patient and healthcare provider
research Microban has identified key areas of
contamination within patient rooms
This research is being supported by a patient room
swab study within Presbyterian Hospital
Huntersville, USA to confirm highly contaminated
products - “hot spots”
Microban is currently in dialogue with
manufacturers of ‘hot spot’ products and more than
half have expressed a high level of interest in
engaging with Microban on a project
35
Patent Protection
With one of the strongest antimicrobial patent positions in the world, Microban
helps its partners create competitive barriers where possible.
36
•
163 patent applications and 42 issued patents protecting
the use of Microban® antimicrobials in various end
products help provide effective barriers to entry by your
competitors.
•
In-house patent attorney surveys patent landscape at
the outset of the project to determine areas of
opportunity for patent protection.
• Protects our partners from infringing on 3rd party’s
rights as well.
•
Proactive patent stance enables us to preserve our
partner’s exclusivity and provide market leverage.
Regulatory Support
Microban regulatory helps partners quickly secure the necessary approvals to
hasten product launches, and ensures aggressive claim compliance.
37
•
In-house VP, Regulatory Affairs with over 20 years of regulatory and
toxicology experience provides partners with unmatched expertise.
•
Former EPA Director is a member of the Microban Board who provides
on-going advice.
•
Washington & Brussels – based regulatory consulting / law firms support
Microban and its partners on a regular basis.
•
Experience working with international regulatory authorities to ensure
compliance on a global basis.
• US - EPA, FDA
- EU - ECHA
• Canada – PMRA
- Australia - AVMPA
• Mexico – Cicoplafest
- UK – HSE
•
Facilitate third part approvals with agencies such as NSF and TUV.
MARKETING SUPPORT
38
Microban Marketing Support
39
• Claims Development
• Sales Training
• Packaging Development
• Microban Website
• Point of Sale Development
• Microban Collateral
• Market Research
• Customer Specific Programmes
• Press Releases
• Website Development
Microban Partner Advertising
40
Healthcare microsite
www.microban.com/partnersites/microban-medical
41
Microban website
World-wide coverage
with direct link to
partner website
42
Microban support literature
Generic, customized and
multilingual – designed for events,
press packs and trade shows
43